DK1054885T3 - Benzisoxasolderivater med D4-antagonistisk virkning - Google Patents

Benzisoxasolderivater med D4-antagonistisk virkning

Info

Publication number: DK1054885T3
Authority: DK; Denmark
Prior art keywords: amino; sulfonyl; group; dialkyl; alkoxy
Prior art date: 1998-02-09

Application number

DK99914450T

Other languages

Danish (da)

English (en)

Inventor

Hartog Jacobus A J Den

Steen Bartholomeus J Van

Martinus T M Tulp

Eric Ronken

Cornelis G Kruse

Josephus H M Lange

Gerben M Visser

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-09

Filing date

1999-02-05

Publication date

2007-10-15

1999-02-05 Application filed by Duphar Int Res filed Critical Duphar Int Res

2007-10-15 Application granted granted Critical

2007-10-15 Publication of DK1054885T3 publication Critical patent/DK1054885T3/da

Links

150000008316 benzisoxazoles Chemical class 0.000 title abstract 2
230000003042 antagnostic effect Effects 0.000 title 1
-1 nitro, amino Chemical group 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 abstract 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK99914450T 1998-02-09 1999-02-05 Benzisoxasolderivater med D4-antagonistisk virkning DK1054885T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98200400		1998-02-09
PCT/EP1999/000852 WO1999040067A2 (en)	1998-02-09	1999-02-05	Benzisoxazole derivatives having d4-antagonistic activity

Publications (1)

Publication Number	Publication Date
DK1054885T3 true DK1054885T3 (da)	2007-10-15

Family

ID=8233376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99914450T DK1054885T3 (da)	1998-02-09	1999-02-05	Benzisoxasolderivater med D4-antagonistisk virkning

Country Status (11)

Country	Link
US (1)	US6335326B1 (de)
EP (1)	EP1054885B1 (de)
JP (1)	JP4627882B2 (de)
AT (1)	ATE367389T1 (de)
AU (1)	AU3327399A (de)
CA (1)	CA2320120C (de)
DE (1)	DE69936572T2 (de)
DK (1)	DK1054885T3 (de)
ES (1)	ES2291023T3 (de)
PT (1)	PT1054885E (de)
WO (1)	WO1999040067A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4627882B2 (ja) *	1998-02-09	2011-02-09	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	Ｄ４−アンタゴニスト活性を有するベンズイソキサゾール誘導体
US7253165B2 (en)	1999-09-14	2007-08-07	Aventis Pharmaceuticals Inc.	Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
HUP0202712A3 (en) *	1999-09-14	2004-12-28	Aventis Pharmaceuticals Inc Br	Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing the compounds
US7125903B1 (en)	1999-09-14	2006-10-24	Aventis Pharmaceuticals Inc.	Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
PL354514A1 (en) *	1999-09-14	2004-01-26	Aventis Pharmaceuticals Inc.	Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4
US7091199B1 (en)	1999-09-14	2006-08-15	Aventis Pharmaceuticals Inc.	Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
ES2209995T3 (es) *	1999-09-14	2004-07-01	Aventis Pharmaceuticals Inc.	Derivados de propilo sustituidos con tienoisoxazolil- y tienopirrazolil-fenoxi, utiles en calidad de antagonistas d4.
WO2002072029A2 (en)	2001-03-12	2002-09-19	The Mclean Hospital Corporation	Dopamine d4 receptor antagonists as treatment for attention deficit-hyperactivity disorder
CA2598516C (en) *	2005-02-25	2010-05-11	Pfizer Inc.	Benzisoxazole derivatives
JP5502733B2 (ja) *	2007-07-26	2014-05-28	エフ．ホフマン−ラロシュアーゲー	５−ｈｔ２ａ及びｄ３受容体の二重のモジュレーター
US8877778B2 (en)	2010-12-15	2014-11-04	Hoffmann-La Roche Inc.	Benzofurane compounds
US8921397B2 (en)	2011-05-04	2014-12-30	Hoffmann-La Roche Inc.	Benzofurane-piperidine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4352811A (en) *	1981-11-12	1982-10-05	Hoechst-Roussel Pharmaceuticals Inc.	3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
EP0602242A4 (en) *	1991-08-22	1994-06-29	Yoshitomi Pharmaceutical	Benzisoxazole compound and use thereof.
JPH0641125A (ja) *	1992-03-26	1994-02-15	Yoshitomi Pharmaceut Ind Ltd	ベンゾイソオキサゾール化合物およびその用途
DK60593D0 (da) *	1993-05-26	1993-05-26	Novo Nordisk As	Kemiske forbindelser, deres fremstilling og anvendelse
FR2749304B1 (fr) *	1996-06-04	1998-06-26	Adir	Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP4627882B2 (ja) *	1998-02-09	2011-02-09	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	Ｄ４−アンタゴニスト活性を有するベンズイソキサゾール誘導体

1999
- 1999-02-05 JP JP2000530498A patent/JP4627882B2/ja not_active Expired - Fee Related
- 1999-02-05 AU AU33273/99A patent/AU3327399A/en not_active Abandoned
- 1999-02-05 DK DK99914450T patent/DK1054885T3/da active
- 1999-02-05 EP EP99914450A patent/EP1054885B1/de not_active Expired - Lifetime
- 1999-02-05 AT AT99914450T patent/ATE367389T1/de active
- 1999-02-05 WO PCT/EP1999/000852 patent/WO1999040067A2/en not_active Ceased
- 1999-02-05 CA CA002320120A patent/CA2320120C/en not_active Expired - Fee Related
- 1999-02-05 US US09/601,795 patent/US6335326B1/en not_active Expired - Lifetime
- 1999-02-05 DE DE69936572T patent/DE69936572T2/de not_active Expired - Lifetime
- 1999-02-05 PT PT99914450T patent/PT1054885E/pt unknown
- 1999-02-05 ES ES99914450T patent/ES2291023T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69936572T2 (de)	2008-06-19
DE69936572D1 (de)	2007-08-30
WO1999040067A2 (en)	1999-08-12
CA2320120C (en)	2009-08-11
US6335326B1 (en)	2002-01-01
AU3327399A (en)	1999-08-23
JP2002502842A (ja)	2002-01-29
ES2291023T3 (es)	2008-02-16
WO1999040067A3 (en)	1999-11-25
CA2320120A1 (en)	1999-08-12
JP4627882B2 (ja)	2011-02-09
EP1054885B1 (de)	2007-07-18
PT1054885E (pt)	2007-10-03
EP1054885A2 (de)	2000-11-29
ATE367389T1 (de)	2007-08-15

Publication	Publication Date	Title
DK0858461T3 (da)	2003-01-27	Kondenserede tropanderivater som neurotransmittergenoptagelsesinhibitorer
DK1054885T3 (da)	2007-10-15	Benzisoxasolderivater med D4-antagonistisk virkning
UA72917C2 (en)	2005-05-16	Cyclic carbamates derivatives, pharmaceutical composition containing said derivatives of cyclic carbamates and active ingredients as modulators of the progesterone receptor
MX9709951A (es)	1998-03-29	Derivados de benzamida y su uso como antagonistas de vasopresina.
NO20033385D0 (no)	2003-07-29	Fuserte heterocykliske forbindelser
DK0765314T3 (da)	2003-08-25	Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer
NO952208D0 (no)	1995-06-02	Amin-derivater
TR199902724T2 (xx)	2000-04-21	Dopamine D3 resept�rleri mod�lat�rleri olarak tetrahidroisokuinolin t�revleri.
ATE175661T1 (de)	1999-01-15	Benzamid-derivate als vasopressin-antagonisten
DE69911580D1 (de)	2003-10-30	Benzamidderivate als vasopressin-antagonisten
EA199901062A1 (ru)	2000-08-28	Производные хинолин-4-карбоксамида как антагонисты рецепторов нк-2 и нк-3
NO964698D0 (no)	1996-11-06	Bicykliske aminderivater som inhibitorer av nitrogenoksid-syntetase
JO2235B1 (en)	2004-10-07	Derivatives of phenyl
PE20060770A1 (es)	2006-10-03	Derivados de n-[(4,5-difenil-3-alquil-2-tienil)metil]amina como antagonistas de los receptores cannabinoides cb1
HUP9700955A2 (hu)	1998-03-02	Szubsztituált 2-naftoil-guanidin-származékok, előállításuk, valamint az e vegyületeket tartalmazó gyógyszerkészítmények
PE20001384A1 (es)	2000-12-30	Derivados de acetamida no peptidicos como antagonistas de receptor de nk1
DE69907636D1 (de)	2003-06-12	2-aminochinolinderivate mit d4-agonistischer wirkung
DK0712406T3 (da)	1999-07-05	Kondenserende indolderivater som 5-HT4-receptorantagonister
ES2132748T3 (es)	1999-08-16	Herbicidas de carbamato.
DK0765322T3 (da)	2001-10-22	Indolderivater som pro-drugs for 5-HT1-lignende receptoragonister