|
US6150328A
(en)
|
1986-07-01 |
2000-11-21 |
Genetics Institute, Inc. |
BMP products
|
|
IL83003A
(en)
*
|
1986-07-01 |
1995-07-31 |
Genetics Inst |
Osteoinductive factors
|
|
US5106748A
(en)
*
|
1986-07-01 |
1992-04-21 |
Genetics Institute, Inc. |
Dna sequences encoding 5 proteins
|
|
US6020313A
(en)
*
|
1987-10-09 |
2000-02-01 |
University Of Kansas |
Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
|
|
US5035901A
(en)
*
|
1987-10-09 |
1991-07-30 |
University Of Kansas |
Bone inducing agent from a human osteosarcoma cell line
|
|
US6586388B2
(en)
|
1988-04-08 |
2003-07-01 |
Stryker Corporation |
Method of using recombinant osteogenic protein to repair bone or cartilage defects
|
|
US5670336A
(en)
*
|
1988-04-08 |
1997-09-23 |
Stryker Corporation |
Method for recombinant production of osteogenic protein
|
|
US5258494A
(en)
*
|
1988-04-08 |
1993-11-02 |
Stryker Corporation |
Osteogenic proteins
|
|
US5250302A
(en)
*
|
1988-04-08 |
1993-10-05 |
Stryker Corporation |
Osteogenic devices
|
|
AU645244B2
(en)
*
|
1988-04-08 |
1994-01-13 |
Genetics Institute, Llc |
Bone and cartilage inductive compositions
|
|
US6919308B2
(en)
|
1988-04-08 |
2005-07-19 |
Stryker Corporation |
Osteogenic devices
|
|
US4968590A
(en)
*
|
1988-04-08 |
1990-11-06 |
Stryker Corporation |
Osteogenic proteins and polypeptides
|
|
US5162114A
(en)
*
|
1989-02-23 |
1992-11-10 |
Stryker Corporation |
Bone collagen matrix for xenogenic implants
|
|
US5266683A
(en)
*
|
1988-04-08 |
1993-11-30 |
Stryker Corporation |
Osteogenic proteins
|
|
US5354557A
(en)
*
|
1988-04-08 |
1994-10-11 |
Stryker Corporation |
Osteogenic devices
|
|
US4975526A
(en)
*
|
1989-02-23 |
1990-12-04 |
Creative Biomolecules, Inc. |
Bone collagen matrix for zenogenic implants
|
|
EP1225225A3
(de)
|
1988-04-08 |
2003-01-08 |
Stryker Corporation |
Osteogene Vorrichtungen
|
|
US5324819A
(en)
*
|
1988-04-08 |
1994-06-28 |
Stryker Corporation |
Osteogenic proteins
|
|
US5344654A
(en)
*
|
1988-04-08 |
1994-09-06 |
Stryker Corporation |
Prosthetic devices having enhanced osteogenic properties
|
|
US5108753A
(en)
*
|
1988-04-08 |
1992-04-28 |
Creative Biomolecules |
Osteogenic devices
|
|
US5284756A
(en)
*
|
1988-10-11 |
1994-02-08 |
Lynn Grinna |
Heterodimeric osteogenic factor
|
|
US5106626A
(en)
*
|
1988-10-11 |
1992-04-21 |
International Genetic Engineering, Inc. |
Osteogenic factors
|
|
US4915301A
(en)
*
|
1988-11-15 |
1990-04-10 |
International Flavors & Fragrances, Inc. |
Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid
|
|
JP3504259B2
(ja)
|
1989-03-28 |
2004-03-08 |
ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー |
骨誘導組成物
|
|
CA2030518C
(en)
*
|
1989-03-28 |
2000-03-21 |
Elizabeth A. Wang |
Osteoinductive compositions
|
|
JPH03151877A
(ja)
*
|
1989-06-02 |
1991-06-28 |
Chiron Corp |
骨カルシウム沈着因子
|
|
CA2020729A1
(en)
*
|
1989-07-19 |
1991-01-20 |
Michael C. Kiefer |
Bone morphogenetic protein
|
|
WO1991002744A1
(en)
*
|
1989-08-21 |
1991-03-07 |
Celtrix Laboratories, Inc. |
Bone-specific protein
|
|
ATE140965T1
(de)
*
|
1989-09-06 |
1996-08-15 |
Takeda Chemical Industries Ltd |
Protein, dna und ihre verwendung
|
|
ATE167486T1
(de)
*
|
1989-10-17 |
1998-07-15 |
Stryker Corp |
Osteogene vorrichtungen
|
|
US5168050A
(en)
*
|
1990-05-24 |
1992-12-01 |
Genentech, Inc. |
Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
|
|
US5645591A
(en)
|
1990-05-29 |
1997-07-08 |
Stryker Corporation |
Synthetic bone matrix
|
|
US5364839A
(en)
*
|
1990-06-18 |
1994-11-15 |
Genetics Institute, Inc. |
Osteoinductive pharmaceutical formulations
|
|
WO1992005199A1
(en)
*
|
1990-09-26 |
1992-04-02 |
Genetics Institute, Inc. |
Bmp-5 derivatives
|
|
US5206023A
(en)
*
|
1991-01-31 |
1993-04-27 |
Robert F. Shaw |
Method and compositions for the treatment and repair of defects or lesions in cartilage
|
|
US5656593A
(en)
*
|
1991-03-11 |
1997-08-12 |
Creative Biomolecules, Inc. |
Morphogen induced periodontal tissue regeneration
|
|
US6495513B1
(en)
|
1991-03-11 |
2002-12-17 |
Curis, Inc. |
Morphogen-enhanced survival and repair of neural cells
|
|
US6090776A
(en)
*
|
1991-03-11 |
2000-07-18 |
Creative Bio Molecules, Inc. |
Morphogen treatment of organ implants
|
|
US6800603B2
(en)
|
1991-03-11 |
2004-10-05 |
Curis, Inc. |
Morphogen-induced neural cell adhesion
|
|
US5674844A
(en)
*
|
1991-03-11 |
1997-10-07 |
Creative Biomolecules, Inc. |
Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
|
|
US6077823A
(en)
*
|
1991-03-11 |
2000-06-20 |
Creative Biomolecules, Inc. |
Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
|
|
US6399569B1
(en)
|
1991-03-11 |
2002-06-04 |
Curis, Inc. |
Morphogen treatments for limiting proliferation of epithelial cells
|
|
US5652118A
(en)
*
|
1991-03-11 |
1997-07-29 |
Creative Biomolecules, Inc. |
Nucleic acid encoding a novel morphogenic protein, OP-3
|
|
US5972884A
(en)
*
|
1991-03-11 |
1999-10-26 |
Creative Biomolecules, Inc. |
Morphogen treatment of gastrointestinal ulcers
|
|
US5849686A
(en)
*
|
1991-03-11 |
1998-12-15 |
Creative Biomolecules, Inc. |
Morphogen-induced liver regeneration
|
|
US7056882B2
(en)
|
1991-03-11 |
2006-06-06 |
Curis, Inc. |
Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
|
|
US5652337A
(en)
*
|
1991-03-11 |
1997-07-29 |
Creative Biomolecules, Inc. |
OP-3-induced morphogenesis
|
|
CA2104678C
(en)
|
1991-03-11 |
2002-05-14 |
Charles M. Cohen |
Protein-induced morphogenesis
|
|
US5318898A
(en)
*
|
1991-04-02 |
1994-06-07 |
Genetics Institute, Inc. |
Production of recombinant bone-inducing proteins
|
|
US5118667A
(en)
*
|
1991-05-03 |
1992-06-02 |
Celtrix Pharmaceuticals, Inc. |
Bone growth factors and inhibitors of bone resorption for promoting bone formation
|
|
AU662155B2
(en)
|
1991-05-10 |
1995-08-24 |
Celtrix Pharmaceuticals, Inc. |
Targeted delivery of bone growth factors
|
|
KR0145278B1
(ko)
*
|
1991-06-21 |
1998-07-15 |
브루스 엠. 에이센 |
골형성원 단백질 약제
|
|
US6022853A
(en)
*
|
1991-08-30 |
2000-02-08 |
Creative Biomolecules, Inc. |
Morphogen-enriched dietary composition
|
|
US5270300A
(en)
*
|
1991-09-06 |
1993-12-14 |
Robert Francis Shaw |
Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
|
|
DE69233022T2
(de)
|
1991-11-04 |
2004-02-12 |
Genetics Institute, LLC, Cambridge |
Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
|
|
CZ287715B6
(en)
*
|
1992-02-12 |
2001-01-17 |
Bioph Biotech Entw Pharm Gmbh |
DNA sequence, recombinant DNA molecule containing thereof, process for preparing protein from the group of TGF-beta substances, pharmaceutical preparation containing such protein, antibody or fragment thereof and its use
|
|
IL106278A0
(en)
*
|
1992-07-13 |
1993-11-15 |
Sumitomo Metal Ind |
Bone formation-inducing protein
|
|
CA2144513C
(en)
*
|
1992-09-15 |
1998-12-15 |
Thangavel Kuberasampath |
Morphogen-induced periodontal tissue regeneration
|
|
AU670334B2
(en)
*
|
1992-09-15 |
1996-07-11 |
Creative Biomolecules, Inc. |
Morphogen-induced periodontal tissue regeneration
|
|
KR100227406B1
(ko)
*
|
1993-05-12 |
1999-12-01 |
브루스 엠. 에이센 |
Bmp-11 조성물
|
|
US6333168B1
(en)
*
|
1993-05-20 |
2001-12-25 |
The Trustees Of Columbia University In The City Of New York |
Cloning, expression and uses of dorsalin-1
|
|
US5385887A
(en)
*
|
1993-09-10 |
1995-01-31 |
Genetics Institute, Inc. |
Formulations for delivery of osteogenic proteins
|
|
US6291206B1
(en)
*
|
1993-09-17 |
2001-09-18 |
Genetics Institute, Inc. |
BMP receptor proteins
|
|
AU689184B2
(en)
|
1993-12-07 |
1998-03-26 |
Genetics Institute, Llc |
BMP-12, BMP-13 and tendon-inducing compositions thereof
|
|
US5906827A
(en)
†
|
1994-06-03 |
1999-05-25 |
Creative Biomolecules, Inc. |
Matrix for the manufacture of autogenous replacement body parts
|
|
HU222664B1
(hu)
*
|
1995-06-05 |
2003-09-29 |
Genetics Institute, Llc |
Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására
|
|
KR19990036272A
(ko)
*
|
1995-08-08 |
1999-05-25 |
사우코넨 주시 제이 |
재조합 c-프로테나제와 이의 공정, 제조방법 및 이의 용도
|
|
US5807981A
(en)
*
|
1995-12-13 |
1998-09-15 |
Fibrogen Inc. |
Peptides which are cleaved by C-proteinase
|
|
JP4847634B2
(ja)
|
1996-03-22 |
2011-12-28 |
ストライカー・コーポレーション |
中枢神経系の虚血または外傷の機能的回復を増大させる方法
|
|
US6498142B1
(en)
|
1996-05-06 |
2002-12-24 |
Curis, Inc. |
Morphogen treatment for chronic renal failure
|
|
CA2272345A1
(en)
*
|
1996-11-22 |
1998-06-04 |
Akzo Nobel Nv |
Bmp-4 promoter and use thereof in screening of therapeutic agents for the prevention and/or treatment of osteoporosis
|
|
JP4388602B2
(ja)
*
|
1997-02-07 |
2009-12-24 |
ストライカー コーポレイション |
マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
|
|
US7041641B2
(en)
|
1997-03-20 |
2006-05-09 |
Stryker Corporation |
Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
|
|
US20010016646A1
(en)
|
1998-03-20 |
2001-08-23 |
David C. Rueger |
Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
|
|
PT980252E
(pt)
|
1997-05-05 |
2005-01-31 |
Curis Inc |
Terapias para insuficiencia renal aguda
|
|
EP2309261A1
(de)
|
1997-05-30 |
2011-04-13 |
Stryker Corporation |
Verfahren zur Beurteilung von Gewebemorphogenese und- aktivität
|
|
US6391311B1
(en)
|
1998-03-17 |
2002-05-21 |
Genentech, Inc. |
Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
|
|
PT2016951E
(pt)
*
|
1998-03-17 |
2012-09-27 |
Genentech Inc |
Polipéptidos homólogos de vegf e de bmp1
|
|
US7147839B2
(en)
|
1998-05-29 |
2006-12-12 |
Curis, Inc. |
Methods for evaluating tissue morphogenesis and activity
|
|
US6916783B2
(en)
|
1998-07-13 |
2005-07-12 |
University Of Southern California |
Methods for accelerating bone and cartilage growth and repair
|
|
JP3686335B2
(ja)
|
1998-07-13 |
2005-08-24 |
ユニヴァースティ オブ サザーン カリフォルニア |
骨および軟骨成長と修復を促進する方法
|
|
US6958149B2
(en)
|
1998-10-06 |
2005-10-25 |
Stryker Corporation |
Repair of larynx, trachea, and other fibrocartilaginous tissues
|
|
EP1119611B1
(de)
|
1998-10-06 |
2006-10-18 |
Rush University Medical Center |
Zusammensetzung zur verwendung in der chemonukleolyse
|
|
US7572440B2
(en)
|
1999-07-30 |
2009-08-11 |
Stryker Corporation |
Method for repairing a defect in an intervertebral disc
|
|
JP3786533B2
(ja)
|
1998-11-12 |
2006-06-14 |
善彦 西村 |
ペプチド及び骨形成促進剤
|
|
US6727224B1
(en)
|
1999-02-01 |
2004-04-27 |
Genetics Institute, Llc. |
Methods and compositions for healing and repair of articular cartilage
|
|
EP1148897B1
(de)
*
|
1999-02-01 |
2003-12-10 |
Genetics Institute, LLC |
Methoden und zusammensetzungen zur heilung und reparatur von gelenkknorpeln
|
|
DE19906096A1
(de)
|
1999-02-13 |
2000-08-17 |
Walter Sebald |
Protein mit einem Heparin-bindenden Epitop
|
|
JP2003510033A
(ja)
*
|
1999-09-01 |
2003-03-18 |
サブサイダリー ナンバースリー インコーポレイテッド |
ヒト細胞遺伝子をダウンレギュレートすることにより、ヒト免疫不全ウイルス感染を阻止するための組成物および方法
|
|
WO2001016323A2
(en)
*
|
1999-09-01 |
2001-03-08 |
Subsidiary N0.3, Inc. |
Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
|
|
WO2001017562A1
(fr)
*
|
1999-09-02 |
2001-03-15 |
Yamanouchi Pharmaceutical Co., Ltd. |
Agents promoteurs de l'osteogenese
|
|
EP2286847A1
(de)
|
1999-10-15 |
2011-02-23 |
Genetics Institute, LLC |
Hyaluronsäure enthaltende Zusammensetzungen zur Abgabe osteogener Proteine
|
|
EP1354890B1
(de)
|
2000-12-28 |
2007-08-08 |
Shionogi & Co., Ltd. |
Chordin-ähnliche polypeptide und deren dns
|
|
TWI329129B
(en)
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
|
US7226587B2
(en)
|
2001-06-01 |
2007-06-05 |
Wyeth |
Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
|
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
|
US7160725B2
(en)
|
2001-11-13 |
2007-01-09 |
Curis, Inc. |
Hedgehog signaling promotes the formation of three dimensional cartilage matrices
|
|
BR0214275A
(pt)
|
2001-11-19 |
2004-09-21 |
Scil Technology Gmbh |
Dispositivo tendo propriedades osteocondutora e osteoindutora
|
|
US8067557B2
(en)
|
2002-03-28 |
2011-11-29 |
The Trustees Of The University Of Pennsylvania |
OCL-2A3 compositions and uses thereof
|
|
US7160994B2
(en)
|
2002-03-28 |
2007-01-09 |
Trustees Of The University Of Pennsylvania |
Osteoclast-specific genes and proteins and uses thereof
|
|
WO2004024199A1
(en)
|
2002-09-10 |
2004-03-25 |
Scil Technology Gmbh |
Metal implant coated under reduced oxygen concentration with osteoinductive protein
|
|
ES2282904T3
(es)
|
2003-09-12 |
2007-10-16 |
Wyeth |
Barras solidas de fosfato calcico inyectables para el suministro de proteinas osteogenicas.
|
|
US8734525B2
(en)
|
2003-12-31 |
2014-05-27 |
Warsaw Orthopedic, Inc. |
Osteoinductive demineralized cancellous bone
|
|
CA2535169A1
(en)
|
2003-12-31 |
2005-07-21 |
Osteotech, Inc. |
Improved bone matrix compositions and methods
|
|
EP1571159A1
(de)
*
|
2004-03-04 |
2005-09-07 |
Bayerische Julius-Maximilians-Universität Würzburg |
Mutein von Knochenmorphogenetisches Protein und seine Verwendung
|
|
PL1737734T3
(pl)
|
2004-03-10 |
2011-02-28 |
Scil Tech Gmbh |
Powlekane implanty, ich wytwarzanie i zastosowanie
|
|
CA2567405A1
(en)
|
2004-05-25 |
2005-12-08 |
Stryker Corporation |
Use of morphogenic proteins for treating cartilage defects
|
|
US8506646B2
(en)
|
2005-04-29 |
2013-08-13 |
Warsaw Orthopedic, Inc. |
Multi-purpose medical implant devices
|
|
AU2006308534B2
(en)
|
2005-11-01 |
2013-02-07 |
Warsaw Orthopedic, Inc. |
Bone matrix compositions and methods
|
|
US20090298761A1
(en)
|
2006-05-17 |
2009-12-03 |
Donald Engelman |
Methods of treating cartilage defects using a soluble morphogenic protein complex
|
|
NZ576445A
(en)
|
2006-11-02 |
2012-03-30 |
Daniel J Capon |
Hybrid immunoglobulins with moving parts
|
|
AU2007234612B2
(en)
|
2006-12-14 |
2013-06-27 |
Johnson & Johnson Regenerative Therapeutics, Llc |
Protein stabilization formulations
|
|
ES2447516T3
(es)
|
2006-12-21 |
2014-03-12 |
Stryker Corporation |
Formulaciones de liberación sostenida que comprenden cristales BMP-7
|
|
EP2167147B1
(de)
|
2007-06-15 |
2017-03-29 |
Warsaw Orthopedic, Inc. |
Knochenmatrixzusammensetzungen und verfahren
|
|
US9554920B2
(en)
|
2007-06-15 |
2017-01-31 |
Warsaw Orthopedic, Inc. |
Bone matrix compositions having nanoscale textured surfaces
|
|
US7678764B2
(en)
|
2007-06-29 |
2010-03-16 |
Johnson & Johnson Regenerative Therapeutics, Llc |
Protein formulations for use at elevated temperatures
|
|
US9358113B2
(en)
|
2007-07-10 |
2016-06-07 |
Warsaw Orthopedic, Inc. |
Delivery system
|
|
US8058237B2
(en)
|
2007-08-07 |
2011-11-15 |
Advanced Technologies & Regenerative Medicine, LLC |
Stable composition of GDF-5 and method of storage
|
|
CA2718592A1
(en)
|
2008-02-13 |
2009-08-20 |
Keith Hruska |
Method of treating vascular sclerosis
|
|
WO2009129101A1
(en)
|
2008-04-14 |
2009-10-22 |
Advanced Technologies And Regenerative Medicine, Llc |
Liquid buffered gdf-5 formulations
|
|
CA2752157A1
(en)
|
2009-02-12 |
2010-08-19 |
Stryker Corporation |
Peripheral administration of proteins including tgf-.beta. superfamily members for systemic treatment of disorders and disease
|
|
JP5819734B2
(ja)
|
2009-02-12 |
2015-11-24 |
ストライカー コーポレイションStryker Corporation |
TGF−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法
|
|
US9220598B2
(en)
|
2009-02-12 |
2015-12-29 |
Warsaw Orthopedic, Inc. |
Delivery systems, tools, and methods of use
|
|
EP2406281B1
(de)
*
|
2009-03-12 |
2016-02-17 |
Haase Investments UG |
Varianten des knochenmorphogenetischen proteins 2 (bone morphogenetic protein 2, bmp2) mit reduzierter bmp-antagonistischer empfindlichkeit
|
|
US20120148539A1
(en)
|
2009-03-24 |
2012-06-14 |
Moulay Hicham Alaoui-Ismaili |
Methods and Compositions for Tissue Engineering
|
|
WO2010144696A1
(en)
|
2009-06-11 |
2010-12-16 |
Burnham Institute For Medical Research |
Directed differentiation of stem cells
|
|
US20120107413A1
(en)
*
|
2009-07-23 |
2012-05-03 |
Singapore Health Services Pte Ltd |
Pre-natal mesenchymal stem cells
|
|
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(en)
|
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|
|
ES2387379T3
(es)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|