DK1101497T3 - Stabiliserende olieagtige præparationer af tobicillin (beta-lactam antibiotikum) - Google Patents
Stabiliserende olieagtige præparationer af tobicillin (beta-lactam antibiotikum)Info
- Publication number
- DK1101497T3 DK1101497T3 DK99925357T DK99925357T DK1101497T3 DK 1101497 T3 DK1101497 T3 DK 1101497T3 DK 99925357 T DK99925357 T DK 99925357T DK 99925357 T DK99925357 T DK 99925357T DK 1101497 T3 DK1101497 T3 DK 1101497T3
- Authority
- DK
- Denmark
- Prior art keywords
- beta
- tobicillin
- lactam antibiotic
- oily preparations
- stabilizing
- Prior art date
Links
- 239000003782 beta lactam antibiotic agent Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000002132 β-lactam antibiotic Substances 0.000 title abstract 2
- 229940124586 β-lactam antibiotics Drugs 0.000 title abstract 2
- MGKUHWMKIYHWOJ-AOHZBQACSA-N Tobicillin Chemical compound CC(C)C(=O)OCC1=CC=CC(OC(=O)[C@H]2C(S[C@H]3N2C([C@H]3NC(=O)CC=2C=CC=CC=2)=O)(C)C)=C1 MGKUHWMKIYHWOJ-AOHZBQACSA-N 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
- 229950004363 tobicillin Drugs 0.000 title 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22016198 | 1998-08-04 | ||
| PCT/JP1999/003233 WO2000007628A1 (en) | 1998-08-04 | 1999-06-16 | STABILIZED PREPARATIONS OF β-LACTAM ANTIBIOTIC |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1101497T3 true DK1101497T3 (da) | 2008-03-31 |
Family
ID=16746851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99925357T DK1101497T3 (da) | 1998-08-04 | 1999-06-16 | Stabiliserende olieagtige præparationer af tobicillin (beta-lactam antibiotikum) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6514962B1 (de) |
| EP (1) | EP1101497B1 (de) |
| JP (1) | JP3531648B2 (de) |
| KR (1) | KR100412231B1 (de) |
| CN (1) | CN1149102C (de) |
| AT (1) | ATE386546T1 (de) |
| CA (1) | CA2339147C (de) |
| DE (1) | DE69938184T2 (de) |
| DK (1) | DK1101497T3 (de) |
| ES (1) | ES2297925T3 (de) |
| HK (1) | HK1041217A1 (de) |
| PT (1) | PT1101497E (de) |
| TW (1) | TW550081B (de) |
| WO (1) | WO2000007628A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230030B1 (hu) | 1999-10-08 | 2015-05-28 | Debiopharm International Sa | Fab I inhibitorok |
| EP1560584B1 (de) * | 2001-04-06 | 2009-01-14 | Affinium Pharmaceuticals, Inc. | Fab-i-inhibitoren |
| EP1575951B1 (de) * | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel |
| WO2004082586A2 (en) * | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| DK1828167T3 (da) * | 2004-06-04 | 2014-10-20 | Debiopharm Int Sa | Acrylamidderivater som antibiotiske midler |
| KR20080075027A (ko) * | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Ｆａｂｉ 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물 |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| EP2125802A4 (de) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | Salze, prodrugs und polymorphe von fab-i-inhibitoren |
| AU2013279021C1 (en) | 2012-06-19 | 2017-03-16 | Debiopharm International Sa | Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| US11744859B2 (en) | 2017-07-07 | 2023-09-05 | Epicentrx, Inc. | Compositions and methods for parenteral administration of therapeutic agents |
| TN2021000159A1 (en) | 2019-02-14 | 2023-04-04 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| SG11202113174SA (en) | 2019-06-14 | 2021-12-30 | Debiopharm Int Sa | Medicament and use thereof for treating bacterial infections involving biofilm |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59176209A (ja) * | 1983-03-28 | 1984-10-05 | Sankyo Co Ltd | β−ラクタム環を有する化合物の直腸投与用組成物 |
| SE8405611D0 (sv) | 1984-11-09 | 1984-11-09 | Astra Laekemedel Ab | Process for stabilization of bacampicillin hydrochloride |
| US4731362A (en) | 1985-08-05 | 1988-03-15 | Shionogi & Co., Ltd. | Alkylcarbamoyloxymethylcephem compounds |
| DK8603837A (de) | 1985-08-13 | 1987-02-14 | ||
| US5063074A (en) * | 1990-01-30 | 1991-11-05 | Rich Products Corporation | Low fat low cholesterol milk products |
| JP3233434B2 (ja) | 1992-04-01 | 2001-11-26 | 塩野義製薬株式会社 | カルバペネム誘導体 |
| FR2698560B1 (fr) | 1992-11-30 | 1995-02-03 | Virbac Laboratoires | Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications. |
| US5602118A (en) * | 1993-03-16 | 1997-02-11 | American Cyanamid Company | 2-thiosubstituted carbapenems |
| JPH06298769A (ja) | 1993-04-13 | 1994-10-25 | Fujisawa Pharmaceut Co Ltd | アンピシリンフェニルエステルおよびその塩 |
-
1999
- 1999-06-16 AT AT99925357T patent/ATE386546T1/de not_active IP Right Cessation
- 1999-06-16 DK DK99925357T patent/DK1101497T3/da active
- 1999-06-16 KR KR10-2001-7000769A patent/KR100412231B1/ko not_active Expired - Fee Related
- 1999-06-16 US US09/774,186 patent/US6514962B1/en not_active Expired - Fee Related
- 1999-06-16 DE DE69938184T patent/DE69938184T2/de not_active Expired - Fee Related
- 1999-06-16 ES ES99925357T patent/ES2297925T3/es not_active Expired - Lifetime
- 1999-06-16 JP JP56296699A patent/JP3531648B2/ja not_active Expired - Lifetime
- 1999-06-16 CA CA002339147A patent/CA2339147C/en not_active Expired - Fee Related
- 1999-06-16 PT PT99925357T patent/PT1101497E/pt unknown
- 1999-06-16 WO PCT/JP1999/003233 patent/WO2000007628A1/ja not_active Ceased
- 1999-06-16 CN CNB998117463A patent/CN1149102C/zh not_active Expired - Fee Related
- 1999-06-16 EP EP99925357A patent/EP1101497B1/de not_active Expired - Lifetime
- 1999-06-16 HK HK02102937.0A patent/HK1041217A1/zh unknown
- 1999-06-24 TW TW088110651A patent/TW550081B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW550081B (en) | 2003-09-01 |
| DE69938184T2 (de) | 2009-03-26 |
| JP3531648B2 (ja) | 2004-05-31 |
| WO2000007628A1 (en) | 2000-02-17 |
| KR20010071964A (ko) | 2001-07-31 |
| PT1101497E (pt) | 2008-04-23 |
| EP1101497A4 (de) | 2002-03-06 |
| ES2297925T3 (es) | 2008-05-01 |
| CN1149102C (zh) | 2004-05-12 |
| DE69938184D1 (de) | 2008-04-03 |
| ATE386546T1 (de) | 2008-03-15 |
| CA2339147A1 (en) | 2000-02-17 |
| CN1322140A (zh) | 2001-11-14 |
| HK1041217A1 (zh) | 2002-07-05 |
| EP1101497B1 (de) | 2008-02-20 |
| KR100412231B1 (ko) | 2003-12-24 |
| US6514962B1 (en) | 2003-02-04 |
| CA2339147C (en) | 2009-04-21 |
| EP1101497A1 (de) | 2001-05-23 |
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