ATE258604T1 - Verfahren zur enzymatischen auflösung von laktamen - Google Patents
Verfahren zur enzymatischen auflösung von laktamenInfo
- Publication number
- ATE258604T1 ATE258604T1 AT99908070T AT99908070T ATE258604T1 AT E258604 T1 ATE258604 T1 AT E258604T1 AT 99908070 T AT99908070 T AT 99908070T AT 99908070 T AT99908070 T AT 99908070T AT E258604 T1 ATE258604 T1 AT E258604T1
- Authority
- AT
- Austria
- Prior art keywords
- lactams
- enzyme
- lactam esters
- enzymatic resolution
- enzymatic dissolution
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000004090 dissolution Methods 0.000 title 1
- 150000003951 lactams Chemical class 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- -1 lactam esters Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 1
- 239000011942 biocatalyst Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7483098P | 1998-02-17 | 1998-02-17 | |
| PCT/US1999/001485 WO1999041405A1 (en) | 1998-02-17 | 1999-02-16 | Process for the enzymatic resolution of lactams |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258604T1 true ATE258604T1 (de) | 2004-02-15 |
Family
ID=22121926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99908070T ATE258604T1 (de) | 1998-02-17 | 1999-02-16 | Verfahren zur enzymatischen auflösung von laktamen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6277626B1 (de) |
| EP (1) | EP1054996B1 (de) |
| JP (1) | JP2003517266A (de) |
| AT (1) | ATE258604T1 (de) |
| AU (1) | AU2758899A (de) |
| DE (1) | DE69914458T2 (de) |
| DK (1) | DK1054996T3 (de) |
| ES (1) | ES2216495T3 (de) |
| PT (1) | PT1054996E (de) |
| WO (1) | WO1999041405A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919672A (en) * | 1998-10-02 | 1999-07-06 | Schering Corporation | Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone |
| GB9907415D0 (en) * | 1999-03-31 | 1999-05-26 | Chirotech Technology Ltd | Biocatalyst and its use |
| US6548293B1 (en) | 1999-10-18 | 2003-04-15 | Fsu Research Foundation, Inc. | Enzymatic process for the resolution of enantiomeric mixtures of β-lactams |
| AU2005276136A1 (en) * | 2004-08-26 | 2006-03-02 | Pfizer Inc. | Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates |
| EP1945632B1 (de) | 2005-11-08 | 2013-09-18 | Vertex Pharmaceuticals Incorporated | Heterozyklische modulatoren von atp-bindenden kassettentransportern |
| US7671221B2 (en) | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| US7754739B2 (en) | 2007-05-09 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
| EP2123769B1 (de) * | 2007-02-19 | 2016-05-18 | Kaneka Corporation | Verfahren zur herstellung von optisch aktivem 3-aminopiperidin oder salz davon |
| US8969386B2 (en) | 2007-05-09 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US8367847B2 (en) * | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| EP2639224B1 (de) | 2007-12-07 | 2016-08-24 | Vertex Pharmaceuticals Incorporated | Verfahren zur Herstellung von Cycloalkylcarboxamidopyridinbenzoesäuren |
| SI2225230T1 (sl) | 2007-12-07 | 2017-03-31 | Vertex Pharmaceuticals Incorporated | Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline |
| NZ720282A (en) | 2008-02-28 | 2017-12-22 | Vertex Pharma | Heteroaryl derivatives as cftr modulators |
| HRP20211752T1 (hr) | 2010-04-07 | 2022-02-18 | Vertex Pharmaceuticals Incorporated | Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena |
| WO2013112804A1 (en) | 2012-01-25 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2.2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| FR2986804A1 (fr) * | 2012-02-09 | 2013-08-16 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels |
| JP6963896B2 (ja) | 2013-11-12 | 2021-11-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Ｃｆｔｒ媒介性疾患の処置のための医薬組成物を調製する方法 |
| PT3221692T (pt) | 2014-11-18 | 2021-09-10 | Vertex Pharma | Processo de realização de testagem de alta produtividade por cromatografia líquida de alta eficiência |
| CN111621541B (zh) * | 2019-02-27 | 2025-10-31 | 广安摩珈生物科技有限公司 | 使用电渗析技术拆分光学异构体的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57198098A (en) * | 1981-05-29 | 1982-12-04 | Sagami Chem Res Center | Preparation of optically active monoester monocarboxylic acid |
| DE3474546D1 (en) | 1983-02-03 | 1988-11-17 | Sumitomo Chemical Co | Optically active 4-hydroxy-2-cyclopentenones, and their production |
| US5585252A (en) | 1988-08-30 | 1996-12-17 | G. D. Searle & Co. | Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents |
| US5106750A (en) | 1988-08-30 | 1992-04-21 | G. D. Searle & Co. | Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents |
| DE3921593A1 (de) * | 1989-06-28 | 1991-01-10 | Schering Ag | Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester |
| US5420037A (en) | 1989-09-26 | 1995-05-30 | E. R. Squibb & Sons, Inc. | Process for separation of enantiomeric 3-mercapto-2-substituted alkanoic acid using lipase P30 and synthesis of captopril type compounds |
| CA2068038A1 (en) | 1991-05-08 | 1992-11-09 | Christopher Yee | Enzymatic resolution of .alpha.-tertiary carboxylic acid esters |
| US5620876A (en) | 1992-04-29 | 1997-04-15 | E. R. Squibb & Sons, Inc. | Enzymatic hydrolysis and esterification processes for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
| US5447865A (en) | 1992-06-10 | 1995-09-05 | Amprost Pharmaceutical, Inc. | Method of resolution of hydroxy substituted cyclopentanone enantiomers using lipase and lithium salt complexation |
| IT1259583B (it) | 1992-06-19 | 1996-03-20 | Gianfranco Palumbo | Imballaggio per confezioni, ad esempio confezioni di prodotti igenico sanitari. |
| US5258517A (en) * | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
| NL9202208A (nl) | 1992-12-18 | 1994-07-18 | Dsm Nv | Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters. |
| JPH06192221A (ja) * | 1992-12-25 | 1994-07-12 | Taiho Yakuhin Kogyo Kk | 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸の製造方法 |
| JPH06199221A (ja) * | 1992-12-28 | 1994-07-19 | Daihatsu Motor Co Ltd | アンチスキッド装置の故障検出方法 |
| US5516676A (en) | 1993-06-15 | 1996-05-14 | Bristol-Myers Squibb Company | Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
| US5529929A (en) | 1995-06-07 | 1996-06-25 | Seprachem, Inc. | Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens |
| CN1246157A (zh) * | 1996-12-27 | 2000-03-01 | 史密丝克莱恩比彻姆有限公司 | 用脂酶进行苯并二氮杂䓬－乙酸酯的酶拆分 |
| JPH11113594A (ja) * | 1997-10-20 | 1999-04-27 | Taiho Yakuhin Kogyo Kk | 光学活性な１−（４−ｔ−ブチルフェニル）−５−オキソ−３−ピロリジンカルボン酸および／またはその鏡像対掌体エステルの製造方法 |
-
1999
- 1999-02-16 ES ES99908070T patent/ES2216495T3/es not_active Expired - Lifetime
- 1999-02-16 EP EP99908070A patent/EP1054996B1/de not_active Expired - Lifetime
- 1999-02-16 PT PT99908070T patent/PT1054996E/pt unknown
- 1999-02-16 AT AT99908070T patent/ATE258604T1/de not_active IP Right Cessation
- 1999-02-16 US US09/250,197 patent/US6277626B1/en not_active Expired - Fee Related
- 1999-02-16 DK DK99908070T patent/DK1054996T3/da active
- 1999-02-16 JP JP2000531586A patent/JP2003517266A/ja active Pending
- 1999-02-16 DE DE69914458T patent/DE69914458T2/de not_active Expired - Fee Related
- 1999-02-16 WO PCT/US1999/001485 patent/WO1999041405A1/en not_active Ceased
- 1999-02-16 AU AU27588/99A patent/AU2758899A/en not_active Abandoned
-
2001
- 2001-06-06 US US09/876,199 patent/US6638758B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69914458T2 (de) | 2004-10-28 |
| DK1054996T3 (da) | 2004-05-24 |
| US20010055798A1 (en) | 2001-12-27 |
| WO1999041405A1 (en) | 1999-08-19 |
| US6638758B2 (en) | 2003-10-28 |
| AU2758899A (en) | 1999-08-30 |
| JP2003517266A (ja) | 2003-05-27 |
| EP1054996A1 (de) | 2000-11-29 |
| EP1054996B1 (de) | 2004-01-28 |
| ES2216495T3 (es) | 2004-10-16 |
| PT1054996E (pt) | 2004-05-31 |
| US6277626B1 (en) | 2001-08-21 |
| DE69914458D1 (de) | 2004-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1054996 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |