DK118286A - Terapeutisk aktive nucleosider, deres anvendelse og farmaceutiske kompositioner indeholdende forbindelserne - Google Patents

Terapeutisk aktive nucleosider, deres anvendelse og farmaceutiske kompositioner indeholdende forbindelserne Download PDF

Info

Publication number
DK118286A
DK118286A DK118286A DK118286A DK118286A DK 118286 A DK118286 A DK 118286A DK 118286 A DK118286 A DK 118286A DK 118286 A DK118286 A DK 118286A DK 118286 A DK118286 A DK 118286A
Authority
DK
Denmark
Prior art keywords
compounds
pharmaceutical compositions
compositions containing
therapeutic active
active nucleosides
Prior art date
Application number
DK118286A
Other languages
English (en)
Other versions
DK118286D0 (da
DK166805B1 (da
Inventor
J L Rideout
D W Barry
S N Lehrman
Clair M H St
P A Furman
Iii L M Beacham
H S Leblanc
G A Freeman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858506868A external-priority patent/GB8506868D0/en
Priority claimed from GB858506869A external-priority patent/GB8506869D0/en
Priority claimed from GB858511774A external-priority patent/GB8511774D0/en
Priority claimed from GB858511775A external-priority patent/GB8511775D0/en
Priority claimed from GB858523881A external-priority patent/GB8523881D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK118286D0 publication Critical patent/DK118286D0/da
Publication of DK118286A publication Critical patent/DK118286A/da
Application granted granted Critical
Publication of DK166805B1 publication Critical patent/DK166805B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK118286A 1985-03-16 1986-03-14 Threo-isomeren af 3'-azido-3'-deoxythymidin til anvendelse ved behandling af eller profylakse for humane retrovirusinfektioner, anvendelse af forbindelsen til fremstilling af et laegemiddel med naevnte indikation og farmaceutisk praeparat indeholdende forbindelsen DK166805B1 (da)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB8506869 1985-03-16
GB858506868A GB8506868D0 (en) 1985-03-16 1985-03-16 Antibacterial compound
GB8506868 1985-03-16
GB858506869A GB8506869D0 (en) 1985-03-16 1985-03-16 Antiviral compound
GB858511774A GB8511774D0 (en) 1985-05-09 1985-05-09 Antiviral compounds
GB8511774 1985-05-09
GB8511775 1985-05-09
GB858511775A GB8511775D0 (en) 1985-05-09 1985-05-09 Antibacterial compounds
GB858523881A GB8523881D0 (en) 1985-09-27 1985-09-27 Antiviral compounds
GB8523881 1985-09-27

Publications (3)

Publication Number Publication Date
DK118286D0 DK118286D0 (da) 1986-03-14
DK118286A true DK118286A (da) 1986-09-17
DK166805B1 DK166805B1 (da) 1993-07-19

Family

ID=27516577

Family Applications (1)

Application Number Title Priority Date Filing Date
DK118286A DK166805B1 (da) 1985-03-16 1986-03-14 Threo-isomeren af 3'-azido-3'-deoxythymidin til anvendelse ved behandling af eller profylakse for humane retrovirusinfektioner, anvendelse af forbindelsen til fremstilling af et laegemiddel med naevnte indikation og farmaceutisk praeparat indeholdende forbindelsen

Country Status (9)

Country Link
EP (1) EP0199451B1 (da)
JP (1) JPH0723314B2 (da)
AT (1) ATE135011T1 (da)
AU (1) AU578809B2 (da)
CA (1) CA1285935C (da)
DE (1) DE3650492T2 (da)
DK (1) DK166805B1 (da)
IE (1) IE73219B1 (da)
MY (1) MY104069A (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448392B1 (en) * 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
HU197209B (en) * 1985-03-16 1989-03-28 Wellcome Found Process for producing pharmaceutical compositions containing 3'-azido-3'-deoxytimidine of antiviral activity againt human retrovirus
IL78158A (en) * 1985-03-16 1988-04-29 Wellcome Found Pharmaceutical compositions containing 3'-azido-3'-deoxythymidine
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
FI892451L (fi) * 1986-11-21 1989-05-19 Max Planck Gesellschaft Foerfarande med vilket virusinfektioner i maenniskor kan skoetas och kompositioner anvaenda daeri.
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
DK140588A (da) * 1987-03-16 1988-09-17 Wellcome Found Terapeutisk nucleosider
EP0286825A3 (en) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
EP0516186A3 (en) * 1987-04-16 1993-01-13 Medivir Aktiebolag Nucleosides and nucleoside analogues, pharmaceutical composition and processes for the preparation of the compounds
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
US4804651A (en) * 1987-06-09 1989-02-14 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of psoriasis
YU110888A (en) * 1987-06-10 1989-08-31 Wellcome Found Process for obtaining timine derivatives
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
USRE33887E (en) * 1987-06-22 1992-04-14 Hoffmann-La Roche Inc. Anti-retroviral compounds
SU1548182A1 (ru) * 1987-12-29 1990-03-07 Институт молекулярной биологии АН СССР 5 @ -Фосфонаты 3 @ -азидо-2 @ ,3 @ -дидезоксинуклеозидов, вл ющиес специфическими ингибиторами вируса СПИД в культуре лимфоцитов человека Н9/ШВ
GB8800276D0 (en) * 1988-01-07 1988-02-10 Univ Liverpool Medical treatment
FR2640267B2 (fr) * 1988-01-19 1992-02-14 Univ Paris Curie Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues
FR2626001B1 (fr) * 1988-01-19 1991-11-08 Univ Paris Curie Procede de synthese de l'azido-3ÿi1ÿ.-desoxy-3ÿi1ÿ.-thymidine et analogues
US4921950A (en) * 1988-06-09 1990-05-01 Burroughs Wellcome Co. Preparation of 3'azido-3-'-deoxythymidine
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
SE8802687D0 (sv) * 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
FR2635778A1 (fr) * 1988-08-26 1990-03-02 Ire Celltarg Sa Nouveaux derives de la 3(prime) azido-3(prime) deoxythymidine (azt) actifs contre le virus hiv du sida
IE980216A1 (en) * 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals
HU205089B (en) * 1989-05-31 1992-03-30 Biogal Gyogyszergyar Process for producing new thymine derivatives and pharmaceutical compositions comprising same
FR2653771B1 (fr) * 1989-10-27 1994-09-23 Univ Paris Curie Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.
FR2656867A1 (fr) * 1990-01-09 1991-07-12 Centre Nat Rech Scient Nouveau derives de la thymidine, leur preparation et les compositions qui les contiennent.
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
US5451671A (en) * 1992-07-27 1995-09-19 Ajinomoto Co., Inc. Method of purifying 2',3'-dideoxynucleosides
WO1994019362A1 (en) * 1993-02-23 1994-09-01 City Of Hope 4-ethoxy 5-fluoro 2'deoxyuridine
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
JPH10507763A (ja) * 1994-10-24 1998-07-28 ジェネンコア インターナショナル インコーポレーテッド Ｌ−ピラノシルヌクレオシド

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2134292A1 (en) * 1971-04-30 1972-12-08 Inst Nat Sante Rech Med Interferon compsns - contg halo desoxyuridines rifamycine or rifampycine

Also Published As

Publication number Publication date
CA1285935C (en) 1991-07-09
DK118286D0 (da) 1986-03-14
IE860676L (en) 1986-09-16
EP0199451A2 (en) 1986-10-29
EP0199451A3 (en) 1990-09-05
IE73219B1 (en) 1997-05-07
AU5475786A (en) 1986-09-18
JPS61257926A (ja) 1986-11-15
DE3650492T2 (de) 1996-10-31
EP0199451B1 (en) 1996-03-06
JPH0723314B2 (ja) 1995-03-15
ATE135011T1 (de) 1996-03-15
AU578809B2 (en) 1988-11-03
DE3650492D1 (de) 1996-04-11
DK166805B1 (da) 1993-07-19
MY104069A (en) 1993-11-30

Similar Documents

Publication Publication Date Title
DK118286D0 (da) Terapeutisk aktive nucleosider, deres anvendelse og farmaceutiske kompositioner indeholdende forbindelserne
MY102693A (en) Antiviral nucleosides
ATE161836T1 (de) 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate
DK224286D0 (da) 2',3'-dideoxy-nucleosider
DK275488A (da) Indolonderivater
SE8804629D0 (sv) New therapeutically active compounds
ES2052732T3 (es) 2',3'-didesoxi-3'-fluorotimidina y compuestos afines para el tratamiento de infecciones por adenovirus.
IT1226727B (it) Farmaci precursori della dopamina.
ATE164848T1 (de) 4''-deoxyerythromycinderivate
ATE173627T1 (de) Medizinische zusammensetzung
NO923721D0 (no) 4-desoksy-4-epipodophyllotoxin-derivat eller farmasoeytiskakseptabelt salt derav
IT1224405B (it) Composti attivi sul sistema cardiovascolare
GR1001511B (el) Στεροειδείς συν?έσεις.
DE68929321D1 (de) Therapeutische Anwendungen von 2',5'-Oligoadenylat-Derivaten
DE3872425D1 (de) Substituierte tetrahydroisochinolin-verbindungen, ihre herstellung und diese enthaltende pharmazeutische mittel.
ES2053434T3 (es) Derivados de arginina y agmatina para el tratamiento de la infecciones protozoarias.
IT8721454A0 (it) Composti ad attivita' antivirale, procedimento per la loro preparazione e relative composizioni farmaceutiche.

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed