DK106897A - Fremgangsmåde til fremstilling af urinstofderivater - Google Patents

Fremgangsmåde til fremstilling af urinstofderivater Download PDF

Info

Publication number: DK106897A
Authority: DK; Denmark
Prior art keywords: preparation; urea derivatives; urea; derivatives
Prior art date: 1982-09-13

Application number

DK106897A

Other languages

English (en)

Other versions

DK172732B1 (da

Inventor

Ronald D Dennis

Terence M Dolak

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-13

Filing date

1997-09-17

Publication date

1997-09-17

1997-09-17 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1997-09-17 Publication of DK106897A publication Critical patent/DK106897A/da

1999-06-21 Application granted granted Critical

1999-06-21 Publication of DK172732B1 publication Critical patent/DK172732B1/da

Links

150000003672 ureas Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK199701068A 1982-09-13 1997-09-17 Fremgangsmåde til fremstilling af urinstofderivater DK172732B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/417,794 US4463176A (en)	1982-09-13	1982-09-13	Process for resolution of optical isomers
US41779482		1982-09-13

Publications (2)

Publication Number	Publication Date
DK106897A true DK106897A (da)	1997-09-17
DK172732B1 DK172732B1 (da)	1999-06-21

Family

ID=23655420

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK198304164A DK172720B1 (da)	1982-09-13	1983-09-13	Fremgangsmåde til opspaltning af en racemisk modifikation af beta-adrenerge aryl- eller heteroarylpropanolaminer i de tilsv
DK199701068A DK172732B1 (da)	1982-09-13	1997-09-17	Fremgangsmåde til fremstilling af urinstofderivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK198304164A DK172720B1 (da)	1982-09-13	1983-09-13	Fremgangsmåde til opspaltning af en racemisk modifikation af beta-adrenerge aryl- eller heteroarylpropanolaminer i de tilsv

Country Status (29)

Country	Link
US (1)	US4463176A (da)
JP (2)	JPS5980616A (da)
KR (1)	KR890000616B1 (da)
AT (1)	AT385032B (da)
AU (1)	AU573535B2 (da)
BE (1)	BE897737A (da)
CA (1)	CA1250290A (da)
CH (1)	CH660732A5 (da)
CY (1)	CY1543A (da)
DE (1)	DE3333025A1 (da)
DK (2)	DK172720B1 (da)
ES (1)	ES525543A0 (da)
FI (1)	FI83767C (da)
FR (1)	FR2540490B1 (da)
GB (2)	GB2127020B (da)
GR (1)	GR81546B (da)
HK (1)	HK97990A (da)
HU (1)	HU193183B (da)
IE (1)	IE55650B1 (da)
IL (1)	IL69708A (da)
IT (1)	IT1170213B (da)
LU (1)	LU84998A1 (da)
NL (1)	NL8303154A (da)
NO (1)	NO159267C (da)
NZ (1)	NZ205554A (da)
PT (1)	PT77331B (da)
SE (2)	SE452608B (da)
YU (1)	YU43327B (da)
ZA (1)	ZA836795B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4849527A (en) *	1982-09-13	1989-07-18	Bristol-Myers Company	Process for resolution of optical isomers
IT1163107B (it) *	1983-02-15	1987-04-08	Simes	Composizioni farmaceutiche e loro uso nel trattamento del glaucoma
US5364872A (en) *	1984-04-16	1994-11-15	Yamanouchi Pharmaceutical Co., Ltd.	Dihydropyridine-3,5-dicarboxylic acid ester derivatives
US5039801A (en) *	1985-12-20	1991-08-13	The United States Of America As Represented By The Department Of Health & Human Services	Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
US4797498A (en) *	1986-07-18	1989-01-10	Pennwalt Corporation	Flavonoxypropanolamines and esters of flavonoxypropanolamines as antiarrhythmic agents
EP0305496A4 (en) *	1987-03-17	1989-07-11	Insite Vision Inc	TIMOLOL DERIVATIVES.
US4889941A (en) *	1987-04-23	1989-12-26	Fisons Corporation	Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase
US4806660A (en) *	1987-11-06	1989-02-21	Pennwalt Corporation	Aurone oxypropanolamines
JP2801768B2 (ja) *	1990-11-17	1998-09-21	日東電工株式会社	新規な光学活性メトプロロール・酒石酸誘導体塩及びその製法、並びにこの塩を用いる光学活性メトプロロールの製法
US5082970A (en) *	1991-03-06	1992-01-21	Pfizer Inc.	Process for recycling amine isomer
ES2065278B1 (es) *	1993-06-24	1995-09-01	Medichem Sa	Procedimiento de obtencion enantioselectivo del levobunolol.
AU702594B2 (en) *	1995-10-13	1999-02-25	Duphar International Research B.V.	Process for the preparation of enantiomerically pure imidazolyl compounds
KR100332399B1 (ko) *	1999-02-22	2002-04-13	김경호	메토프롤롤 라세미체로부터 메토프롤롤 에난티오머의 제조방법
BE1012622A3 (fr)	1999-04-21	2001-01-09	Solvay	Procede pour la separation d'enantiomeres et reactif enantiopur.
US7138538B2 (en) *	2000-04-14	2006-11-21	Solvay (Societe Anonyme)	Process for the separation of enantiomers and enantiopure reagent
AU2003250483A1 (en)	2002-08-19	2004-03-11	Pfizer Products Inc.	Combination therapy for hyperproliferative diseases
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
WO2008112287A1 (en)	2007-03-12	2008-09-18	Nektar Therapeutics	Oligomer-beta blocker conjugates
EP2986599A1 (en)	2013-04-17	2016-02-24	Pfizer Inc.	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
BR112021013807A2 (pt)	2019-01-18	2021-11-30	Astrazeneca Ab	Inibidores de pcsk9 e seus métodos de uso

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US234595A (en) *		1880-11-16		Juan f
GB1211589A (en) *	1968-08-06	1970-11-11	Ici Ltd	Enantiomer isolation process
BE786963A (fr) *	1971-07-30	1973-01-29	Degussa	Procede pour le dedoublement racemique de d,1-phenylpropanolamine
US4234595A (en) *	1977-07-13	1980-11-18	Mead Johnson & Company	3-Indolyl-tertiary butylaminopropanols
US4314943A (en) *	1977-07-13	1982-02-09	Mead Johnson & Company	Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
IT1113029B (it) *	1979-03-01	1986-01-20	Simes	Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
JPS5770884A (en) *	1980-10-21	1982-05-01	Kyowa Hakko Kogyo Co Ltd	Novel piperidine derivative and its preparation
FI76551C (fi) *	1980-11-06	1988-11-10	Sandoz Ag	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-aminopropoxifenylderivat.

1982
- 1982-09-13 US US06/417,794 patent/US4463176A/en not_active Expired - Lifetime
1983
- 1983-09-12 SE SE8304887A patent/SE452608B/sv not_active IP Right Cessation
- 1983-09-12 PT PT77331A patent/PT77331B/pt unknown
- 1983-09-12 BE BE0/211517A patent/BE897737A/fr not_active IP Right Cessation
- 1983-09-12 GR GR72427A patent/GR81546B/el unknown
- 1983-09-12 LU LU84998A patent/LU84998A1/fr unknown
- 1983-09-12 NZ NZ205554A patent/NZ205554A/en unknown
- 1983-09-12 FR FR8314464A patent/FR2540490B1/fr not_active Expired
- 1983-09-12 CA CA000436530A patent/CA1250290A/en not_active Expired
- 1983-09-12 IE IE2134/83A patent/IE55650B1/en not_active IP Right Cessation
- 1983-09-12 CH CH4958/83A patent/CH660732A5/fr not_active IP Right Cessation
- 1983-09-12 NO NO833254A patent/NO159267C/no not_active IP Right Cessation
- 1983-09-12 ES ES525543A patent/ES525543A0/es active Granted
- 1983-09-12 IT IT22852/83A patent/IT1170213B/it active
- 1983-09-13 IL IL69708A patent/IL69708A/xx not_active IP Right Cessation
- 1983-09-13 YU YU1846/83A patent/YU43327B/xx unknown
- 1983-09-13 HU HU833181A patent/HU193183B/hu unknown
- 1983-09-13 DK DK198304164A patent/DK172720B1/da not_active IP Right Cessation
- 1983-09-13 DE DE19833333025 patent/DE3333025A1/de active Granted
- 1983-09-13 AT AT0326383A patent/AT385032B/de not_active IP Right Cessation
- 1983-09-13 KR KR1019830004298A patent/KR890000616B1/ko not_active Expired
- 1983-09-13 JP JP58167667A patent/JPS5980616A/ja active Granted
- 1983-09-13 NL NL8303154A patent/NL8303154A/nl active Search and Examination
- 1983-09-13 GB GB08324536A patent/GB2127020B/en not_active Expired
- 1983-09-13 AU AU19081/83A patent/AU573535B2/en not_active Expired
- 1983-09-13 ZA ZA836795A patent/ZA836795B/xx unknown
- 1983-10-13 FI FI833270A patent/FI83767C/fi not_active IP Right Cessation
1986
- 1986-02-24 GB GB08604515A patent/GB2169294B/en not_active Expired
- 1986-06-18 SE SE8602724A patent/SE8602724D0/xx not_active Application Discontinuation
1990
- 1990-11-22 HK HK979/90A patent/HK97990A/xx not_active IP Right Cessation
1991
- 1991-03-22 CY CY1543A patent/CY1543A/en unknown
- 1991-09-25 JP JP3315620A patent/JP2759184B2/ja not_active Expired - Lifetime
1997
- 1997-09-17 DK DK199701068A patent/DK172732B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB8324536D0 (en)	1983-10-12
AU573535B2 (en)	1988-06-16
DK416483A (da)	1984-03-14
PT77331B (en)	1986-08-28
IL69708A (en)	1987-02-27
SE8602724L (sv)	1986-06-18
ZA836795B (en)	1984-04-25
GB2169294B (en)	1987-05-13
CA1250290A (en)	1989-02-21
YU184683A (en)	1986-02-28
FR2540490B1 (fr)	1986-09-05
DK172732B1 (da)	1999-06-21
IE55650B1 (en)	1990-12-05
NZ205554A (en)	1987-09-30
AU1908183A (en)	1984-03-22
NO159267C (no)	1988-12-14
US4463176A (en)	1984-07-31
GB2169294A (en)	1986-07-09
NO159267B (no)	1988-09-05
FI833270A0 (fi)	1983-09-13
GB8604515D0 (en)	1986-04-03
AT385032B (de)	1988-02-10
IL69708A0 (en)	1983-12-30
DK172720B1 (da)	1999-06-14
SE8304887L (sv)	1984-03-14
CY1543A (en)	1991-03-22
FR2540490A1 (fr)	1984-08-10
SE452608B (sv)	1987-12-07
SE8602724D0 (sv)	1986-06-18
DE3333025A1 (de)	1984-03-29
LU84998A1 (fr)	1984-04-24
GB2127020B (en)	1987-05-07
HU193183B (en)	1987-08-28
JPS5980616A (ja)	1984-05-10
ES8504104A1 (es)	1985-04-16
YU43327B (en)	1989-06-30
SE8304887D0 (sv)	1983-09-12
PT77331A (en)	1983-10-01
BE897737A (fr)	1984-03-12
NL8303154A (nl)	1984-04-02
FI833270L (fi)	1984-03-14
HK97990A (en)	1990-11-30
FI83767B (fi)	1991-05-15
NO833254L (no)	1984-03-14
KR890000616B1 (ko)	1989-03-22
ATA326383A (de)	1987-07-15
DK416483D0 (da)	1983-09-13
ES525543A0 (es)	1985-04-16
DE3333025C2 (da)	1992-01-23
JPH0414086B2 (da)	1992-03-11
IE832134L (en)	1984-03-13
JP2759184B2 (ja)	1998-05-28
IT1170213B (it)	1987-06-03
FI83767C (fi)	1991-08-26
GR81546B (da)	1984-12-11
KR840005998A (ko)	1984-11-21
JPH0859597A (ja)	1996-03-05
IT8322852A0 (it)	1983-09-12
CH660732A5 (fr)	1987-06-15
GB2127020A (en)	1984-04-04

Legal Events

Date	Code	Title	Description
1999-06-21	B1	Patent granted (law 1993)
2003-10-06	PUP	Patent expired

Publication	Publication Date	Title
DK106897A (da)	1997-09-17	Fremgangsmåde til fremstilling af urinstofderivater
DK301383D0 (da)	1983-06-30	Fremgangsmade til fremstilling af imidazolderivater
DK513883A (da)	1984-05-13	Fremgangsmaade til fremstilling af aminderivater
DK95483A (da)	1983-08-28	Fremgangsmaade til fremstilling af tetrahydropyranderivater
DK241883D0 (da)	1983-05-27	Fremgangsmade til fremstilling af 1-sulfo-2-oxoazetidinderivater
DK372283A (da)	1984-02-18	Fremgangsmaade til fremstilling af desoxyuridinderivater
DK155984D0 (da)	1984-03-14	Fremgangsmade til fremstilling af thiadiazolderivater
DK63683D0 (da)	1983-02-14	Fremgangsmade til fremstilling af cephemderivater
DK53483D0 (da)	1983-02-08	Fremgangsmade til fremstilling af guanidinderivater
DK323083A (da)	1984-01-15	Fremgangsmaade til fremstilling af 19-thio-androstanderivater
DK435483D0 (da)	1983-09-23	Fremgangsmade til fremstilling af fenylcyklobutylderivater
DK427083D0 (da)	1983-09-19	Fremgangsmade til fremstilling af cephemderivater
DK140584A (da)	1984-09-09	Fremgangsmaade til fremstilling af carbapenemderivater
DK261883A (da)	1983-12-11	Fremgangsmaade til fremstilling af prostaglandin-d-derivater
DK162230C (da)	1992-03-02	Fremgangsmaade til fremstilling af 2-thiacephemderivater
DK317283D0 (da)	1983-07-08	Fremgangsmade til fremstilling af thiadiazolderivater
DK426683D0 (da)	1983-09-19	Fremgangsmade til fremstilling af oxacephalosporinderivater
DK340483D0 (da)	1983-07-25	Fremgangsmade til fremstilling af fluoralkylerede carbapenemderivater
DK165583D0 (da)	1983-04-15	Fremgangsmade til fremstilling af furanderivater
DK482983A (da)	1984-04-22	Fremgangsmaade til fremstilling af phenylderivater
DK542383D0 (da)	1983-11-25	Fremgangsmade til fremstilling af acridanonderivater
DK164283D0 (da)	1983-04-14	Fremgangsmade til fremstilling af benzimidazolderivater
DK96383D0 (da)	1983-02-28	Fremgangsmade til fremstilling af 3-azetidinylaetyl-1-fenyl-2-imidazolidinonderivater
DK88283D0 (da)	1983-02-24	Fremgangsmade til fremstilling af triazolderivater
DK159283A (da)	1983-10-14	Fremgangsmaade til fremstilling af indolderivater