DK1205484T3 - Fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1, 1-bisphosphonsyre og dets trihydrerede mononatriumsalt - Google Patents

Fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1, 1-bisphosphonsyre og dets trihydrerede mononatriumsalt

Info

Publication number: DK1205484T3
Authority: DK; Denmark
Prior art keywords: hydroxybutylidene; amino; preparation; monosodium salt; bisphosphonic acid
Prior art date: 1999-08-06

Application number

DK00945957T

Other languages

Danish (da)

English (en)

Inventor

Lista Eugenia Pagans

Miguel M Del Carmen Onrubia

I Llado Jordi Bosch

Original Assignee

Medichem Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2000-07-17

Publication date

2003-08-11

2000-07-17 Application filed by Medichem Sa filed Critical Medichem Sa

2003-08-11 Application granted granted Critical

2003-08-11 Publication of DK1205484T3 publication Critical patent/DK1205484T3/da

Links

KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
IZDROVVXIHRYMH-UHFFFAOYSA-N methanesulfonic anhydride Chemical compound CS(=O)(=O)OS(C)(=O)=O IZDROVVXIHRYMH-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK00945957T 1999-08-06 2000-07-17 Fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1, 1-bisphosphonsyre og dets trihydrerede mononatriumsalt DK1205484T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009901806A ES2153794B1 (es)	1999-08-06	1999-08-06	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PCT/ES2000/000254 WO2001010874A1 (fr)	1999-08-06	2000-07-17	Procede d'obtention d'acide 4-amino-1-hidroxybutylidene-1,1-bisphosphonique et de son sel monosodique trihydrate

Publications (1)

Publication Number	Publication Date
DK1205484T3 true DK1205484T3 (da)	2003-08-11

Family

ID=8309563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00945957T DK1205484T3 (da)	1999-08-06	2000-07-17	Fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1, 1-bisphosphonsyre og dets trihydrerede mononatriumsalt

Country Status (18)

Country	Link
US (1)	US6573401B1 (fr)
EP (1)	EP1205484B1 (fr)
KR (1)	KR100688287B1 (fr)
AT (1)	ATE238317T1 (fr)
AU (1)	AU5987300A (fr)
BR (1)	BR0013031A (fr)
CA (1)	CA2380841C (fr)
CR (1)	CR6575A (fr)
DE (1)	DE60002347T2 (fr)
DK (1)	DK1205484T3 (fr)
ES (2)	ES2153794B1 (fr)
HU (1)	HUP0202196A3 (fr)
IL (1)	IL148000A (fr)
MX (1)	MXPA02001293A (fr)
PL (1)	PL191733B1 (fr)
PT (1)	PT1205484E (fr)
SI (1)	SI1205484T1 (fr)
WO (1)	WO2001010874A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100897837B1 (ko) *	2001-12-24	2009-05-15	테바 파마슈티컬 인더스트리즈 리미티드	분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
ITMI20020908A1 (it)	2002-04-29	2003-10-29	Chemi Spa	Processo di preparazione di sodio alendronato
KR100681282B1 (ko) *	2002-05-17	2007-02-12	테바 파마슈티컬 인더스트리즈 리미티드	특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005035542A1 (fr) *	2003-10-14	2005-04-21	Pliva-Istrazivanje I Razvoj D.O.O.	Forme solide d'alendronate sodique et sa preparation
EP1883644A2 (fr) *	2005-05-06	2008-02-06	Medichem, S.A.	Processus de fabrication d'acides bisphosphoniques gemines et de sels et/ou d'hydrates de ceux-ci repondant aux normes pharmaceutiques
WO2006134603A1 (fr)	2005-06-13	2006-12-21	Jubilant Organosys Limited	Procédé de production d’acides bisphosphoniques et de formes de ceux-ci
US8003820B2 (en) *	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
WO2007083240A2 (fr)	2006-01-20	2007-07-26	Aurobindo Pharma Limited	Procede ameliore de preparation d’acides bisphosphoniques
WO2007132478A2 (fr) *	2006-05-11	2007-11-22	Ind-Swift Laboratories Limited	Procédé de préparation de l'acide risédronique pur ou de ses sels
PL2483283T3 (pl)	2009-10-02	2015-06-30	Monsanto Technology Llc	Sposób wytwarzania kwasów aminohydroksydifosfonowych

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3016289A1 (de)	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4639338A (en) *	1984-08-06	1987-01-27	Ciba-Geigy Corporation	Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) *	1984-09-21	1986-04-03	Henkel KGaA, 4000 Düsseldorf	4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it)	1984-10-29	1988-11-16	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en)	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
GB2248061A (en) *	1990-09-18	1992-03-25	Merck & Co Inc	Amino-hydroxy-alkylidene bis phosphonic acids
US5039819A (en)	1990-09-18	1991-08-13	Merck & Co., Inc.	Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) *	1991-01-08	1994-12-12	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici e loro sali
TW257765B (fr)	1993-08-25	1995-09-21	Merck & Co Inc
US5510517A (en)	1993-08-25	1996-04-23	Merck & Co., Inc.	Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
CA2197267C (fr) *	1997-02-11	2000-02-08	Yong Tao	Procede pour la preparation de l'acide 4-amino-1-hydroxybutylidene-1,1-bisphosphonique ou de ses sels
EP1169326B1 (fr) *	1999-02-17	2004-07-14	Teva Pharmaceutical Industries Ltd.	Procede de preparation d'acide alendronique

1999
- 1999-08-06 ES ES009901806A patent/ES2153794B1/es not_active Expired - Fee Related
2000
- 2000-07-17 PT PT00945957T patent/PT1205484E/pt unknown
- 2000-07-17 KR KR1020027001589A patent/KR100688287B1/ko not_active Expired - Fee Related
- 2000-07-17 IL IL14800000A patent/IL148000A/xx not_active IP Right Cessation
- 2000-07-17 EP EP00945957A patent/EP1205484B1/fr not_active Expired - Lifetime
- 2000-07-17 US US10/048,267 patent/US6573401B1/en not_active Expired - Fee Related
- 2000-07-17 AU AU59873/00A patent/AU5987300A/en not_active Abandoned
- 2000-07-17 SI SI200030140T patent/SI1205484T1/xx unknown
- 2000-07-17 CA CA002380841A patent/CA2380841C/fr not_active Expired - Fee Related
- 2000-07-17 PL PL354033A patent/PL191733B1/pl not_active IP Right Cessation
- 2000-07-17 AT AT00945957T patent/ATE238317T1/de not_active IP Right Cessation
- 2000-07-17 HU HU0202196A patent/HUP0202196A3/hu unknown
- 2000-07-17 MX MXPA02001293A patent/MXPA02001293A/es active IP Right Grant
- 2000-07-17 ES ES00945957T patent/ES2194753T3/es not_active Expired - Lifetime
- 2000-07-17 BR BR0013031-1A patent/BR0013031A/pt not_active Application Discontinuation
- 2000-07-17 DK DK00945957T patent/DK1205484T3/da active
- 2000-07-17 DE DE60002347T patent/DE60002347T2/de not_active Expired - Fee Related
- 2000-07-17 WO PCT/ES2000/000254 patent/WO2001010874A1/fr not_active Ceased
2002
- 2002-01-31 CR CR6575A patent/CR6575A/es unknown

Also Published As

Publication number	Publication date
SI1205484T1 (en)	2003-12-31
AU5987300A (en)	2001-03-05
BR0013031A (pt)	2002-04-16
DE60002347T2 (de)	2004-02-12
EP1205484A1 (fr)	2002-05-15
EP1205484B1 (fr)	2003-04-23
DE60002347D1 (de)	2003-05-28
ATE238317T1 (de)	2003-05-15
PT1205484E (pt)	2003-08-29
MXPA02001293A (es)	2002-07-22
CR6575A (es)	2002-08-16
CA2380841C (fr)	2009-09-15
KR100688287B1 (ko)	2007-02-28
IL148000A0 (en)	2002-09-12
HUP0202196A2 (en)	2002-10-28
PL191733B1 (pl)	2006-06-30
WO2001010874A1 (fr)	2001-02-15
ES2153794A1 (es)	2001-03-01
ES2153794B1 (es)	2001-10-16
HUP0202196A3 (en)	2002-12-28
PL354033A1 (en)	2003-12-15
ES2194753T3 (es)	2003-12-01
IL148000A (en)	2005-12-18
US6573401B1 (en)	2003-06-03
KR20020024320A (ko)	2002-03-29
CA2380841A1 (fr)	2001-02-15

Publication	Publication Date	Title
DK1205484T3 (da)	2003-08-11	Fremgangsmåde til fremstilling af 4-amino-1-hydroxybutyliden-1, 1-bisphosphonsyre og dets trihydrerede mononatriumsalt
AU625704C (en)	2001-07-26	4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof, compositions and uses therefor and processes of preparation.
ATE233270T1 (de)	2003-03-15	Verfahren zur herstellung von dialkylphosphinsäuren
EP1425400A4 (fr)	2005-10-12	Procede de production d'animaux transgeniques
ES2180141T3 (es)	2003-02-01	Procedimiento de produccion de acido 4-amino-1-hidroxibutiliden-1,1-bifosfonico o sus sales.
AU4878693A (en)	1994-04-28	Production of polysuccinimide by thermal polymerization of maleamic acid
MXPA03005885A (es)	2005-04-19	Procedimiento para fabricar maleato de amlodipina.
DK1097130T3 (da)	2006-09-25	Fremgangsmåde til fremstilling af hydroxymethylthiosmörsyre
PL360499A1 (en)	2004-02-09	Method of manufacture of donepezyl
IT1312331B1 (it)	2002-04-15	Procedimento per la produzione di diamminodifenilmetano e suoiomologhi superiori.
DE50005649D1 (de)	2004-04-22	Verfahren zur Herstellung von Alkylphosphonsäuren
IL157046A0 (en)	2004-02-08	Phthalic acid diamide, method for the production thereof and the use of the same as a pesticide
NO20014885D0 (no)	2001-10-08	Fremgangsmåte til fremstilling av en amidforbindelse
MY110796A (en)	1999-04-30	Process for the manufacture of aminomethanephosphonic acid
DE69810959D1 (de)	2003-02-27	Verfahren zur herstellung von pyrrolamiden
HUP0204173A2 (hu)	2003-03-28	Eljárás konjugált linolénsav előállítására
AU1876688A (en)	1989-01-12	Process for synthesis of aminomethylene phosphonoalkylphosphinates
DE69914493D1 (de)	2004-03-04	Verfahren zur herstellung von 2-hydroxy-6-trifluormethylpyridin
EP1211239A4 (fr)	2003-08-06	Procedes de preparation de composes 2,3-dihydroazepine
FR2787445B1 (fr)	2001-01-19	Procede de preparation de para-trifluoromethylanilines polyhalogenees
ATE301723T1 (de)	2005-08-15	Verfahren zur herstellung von nukleosid- verbindung
DK1052249T3 (da)	2003-12-01	Fremgangsmåde til fremstilling af hydroxamsyrer
ATE236135T1 (de)	2003-04-15	Verfahren zur herstellung von 4,6- dichlorpyrimidin