ATE231864T1 - Verfahren zur herstellung von riboflavinsprühgranulaten - Google Patents

Verfahren zur herstellung von riboflavinsprühgranulaten

Info

Publication number: ATE231864T1
Authority: AT; Austria
Prior art keywords: riboflaven; producing; spray drying; drying process; spray granules
Prior art date: 1999-04-30

Application number

AT00108560T

Other languages

English (en)

Inventor

Markus Nowotny

Jean-Claude Tritsch

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-30

Filing date

2000-04-19

Publication date

2003-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8238078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE231864(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-04-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE231864T1 publication Critical patent/ATE231864T1/de

Links

239000008187 granular material Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000007921 spray Substances 0.000 title 1
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 4
238000000034 method Methods 0.000 abstract 4
238000001694 spray drying Methods 0.000 abstract 3
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 2
239000013078 crystal Substances 0.000 abstract 2
229960002477 riboflavin Drugs 0.000 abstract 2
235000019192 riboflavin Nutrition 0.000 abstract 2
239000002151 riboflavin Substances 0.000 abstract 2
239000007900 aqueous suspension Substances 0.000 abstract 1
230000009969 flowable effect Effects 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
- C07D475/14—Benz [g] pteridines, e.g. riboflavin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT00108560T 1999-04-30 2000-04-19 Verfahren zur herstellung von riboflavinsprühgranulaten ATE231864T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99108476		1999-04-30

Publications (1)

Publication Number	Publication Date
ATE231864T1 true ATE231864T1 (de)	2003-02-15

Family

ID=8238078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00108560T ATE231864T1 (de)	1999-04-30	2000-04-19	Verfahren zur herstellung von riboflavinsprühgranulaten

Country Status (16)

Country	Link
US (1)	US6723346B1 (de)
EP (1)	EP1048668B2 (de)
JP (1)	JP4965013B2 (de)
KR (1)	KR100720202B1 (de)
CN (1)	CN1198595C (de)
AT (1)	ATE231864T1 (de)
AU (1)	AU770320B2 (de)
BR (1)	BR0002390A (de)
CA (1)	CA2306502A1 (de)
DE (1)	DE60001286T3 (de)
DK (1)	DK1048668T3 (de)
ES (1)	ES2189711T5 (de)
ID (1)	ID25698A (de)
MX (1)	MXPA00004185A (de)
NO (1)	NO318219B1 (de)
TW (1)	TWI253347B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0219815D0 (en) *	2002-08-24	2002-10-02	Accentus Plc	Preparation of small crystals
DE10317051A1 (de)	2003-04-11	2004-10-21	Basf Ag	Verfahren zur Herstellung von Riboflavin der Modifikation B/C in Granulatform
ATE442369T1 (de)	2003-07-22	2009-09-15	Dsm Ip Assets Bv	Verfahren zur aufreinigung von riboflavin
US8689459B2 (en) *	2006-12-07	2014-04-08	Friesland Brands B.V.	Method and apparatus for spray drying and powder produced using said method
CN104961740B (zh) *	2015-06-02	2016-04-27	湖北广济药业股份有限公司	一种含核黄素的固体制剂及其制备方法
ES2949057T3 (es)	2018-11-07	2023-09-25	Dsm Ip Assets Bv	Medicamentos con contenido en riboflavina que exhiben una fluidez mejorada

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0307767B1 (de) *	1987-09-18	1993-07-21	F. Hoffmann-La Roche Ag	Neue Form des Riboflavins
DE3819745A1 (de) *	1988-06-10	1989-12-14	Basf Ag	Verfahren zur herstellung von auf mikrobiellem wege hergestelltem riboflavin in form von sprueh- oder mikrogranulaten
JP2634285B2 (ja) *	1989-03-28	1997-07-23	積水化学工業株式会社	放射性物質取扱所の被覆材用非灰分性樹脂組成物
DE3927810A1 (de)	1989-08-23	1991-02-28	Basf Ag	Riboflavingranulate
US4994458A (en) *	1990-04-30	1991-02-19	Basf Corporation	Process for rotary fluid bed granulation of riboflavin
US5236920A (en) *	1990-04-30	1993-08-17	Basf Corporation	Granulated riboflavin product having high flowability, high riboflavin content
DE4014262A1 (de)	1990-05-04	1991-11-07	Basf Ag	Gut rieselfaehige, nichtstaubende bindemittelfreie riboflavinspruehgranulate oder -mikrogranulate aus reinem riboflavin und ein verfahren zu deren herstellung
US5000888A (en) *	1990-05-23	1991-03-19	Basf Corporation	Process for spray drying riboflavin to produce a granulate product having low binder content
JP2000112883A (ja) *	1998-09-24	2000-04-21	Internatl Business Mach Corp <Ibm>	情報処理方法、情報処理装置、情報処理プログラムを格納する記憶媒体
CA2282908A1 (en)	1998-10-19	2000-04-19	F. Hoffmann-La Roche Ag	Purification and crystallization process for riboflavin
US6093715A (en) *	1999-03-24	2000-07-25	Basf Aktiengesellschaft	Process for producing riboflavin-containing granules

2000
- 2000-04-17 US US09/550,971 patent/US6723346B1/en not_active Expired - Lifetime
- 2000-04-19 EP EP00108560A patent/EP1048668B2/de not_active Expired - Lifetime
- 2000-04-19 AT AT00108560T patent/ATE231864T1/de not_active IP Right Cessation
- 2000-04-19 DK DK00108560T patent/DK1048668T3/da active
- 2000-04-19 DE DE60001286T patent/DE60001286T3/de not_active Expired - Lifetime
- 2000-04-19 ES ES00108560T patent/ES2189711T5/es not_active Expired - Lifetime
- 2000-04-20 CA CA002306502A patent/CA2306502A1/en not_active Abandoned
- 2000-04-26 TW TW089107796A patent/TWI253347B/zh not_active IP Right Cessation
- 2000-04-26 ID IDP20000337A patent/ID25698A/id unknown
- 2000-04-27 JP JP2000126926A patent/JP4965013B2/ja not_active Expired - Fee Related
- 2000-04-28 KR KR1020000022706A patent/KR100720202B1/ko not_active Expired - Fee Related
- 2000-04-28 AU AU30189/00A patent/AU770320B2/en not_active Ceased
- 2000-04-28 CN CNB001180525A patent/CN1198595C/zh not_active Expired - Fee Related
- 2000-04-28 NO NO20002283A patent/NO318219B1/no unknown
- 2000-04-28 BR BR0002390-6A patent/BR0002390A/pt active IP Right Grant
- 2000-04-28 MX MXPA00004185A patent/MXPA00004185A/es unknown

Also Published As

Publication number	Publication date
ES2189711T3 (es)	2003-07-16
KR100720202B1 (ko)	2007-05-21
EP1048668A3 (de)	2001-03-28
CN1275375A (zh)	2000-12-06
EP1048668B1 (de)	2003-01-29
KR20010029668A (ko)	2001-04-06
JP2000327562A (ja)	2000-11-28
NO20002283L (no)	2000-10-31
CA2306502A1 (en)	2000-10-30
DE60001286T3 (de)	2010-10-28
AU770320B2 (en)	2004-02-19
ID25698A (id)	2000-11-02
EP1048668A2 (de)	2000-11-02
DE60001286T2 (de)	2003-11-06
JP4965013B2 (ja)	2012-07-04
ES2189711T5 (es)	2010-07-28
EP1048668B2 (de)	2010-06-09
NO20002283D0 (no)	2000-04-28
DK1048668T3 (da)	2003-05-26
NO318219B1 (no)	2005-02-21
US6723346B1 (en)	2004-04-20
AU3018900A (en)	2000-11-02
CN1198595C (zh)	2005-04-27
TWI253347B (en)	2006-04-21
MXPA00004185A (es)	2002-03-08
BR0002390A (pt)	2000-10-31
DE60001286D1 (de)	2003-03-06

Legal Events

Date	Code	Title	Description
2003-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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