DK1060187T3 - S-substituerede 11beta-benzaldoxim-estra-4,9-dien-carboxylsyrethiolestere, fremgangsmåde til deres fremstilling og farmaceutiske tilberedninger indeholdende disse forbindelser - Google Patents

S-substituerede 11beta-benzaldoxim-estra-4,9-dien-carboxylsyrethiolestere, fremgangsmåde til deres fremstilling og farmaceutiske tilberedninger indeholdende disse forbindelser

Info

Publication number: DK1060187T3
Authority: DK; Denmark
Prior art keywords: compounds; benzaldoxime; 11beta; estra; substituted
Prior art date: 1998-03-03

Application number

DK99915475T

Other languages

English (en)

Inventor

Gerd Schubert

Sven Ring

Guenther Kaufmann

Walter Elger

Birgit Schneider

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-03

Filing date

1999-02-10

Publication date

2003-08-11

1999-02-10 Application filed by Schering Ag filed Critical Schering Ag

2003-08-11 Application granted granted Critical

2003-08-11 Publication of DK1060187T3 publication Critical patent/DK1060187T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003862 glucocorticoid Substances 0.000 abstract 1
102000003998 progesterone receptors Human genes 0.000 abstract 1
108090000468 progesterone receptors Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
150000007970 thio esters Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK99915475T 1998-03-03 1999-02-10 S-substituerede 11beta-benzaldoxim-estra-4,9-dien-carboxylsyrethiolestere, fremgangsmåde til deres fremstilling og farmaceutiske tilberedninger indeholdende disse forbindelser DK1060187T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19809845A DE19809845A1 (de)	1998-03-03	1998-03-03	S-substituierte 11beta-Benzaldoxim-estra-4,9-dien-kohlensäurethiolester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
PCT/DE1999/000408 WO1999045023A1 (de)	1998-03-03	1999-02-10	S-SUBSTITUIERTE 11β-BENZALDOXIM-ESTRA-4,9-DIEN-KOHLENSÄURETHIOLESTER, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENE PHARMAZEUTISCHE ZUBEREITUNGEN

Publications (1)

Publication Number	Publication Date
DK1060187T3 true DK1060187T3 (da)	2003-08-11

Family

ID=7860080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99915475T DK1060187T3 (da)	1998-03-03	1999-02-10	S-substituerede 11beta-benzaldoxim-estra-4,9-dien-carboxylsyrethiolestere, fremgangsmåde til deres fremstilling og farmaceutiske tilberedninger indeholdende disse forbindelser

Country Status (28)

Country	Link
US (1)	US6365582B1 (da)
EP (1)	EP1060187B1 (da)
JP (1)	JP3796405B2 (da)
KR (1)	KR100488823B1 (da)
CN (1)	CN1208341C (da)
AT (1)	ATE237627T1 (da)
AU (1)	AU749163B2 (da)
BG (1)	BG64735B1 (da)
BR (1)	BR9908458A (da)
CA (1)	CA2322471C (da)
CZ (1)	CZ20003125A3 (da)
DE (2)	DE19809845A1 (da)
DK (1)	DK1060187T3 (da)
EA (1)	EA002766B1 (da)
EE (1)	EE04242B1 (da)
ES (1)	ES2197634T3 (da)
HU (1)	HUP0100962A3 (da)
ID (1)	ID26972A (da)
IL (1)	IL137851A (da)
IS (1)	IS5579A (da)
NO (1)	NO316977B1 (da)
NZ (1)	NZ506048A (da)
PL (1)	PL193687B1 (da)
PT (1)	PT1060187E (da)
SK (1)	SK284177B6 (da)
TR (1)	TR200002506T2 (da)
UA (1)	UA59437C2 (da)
WO (1)	WO1999045023A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19906152B4 (de)	1999-02-10	2005-02-10	Jenapharm Gmbh & Co. Kg	Wirkstoffhaltige Laminate für Transdermalsysteme
EP1605924B1 (en) *	1999-08-31	2008-11-05	Bayer Schering Pharma Aktiengesellschaft	Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt)
ES2295050T3 (es) *	1999-08-31	2008-04-16	Bayer Schering Pharma Aktiengesellschaft	Mesoprogestinas para el tratamiento y la prevencion de trastornos ginecologicos benignos dependientes de hormonas.
US7629334B1 (en) *	1999-08-31	2009-12-08	Bayer Schering Pharma Aktiengesellschaft	Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT)
EP1605949A2 (en) *	1999-08-31	2005-12-21	Schering Aktiengesellschaft	Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives
US8193252B1 (en)	1999-08-31	2012-06-05	Bayer Pharma AG	Mesoprogestins (progesterone receptor modulators) for the treatment and prevention of benign hormone dependent gynecological disorders
EP1285927A3 (de) *	2001-08-16	2005-06-29	Schering Aktiengesellschaft	Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems
DE10221034A1 (de)	2002-05-03	2003-11-20	Schering Ag	17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE10236405A1 (de) *	2002-08-02	2004-02-19	Schering Ag	Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie
ATE338763T1 (de) *	2002-08-02	2006-09-15	Schering Ag	Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie
DE102005059222B4 (de) *	2005-12-08	2007-10-11	Bayer Schering Pharma Ag	11ß-Benzaldoximderivate von D-Homoestra-4,9-dien-3-onen
MY150763A (en)	2006-10-24	2014-02-28	Repros Therapeutics Inc	Compositions and methods for suppressing endometrial proliferation
WO2008109719A2 (en) *	2007-03-07	2008-09-12	Janssen Pharmaceutica N.V.	Steroids derivatives as selective progesterone receptor modulators
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
DE102009034525A1 (de) *	2009-07-21	2011-01-27	Bayer Schering Pharma Aktiengesellschaft	17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
MX2012010327A (es)	2010-03-22	2012-11-16	Repros Therapeutics Inc	Composiciones y metodos para la administracion no toxica de antiprogestinas.
EP2664325A1 (en) *	2012-05-16	2013-11-20	PregLem S.A.	Methods for preventing or treating androgen mediated diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4039677A (en) *	1976-03-01	1977-08-02	Syntex (U.S.A.) Inc.	Novel 1-phenethylimidazoles
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3504421A1 (de) *	1985-02-07	1986-08-07	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate
DE4332284C2 (de) *	1993-09-20	1997-05-28	Jenapharm Gmbh	11-Benzaldoxim-17beta-methoxy-17alpha-methoxymethyl-estradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4332283A1 (de) *	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5576310A (en) *	1994-09-20	1996-11-19	Jenapharm Gmbh	11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
NZ295365A (en)	1994-10-24	1999-07-29	Schering Ag	Competitive progesterone antagonists for regulating female fertility as required
ZA9510926B (en) *	1994-12-23	1996-07-03	Schering Ag	Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
KR100434239B1 (ko)	1995-03-14	2004-06-09	보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템	경관 팽창 및 신장 조절을 위한 산화질소 공여체 또는산화질소 억제제의 용도

1998
- 1998-03-03 DE DE19809845A patent/DE19809845A1/de not_active Ceased
1999
- 1999-02-10 EP EP99915475A patent/EP1060187B1/de not_active Expired - Lifetime
- 1999-02-10 CA CA002322471A patent/CA2322471C/en not_active Expired - Fee Related
- 1999-02-10 DK DK99915475T patent/DK1060187T3/da active
- 1999-02-10 JP JP2000534565A patent/JP3796405B2/ja not_active Expired - Fee Related
- 1999-02-10 EA EA200000896A patent/EA002766B1/ru not_active IP Right Cessation
- 1999-02-10 KR KR10-2000-7009712A patent/KR100488823B1/ko not_active Expired - Fee Related
- 1999-02-10 PT PT99915475T patent/PT1060187E/pt unknown
- 1999-02-10 CZ CZ20003125A patent/CZ20003125A3/cs unknown
- 1999-02-10 HU HU0100962A patent/HUP0100962A3/hu unknown
- 1999-02-10 IL IL13785199A patent/IL137851A/xx not_active IP Right Cessation
- 1999-02-10 AT AT99915475T patent/ATE237627T1/de not_active IP Right Cessation
- 1999-02-10 EE EEP200000500A patent/EE04242B1/xx not_active IP Right Cessation
- 1999-02-10 NZ NZ506048A patent/NZ506048A/en unknown
- 1999-02-10 WO PCT/DE1999/000408 patent/WO1999045023A1/de not_active Ceased
- 1999-02-10 PL PL99342449A patent/PL193687B1/pl unknown
- 1999-02-10 CN CNB998036080A patent/CN1208341C/zh not_active Expired - Fee Related
- 1999-02-10 US US09/622,803 patent/US6365582B1/en not_active Expired - Fee Related
- 1999-02-10 SK SK1305-2000A patent/SK284177B6/sk unknown
- 1999-02-10 TR TR2000/02506T patent/TR200002506T2/xx unknown
- 1999-02-10 BR BR9908458-9A patent/BR9908458A/pt not_active Application Discontinuation
- 1999-02-10 DE DE59905075T patent/DE59905075D1/de not_active Expired - Fee Related
- 1999-02-10 ID IDW20001706A patent/ID26972A/id unknown
- 1999-02-10 ES ES99915475T patent/ES2197634T3/es not_active Expired - Lifetime
- 1999-02-10 AU AU34067/99A patent/AU749163B2/en not_active Ceased
- 1999-10-02 UA UA2000105635A patent/UA59437C2/uk unknown
2000
- 2000-07-28 IS IS5579A patent/IS5579A/is unknown
- 2000-08-28 BG BG104712A patent/BG64735B1/bg unknown
- 2000-09-01 NO NO20004362A patent/NO316977B1/no unknown

Also Published As

Publication number	Publication date
NZ506048A (en)	2003-05-30
WO1999045023A1 (de)	1999-09-10
EA200000896A1 (ru)	2001-04-23
UA59437C2 (uk)	2003-09-15
SK13052000A3 (sk)	2001-11-06
NO20004362D0 (no)	2000-09-01
SK284177B6 (sk)	2004-10-05
HUP0100962A2 (hu)	2001-09-28
PL193687B1 (pl)	2007-03-30
JP3796405B2 (ja)	2006-07-12
PT1060187E (pt)	2003-09-30
TR200002506T2 (tr)	2000-12-21
ES2197634T3 (es)	2004-01-01
IS5579A (is)	2000-07-28
IL137851A (en)	2005-06-19
CZ20003125A3 (cs)	2002-01-16
BG64735B1 (bg)	2006-01-31
NO316977B1 (no)	2004-07-12
NO20004362L (no)	2000-10-31
CN1208341C (zh)	2005-06-29
CA2322471A1 (en)	1999-09-10
AU749163B2 (en)	2002-06-20
ID26972A (id)	2001-02-22
DE59905075D1 (de)	2003-05-22
EA002766B1 (ru)	2002-08-29
KR100488823B1 (ko)	2005-05-12
EE04242B1 (et)	2004-02-16
BG104712A (en)	2001-02-28
ATE237627T1 (de)	2003-05-15
IL137851A0 (en)	2001-10-31
BR9908458A (pt)	2000-11-14
CA2322471C (en)	2007-04-24
PL342449A1 (en)	2001-06-04
EE200000500A (et)	2002-02-15
EP1060187B1 (de)	2003-04-16
JP2002505335A (ja)	2002-02-19
CN1291990A (zh)	2001-04-18
DE19809845A1 (de)	1999-09-09
EP1060187A1 (de)	2000-12-20
US6365582B1 (en)	2002-04-02
AU3406799A (en)	1999-09-20
HUP0100962A3 (en)	2002-07-29
KR20010041536A (ko)	2001-05-25

Publication	Publication Date	Title
IS5579A (is)	2000-07-28	S-setnir 11ß-bensaldoxím-estra-4,9-díen-karbónsýru þíólesterar, aðferð til framleiðslu á þeim og lyfjasamsetningar sem innhalda þessi efnasambönd
NO20005431D0 (no)	2000-10-27	Gelérbare farmasøytiske preparater
CY1107438T1 (el)	2012-12-19	Παραγωγα καρβοξυλικου οξεος, τα οποια παρεμποδιζουν την συνδεσιν ιντεγκρινων εις τους υποδοχεις των
FI973733A0 (fi)	1997-09-19	Farmaceutiskt preparat och foerfarande foer dess framstaellning
DK1135117T3 (da)	2005-08-15	Medikament til behandling af kronisk obstruktiv lungesygdom
ATE404211T1 (de)	2008-08-15	Xenon als nmda-antogonist zur neuroprotektion
NO20015419D0 (no)	2001-11-06	Propionsyrederivater som hemmer binding av integriner til deres reseptorer
DE3481419D1 (de)	1990-04-05	Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten.
UA35607C2 (uk)	2001-04-16	Похідні оксазолідинонкарбонової кислоти, спосіб їх одержання, фармацевтична композиція і спосіб її одержання
BG104981A (en)	2001-07-31	Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
DK164159C (da)	1992-10-19	Oeoeoe(3-pyridinyl)methylenaaaminoaaoxyaaalkansyrederivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
CY1105591T1 (el)	2010-07-28	Αναστολεις για συνθαση του 20-ηετε
MX9400200A (es)	1994-07-29	Derivados de acido nonatetraenoico, proceso para su preparacion y composicion farmaceutica que los contiene.
HUP0105307A3 (en)	2002-10-28	Acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as tace inhibitors and pharmaceutical compositions thereof and process for preparation the compounds
DK1090028T3 (da)	2002-04-29	Umættede 14,15-cyclopropano-androstaner, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser
YU74401A (sh)	2004-07-15	Postupak za dobijanje 2s-3-amino-3-arilpropionske kiseline i njenih derivata
BR9810031A (pt)	2000-09-12	Derivados de ácido pirrolidina carboxìlico como antagonistas á endotelina
JPH0769883A (ja)	1995-03-14	アロマターゼ阻害剤
HUT54039A (en)	1991-01-28	Process for producing galenic compositions ensuring optimal biological accessibility of 2-hydroxy-5-methyllaurophenoneoxime active ingredient
ES8405370A1 (es)	1984-06-01	Un procedimiento para preparar diasteredisomeros derivados de pirrolidina
SE9901340D0 (sv)	1999-04-15	Novel process
ECSP951622A (es)	1997-06-11	Compuestos quimicos
ES8503657A1 (es)	1985-04-01	Un procedimiento para la preparacion de derivados de 3-sulfonamidopiridinas 2 -sustituidas.
ES465758A1 (es)	1978-11-16	Procedimiento de obtencion del monoester del acido p-cloro- fenoxi-isobutirico con 2,6-piridindimetanol, nuevo farmaco con accion hipocolesteremiante.