DK1121145T3 - Insulinpræparater til indgivelse via lungerne, som indeholder mentol - Google Patents

Insulinpræparater til indgivelse via lungerne, som indeholder mentol

Info

Publication number: DK1121145T3
Authority: DK; Denmark
Prior art keywords: insulin; formulation; administration via; insulin preparations; menthol
Prior art date: 1998-10-16

Application number

DK99948726T

Other languages

Danish (da)

English (en)

Inventor

Svend Havelund

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-15

Publication date

2002-08-12

1999-10-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2002-08-12 Application granted granted Critical

2002-08-12 Publication of DK1121145T3 publication Critical patent/DK1121145T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
102000004877 Insulin Human genes 0.000 title abstract 4
108090001061 Insulin Proteins 0.000 title abstract 4
229940125396 insulin Drugs 0.000 title abstract 4
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 title abstract 3
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 title abstract 3
229940041616 menthol Drugs 0.000 title abstract 3
210000004072 lung Anatomy 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000009472 formulation Methods 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
150000002500 ions Chemical class 0.000 abstract 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
150000002989 phenols Chemical class 0.000 abstract 1
230000002685 pulmonary effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Zoology (AREA)
Obesity (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

DK99948726T 1998-10-16 1999-10-15 Insulinpræparater til indgivelse via lungerne, som indeholder mentol DK1121145T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA199801326		1998-10-16
PCT/DK1999/000557 WO2000023099A1 (en)	1998-10-16	1999-10-15	Insulin preparations for pulmonary delivery containing menthol

Publications (1)

Publication Number	Publication Date
DK1121145T3 true DK1121145T3 (da)	2002-08-12

Family

ID=8103609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99948726T DK1121145T3 (da)	1998-10-16	1999-10-15	Insulinpræparater til indgivelse via lungerne, som indeholder mentol

Country Status (20)

Country	Link
EP (1)	EP1121145B1 (de)
JP (1)	JP2002527488A (de)
KR (1)	KR20010080132A (de)
CN (1)	CN1323220A (de)
AT (1)	ATE216258T1 (de)
AU (1)	AU758108B2 (de)
BR (1)	BR9914568A (de)
CA (1)	CA2346884A1 (de)
CZ (1)	CZ20011133A3 (de)
DE (1)	DE69901314T2 (de)
DK (1)	DK1121145T3 (de)
ES (1)	ES2177324T3 (de)
HU (1)	HUP0103606A3 (de)
IL (1)	IL142002A0 (de)
NO (1)	NO20011841L (de)
PL (1)	PL347171A1 (de)
PT (1)	PT1121145E (de)
UA (1)	UA67798C2 (de)
WO (1)	WO2000023099A1 (de)
ZA (1)	ZA200102068B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7089053B1 (en)	1999-10-14	2006-08-08	Pola Chemical Industries Inc	Compositions for drug administration by electroporation
ATE328581T1 (de) *	1999-10-15	2006-06-15	Pola Chem Ind Inc	Perkutane absorptionsbeschleuniger für die elektroporation
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
CN102256618A (zh)	2008-10-17	2011-11-23	赛诺菲-安万特德国有限公司	胰岛素和glp-1激动剂的组合
PL2451437T3 (pl)	2009-07-06	2017-05-31	Sanofi-Aventis Deutschland Gmbh	Wodne preparaty insuliny zawierające metioninę
TR201809460T4 (tr)	2009-11-13	2018-07-23	Sanofi Aventis Deutschland	Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
NZ599847A (en)	2009-11-13	2013-09-27	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
WO2012028172A1 (en)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
PE20171622A1 (es)	2014-12-12	2017-11-02	Sanofi Aventis Deutschland	Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
GB201906917D0 (en) *	2019-05-16	2019-07-03	Intract Pharma Ltd	Novel compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5635161A (en) *	1995-06-07	1997-06-03	Abbott Laboratories	Aerosol drug formulations containing vegetable oils
PL188736B1 (pl) *	1996-06-20	2005-04-29	Novo Nordisk As	Wodny preparat insuliny oraz sposób jego przygotowania
ATE219942T1 (de) *	1997-03-20	2002-07-15	Novo Nordisk As	Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

1999
- 1999-10-15 EP EP99948726A patent/EP1121145B1/de not_active Expired - Lifetime
- 1999-10-15 ES ES99948726T patent/ES2177324T3/es not_active Expired - Lifetime
- 1999-10-15 JP JP2000576872A patent/JP2002527488A/ja not_active Withdrawn
- 1999-10-15 DE DE69901314T patent/DE69901314T2/de not_active Expired - Fee Related
- 1999-10-15 AT AT99948726T patent/ATE216258T1/de not_active IP Right Cessation
- 1999-10-15 CN CN99812209A patent/CN1323220A/zh active Pending
- 1999-10-15 CZ CZ20011133A patent/CZ20011133A3/cs unknown
- 1999-10-15 IL IL14200299A patent/IL142002A0/xx unknown
- 1999-10-15 KR KR1020017004638A patent/KR20010080132A/ko not_active Withdrawn
- 1999-10-15 PT PT99948726T patent/PT1121145E/pt unknown
- 1999-10-15 DK DK99948726T patent/DK1121145T3/da active
- 1999-10-15 WO PCT/DK1999/000557 patent/WO2000023099A1/en not_active Ceased
- 1999-10-15 PL PL99347171A patent/PL347171A1/xx unknown
- 1999-10-15 AU AU61890/99A patent/AU758108B2/en not_active Ceased
- 1999-10-15 BR BR9914568-5A patent/BR9914568A/pt not_active IP Right Cessation
- 1999-10-15 UA UA2001042149A patent/UA67798C2/uk unknown
- 1999-10-15 HU HU0103606A patent/HUP0103606A3/hu unknown
- 1999-10-15 CA CA002346884A patent/CA2346884A1/en not_active Abandoned
2001
- 2001-03-13 ZA ZA200102068A patent/ZA200102068B/en unknown
- 2001-04-10 NO NO20011841A patent/NO20011841L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2002527488A (ja)	2002-08-27
NO20011841D0 (no)	2001-04-10
DE69901314T2 (de)	2002-11-21
CN1323220A (zh)	2001-11-21
NO20011841L (no)	2001-06-15
CZ20011133A3 (cs)	2001-08-15
BR9914568A (pt)	2001-07-03
WO2000023099A1 (en)	2000-04-27
AU6189099A (en)	2000-05-08
HUP0103606A2 (hu)	2002-02-28
AU758108B2 (en)	2003-03-13
ZA200102068B (en)	2001-10-12
HUP0103606A3 (en)	2002-05-28
EP1121145B1 (de)	2002-04-17
DE69901314D1 (de)	2002-05-23
KR20010080132A (ko)	2001-08-22
PL347171A1 (en)	2002-03-25
IL142002A0 (en)	2002-03-10
PT1121145E (pt)	2002-09-30
ATE216258T1 (de)	2002-05-15
EP1121145A1 (de)	2001-08-08
CA2346884A1 (en)	2000-04-27
ES2177324T3 (es)	2002-12-01
UA67798C2 (uk)	2004-07-15

Publication	Publication Date	Title
DK1121145T3 (da)	2002-08-12	Insulinpræparater til indgivelse via lungerne, som indeholder mentol
CO5271759A1 (es)	2003-04-30	Formulacion en solucion que contiene una mezcla de disolventes
DE69901726D1 (de)	2002-07-11	Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
BR0012013A (pt)	2002-03-26	Métodos de aerossolizar uma formulação farmacêutica, e de administrar uma formulação farmacêutica, dispositivo de aerossolização, sistema de aerossolização, e, receptáculo
YU59192A (sh)	1994-12-28	Formulacija aerosola koje ne sadrže hlorofluorougljenična jedinjenja
YU59092A (sh)	1994-12-28	Formulacije aerosola koji ne sadrže hlorofluorougljenična jedinjenja
TR200002692T2 (tr)	2001-02-21	Aerosol haline getirilen aktif maddenin verilmesi.
CO4410203A1 (es)	1997-01-09	Formulaciones de analogos de insulina
BR9811249A (pt)	2000-09-05	Nova formulação para inalação; apresentando densidade volumétrica, quando derramada, de 0,20 à 0,38g/ml, processo para preparação de formulação e uso da mesma
HRP20000867B1 (en)	2010-10-31	Pharmaceutical formulations for aerosols with two or more active substances
BR9917089A (pt)	2001-10-16	Composições e métodos para distribuição mucosal
RU94040387A (ru)	1996-10-20	Композиция, способствующая прекращению курения, никотиносодержащий распыляемый раствор, способ снижения потребности в курении табака, способ замены курения табака
MY129112A (en)	2007-03-30	Flow resistance modulated aerosolized active agent delivery
YU54499A (sh)	2002-06-19	Farmaceutski preparat za primenu na mukozu
DK1146896T3 (da)	2002-09-02	Formuleringer, som indeholder monodisperse hexamere acylerede insulin-analoger
IL140848A (en)	2005-05-17	Pharmaceutical compositions containing phenylacetylglutamine, phenylacetylisoglutamine and/or phenylacetate
DE50100958D1 (de)	2003-12-18	Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung enthaltend desmopressin
Morris	1997	Uptake of acetaldehyde vapor and aldehyde dehydrogenase levels in the upper respiratory tracts of the mouse, rat, hamster, and guinea pig
BRPI0014878B8 (pt)	2021-05-25	composição farmacêutica contendo ciclosonida para aplicação à mucosa
ATE350024T1 (de)	2007-01-15	Flüssige zubereitung enthaltend tobramycin
MY136546A (en)	2008-10-31	A pharmaceutical component based on human parathyroid harmone and a pharmaceutical composition for intranasal administration comprising the component
EP1297838A4 (de)	2003-07-09	Pralmorelin-haltige nasentropfen-präparate
BR0006237A (pt)	2001-11-27	Inalador em aerossol, e, processo de tratamentode um sujeito com um agente farmacêutico
SE9904132D0 (sv)	1999-11-16	Pharmaceutical composition for treatment of diarrhea