DK1048668T3 - Fremgangsmåde til fremstilling af riboflavinholdige spraygranulater - Google Patents

Fremgangsmåde til fremstilling af riboflavinholdige spraygranulater

Info

Publication number: DK1048668T3
Authority: DK; Denmark
Prior art keywords: spray drying; riboflavin; drying process; spray granules; containing spray
Prior art date: 1999-04-30

Application number

DK00108560T

Other languages

English (en)

Inventor

Markus Nowotny

Jean-Claude Tritsch

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-30

Filing date

2000-04-19

Publication date

2003-05-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8238078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1048668(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-04-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-05-26 Application granted granted Critical

2003-05-26 Publication of DK1048668T3 publication Critical patent/DK1048668T3/da

Links

AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 6
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title abstract 3
229960002477 riboflavin Drugs 0.000 title abstract 3
235000019192 riboflavin Nutrition 0.000 title abstract 3
239000002151 riboflavin Substances 0.000 title abstract 3
239000008187 granular material Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000007921 spray Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 4
238000001694 spray drying Methods 0.000 abstract 3
239000013078 crystal Substances 0.000 abstract 2
239000007900 aqueous suspension Substances 0.000 abstract 1
230000009969 flowable effect Effects 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
- C07D475/14—Benz [g] pteridines, e.g. riboflavin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK00108560T 1999-04-30 2000-04-19 Fremgangsmåde til fremstilling af riboflavinholdige spraygranulater DK1048668T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99108476		1999-04-30

Publications (1)

Publication Number	Publication Date
DK1048668T3 true DK1048668T3 (da)	2003-05-26

Family

ID=8238078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00108560T DK1048668T3 (da)	1999-04-30	2000-04-19	Fremgangsmåde til fremstilling af riboflavinholdige spraygranulater

Country Status (16)

Country	Link
US (1)	US6723346B1 (da)
EP (1)	EP1048668B2 (da)
JP (1)	JP4965013B2 (da)
KR (1)	KR100720202B1 (da)
CN (1)	CN1198595C (da)
AT (1)	ATE231864T1 (da)
AU (1)	AU770320B2 (da)
BR (1)	BR0002390A (da)
CA (1)	CA2306502A1 (da)
DE (1)	DE60001286T3 (da)
DK (1)	DK1048668T3 (da)
ES (1)	ES2189711T5 (da)
ID (1)	ID25698A (da)
MX (1)	MXPA00004185A (da)
NO (1)	NO318219B1 (da)
TW (1)	TWI253347B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0219815D0 (en) *	2002-08-24	2002-10-02	Accentus Plc	Preparation of small crystals
DE10317051A1 (de) *	2003-04-11	2004-10-21	Basf Ag	Verfahren zur Herstellung von Riboflavin der Modifikation B/C in Granulatform
EP1670799B1 (en) *	2003-07-22	2009-09-09	DSM IP Assets B.V.	Process for the purification of riboflavin
US8689459B2 (en) *	2006-12-07	2014-04-08	Friesland Brands B.V.	Method and apparatus for spray drying and powder produced using said method
CN104961740B (zh) *	2015-06-02	2016-04-27	湖北广济药业股份有限公司	一种含核黄素的固体制剂及其制备方法
EP3876912B1 (en)	2018-11-07	2023-04-19	DSM IP Assets B.V.	Medicaments containing riboflavin exhibiting improved flowability

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3882466T2 (de) *	1987-09-18	1993-11-11	Hoffmann La Roche	Neue Form des Riboflavins.
DE3819745A1 (de) *	1988-06-10	1989-12-14	Basf Ag	Verfahren zur herstellung von auf mikrobiellem wege hergestelltem riboflavin in form von sprueh- oder mikrogranulaten
JP2634285B2 (ja) *	1989-03-28	1997-07-23	積水化学工業株式会社	放射性物質取扱所の被覆材用非灰分性樹脂組成物
DE3927810A1 (de)	1989-08-23	1991-02-28	Basf Ag	Riboflavingranulate
US4994458A (en) *	1990-04-30	1991-02-19	Basf Corporation	Process for rotary fluid bed granulation of riboflavin
US5236920A (en) *	1990-04-30	1993-08-17	Basf Corporation	Granulated riboflavin product having high flowability, high riboflavin content
DE4014262A1 (de)	1990-05-04	1991-11-07	Basf Ag	Gut rieselfaehige, nichtstaubende bindemittelfreie riboflavinspruehgranulate oder -mikrogranulate aus reinem riboflavin und ein verfahren zu deren herstellung
US5000888A (en) *	1990-05-23	1991-03-19	Basf Corporation	Process for spray drying riboflavin to produce a granulate product having low binder content
JP2000112883A (ja) *	1998-09-24	2000-04-21	Internatl Business Mach Corp <Ibm>	情報処理方法、情報処理装置、情報処理プログラムを格納する記憶媒体
CA2282908A1 (en)	1998-10-19	2000-04-19	F. Hoffmann-La Roche Ag	Purification and crystallization process for riboflavin
US6093715A (en) *	1999-03-24	2000-07-25	Basf Aktiengesellschaft	Process for producing riboflavin-containing granules

2000
- 2000-04-17 US US09/550,971 patent/US6723346B1/en not_active Expired - Lifetime
- 2000-04-19 DE DE60001286T patent/DE60001286T3/de not_active Expired - Lifetime
- 2000-04-19 ES ES00108560T patent/ES2189711T5/es not_active Expired - Lifetime
- 2000-04-19 DK DK00108560T patent/DK1048668T3/da active
- 2000-04-19 AT AT00108560T patent/ATE231864T1/de not_active IP Right Cessation
- 2000-04-19 EP EP00108560A patent/EP1048668B2/en not_active Expired - Lifetime
- 2000-04-20 CA CA002306502A patent/CA2306502A1/en not_active Abandoned
- 2000-04-26 ID IDP20000337A patent/ID25698A/id unknown
- 2000-04-26 TW TW089107796A patent/TWI253347B/zh not_active IP Right Cessation
- 2000-04-27 JP JP2000126926A patent/JP4965013B2/ja not_active Expired - Fee Related
- 2000-04-28 MX MXPA00004185A patent/MXPA00004185A/es unknown
- 2000-04-28 NO NO20002283A patent/NO318219B1/no unknown
- 2000-04-28 CN CNB001180525A patent/CN1198595C/zh not_active Expired - Fee Related
- 2000-04-28 KR KR1020000022706A patent/KR100720202B1/ko not_active Expired - Fee Related
- 2000-04-28 AU AU30189/00A patent/AU770320B2/en not_active Ceased
- 2000-04-28 BR BR0002390-6A patent/BR0002390A/pt active IP Right Grant

Also Published As

Publication number	Publication date
DE60001286T3 (de)	2010-10-28
CN1198595C (zh)	2005-04-27
ES2189711T5 (es)	2010-07-28
JP2000327562A (ja)	2000-11-28
ATE231864T1 (de)	2003-02-15
DE60001286D1 (de)	2003-03-06
ES2189711T3 (es)	2003-07-16
EP1048668A2 (en)	2000-11-02
US6723346B1 (en)	2004-04-20
KR100720202B1 (ko)	2007-05-21
MXPA00004185A (es)	2002-03-08
TWI253347B (en)	2006-04-21
NO20002283L (no)	2000-10-31
AU770320B2 (en)	2004-02-19
EP1048668B1 (en)	2003-01-29
EP1048668A3 (en)	2001-03-28
NO20002283D0 (no)	2000-04-28
CN1275375A (zh)	2000-12-06
EP1048668B2 (en)	2010-06-09
AU3018900A (en)	2000-11-02
BR0002390A (pt)	2000-10-31
ID25698A (id)	2000-11-02
DE60001286T2 (de)	2003-11-06
JP4965013B2 (ja)	2012-07-04
NO318219B1 (no)	2005-02-21
KR20010029668A (ko)	2001-04-06
CA2306502A1 (en)	2000-10-30

Similar Documents

Publication	Publication Date	Title
MX9200817A (es)	1992-08-01	Derivados de piranil cianoguanidina y proceso para su preparacion.
WO2000061568A3 (de)	2001-04-19	Mit zuckerresten substituierte 1,4-benzothiazepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DK0446913T3 (da)	1997-07-07	Fremgangsmåde til fremstilling af chlorthiazolderivater.
HUT64310A (en)	1993-12-28	Compositions containing substituted aryl-halogenalkyl-pyrazol derivatives having herbicidal activity and process for producing said compounds
FI102069B (fi)	1998-10-15	Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmist amiseksi
HUT62893A (en)	1993-06-28	Process for producing substituted pyrimidine derivatives and pharmaceutical compositions comprising such compounds as active ingredient
DE3863328D1 (de)	1991-07-25	Granuliertes produkt.
WO1992020649A3 (en)	1993-01-07	Substituted 2-carboxyindoles having pharmaceutical activity
NO20002283D0 (no)	2000-04-28	FremgangsmÕte ved fremstilling av spraygranuler inneholdende riboflavin
ES2147749T3 (es)	2000-10-01	Procedimiento para la preparacion de derivados de ciano-metoxiiminometilo.
DE60238056D1 (de)	2010-12-02	Verfahren zum kristallisieren von reduziertem coenzym q10 aus wässriger lösung
CN101421254B (zh)	2012-08-22	用双环基团n-取代的二氨基-1，3，5-三嗪、其制备方法、其组合物及其用作除草剂和植物生长调节剂的用途
DE69833951D1 (de)	2006-05-11	Verfahren zur herstellung von substituierten alkylaminen oder salzen davon
IS3855A (is)	1992-11-08	Aðferð til framleiðslu nýs sýkladrepandi efnasambands Thiomarinol, fengið með ræktun Alteromanas rava SANK 73390
HU0003991D0 (en)	2000-12-28	Serotonin-reuptake inhibitor ciano-indole derivatives, process for their preparation and pharmaceutical compositions containing them
DK0839800T3 (da)	2003-02-24	Fremgangsmåde til fremstilling af halogenacetamidderivater
WO2003004464A8 (de)	2004-03-04	Heterozyklische amidderivate und deren verwendung als schädlingsbekämpfungsmittel
FR2688503B1 (fr)	1994-05-06	Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
DK1325740T3 (da)	2004-08-16	Stabile granulater indeholdende s-adenosylmethionin og fremgangsmåde til fremstilling deraf
AU2002352097A1 (en)	2003-06-17	Method for producing bleach activator granules
NO20040423L (no)	2004-03-08	Salter av substituerte 1,2,3,4-tetrahydroisokinolin-2-karboksylsyrederivater.
AU5579500A (en)	2001-01-31	Process for the production of melamine from urea
NO20013453L (no)	2001-09-04	Fremgangsmate for fremstilling av salter av cyanobenzylaminer
IT9022255A0 (it)	1990-11-30	Ripartitore di terre o granuli associabile a soli, specie per la produzione di graniti ceramici.
JPS5555165A (en)	1980-04-22	N-(benzoylmercapto substituted acyl)-histidine