DK1248768T3 - Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disse - Google Patents

Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disse

Info

Publication number
DK1248768T3
DK1248768T3 DK00958461T DK00958461T DK1248768T3 DK 1248768 T3 DK1248768 T3 DK 1248768T3 DK 00958461 T DK00958461 T DK 00958461T DK 00958461 T DK00958461 T DK 00958461T DK 1248768 T3 DK1248768 T3 DK 1248768T3
Authority
DK
Denmark
Prior art keywords
preparation
diagnostics
drugs
processes
medicaments containing
Prior art date
Application number
DK00958461T
Other languages
English (en)
Inventor
Heinz-Werner Kleemann
Armin Hofmeister
Eugen Falk
Hans-Willi Jansen
Hans-Ludwig Schaefer
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of DK1248768T3 publication Critical patent/DK1248768T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK00958461T 1999-09-02 2000-08-17 Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disse DK1248768T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19941764A DE19941764A1 (de) 1999-09-02 1999-09-02 Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente

Publications (1)

Publication Number Publication Date
DK1248768T3 true DK1248768T3 (da) 2006-03-27

Family

ID=7920512

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00958461T DK1248768T3 (da) 1999-09-02 2000-08-17 Substituerede acylguanidiner, fremgangsmåde til deres fremstilling, deres anvendelse som medikamenter eller diagnostika samt medikamenter, der indeholder disse

Country Status (11)

Country Link
US (1) US6451781B1 (da)
EP (1) EP1248768B1 (da)
JP (1) JP4768941B2 (da)
AT (1) ATE309981T1 (da)
AU (1) AU774083B2 (da)
CA (1) CA2383729A1 (da)
DE (2) DE19941764A1 (da)
DK (1) DK1248768T3 (da)
ES (1) ES2251403T3 (da)
IL (1) IL148250A0 (da)
WO (1) WO2001017954A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ563604A (en) * 2001-11-29 2009-04-30 Theracos Inc Compounds for treatment of inflammation, diabetes and related disorders
WO2018129556A1 (en) * 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10543207B2 (en) 2008-12-31 2020-01-28 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN103819403B (zh) * 2008-12-31 2017-01-04 阿德利克斯公司 用于治疗与体液潴留或盐超负荷有关的病症和胃肠道病症的化合物和方法
MX363056B (es) * 2012-08-21 2019-03-06 Ardelyx Inc Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal.
CN105392483B (zh) 2013-04-12 2019-03-15 阿德利克斯公司 用于抑制磷酸盐转运的nhe3结合化合物和方法
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
KR20240090875A (ko) 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
WO2020117945A1 (en) 2018-12-04 2020-06-11 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
CN120757601A (zh) 2019-05-10 2025-10-10 哈佛大学的校长及成员们 肠道细菌胆汁酸代谢的小分子调节剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0667846B2 (ja) * 1989-04-28 1994-08-31 一 滝川 利胆剤
TW289021B (da) 1993-05-08 1996-10-21 Hoechst Ag
IT1274000B (it) * 1994-04-06 1997-07-14 Alfa Wassermann Spa Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi
JPH09315979A (ja) * 1996-05-24 1997-12-09 Tokyo Tanabe Co Ltd 利胆剤
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CA2383729A1 (en) 2001-03-15
JP4768941B2 (ja) 2011-09-07
DE50011660D1 (de) 2005-12-22
ATE309981T1 (de) 2005-12-15
DE19941764A1 (de) 2001-03-15
IL148250A0 (en) 2002-09-12
AU6996500A (en) 2001-04-10
US6451781B1 (en) 2002-09-17
ES2251403T3 (es) 2006-05-01
AU774083B2 (en) 2004-06-17
EP1248768A1 (de) 2002-10-16
WO2001017954A1 (de) 2001-03-15
EP1248768B1 (de) 2005-11-16
JP2003508513A (ja) 2003-03-04

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