DK1248802T3 - Oplöselige CTLA4-mutantmolekyler og anvendelser deraf - Google Patents

Oplöselige CTLA4-mutantmolekyler og anvendelser deraf

Info

Publication number
DK1248802T3
DK1248802T3 DK01937764T DK01937764T DK1248802T3 DK 1248802 T3 DK1248802 T3 DK 1248802T3 DK 01937764 T DK01937764 T DK 01937764T DK 01937764 T DK01937764 T DK 01937764T DK 1248802 T3 DK1248802 T3 DK 1248802T3
Authority
DK
Denmark
Prior art keywords
soluble ctla4
mutant molecules
amino acid
ctla4
molecules
Prior art date
Application number
DK01937764T
Other languages
Danish (da)
English (en)
Inventor
Joseph R Naemura
Peter S Linsley
Jurgen Bajorath
Robert J Peach
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1248802T3 publication Critical patent/DK1248802T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01937764T 2000-05-26 2001-05-23 Oplöselige CTLA4-mutantmolekyler og anvendelser deraf DK1248802T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof
EP01937764A EP1248802B9 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (1)

Publication Number Publication Date
DK1248802T3 true DK1248802T3 (da) 2004-11-15

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01937764T DK1248802T3 (da) 2000-05-26 2001-05-23 Oplöselige CTLA4-mutantmolekyler og anvendelser deraf

Country Status (41)

Country Link
EP (3) EP1248802B9 (sr)
JP (1) JP4328525B2 (sr)
KR (2) KR100889887B1 (sr)
CN (2) CN101255192A (sr)
AR (1) AR031699A1 (sr)
AT (1) ATE271066T1 (sr)
AU (2) AU6346601A (sr)
BE (1) BE2011C041I2 (sr)
BR (1) BRPI0111191B8 (sr)
CA (1) CA2409748C (sr)
CY (2) CY2011019I1 (sr)
CZ (1) CZ304451B6 (sr)
DE (2) DE60104282T2 (sr)
DK (1) DK1248802T3 (sr)
EC (1) ECSP024365A (sr)
EE (2) EE05557B1 (sr)
EG (1) EG24459A (sr)
ES (2) ES2225549T3 (sr)
FR (1) FR11C0053I2 (sr)
GE (1) GEP20053658B (sr)
HK (1) HK1048126B (sr)
HU (2) HU228137B1 (sr)
IL (1) IL152315A (sr)
LT (1) LT5133B (sr)
LU (1) LU91902I2 (sr)
LV (1) LV12994B (sr)
MX (1) MXPA02011534A (sr)
MY (1) MY136113A (sr)
NO (2) NO330797B1 (sr)
PE (1) PE20011338A1 (sr)
PL (1) PL206267B1 (sr)
PT (1) PT1248802E (sr)
RU (1) RU2283847C2 (sr)
SI (1) SI1248802T1 (sr)
SK (1) SK288131B6 (sr)
TR (1) TR200402703T4 (sr)
TW (2) TWI319405B (sr)
UA (1) UA87432C2 (sr)
UY (1) UY26723A1 (sr)
WO (1) WO2001092337A2 (sr)
ZA (1) ZA200208944B (sr)

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US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
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Also Published As

Publication number Publication date
MXPA02011534A (es) 2004-08-12
NO2011027I2 (sr) 2011-12-15
EE201100050A (et) 2011-10-17
BE2011C041I2 (sr) 2020-08-20
CA2409748A1 (en) 2001-12-06
FR11C0053I1 (sr) 2012-01-13
AU2001263466C1 (en) 2006-10-26
LT5133B (lt) 2004-05-25
IL152315A (en) 2010-04-15
PE20011338A1 (es) 2002-01-13
EP3029062A1 (en) 2016-06-08
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
KR20030009502A (ko) 2003-01-29
PL206267B1 (pl) 2010-07-30
HUP0302201A2 (hu) 2003-10-28
ES2225549T3 (es) 2005-03-16
EE200200659A (et) 2004-06-15
MY136113A (en) 2008-08-29
ZA200208944B (en) 2004-02-13
RU2283847C2 (ru) 2006-09-20
NO2011027I1 (no) 2012-01-09
HK1048126B (en) 2005-03-04
JP2004511213A (ja) 2004-04-15
CN1441810A (zh) 2003-09-10
NO20025656D0 (no) 2002-11-25
TWI314933B (en) 2009-09-21
HK1048126A1 (en) 2003-03-21
EP1248802B9 (en) 2005-05-11
ATE271066T1 (de) 2004-07-15
KR100889887B1 (ko) 2009-03-24
EG24459A (en) 2009-07-16
SK288131B6 (sk) 2013-10-02
UA87432C2 (uk) 2009-07-27
TR200402703T4 (tr) 2004-11-22
CY1117625T1 (el) 2017-04-26
BRPI0111191B8 (pt) 2021-05-25
ECSP024365A (es) 2003-03-31
WO2001092337A2 (en) 2001-12-06
HU228137B1 (en) 2012-12-28
TWI319405B (en) 2010-01-11
TW200906857A (en) 2009-02-16
PL366231A1 (en) 2005-01-24
LV12994B (en) 2003-08-20
SI1248802T1 (en) 2005-02-28
HUS1300012I1 (hu) 2016-08-29
UY26723A1 (es) 2001-12-28
WO2001092337A3 (en) 2002-05-10
EP1248802B1 (en) 2004-07-14
NO330797B1 (no) 2011-07-18
DE122011100063I1 (de) 2012-06-14
LT2002114A (en) 2003-12-29
CN101255192A (zh) 2008-09-03
JP4328525B2 (ja) 2009-09-09
BRPI0111191B1 (pt) 2019-12-31
EE05557B1 (et) 2012-08-15
CZ304451B6 (cs) 2014-05-14
CA2409748C (en) 2008-09-16
DE60104282D1 (de) 2004-08-19
HK1071931A1 (en) 2005-08-05
FR11C0053I2 (fr) 2013-01-11
AU6346601A (en) 2001-12-11
EE05458B1 (et) 2011-08-15
SK15702002A3 (sk) 2004-01-08
CZ20023892A3 (cs) 2003-09-17
EP1536234A3 (en) 2009-06-03
CN1309735C (zh) 2007-04-11
ES2571852T3 (es) 2016-05-27
EP1536234A2 (en) 2005-06-01
AU2001263466B2 (en) 2006-04-27
IL152315A0 (en) 2003-05-29
PT1248802E (pt) 2004-11-30
GEP20053658B (en) 2005-11-10
EP1536234B1 (en) 2016-03-16
NO20025656L (no) 2002-11-25
DE60104282T2 (de) 2005-10-13
HUP0302201A3 (en) 2010-01-28
AR031699A1 (es) 2003-10-01
CY2011019I1 (el) 2016-12-14
KR100895134B1 (ko) 2009-05-04
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
BR0111191A (pt) 2004-07-06

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