DK1051177T3 - Steroide 3-O-Sulfamatderivater som inhibitorer af östronsulfatase - Google Patents
Steroide 3-O-Sulfamatderivater som inhibitorer af östronsulfataseInfo
- Publication number
- DK1051177T3 DK1051177T3 DK98957031T DK98957031T DK1051177T3 DK 1051177 T3 DK1051177 T3 DK 1051177T3 DK 98957031 T DK98957031 T DK 98957031T DK 98957031 T DK98957031 T DK 98957031T DK 1051177 T3 DK1051177 T3 DK 1051177T3
- Authority
- DK
- Denmark
- Prior art keywords
- steroidal
- inhibitors
- oestrone
- sulfamate derivatives
- sulfatase
- Prior art date
Links
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 title abstract 4
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003399 estrone Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000005262 Sulfatase Human genes 0.000 title 1
- 230000003637 steroidlike Effects 0.000 title 1
- 108060007951 sulfatase Proteins 0.000 title 1
- -1 sulphamate compound Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Biological Treatment Of Waste Water (AREA)
- Lubricants (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9725750A GB2331988B (en) | 1997-12-04 | 1997-12-04 | Polycyclic sulphamate inhibitors or oestrone sulphatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1051177T3 true DK1051177T3 (da) | 2006-07-24 |
Family
ID=10823156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98957031T DK1051177T3 (da) | 1997-12-04 | 1998-12-03 | Steroide 3-O-Sulfamatderivater som inhibitorer af östronsulfatase |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6949561B1 (da) |
| EP (1) | EP1051177B1 (da) |
| JP (1) | JP3820349B2 (da) |
| AT (1) | ATE323495T1 (da) |
| AU (1) | AU1345699A (da) |
| DE (1) | DE69834271T2 (da) |
| DK (1) | DK1051177T3 (da) |
| ES (1) | ES2260856T3 (da) |
| GB (2) | GB2331988B (da) |
| WO (1) | WO1999027935A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
| JP2002517449A (ja) * | 1998-06-10 | 2002-06-18 | ステリックス リミテッド | エストロンスルファターゼの阻害のための腫瘍壊死因子ａおよび２−メトキシエストロン−３−ｏ−スルファメートを有する薬学的組成物 |
| US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
| US20080015174A1 (en) * | 1998-11-24 | 2008-01-17 | Reading Christopher L | Metabolic Disease Treatments |
| JP5042411B2 (ja) * | 1999-04-30 | 2012-10-03 | ステリックス リミテッド | 抗腫瘍剤としてのエストロン誘導体の使用 |
| US7078395B1 (en) | 1999-06-16 | 2006-07-18 | Sterix Limited | Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling |
| GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
| CO5261573A1 (es) * | 1999-11-19 | 2003-03-31 | Novartis Ag | Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| JPWO2001081364A1 (ja) | 2000-04-24 | 2004-01-08 | 協和醗酵工業株式会社 | エストラ−１，３，５（１０）−トリエン誘導体 |
| DE10307103A1 (de) * | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
| US7910755B2 (en) * | 2004-09-29 | 2011-03-22 | Harbor Biosciences, Inc. | Stem cell expansion and uses |
| US10030478B2 (en) | 2014-05-20 | 2018-07-24 | Baker Hughes, A Ge Company, Llc | Mechanically actuated variable choke system for subterranean use |
| CN104311621B (zh) * | 2014-11-18 | 2016-05-11 | 郑州大学 | D环修饰的甾体β-内酰胺类化合物、其制备方法及其应用 |
| WO2016084790A1 (ja) * | 2014-11-25 | 2016-06-02 | 第一三共株式会社 | ヒドロナフトキノリン誘導体 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2324592A1 (de) * | 1973-05-16 | 1974-12-05 | Basf Ag | Substituierte benzofuranylester |
| DE2402370A1 (de) * | 1974-01-18 | 1975-07-31 | Basf Ag | Substituierte benzofuranylester |
| US4155918A (en) | 1976-10-28 | 1979-05-22 | Hoffmann-La Roche Inc. | Novel D-homosteroids |
| HU175287B (hu) * | 1977-08-18 | 1980-06-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh proizvodnykh 3-amino-17al'fa-aza-d-gomo-androstana,dalee ikh kislotoaddicionnykh i chetvjortichnykh solej |
| DE2755578A1 (de) | 1977-12-09 | 1979-06-13 | Schering Ag | C-homo-oestratriene |
| DE3243158A1 (de) * | 1982-11-23 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | Neue sulfonsaeureester von hydroxycumarinen, ihre herstellung und sie enthaltende arzneimittel |
| JPS61502186A (ja) | 1984-05-21 | 1986-10-02 | エス・ア−ル・アイ・インタ−ナシヨナル | １７αβ−ヒドロキシ−７α−メチル−Ｄ−ホモ−１９−ノルアンドロスト−４，１６−ジエン−３−オンおよびその１７−エステル、ならびにその製法および使用 |
| US4874891A (en) | 1986-05-01 | 1989-10-17 | Washington University | Open "D" ring hormone analogs |
| PT94305B (pt) * | 1989-06-12 | 1997-02-28 | Robins Co Inc A H | Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos |
| US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| US6083978A (en) | 1996-03-05 | 2000-07-04 | Sterix Limited | Compounds with a sulfamate group |
| GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
| GB9118478D0 (en) | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| GB9603325D0 (en) * | 1996-02-16 | 1996-04-17 | Imperial College | A compound |
| GB9118465D0 (en) | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| JP2746041B2 (ja) | 1992-02-14 | 1998-04-28 | 三菱化学株式会社 | 新規なステロイド誘導体 |
| US5260299A (en) | 1992-03-05 | 1993-11-09 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-Carboalkoxy)Sulfamates Useful as Immunosuppressive Agents |
| PT633886E (pt) | 1992-04-03 | 2001-03-30 | Upjohn Co | Aminas biciclicas-heterociclicas farmaceuticamente activas |
| WO1997005126A1 (en) | 1995-07-29 | 1997-02-13 | Smithkline Beecham Plc | Mupirocinsulfamates with antibacterial activity |
| AU713341B2 (en) * | 1996-09-12 | 1999-12-02 | Teikoku Hormone Mfg. Co., Ltd. | 3-substituted-d-homo-1,3,5,(10)-estratriene derivatives |
| DE19712488A1 (de) | 1997-03-25 | 1998-10-01 | Knoell Hans Forschung Ev | Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben |
| US6248780B1 (en) | 1998-10-01 | 2001-06-19 | Duquesne University Of The Holy Ghost | Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same |
-
1997
- 1997-12-04 GB GB9725750A patent/GB2331988B/en not_active Expired - Fee Related
-
1998
- 1998-12-03 DE DE69834271T patent/DE69834271T2/de not_active Expired - Lifetime
- 1998-12-03 WO PCT/GB1998/003616 patent/WO1999027935A1/en not_active Ceased
- 1998-12-03 JP JP2000522920A patent/JP3820349B2/ja not_active Expired - Fee Related
- 1998-12-03 AU AU13456/99A patent/AU1345699A/en not_active Abandoned
- 1998-12-03 ES ES98957031T patent/ES2260856T3/es not_active Expired - Lifetime
- 1998-12-03 EP EP98957031A patent/EP1051177B1/en not_active Expired - Lifetime
- 1998-12-03 AT AT98957031T patent/ATE323495T1/de active
- 1998-12-03 DK DK98957031T patent/DK1051177T3/da active
-
2000
- 2000-05-17 US US09/572,246 patent/US6949561B1/en not_active Expired - Fee Related
-
2002
- 2002-11-27 GB GB0227655A patent/GB2380939B/en not_active Expired - Fee Related
-
2004
- 2004-09-30 US US10/955,962 patent/US20050124643A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001524524A (ja) | 2001-12-04 |
| ATE323495T1 (de) | 2006-05-15 |
| GB0227655D0 (en) | 2003-01-08 |
| GB2331988B (en) | 2003-04-16 |
| GB2380939B (en) | 2003-09-10 |
| EP1051177B1 (en) | 2006-04-19 |
| GB2331988A (en) | 1999-06-09 |
| JP3820349B2 (ja) | 2006-09-13 |
| AU1345699A (en) | 1999-06-16 |
| GB9725750D0 (en) | 1998-02-04 |
| US6949561B1 (en) | 2005-09-27 |
| WO1999027935A1 (en) | 1999-06-10 |
| GB2380939A (en) | 2003-04-23 |
| ES2260856T3 (es) | 2006-11-01 |
| DE69834271D1 (de) | 2006-05-24 |
| DE69834271T2 (de) | 2006-10-19 |
| EP1051177A1 (en) | 2000-11-15 |
| US20050124643A1 (en) | 2005-06-09 |
| GB2331988A9 (en) |
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