DK1222207T3 - C-peptid til forbedret fremstilling af insulin og insulinanaloge - Google Patents

C-peptid til forbedret fremstilling af insulin og insulinanaloge

Info

Publication number: DK1222207T3
Authority: DK; Denmark
Prior art keywords: insulin; chain; amino acid; human insulin; peptide
Prior art date: 1999-10-02

Application number

DK00960664T

Other languages

English (en)

Inventor

Paul Habermann

Johannes Meiwes

Gerhard Seipke

Johann Ertl

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-02

Filing date

2000-09-15

Publication date

2008-03-17

2000-09-15 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2008-03-17 Application granted granted Critical

2008-03-17 Publication of DK1222207T3 publication Critical patent/DK1222207T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 5
239000004026 insulin derivative Substances 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 title 1
108010075254 C-Peptide Proteins 0.000 title 1
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 4
150000001413 amino acids Chemical group 0.000 abstract 4
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 4
239000002243 precursor Substances 0.000 abstract 3
101100379079 Emericella variicolor andA gene Proteins 0.000 abstract 1
238000007792 addition Methods 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK00960664T 1999-10-02 2000-09-15 C-peptid til forbedret fremstilling af insulin og insulinanaloge DK1222207T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19947456A DE19947456A1 (de)	1999-10-02	1999-10-02	C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
PCT/EP2000/009017 WO2001025278A1 (de)	1999-10-02	2000-09-15	C-peptid zur verbesserten herstellung von insulin und insulinanaloga

Publications (1)

Publication Number	Publication Date
DK1222207T3 true DK1222207T3 (da)	2008-03-17

Family

ID=7924253

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00960664T DK1222207T3 (da)	1999-10-02	2000-09-15	C-peptid til forbedret fremstilling af insulin og insulinanaloge

Country Status (25)

Country	Link
US (1)	US6534288B1 (da)
EP (1)	EP1222207B1 (da)
JP (1)	JP4681784B2 (da)
KR (1)	KR100823463B1 (da)
CN (1)	CN1193042C (da)
AT (1)	ATE380196T1 (da)
AU (1)	AU778369B2 (da)
BR (2)	BR0014464A (da)
CA (1)	CA2385857C (da)
CY (1)	CY1107860T1 (da)
DE (2)	DE19947456A1 (da)
DK (1)	DK1222207T3 (da)
ES (1)	ES2295054T3 (da)
HK (1)	HK1049016B (da)
HU (1)	HU228313B1 (da)
IL (2)	IL148942A0 (da)
MX (1)	MXPA02003103A (da)
NO (1)	NO329975B1 (da)
NZ (1)	NZ518066A (da)
PL (1)	PL203195B1 (da)
PT (1)	PT1222207E (da)
SI (1)	SI1222207T1 (da)
TW (1)	TWI265168B (da)
WO (1)	WO2001025278A1 (da)
ZA (1)	ZA200202520B (da)

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US7176278B2 (en)	2001-08-30	2007-02-13	Biorexis Technology, Inc.	Modified transferrin fusion proteins
US20050250676A1 (en) *	2001-11-19	2005-11-10	Aventis Pharma Deutschland Gmbh	Method of activating insulin receptor substrate-2 to stimulate insulin production
US20040038864A1 (en) *	2002-06-27	2004-02-26	Per Balschmidt	Use of dimethyl sulfone as isotonicity agent
DE10235168A1 (de)	2002-08-01	2004-02-12	Aventis Pharma Deutschland Gmbh	Verfahren zur Reinigung von Preproinsulin
JP5697831B2 (ja) *	2003-12-03	2015-04-08	ノヴォノルディスクアー／エス	単鎖インシュリン
CN1663960B (zh) *	2004-03-01	2012-07-04	重庆富进生物医药有限公司	高效表达重组人胰岛素原及其类似物的新型c肽
US8927015B2 (en) *	2006-04-12	2015-01-06	Emisphere Technologies, Inc.	Formulations for delivering insulin
BRPI0907119A2 (pt) *	2008-01-09	2015-07-14	Sanofi Aventis Deutschland	Derivados de insulina tendo um perfil de ação de tempo extremamente retardado
DE102008003568A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
AU2009203809B2 (en) *	2008-01-09	2013-07-25	Sanofi-Aventis Deutschland Gmbh	Novel insulin derivatives having an extremely delayed time-action profile
DE102008003566A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025007A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025008A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
DK2498802T3 (da)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Farmaceutisk præparat omfattende en glp-1-agonist, et insulin og en methionin
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
TWI641381B (zh)	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
CN112957455A (zh)	2014-01-09	2021-06-15	赛诺菲	胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
EP3091965A1 (en)	2014-01-09	2016-11-16	Sanofi	Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
SG11201604706TA (en)	2014-01-09	2016-07-28	Sanofi Sa	Stabilized pharmaceutical formulations of insulin aspart
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
WO2025099208A1 (en)	2023-11-10	2025-05-15	Intervet International B.V.	Recombinant insulin precursor

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ZA811972B (en) *	1980-03-27	1982-11-24	Lilly Co Eli	Process for producing an insulin precursor
US4430266A (en) *	1980-11-28	1984-02-07	Eli Lilly And Company	Process for producing an insulin precursor
HRP940432B1 (en) *	1994-08-05	2003-10-31	Pliva Pharm & Chem Works	Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
DE59711533D1 (de) *	1996-07-26	2004-05-27	Aventis Pharma Gmbh	Insulinderivate mit erhöhter Zinkbindung
DE19726167B4 (de) *	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung

1999
- 1999-10-02 DE DE19947456A patent/DE19947456A1/de not_active Withdrawn
2000
- 2000-09-15 BR BR0014464-9A patent/BR0014464A/pt not_active IP Right Cessation
- 2000-09-15 KR KR1020027004275A patent/KR100823463B1/ko not_active Expired - Lifetime
- 2000-09-15 CN CNB008137137A patent/CN1193042C/zh not_active Expired - Lifetime
- 2000-09-15 HK HK03101211.8A patent/HK1049016B/zh not_active IP Right Cessation
- 2000-09-15 HU HU0202755A patent/HU228313B1/hu unknown
- 2000-09-15 NZ NZ518066A patent/NZ518066A/en not_active IP Right Cessation
- 2000-09-15 WO PCT/EP2000/009017 patent/WO2001025278A1/de not_active Ceased
- 2000-09-15 AT AT00960664T patent/ATE380196T1/de active
- 2000-09-15 MX MXPA02003103A patent/MXPA02003103A/es active IP Right Grant
- 2000-09-15 JP JP2001528218A patent/JP4681784B2/ja not_active Expired - Lifetime
- 2000-09-15 SI SI200030981T patent/SI1222207T1/sl unknown
- 2000-09-15 BR BRPI0014464A patent/BRPI0014464B8/pt unknown
- 2000-09-15 DK DK00960664T patent/DK1222207T3/da active
- 2000-09-15 EP EP00960664A patent/EP1222207B1/de not_active Expired - Lifetime
- 2000-09-15 DE DE50014830T patent/DE50014830D1/de not_active Expired - Lifetime
- 2000-09-15 IL IL14894200A patent/IL148942A0/xx unknown
- 2000-09-15 PL PL354078A patent/PL203195B1/pl unknown
- 2000-09-15 CA CA2385857A patent/CA2385857C/en not_active Expired - Lifetime
- 2000-09-15 PT PT00960664T patent/PT1222207E/pt unknown
- 2000-09-15 AU AU72877/00A patent/AU778369B2/en not_active Expired
- 2000-09-15 ES ES00960664T patent/ES2295054T3/es not_active Expired - Lifetime
- 2000-09-29 TW TW089120149A patent/TWI265168B/zh not_active IP Right Cessation
- 2000-10-02 US US09/676,787 patent/US6534288B1/en not_active Expired - Lifetime
2002
- 2002-03-18 NO NO20021335A patent/NO329975B1/no not_active IP Right Cessation
- 2002-03-28 ZA ZA200202520A patent/ZA200202520B/xx unknown
- 2002-03-31 IL IL148942A patent/IL148942A/en active IP Right Grant
2008
- 2008-01-18 CY CY20081100078T patent/CY1107860T1/el unknown

Also Published As

Publication number	Publication date
AU778369B2 (en)	2004-12-02
DE19947456A1 (de)	2001-04-05
NZ518066A (en)	2004-05-28
CN1193042C (zh)	2005-03-16
HK1049016B (zh)	2005-10-14
BRPI0014464B8 (pt)	2021-05-25
SI1222207T1 (sl)	2008-04-30
DE50014830D1 (de)	2008-01-17
BRPI0014464B1 (pt)	2018-03-13
ATE380196T1 (de)	2007-12-15
IL148942A0 (en)	2002-09-12
NO329975B1 (no)	2011-01-31
ES2295054T3 (es)	2008-04-16
KR20020047209A (ko)	2002-06-21
HUP0202755A2 (hu)	2002-12-28
TWI265168B (en)	2006-11-01
CA2385857A1 (en)	2001-04-12
EP1222207A1 (de)	2002-07-17
CA2385857C (en)	2012-05-22
ZA200202520B (en)	2002-12-24
BR0014464A (pt)	2002-06-11
AU7287700A (en)	2001-05-10
CY1107860T1 (el)	2013-06-19
NO20021335L (no)	2002-06-03
HU228313B1 (en)	2013-03-28
HK1049016A1 (en)	2003-04-25
JP2003511018A (ja)	2003-03-25
US6534288B1 (en)	2003-03-18
IL148942A (en)	2010-02-17
MXPA02003103A (es)	2002-09-30
CN1377370A (zh)	2002-10-30
PT1222207E (pt)	2008-02-11
EP1222207B1 (de)	2007-12-05
HUP0202755A3 (en)	2005-01-28
JP4681784B2 (ja)	2011-05-11
PL203195B1 (pl)	2009-09-30
NO20021335D0 (no)	2002-03-18
WO2001025278A1 (de)	2001-04-12
PL354078A1 (en)	2003-12-15
KR100823463B1 (ko)	2008-04-21

Publication	Publication Date	Title
NO20021335D0 (no)	2002-03-18	C-peptid for forbedret fremstilling av insulin og insulinanaloger
BR9906796A (pt)	2000-11-14	Método para a administração de análogos de insulina monoméricos
ATE124997T1 (de)	1995-07-15	Enzymatische entfernung einer aminoterminalen proteinsequenz.
ES2188767T3 (es)	2003-07-01	Composicion a base de oxido de circonio y de oxido de cerio, procedimiento de preparacion y utilizacion.
HUP9801886A2 (hu)	1999-01-28	Eljárás megfelelően kapcsolódó cisztinhidakat tartalmazó inzulin-prekurzorok előállítására
EP2022505A3 (en)	2009-05-27	GLP-1, exendin-4, peptide analogs and uses thereof
MY128441A (en)	2007-02-28	Bipiperidine derivatives as modulators of ccr3 activity and as h1 antogonists
TR200401029T4 (tr)	2004-06-21	Asilfenil-üre türevleri, imalat yöntemleri ve ilaç maddesi olarak kullanımları
TR200901979T2 (tr)	2009-05-21	Antikolinerjik etkili bileşik ve ?-mimetikler bazında yeni ilaç bileşimleri.
EP1423111A4 (en)	2007-04-18	FXR NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS
ATE417595T1 (de)	2009-01-15	Keratin-bindende polypeptide
DE60233722D1 (de)	2009-10-29	Insulinvorstufen und verfahren zu deren herstellung
ATE389662T1 (de)	2008-04-15	Cardioprotektive phosphonate
DK1439830T3 (da)	2006-02-13	Farmaceutisk præparat med 2-(4-isobutylphenyl)propionsyre
DK1501936T3 (da)	2008-12-08	Familie af cytokin-proteiner
ATE333901T1 (de)	2006-08-15	Pharmazeutische zusammensetzung eines biguanin (metformin) und arginin
DE60044728D1 (de)	2010-09-02	VERFAHREN ZUR HERSTELLUNG VON INSULINVORLäUFERN UND ANALOGEN VON INSULINVORLÄUFERN MIT VERBESSERTER FERMENTATIONSAUSBEUTE IN HEFE
BR9714066A (pt)	2000-05-09	Processo para a preparação de derivados de tiazol.
ITRM20000340A0 (it)	2000-06-23	Uso dell'acido pamoico o di un suo derivato, o di un suo analogo, perla preparazione di un medicamento per il trattamento di patologie cara
MXPA04005788A (es)	2004-09-13	Proceso para preparacion de derivados de [1,4,5]-oxadiazepina.
DK1127064T3 (da)	2006-05-22	Hidtil ukendte aminosyresekvenser, DNA, der koder for aminosyresekvenserme, antistoffer, der er rettet mod sådanne sekvenser, og forskellige anvendelser deraf
SE0101978D0 (sv)	2001-06-01	New compounds
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