DK106288A - Osteoinduktive praeparater - Google Patents

Osteoinduktive praeparater

Info

Publication number
DK106288A
DK106288A DK106288A DK106288A DK106288A DK 106288 A DK106288 A DK 106288A DK 106288 A DK106288 A DK 106288A DK 106288 A DK106288 A DK 106288A DK 106288 A DK106288 A DK 106288A
Authority
DK
Denmark
Prior art keywords
osteoinductive
preparations
factors
defects
investigating
Prior art date
Application number
DK106288A
Other languages
English (en)
Other versions
DK172275B1 (da
DK106288D0 (da
Inventor
Elizabeth A Wang
John M Wozney
Vicki A Rosen
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/031,346 external-priority patent/US4877864A/en
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of DK106288D0 publication Critical patent/DK106288D0/da
Publication of DK106288A publication Critical patent/DK106288A/da
Application granted granted Critical
Publication of DK172275B1 publication Critical patent/DK172275B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Photoreceptors In Electrophotography (AREA)
DK106288A 1986-07-01 1988-02-29 Gener, som koder for BMP-2- og BMP-4-proteiner, vektorer indeholdende sådanne gener, celler transformeret med sådanne vektorer, BMP-2- og BMP-4-proteiner, fremgangsmåde til disses fremstilling, farmaceutiske præparater deraf og anvendelse deraf DK172275B1 (da)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US88077686A 1986-07-01 1986-07-01
US88077686 1986-07-01
US94333286A 1986-12-17 1986-12-17
US94333286 1986-12-17
US2828587A 1987-03-20 1987-03-20
US2828587 1987-03-20
US3134687 1987-03-26
US07/031,346 US4877864A (en) 1987-03-26 1987-03-26 Osteoinductive factors
US8701537 1987-06-30
PCT/US1987/001537 WO1988000205A1 (en) 1986-07-01 1987-06-30 Novel osteoinductive compositions

Publications (3)

Publication Number Publication Date
DK106288D0 DK106288D0 (da) 1988-02-29
DK106288A true DK106288A (da) 1988-04-28
DK172275B1 DK172275B1 (da) 1998-02-16

Family

ID=27487661

Family Applications (2)

Application Number Title Priority Date Filing Date
DK106288A DK172275B1 (da) 1986-07-01 1988-02-29 Gener, som koder for BMP-2- og BMP-4-proteiner, vektorer indeholdende sådanne gener, celler transformeret med sådanne vektorer, BMP-2- og BMP-4-proteiner, fremgangsmåde til disses fremstilling, farmaceutiske præparater deraf og anvendelse deraf
DK199700534A DK172503B1 (da) 1986-07-01 1997-05-09 Gen, som koder for BMP-3-protein, vektor indeholdende et sådant gen, celle transformeret med en sådan vektor, BMP-3-protein

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK199700534A DK172503B1 (da) 1986-07-01 1997-05-09 Gen, som koder for BMP-3-protein, vektor indeholdende et sådant gen, celle transformeret med en sådan vektor, BMP-3-protein

Country Status (18)

Country Link
EP (3) EP0313578B1 (da)
JP (3) JP2713715B2 (da)
AT (3) ATE234921T1 (da)
AU (1) AU613314B2 (da)
CA (1) CA1341212C (da)
DE (4) DE3751887T2 (da)
DK (2) DK172275B1 (da)
ES (1) ES2007625A6 (da)
GR (1) GR871028B (da)
IE (1) IE75881B1 (da)
IL (1) IL83003A (da)
LU (1) LU91005I2 (da)
MX (1) MX170919B (da)
MY (1) MY102505A (da)
NL (1) NL300116I2 (da)
NZ (1) NZ220894A (da)
PT (1) PT85225B (da)
WO (1) WO1988000205A1 (da)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5035901A (en) * 1987-10-09 1991-07-30 University Of Kansas Bone inducing agent from a human osteosarcoma cell line
US6020313A (en) * 1987-10-09 2000-02-01 University Of Kansas Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
AU645244B2 (en) * 1988-04-08 1994-01-13 Genetics Institute, Llc Bone and cartilage inductive compositions
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
JP2522568B2 (ja) * 1988-04-08 1996-08-07 ストライカー・コーポレーション 骨形成デバイス
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5344654A (en) * 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US4915301A (en) * 1988-11-15 1990-04-10 International Flavors & Fragrances, Inc. Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid
DE69031939T2 (de) * 1989-03-28 1998-09-10 Genetics Institute, Inc., Cambridge, Mass. Osteoinduktive zusammensetzungen
JP3504259B2 (ja) 1989-03-28 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 骨誘導組成物
JPH03151877A (ja) * 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
CA2064878A1 (en) * 1989-08-21 1991-02-22 Hanne Bentz Bone-specific protein
CA2024629C (en) * 1989-09-06 2001-07-24 Taiheiyo Cement Corporation Xenopus laevis bone morphogenic protein, dna encoding same and use thereof
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
EP0550625B1 (en) * 1990-09-26 2003-11-05 Genetics Institute, LLC Bmp-5 derivatives
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5739107A (en) 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
JPH07500315A (ja) 1991-05-10 1995-01-12 セルトリックス　ファーマシューティカルズ，インコーポレイテッド 骨成長因子の標的送達
WO1993000050A1 (en) * 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
DK0625989T3 (da) * 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
ATE182778T1 (de) * 1992-09-15 1999-08-15 Creative Biomolecules Inc Durch morphogen induzierte periodontolgeweberegeneration
WO1994006399A1 (en) * 1992-09-15 1994-03-31 Creative Biomolecules, Inc. Morphogen-induced periodontal tissue regeneration
BR9406715A (pt) * 1993-05-12 1996-02-06 Genetics Inst Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-11) polipeptideo de proteina-11 morfogenética de osso purificada (BMP-11) e molécula de DNA quimérica
US6333168B1 (en) * 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
WO1996039169A1 (en) * 1995-06-05 1996-12-12 Genetics Institute, Inc. Methods and compositions for healing and repair of connective tissue attachment
KR19990036272A (ko) * 1995-08-08 1999-05-25 사우코넨 주시 제이 재조합 ｃ-프로테나제와 이의 공정, 제조방법 및 이의 용도
US5807981A (en) * 1995-12-13 1998-09-15 Fibrogen Inc. Peptides which are cleaved by C-proteinase
KR20000064752A (ko) 1996-03-22 2000-11-06 더 제네랄 호스피탈 코포레이션 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
EP0937145A1 (en) * 1996-11-22 1999-08-25 Akzo Nobel N.V. Bmp-4 promoter and use thereof in screening of therapeutic agents for the prevention and/or treatment of osteoporosis
EP0957943B2 (en) * 1997-02-07 2008-11-26 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
WO1998050060A1 (en) 1997-05-05 1998-11-12 Creative Biomolecules, Inc. Therapies for acute renal failure
CA2291514C (en) 1997-05-30 2011-07-12 Mariel Therapeutics, Inc. Methods for evaluating tissue morphogenesis and activity
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
DE69939374D1 (de) 1998-03-17 2008-10-02 Genentech Inc Zu vegf und bmp1 homologe polypeptide
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
ATE250423T1 (de) 1998-07-13 2003-10-15 Univ Southern California Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel
US6916783B2 (en) 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
MXPA01003538A (es) 1998-10-06 2005-09-08 Rush Presbyterian St Luke Metodo para el tratamiento de quimionucleolisis.
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
JP3786533B2 (ja) 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
WO2000044413A1 (en) * 1999-02-01 2000-08-03 Genetics Institute, Inc. Methods and compositions for healing and repair of articular cartilage
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
AU771546B2 (en) * 1999-09-01 2004-03-25 Ppd Development, Lp Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
WO2001016323A2 (en) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
WO2001017562A1 (fr) * 1999-09-02 2001-03-15 Yamanouchi Pharmaceutical Co., Ltd. Agents promoteurs de l'osteogenese
PT1223990E (pt) 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
DE60129848T2 (de) 2000-12-28 2008-04-24 Shionogi & Co., Ltd. Chordin-ähnliche polypeptide und deren dns
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
EP1399023B1 (en) 2001-06-01 2008-04-30 Wyeth COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9;
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7160725B2 (en) 2001-11-13 2007-01-09 Curis, Inc. Hedgehog signaling promotes the formation of three dimensional cartilage matrices
ATE303169T1 (de) 2001-11-19 2005-09-15 Scil Technology Gmbh Homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften
US8067557B2 (en) 2002-03-28 2011-11-29 The Trustees Of The University Of Pennsylvania OCL-2A3 compositions and uses thereof
US7160994B2 (en) 2002-03-28 2007-01-09 Trustees Of The University Of Pennsylvania Osteoclast-specific genes and proteins and uses thereof
AU2003253049A1 (en) 2002-09-10 2004-04-30 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
AU2004272072B2 (en) 2003-09-12 2010-07-08 Etex Corporation Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
CA2535169A1 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
EP1571159A1 (en) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
US8372419B2 (en) 2004-03-10 2013-02-12 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
ES2369629T3 (es) 2004-05-25 2011-12-02 Stryker Corporation Uso de op-1 para tratar defectos del cartílago.
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
CA2627907C (en) 2005-11-01 2014-06-17 Osteotech, Inc. Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier
EP2035030A2 (en) 2006-05-17 2009-03-18 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
CA2668208C (en) 2006-11-02 2017-09-12 Daniel J. Capon Hybrid immunoglobulins with moving parts
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
CA2671925A1 (en) 2006-12-21 2008-07-10 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US9358113B2 (en) 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
CN101801405A (zh) 2007-08-07 2010-08-11 先进科技及再生医学有限责任公司 包含于酸性水溶液中的gdf-5的蛋白质配方
EP2268302B1 (en) 2008-02-13 2014-04-09 Keith Hruska Bmp-7 for use in treating neointimal hyperplasia
BRPI0911048A2 (pt) 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
WO2010093955A1 (en) 2009-02-12 2010-08-19 Osteotech,Inc. Segmented delivery system
WO2010093925A2 (en) 2009-02-12 2010-08-19 Stryker Corporation PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS FOR TREATMENT OF SYSTEMIC DISORDERS AND DISEASE
SG173634A1 (en) 2009-02-12 2011-09-29 Stryker Corp COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS
WO2010103070A2 (en) * 2009-03-12 2010-09-16 Charité - Universitätsmedizin Berlin Bone morphogenetic protein 2 (bmp2) variants with reduced bmp antagonist sensitivity
US20120148539A1 (en) 2009-03-24 2012-06-14 Moulay Hicham Alaoui-Ismaili Methods and Compositions for Tissue Engineering
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
EP2456861A4 (en) * 2009-07-23 2013-12-04 Agency Science Tech & Res PRENATAL MESENCHYMAL STEM CELLS
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
EP2352750B1 (en) 2009-09-17 2012-06-13 Stryker Corporation Buffers for controlling the ph of bone morphogenetic proteins
WO2011087768A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
CA3044371C (en) 2016-12-30 2024-01-16 Biogend Therapeutics Co., Ltd. Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
CA1229789A (en) * 1983-06-06 1987-12-01 David Baylink Polypeptides exhibiting skeletal growth factor activity
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
NZ210699A (en) * 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
ZA848495B (en) 1984-01-31 1985-09-25 Idaho Res Found Production of polypeptides in insect cells
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
NZ228031A (en) 1984-07-06 1991-12-23 Sandoz Ltd Primate gm-csf and method of extraction
DE3588058T3 (de) 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Knorpel-induzierende Polypeptid-Faktoren aus Knochen
ATE78515T1 (de) 1984-10-05 1992-08-15 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors

Also Published As

Publication number Publication date
IE75881B1 (en) 1997-09-24
DE3752364T2 (de) 2004-03-04
IL83003A (en) 1995-07-31
MY102505A (en) 1992-07-31
DE3751887T2 (de) 1997-03-06
JPH06298800A (ja) 1994-10-25
MX170919B (es) 1993-09-22
EP0688869A1 (en) 1995-12-27
JP3093682B2 (ja) 2000-10-03
ATE141928T1 (de) 1996-09-15
EP0688869B1 (en) 2003-03-19
EP1254956B1 (en) 2008-12-31
ES2007625A6 (es) 1989-07-01
EP0313578B1 (en) 1996-08-28
DE3751887D1 (de) 1996-10-02
EP1254956A2 (en) 2002-11-06
JP2729222B2 (ja) 1998-03-18
DK172275B1 (da) 1998-02-16
DE10399007I2 (de) 2006-03-16
DE3752393D1 (de) 2009-02-12
DK106288D0 (da) 1988-02-29
EP0313578A1 (en) 1989-05-03
EP1254956A3 (en) 2002-11-13
EP0313578A4 (en) 1990-10-03
DE3752364D1 (de) 2003-04-24
NL300116I2 (nl) 2003-06-02
LU91005I2 (en) 2003-03-31
NZ220894A (en) 1990-05-28
IL83003A0 (en) 1987-12-20
DE10399007I1 (de) 2003-07-31
IE871739L (en) 1988-01-01
PT85225B (pt) 1990-03-30
JPH02500241A (ja) 1990-02-01
AU613314B2 (en) 1991-08-01
DK172503B1 (da) 1998-10-26
AU7783587A (en) 1988-01-29
IE970378L (en) 1988-01-01
NL300116I1 (nl) 2003-05-01
PT85225A (en) 1987-08-01
DK53497A (da) 1997-05-09
ATE419349T1 (de) 2009-01-15
JPH1070989A (ja) 1998-03-17
JP2713715B2 (ja) 1998-02-16
CA1341212C (en) 2001-04-10
GR871028B (da) 1988-01-11
ATE234921T1 (de) 2003-04-15
WO1988000205A1 (en) 1988-01-14

Similar Documents

Publication Publication Date Title
DK106288A (da) Osteoinduktive praeparater
NZ227787A (en) Peptides and compositions having growth hormone regulatory effects
FI884051L (fi) Menetelmä stabiloitujen humaaniproteiinivalmisteiden valmistamiseksi
FI881518L (fi) Istukasta eristettyjä injektioitavia materiaaleja pehmeän kudoksen lisäämistä varten sekä menetelmä niiden valmistamiseksi
DK313087A (da) Fremgangsmaade til kaedekombination til dannelse af biologisk aktivt humant relaxin eller analoge dertil samt humant-relaxin-analoge og fremgangsmaade til fremkaldelse af foedsel
FI873738A7 (fi) Menetelmä tekstiilipintojen käsittelemiseksi ja siinä käytetty seos.
EP0243929A3 (en) Polypeptide and protein derivatives and process for their preparation
FI883299A7 (fi) Menetelmät ja laitteet elintarvikkeiden säilömiseksi
DE3788231D1 (de) Kosmetisches mittel und zusammensetzung zur behandlung der haut.
EE9700225A (et) Meetod diabetes mellituse raviks, kasutades KKF
FI874975A7 (fi) Antioksidantteja koostumuksia ja menetelmä niiden valmistamiseksi.
FI882707A7 (fi) Menetelmä ja valmiste maidon proteiinipitoisuuden lisäämiseksi.
NO874756L (no) Fremgangsmaate og apparat for vakuumpakking.
FI873599A7 (fi) Menetelmä ja seos luuvaurion parantamiseksi.
FR2491334B1 (da)
ES542817A0 (es) Procedimiento para preparar gluconato de 2-amino-3-etoxicar-bonil-amino-6-(p-fluoro-bencilamino)-piridina
FI880954A7 (fi) Seos ja menetelmä immunologista kastrointia varten.
FI880636A7 (fi) Menetelmä vaipallisten virusten inaktivoimiseksi solun avulla in vitro valmistetuissa proteiinivalmisteissa.
DK325289A (da) Strontiumsalt, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende saltet
FI893545A7 (fi) Ihmisen proteiini C:n mutantteja ja menetelmä niiden valmistamiseksi
GR3005231T3 (da)
NO862453L (no) Fremgangsmÿte for fremstilling av proteinprodukt og apparat for anvendelse ved fremgangsmÿten.
AR240007A1 (es) Protesis dental para animales ovinos y bovinos.

Legal Events

Date Code Title Description
CTFG Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: DIBOTERMIN ALFA

Spc suppl protection certif: CA 2003 00001

Filing date: 20030107

PUP Patent expired