DK1121364T3 - Fremgangsmåde til fremstilling af epothilon B og derivater samt mellemprodukter til fremstilling deraf - Google Patents

Fremgangsmåde til fremstilling af epothilon B og derivater samt mellemprodukter til fremstilling deraf

Info

Publication number: DK1121364T3
Authority: DK; Denmark
Prior art keywords: derivatives; intermediates; preparation; epothilone; preparing epothilone
Prior art date: 1998-10-14

Application number

DK99952569T

Other languages

English (en)

Inventor

Johann Mulzer

Andreas Mantoulidis

Elisabeth Oehler

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-14

Filing date

1999-10-14

Publication date

2003-03-17

1999-10-14 Application filed by Schering Ag filed Critical Schering Ag

2003-03-17 Application granted granted Critical

2003-03-17 Publication of DK1121364T3 publication Critical patent/DK1121364T3/da

Links

QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 title abstract 3
HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 title abstract 3
QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 title abstract 3
150000003883 epothilone derivatives Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
239000013067 intermediate product Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Thiazole And Isothizaole Compounds (AREA)
Silicon Polymers (AREA)

DK99952569T 1998-10-14 1999-10-14 Fremgangsmåde til fremstilling af epothilon B og derivater samt mellemprodukter til fremstilling deraf DK1121364T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19848306A DE19848306A1 (de)	1998-10-14	1998-10-14	Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren
PCT/EP1999/007746 WO2000023452A1 (de)	1998-10-14	1999-10-14	Verfahren zur herstellung von epothilon b und derivaten sowie zwischenprodukte für dieses verfahren

Publications (1)

Publication Number	Publication Date
DK1121364T3 true DK1121364T3 (da)	2003-03-17

Family

ID=7885043

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99952569T DK1121364T3 (da)	1998-10-14	1999-10-14	Fremgangsmåde til fremstilling af epothilon B og derivater samt mellemprodukter til fremstilling deraf

Country Status (11)

Country	Link
US (2)	US6605726B1 (da)
EP (1)	EP1121364B1 (da)
JP (1)	JP2002527521A (da)
AT (1)	ATE230751T1 (da)
AU (1)	AU763717B2 (da)
CA (1)	CA2346493A1 (da)
DE (2)	DE19848306A1 (da)
DK (1)	DK1121364T3 (da)
ES (1)	ES2189508T3 (da)
PT (1)	PT1121364E (da)
WO (1)	WO2000023452A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204388B1 (en) *	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
EP1386922B1 (en)	1996-12-03	2012-04-11	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereof, analogues and uses thereof
US20050043376A1 (en) *	1996-12-03	2005-02-24	Danishefsky Samuel J.	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
FR2775187B1 (fr) *	1998-02-25	2003-02-21	Novartis Ag	Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US6989450B2 (en) *	2000-10-13	2006-01-24	The University Of Mississippi	Synthesis of epothilones and related analogs
ES2315399T3 (es) *	2001-08-23	2009-04-01	Novartis Ag	Analogos de epotilona ciclobutilo y ciclopropilo.
AU2003218110A1 (en)	2002-03-12	2003-09-29	Bristol-Myers Squibb Company	C3-cyano epothilone derivatives
ATE350383T1 (de)	2002-08-23	2007-01-15	Sloan Kettering Inst Cancer	Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
EP2634252B1 (en)	2005-02-11	2018-12-19	University of Southern California	Method of expressing proteins with disulfide bridges
US8008256B2 (en) *	2006-05-01	2011-08-30	University Of Southern California	Combination therapy for treatment of cancer
US8802394B2 (en)	2008-11-13	2014-08-12	Radu O. Minea	Method of expressing proteins with disulfide bridges with enhanced yields and activity
CA2927832C (en)	2010-05-18	2021-03-23	Cerulean Pharma Inc.	Cyclodextrin-containing polymer-therapeutic agent conjugates and their use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4138042C2 (de)	1991-11-19	1993-10-14	Biotechnolog Forschung Gmbh	Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
US5745850A (en) *	1994-10-24	1998-04-28	Lucent Technologies, Inc.	Apparatus and method for mobile (e.g. cellular or wireless) telephone call handover and impersonation
US5734699A (en) *	1995-05-04	1998-03-31	Interwave Communications International, Ltd.	Cellular private branch exchanges
DE59609305D1 (de) *	1995-11-17	2002-07-11	Biotechnolog Forschung Gmbh	Epothilon-Derivate und deren Herstellung
US5809415A (en) *	1995-12-11	1998-09-15	Unwired Planet, Inc.	Method and architecture for an interactive two-way data communication network
US6055427A (en) *	1996-07-18	2000-04-25	Nokia Telecommunications Oy	Hard handoff and a radio system
US6441186B1 (en)	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
US6119006A (en) *	1997-01-03	2000-09-12	Siemens Information And Communication Systems, Inc.	System and method for calendar-based cellular smart switching
US6430395B2 (en) *	2000-04-07	2002-08-06	Commil Ltd.	Wireless private branch exchange (WPBX) and communicating between mobile units and base stations

1998
- 1998-10-14 DE DE19848306A patent/DE19848306A1/de not_active Ceased
1999
- 1999-10-14 PT PT99952569T patent/PT1121364E/pt unknown
- 1999-10-14 ES ES99952569T patent/ES2189508T3/es not_active Expired - Lifetime
- 1999-10-14 US US09/807,370 patent/US6605726B1/en not_active Expired - Fee Related
- 1999-10-14 AT AT99952569T patent/ATE230751T1/de not_active IP Right Cessation
- 1999-10-14 JP JP2000577178A patent/JP2002527521A/ja active Pending
- 1999-10-14 AU AU64717/99A patent/AU763717B2/en not_active Ceased
- 1999-10-14 CA CA002346493A patent/CA2346493A1/en not_active Abandoned
- 1999-10-14 EP EP99952569A patent/EP1121364B1/de not_active Expired - Lifetime
- 1999-10-14 DK DK99952569T patent/DK1121364T3/da active
- 1999-10-14 WO PCT/EP1999/007746 patent/WO2000023452A1/de not_active Ceased
- 1999-10-14 DE DE59903993T patent/DE59903993D1/de not_active Expired - Lifetime
2003
- 2003-04-23 US US10/420,716 patent/US20030220503A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU6471799A (en)	2000-05-08
DE59903993D1 (de)	2003-02-13
ES2189508T3 (es)	2003-07-01
EP1121364B1 (de)	2003-01-08
US20030220503A1 (en)	2003-11-27
CA2346493A1 (en)	2000-04-27
AU763717B2 (en)	2003-07-31
PT1121364E (pt)	2003-04-30
EP1121364A1 (de)	2001-08-08
ATE230751T1 (de)	2003-01-15
US6605726B1 (en)	2003-08-12
WO2000023452A1 (de)	2000-04-27
DE19848306A1 (de)	2000-04-20
JP2002527521A (ja)	2002-08-27

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