DK1049699T3 - Pyrazolotriaziner som CRF-antagonister - Google Patents

Pyrazolotriaziner som CRF-antagonister

Info

Publication number: DK1049699T3
Authority: DK; Denmark
Prior art keywords: pyrazolotriazines; crf antagonists; crf; antagonists; psychiatric
Prior art date: 1998-01-28

Application number

DK99904382T

Other languages

English (en)

Inventor

Liqi He

Paul Gilligan

Robert Chorvat

Argyrios Georgios Arvanitis

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-28

Filing date

1999-01-28

Publication date

2004-07-05

1998-01-28 Priority claimed from US09/015,001 external-priority patent/US6060478A/en

1998-01-28 Priority claimed from US09/015,002 external-priority patent/US6191131B1/en

1998-01-28 Priority claimed from US09/014,734 external-priority patent/US6313124B1/en

1999-01-28 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2004-07-05 Application granted granted Critical

2004-07-05 Publication of DK1049699T3 publication Critical patent/DK1049699T3/da

Links

239000005557 antagonist Substances 0.000 title abstract 2
PEYVWBGHBCDXRT-UHFFFAOYSA-N N1=NNC2=CN=NC2=C1 Chemical class N1=NNC2=CN=NC2=C1 PEYVWBGHBCDXRT-UHFFFAOYSA-N 0.000 title 1
102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 2
108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 2
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
230000000112 colonic effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000009610 hypersensitivity Effects 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Virology (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Addiction (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)

DK99904382T 1998-01-28 1999-01-28 Pyrazolotriaziner som CRF-antagonister DK1049699T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US09/015,001 US6060478A (en)	1996-07-24	1998-01-28	Azolo triazines and pyrimidines
US09/015,002 US6191131B1 (en)	1997-07-23	1998-01-28	Azolo triazines and pyrimidines
US09/014,734 US6313124B1 (en)	1997-07-23	1998-01-28	Tetrazine bicyclic compounds
PCT/US1999/001824 WO1999038868A1 (en)	1998-01-28	1999-01-28	Azolo triazines and pyrimidines

Publications (1)

Publication Number	Publication Date
DK1049699T3 true DK1049699T3 (da)	2004-07-05

Family

ID=27360164

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99904382T DK1049699T3 (da)	1998-01-28	1999-01-28	Pyrazolotriaziner som CRF-antagonister
DK03075887T DK1344779T3 (da)	1998-01-28	1999-01-28	Azolo-pyrimidiner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK03075887T DK1344779T3 (da)	1998-01-28	1999-01-28	Azolo-pyrimidiner

Country Status (19)

Country	Link
EP (2)	EP1049699B1 (da)
JP (1)	JP4228332B2 (da)
KR (1)	KR100574313B1 (da)
CN (2)	CN1542010A (da)
AT (2)	ATE301657T1 (da)
AU (1)	AU748818C (da)
BR (1)	BR9908206A (da)
CA (2)	CA2614603C (da)
DE (2)	DE69926665T2 (da)
DK (2)	DK1049699T3 (da)
ES (2)	ES2218991T3 (da)
IL (1)	IL137019A0 (da)
NZ (2)	NZ505079A (da)
PL (1)	PL200939B1 (da)
PT (2)	PT1344779E (da)
SG (1)	SG111076A1 (da)
SI (2)	SI1344779T1 (da)
TW (1)	TW520372B (da)
WO (1)	WO1999038868A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000059907A2 (en) *	1999-04-06	2000-10-12	Du Pont Pharmaceuticals Company	Pyrazolotriazines as crf antagonists
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
IL148903A0 (en)	1999-09-30	2002-09-12	Neurogen Corp	Certain alkylene diamine-substituted heterocycles
JP2003510325A (ja)	1999-09-30	2003-03-18	ニューロジェン・コーポレーション	ある種のアルキレンジアミン−置換ピラゾロ［１，５−ａ］−１，５−ピリミジン及びピラゾロ［１，５−ａ］−１，３，５−トリアジン
US6525067B1 (en)	1999-11-23	2003-02-25	Pfizer Inc	Substituted heterocyclic derivatives
AU2001263329A1 (en) *	2000-05-18	2001-11-26	Neurocrine Biosciences, Inc.	Crf receptor antagonists and methods relating thereto
AU2001275784A1 (en) *	2000-08-02	2002-02-13	Malope Company Limited	Diagnosis and treatment of non-ulcer dyspepsia based on hypothalamic-pituitary-adrenal axis abnormality
BR0208357A (pt) *	2001-03-13	2004-06-29	Bristol Myers Squibb Pharma Co	Composto, composição farmacêutica, método de antagonização de um receptor de fator de liberação de corticotropina (crf), método de tratamento de disfunção, método de triagem de ligantes, método de detecção de receptores de crf, método de inibição da ligação de crf, artigo industrializado e usos do composto
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
US7034023B2 (en) *	2003-04-04	2006-04-25	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US7056920B2 (en)	2003-04-04	2006-06-06	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US20070293511A1 (en) *	2003-12-22	2007-12-20	Sb Pharmco Puerto Rico Inc. And Neurocrine Biosciences, Inc., A Corporation	Crf Receptor Antagonists and Methods
CA2550948A1 (en) *	2003-12-22	2005-07-14	Sb Pharmco Puerto Rico Inc.	Crf receptor antagonists and methods relating thereto
WO2005079868A2 (en) *	2004-02-13	2005-09-01	Sb Pharmco Puerto Rico Inc	Crf receptor antagonists, their preparations, their pharmaceutical composition and their uses
GB0519957D0 (en)	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
PE20070855A1 (es) *	2005-12-02	2007-10-14	Bayer Pharmaceuticals Corp	Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
US7851468B2 (en) *	2006-05-15	2010-12-14	Cephalon, Inc.	Substituted pyrazolo[3,4-d]pyrimidines
US10166271B2 (en)	2006-06-21	2019-01-01	The Regents Of The University Of California	Methods for promoting hair growth
WO2008078091A1 (en)	2006-12-22	2008-07-03	Astex Therapeutics Limited	Bicyclic heterocyclic compounds as fgfr inhibitors
CN101679409B (zh)	2006-12-22	2014-11-26	Astex治疗学有限公司	双环杂环衍生化合物、其医药组合物和其用途
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
CN104876935B (zh) *	2015-05-18	2017-04-19	南方医科大学	2‑氨基吡咯并[1,2‑f][1,2,4]三嗪类化合物、合成方法及应用
CN107949563B (zh) *	2015-06-24	2020-06-05	库洛维公司	治疗中有用的吡唑并[1,5-a]三嗪-4-胺衍生物
CN118845788A (zh)	2017-08-14	2024-10-29	云杉生物科学公司	促肾上腺皮质激素释放因子受体拮抗剂
EA202090321A1 (ru) *	2017-08-14	2020-09-24	Спрюс Биосайнсес, Инк.	Антагонисты рецептора кортикотропин-рилизинг фактора
CN112592346B (zh) *	2019-07-30	2022-04-26	厦门宝太生物科技股份有限公司	一种a2a和/或a2b抑制剂中间体的制备方法
BR112023002497A2 (pt)	2020-08-12	2023-05-02	Spruce Biosciences Inc	Métodos e composições para tratamento da síndrome dos ovários policísticos
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW530047B (en) *	1994-06-08	2003-05-01	Pfizer	Corticotropin releasing factor antagonists
US6020492A (en) *	1995-05-12	2000-02-01	Neurogen Corporation	Deazapurine derivatives; a new class of CRF1 specific ligands
JP3356291B2 (ja) *	1996-02-07	2002-12-16	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｃｒｆレセプター拮抗薬としてのピラゾロピリミジン類
HU228962B1 (en) *	1996-07-24	2013-07-29	Bristol Myers Squibb Pharma Co	Azolo triazines, pharmaceutical compositions containing them and use of the compounds
IL127566A0 (en) *	1996-08-28	1999-10-28	Pfizer	Substituted 6,5-hetero- bicyclic derivatives

1999
- 1999-01-28 EP EP99904382A patent/EP1049699B1/en not_active Expired - Lifetime
- 1999-01-28 SI SI9930817T patent/SI1344779T1/sl unknown
- 1999-01-28 BR BR9908206-3A patent/BR9908206A/pt not_active Application Discontinuation
- 1999-01-28 AT AT03075887T patent/ATE301657T1/de active
- 1999-01-28 SI SI9930578T patent/SI1049699T1/xx unknown
- 1999-01-28 KR KR1020007008188A patent/KR100574313B1/ko not_active Expired - Fee Related
- 1999-01-28 AU AU24787/99A patent/AU748818C/en not_active Ceased
- 1999-01-28 CA CA2614603A patent/CA2614603C/en not_active Expired - Fee Related
- 1999-01-28 JP JP2000529335A patent/JP4228332B2/ja not_active Expired - Fee Related
- 1999-01-28 WO PCT/US1999/001824 patent/WO1999038868A1/en not_active Ceased
- 1999-01-28 DK DK99904382T patent/DK1049699T3/da active
- 1999-01-28 IL IL13701999A patent/IL137019A0/xx unknown
- 1999-01-28 AT AT99904382T patent/ATE264860T1/de active
- 1999-01-28 DE DE69926665T patent/DE69926665T2/de not_active Expired - Lifetime
- 1999-01-28 PT PT03075887T patent/PT1344779E/pt unknown
- 1999-01-28 PL PL342183A patent/PL200939B1/pl unknown
- 1999-01-28 SG SG200204556A patent/SG111076A1/en unknown
- 1999-01-28 DE DE69916578T patent/DE69916578T2/de not_active Expired - Lifetime
- 1999-01-28 CA CA002314613A patent/CA2314613C/en not_active Expired - Fee Related
- 1999-01-28 ES ES99904382T patent/ES2218991T3/es not_active Expired - Lifetime
- 1999-01-28 EP EP03075887A patent/EP1344779B1/en not_active Expired - Lifetime
- 1999-01-28 PT PT99904382T patent/PT1049699E/pt unknown
- 1999-01-28 NZ NZ505079A patent/NZ505079A/en not_active IP Right Cessation
- 1999-01-28 CN CNA2003101225466A patent/CN1542010A/zh active Pending
- 1999-01-28 DK DK03075887T patent/DK1344779T3/da active
- 1999-01-28 ES ES03075887T patent/ES2247478T3/es not_active Expired - Lifetime
- 1999-01-28 NZ NZ524842A patent/NZ524842A/en not_active IP Right Cessation
- 1999-01-28 CN CNB998023639A patent/CN1137123C/zh not_active Expired - Fee Related
- 1999-02-23 TW TW088102636A patent/TW520372B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR20010040426A (ko)	2001-05-15
DE69926665D1 (de)	2005-09-15
ES2247478T3 (es)	2006-03-01
EP1049699A1 (en)	2000-11-08
PT1344779E (pt)	2005-10-31
ATE301657T1 (de)	2005-08-15
CA2614603A1 (en)	1999-08-05
CN1137123C (zh)	2004-02-04
AU748818C (en)	2003-11-20
ATE264860T1 (de)	2004-05-15
BR9908206A (pt)	2000-12-05
KR100574313B1 (ko)	2006-04-27
JP4228332B2 (ja)	2009-02-25
SG111076A1 (en)	2005-05-30
TW520372B (en)	2003-02-11
IL137019A0 (en)	2001-06-14
NZ524842A (en)	2003-10-31
CN1289335A (zh)	2001-03-28
DE69916578D1 (de)	2004-05-27
NZ505079A (en)	2003-08-29
HK1060348A1 (en)	2004-08-06
DE69916578T2 (de)	2005-03-31
CN1542010A (zh)	2004-11-03
ES2218991T3 (es)	2004-11-16
JP2002501922A (ja)	2002-01-22
AU748818B2 (en)	2002-06-13
CA2314613C (en)	2009-12-08
EP1049699B1 (en)	2004-04-21
CA2614603C (en)	2011-08-16
WO1999038868A1 (en)	1999-08-05
PL200939B1 (pl)	2009-02-27
PT1049699E (pt)	2004-08-31
EP1344779A1 (en)	2003-09-17
EP1344779B1 (en)	2005-08-10
PL342183A1 (en)	2001-05-21
DK1344779T3 (da)	2005-09-05
DE69926665T2 (de)	2006-06-08
SI1344779T1 (sl)	2006-02-28
AU2478799A (en)	1999-08-16
CA2314613A1 (en)	1999-08-05
SI1049699T1 (en)	2004-10-31

Publication	Publication Date	Title
DK1049699T3 (da)	2004-07-05	Pyrazolotriaziner som CRF-antagonister
LV12292A (lv)	1999-06-20	Triazinu un pirimidinu azoloatvasinajumi
PT901374E (pt)	2004-04-30	Tetra-hidropteridinas e piridilpiperazinas para o tratamento de disturbios neurologicos
BR9814458A (pt)	2001-10-23	Composto, composição farmacêutica e método de tratamento de disfunções afetivas
CY1106607T1 (el)	2012-01-25	4-(2-βουτυλαμιονο)-2,7-διμεθυλ-8-(2-μεθυλ-6-μεθοξυπυριδ-3-υλ) πυραζολο-1,5-αι-1,3,5-τριαζινη, τα εναντιομορα και φαρμακευτικως παραδεκτα αλατα αυτης ως συναρμοτες του υποδοχεα του παραγοντος απελευθερωσης κορτικοτροπινης
DK0674641T3 (da)	1999-09-27	Pyrrolopyrimidiner som CRF-antagonister
LV12262A (lv)	1999-04-20	Ar arilaminu kondenseti piridini un pirimidini
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