DK1212311T3 - Chalconcumariner - Google Patents

Chalconcumariner

Info

Publication number: DK1212311T3
Authority: DK; Denmark
Prior art keywords: cell growth; agents; chalconcumariner; hydroxyphenyllactate; antitumor
Prior art date: 1999-09-03

Application number

DK00965902T

Other languages

English (en)

Inventor

Ezio Bombardelli

Piero Valenti

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-03

Filing date

2000-08-28

Publication date

2003-06-23

2000-08-28 Application filed by Indena Spa filed Critical Indena Spa

2003-06-23 Application granted granted Critical

2003-06-23 Publication of DK1212311T3 publication Critical patent/DK1212311T3/da

Links

230000010261 cell growth Effects 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000006028 immune-suppresssive effect Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000003211 malignant effect Effects 0.000 abstract 1
PDFUCDWETSQSSU-UHFFFAOYSA-N methyl 2-hydroxy-3-(4-hydroxyphenyl)propanoate Chemical compound COC(=O)C(O)CC1=CC=C(O)C=C1 PDFUCDWETSQSSU-UHFFFAOYSA-N 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyridine Compounds (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Glass Compositions (AREA)
Fire-Extinguishing Compositions (AREA)
Epoxy Compounds (AREA)
General Preparation And Processing Of Foods (AREA)

DK00965902T 1999-09-03 2000-08-28 Chalconcumariner DK1212311T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9920908.2A GB9920908D0 (en)	1999-09-03	1999-09-03	Chalcone coumarins
PCT/EP2000/008367 WO2001017984A1 (en)	1999-09-03	2000-08-28	Chalcone coumarins

Publications (1)

Publication Number	Publication Date
DK1212311T3 true DK1212311T3 (da)	2003-06-23

Family

ID=10860344

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00965902T DK1212311T3 (da)	1999-09-03	2000-08-28	Chalconcumariner

Country Status (22)

Country	Link
US (1)	US6767916B2 (da)
EP (1)	EP1212311B1 (da)
JP (1)	JP2003508523A (da)
KR (1)	KR100819574B1 (da)
CN (1)	CN1142927C (da)
AT (1)	ATE235480T1 (da)
AU (1)	AU775083B2 (da)
CA (1)	CA2382112A1 (da)
CZ (1)	CZ2002786A3 (da)
DE (1)	DE60001850T2 (da)
DK (1)	DK1212311T3 (da)
ES (1)	ES2191643T3 (da)
GB (1)	GB9920908D0 (da)
HK (1)	HK1043997B (da)
HU (1)	HUP0202581A3 (da)
NO (1)	NO20021048L (da)
PL (1)	PL353245A1 (da)
PT (1)	PT1212311E (da)
RU (1)	RU2266291C2 (da)
SE (1)	SE1212311T5 (da)
SK (1)	SK3102002A3 (da)
WO (1)	WO2001017984A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030229136A1 (en)	2002-04-18	2003-12-11	Nurulain Zaveri	Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US7638554B2 (en)	2002-04-18	2009-12-29	Sri International	Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
CA2611608A1 (en)	2005-06-08	2006-12-14	Temple University - Of The Commonwealth System Of Higher Education	3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof
CN101041646B (zh) *	2007-04-30	2011-07-20	浙江大学	含氮查耳酮衍生物的制备方法和用途
CN101121706B (zh) *	2007-09-18	2010-11-24	南京中瑞药业有限公司	一种香豆素衍生物及其制备方法和用途
JP5479105B2 (ja) *	2007-11-05	2014-04-23	国立大学法人佐賀大学	新規ユビキリン結合性小分子
EP2601183A1 (en)	2010-08-05	2013-06-12	Council Of Scientific & Industrial Research	Coumarin-chalcones as anticancer agents
WO2012174436A1 (en)	2011-06-15	2012-12-20	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Nuclear receptor modulators and their use for the treatment and prevention of cancer
CN104987328A (zh) *	2012-05-23	2015-10-21	复旦大学	7-氧、硫或氮杂取代香豆素及其衍生物和用途
CN102731457A (zh) *	2012-06-25	2012-10-17	西南石油大学	一种水溶性荧光示踪聚合物及其制备方法
RU2760006C1 (ru) *	2017-11-16	2021-11-22	Дзе Инститьют оф Кансер Рисерч: Ройал Кансер Хоспитал	Производное кумарина для лечения или профилактики расстройства пролиферации клеток
CN109293616B (zh) *	2018-09-29	2022-06-21	贵州大学	一种含香豆素查尔酮类衍生物、其制备方法及应用
JP2022547358A (ja)	2019-09-13	2022-11-14	ジインスティテュートオブキャンサーリサーチ：ロイヤルキャンサーホスピタル	治療組成物、組み合わせ、及び使用方法
US11873296B2 (en)	2022-06-07	2024-01-16	Verastem, Inc.	Solid forms of a dual RAF/MEK inhibitor
PL448929A1 (pl) *	2024-06-21	2025-12-22	Instytut Chemii Organicznej Polskiej Akademii Nauk	Nowe (kumaryno-7-amino)-acetamidy oraz ich zastosowania

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2387956A1 (fr) *	1977-04-20	1978-11-17	Unicler	Derives de la pyridine et leur preparation
US5023341A (en) *	1989-09-19	1991-06-11	Allergan, Inc.	Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
US5399561A (en) *	1989-09-19	1995-03-21	Allergan, Inc.	Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity
AU7963691A (en) *	1990-05-17	1991-12-10	Baylor College Of Medicine	Growth inhibitors and methods of treating cancer and cell proliferative diseases
IT1271301B (it) *	1994-12-20	1997-05-27	Indena Spa	Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono
US5525625A (en) *	1995-01-24	1996-06-11	Warner-Lambert Company	2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders

1999
- 1999-09-03 GB GBGB9920908.2A patent/GB9920908D0/en not_active Ceased
2000
- 2000-08-28 HK HK02105581.2A patent/HK1043997B/en unknown
- 2000-08-28 JP JP2001521731A patent/JP2003508523A/ja not_active Withdrawn
- 2000-08-28 AT AT00965902T patent/ATE235480T1/de not_active IP Right Cessation
- 2000-08-28 AU AU76488/00A patent/AU775083B2/en not_active Ceased
- 2000-08-28 DK DK00965902T patent/DK1212311T3/da active
- 2000-08-28 SE SE00965902T patent/SE1212311T5/xx unknown
- 2000-08-28 CN CNB00812163XA patent/CN1142927C/zh not_active Expired - Fee Related
- 2000-08-28 DE DE60001850T patent/DE60001850T2/de not_active Expired - Fee Related
- 2000-08-28 ES ES00965902T patent/ES2191643T3/es not_active Expired - Lifetime
- 2000-08-28 PT PT00965902T patent/PT1212311E/pt unknown
- 2000-08-28 EP EP00965902A patent/EP1212311B1/en not_active Expired - Lifetime
- 2000-08-28 CA CA002382112A patent/CA2382112A1/en not_active Abandoned
- 2000-08-28 HU HU0202581A patent/HUP0202581A3/hu unknown
- 2000-08-28 CZ CZ2002786A patent/CZ2002786A3/cs unknown
- 2000-08-28 RU RU2002108567/04A patent/RU2266291C2/ru not_active IP Right Cessation
- 2000-08-28 SK SK310-2002A patent/SK3102002A3/sk unknown
- 2000-08-28 KR KR1020027002799A patent/KR100819574B1/ko not_active Expired - Fee Related
- 2000-08-28 WO PCT/EP2000/008367 patent/WO2001017984A1/en not_active Ceased
- 2000-08-28 PL PL00353245A patent/PL353245A1/xx not_active IP Right Cessation
2002
- 2002-02-15 US US10/075,625 patent/US6767916B2/en not_active Expired - Fee Related
- 2002-03-01 NO NO20021048A patent/NO20021048L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1371370A (zh)	2002-09-25
PL353245A1 (en)	2003-11-03
HK1043997B (en)	2003-08-15
KR100819574B1 (ko)	2008-04-04
DE60001850D1 (de)	2003-04-30
SK3102002A3 (en)	2003-10-07
EP1212311A1 (en)	2002-06-12
US20020161036A1 (en)	2002-10-31
HUP0202581A3 (en)	2003-07-28
US6767916B2 (en)	2004-07-27
SE1212311T5 (da)	2003-06-10
EP1212311B1 (en)	2003-03-26
WO2001017984A1 (en)	2001-03-15
NO20021048D0 (no)	2002-03-01
GB9920908D0 (en)	1999-11-10
SE1212311T3 (da)	2003-05-06
DE60001850T2 (de)	2003-12-11
HUP0202581A2 (hu)	2002-11-28
AU7648800A (en)	2001-04-10
RU2002108567A (ru)	2004-01-10
CA2382112A1 (en)	2001-03-15
HK1043997A1 (en)	2002-10-04
KR20020030800A (ko)	2002-04-25
NO20021048L (no)	2002-05-03
AU775083B2 (en)	2004-07-15
ATE235480T1 (de)	2003-04-15
CN1142927C (zh)	2004-03-24
ES2191643T3 (es)	2003-09-16
RU2266291C2 (ru)	2005-12-20
CZ2002786A3 (cs)	2002-06-12
PT1212311E (pt)	2003-08-29
JP2003508523A (ja)	2003-03-04

Publication	Publication Date	Title
NO20021048D0 (no)	2002-03-01	Chalconkumariner
ATE302775T1 (de)	2005-09-15	Carbolinderivate
BR0108396A (pt)	2003-03-11	Derivados de pirimidina-4-0na como inibidores de ldl-pla(2)
TR200200068T2 (tr)	2002-05-21	Nematisital triflüorobütenler
PT1109812E (pt)	2005-09-30	Pirrolobenzodiazepinas
AR023777A1 (es)	2002-09-04	Nuevos compuestos
AU2795000A (en)	2000-07-12	Epothilone derivatives and their use as antitumor agents
EA200300595A1 (ru)	2003-10-30	Соединения пиперазинилпиразинов в качестве антагонистов серотонин 5-ht2 рецептора
ATE300541T1 (de)	2005-08-15	Pyrazolopyridinderivate
ATE346067T1 (de)	2006-12-15	Carbolinderivate
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
DE3887151D1 (de)	1994-02-24	Inhibitoren für zellenzuwachs und methoden für krebsbehandlung.
MXPA03002911A (es)	2003-09-10	Compuestos quimicos.
AU2001266575A1 (en)	2002-01-08	Chemical compounds
MY133969A (en)	2007-11-30	Indoloquinazolinones
TR200102742T2 (tr)	2002-05-21	Rezorsinol türevleri
ATE259813T1 (de)	2004-03-15	Triazolopyrimidinderivate
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
AR020563A1 (es)	2002-05-15	Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion
AU2001263278A1 (en)	2002-01-08	Cyclic gmp-specific phosphodiesterase inhibitors
MXPA02012472A (es)	2004-01-26	Compuestos quimicos.
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
MXPA03003971A (es)	2004-02-12	Derivados de indol como inhibidores de pde5.
SE9904128D0 (sv)	1999-11-15	Novel compounds
NZ504614A (en)	2002-12-20	Echinocandin derivatives and application as anti-fungal agents