ECSP024365A - Moleculas mutantes solubles ctla4 y sus aplicaciones - Google Patents

Moleculas mutantes solubles ctla4 y sus aplicaciones

Info

Publication number
ECSP024365A
ECSP024365A EC2002004365A ECSP024365A ECSP024365A EC SP024365 A ECSP024365 A EC SP024365A EC 2002004365 A EC2002004365 A EC 2002004365A EC SP024365 A ECSP024365 A EC SP024365A EC SP024365 A ECSP024365 A EC SP024365A
Authority
EC
Ecuador
Prior art keywords
ctla4
mutant molecules
applications
amino acid
molecules
Prior art date
Application number
EC2002004365A
Other languages
English (en)
Inventor
Juergen Bajorath
Robert J Peach
Joseph R Naemura
Peter S Linsley
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ECSP024365A publication Critical patent/ECSP024365A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención ofrece las moléculas mutantes CTLA4 solubles que se ligan con mayor intensidad a los antígenos CD80 y/o CD86 que a los CTLA4 de tipo agresivo o CTLA4 Ig no mutados. Las moléculas CTLA4 solubles tienen una primera secuencia de aminoácido conteniendo el dominio extracelular de CTLA4, donde ciertos residuos de aminoácidos son mutados en las regiones 825- R33 Y M97-G107. Las molécular mutantes de la invención pueden también incluir una segunda secuencia de aminoácidos que aumentan la solubilidad de las moléculas mutantes.
EC2002004365A 2000-05-26 2002-11-26 Moleculas mutantes solubles ctla4 y sus aplicaciones ECSP024365A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26

Publications (1)

Publication Number Publication Date
ECSP024365A true ECSP024365A (es) 2003-03-31

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004365A ECSP024365A (es) 2000-05-26 2002-11-26 Moleculas mutantes solubles ctla4 y sus aplicaciones

Country Status (41)

Country Link
EP (3) EP1248802B9 (es)
JP (1) JP4328525B2 (es)
KR (2) KR100895134B1 (es)
CN (2) CN1309735C (es)
AR (1) AR031699A1 (es)
AT (1) ATE271066T1 (es)
AU (2) AU2001263466C1 (es)
BE (1) BE2011C041I2 (es)
BR (1) BRPI0111191B8 (es)
CA (1) CA2409748C (es)
CY (2) CY2011019I2 (es)
CZ (1) CZ304451B6 (es)
DE (2) DE60104282T2 (es)
DK (1) DK1248802T3 (es)
EC (1) ECSP024365A (es)
EE (2) EE05557B1 (es)
EG (1) EG24459A (es)
ES (2) ES2571852T3 (es)
FR (1) FR11C0053I2 (es)
GE (1) GEP20053658B (es)
HK (1) HK1048126B (es)
HU (2) HU228137B1 (es)
IL (1) IL152315A (es)
LT (1) LT5133B (es)
LU (1) LU91902I2 (es)
LV (1) LV12994B (es)
MX (1) MXPA02011534A (es)
MY (1) MY136113A (es)
NO (2) NO330797B1 (es)
PE (1) PE20011338A1 (es)
PL (1) PL206267B1 (es)
PT (1) PT1248802E (es)
RU (1) RU2283847C2 (es)
SI (1) SI1248802T1 (es)
SK (1) SK288131B6 (es)
TR (1) TR200402703T4 (es)
TW (2) TWI314933B (es)
UA (1) UA87432C2 (es)
UY (1) UY26723A1 (es)
WO (1) WO2001092337A2 (es)
ZA (1) ZA200208944B (es)

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KR20030009502A (ko) 2003-01-29
MY136113A (en) 2008-08-29
SI1248802T1 (en) 2005-02-28
PT1248802E (pt) 2004-11-30
EP1536234A2 (en) 2005-06-01
NO2011027I2 (es) 2011-12-15
DE60104282T2 (de) 2005-10-13
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
EE201100050A (et) 2011-10-17
WO2001092337A2 (en) 2001-12-06
MXPA02011534A (es) 2004-08-12
CA2409748A1 (en) 2001-12-06
CY1117625T1 (el) 2017-04-26
ZA200208944B (en) 2004-02-13
EP1536234A3 (en) 2009-06-03
BRPI0111191B8 (pt) 2021-05-25
HUP0302201A3 (en) 2010-01-28
CZ20023892A3 (cs) 2003-09-17
TW200906857A (en) 2009-02-16
CN1441810A (zh) 2003-09-10
KR100889887B1 (ko) 2009-03-24
DK1248802T3 (da) 2004-11-15
LT2002114A (en) 2003-12-29
TR200402703T4 (tr) 2004-11-22
WO2001092337A3 (en) 2002-05-10
ES2225549T3 (es) 2005-03-16
ATE271066T1 (de) 2004-07-15
HK1071931A1 (en) 2005-08-05
CN1309735C (zh) 2007-04-11
EP1248802B9 (en) 2005-05-11
EP1536234B1 (en) 2016-03-16
AU6346601A (en) 2001-12-11
NO330797B1 (no) 2011-07-18
UA87432C2 (uk) 2009-07-27
ES2571852T3 (es) 2016-05-27
CN101255192A (zh) 2008-09-03
NO20025656D0 (no) 2002-11-25
NO2011027I1 (no) 2012-01-09
KR100895134B1 (ko) 2009-05-04
HK1048126A1 (en) 2003-03-21
LT5133B (lt) 2004-05-25
AR031699A1 (es) 2003-10-01
LV12994B (en) 2003-08-20
EE05557B1 (et) 2012-08-15
IL152315A0 (en) 2003-05-29
TWI319405B (en) 2010-01-11
FR11C0053I1 (es) 2012-01-13
PL366231A1 (en) 2005-01-24
HU228137B1 (en) 2012-12-28
FR11C0053I2 (fr) 2013-01-11
AU2001263466B2 (en) 2006-04-27
TWI314933B (en) 2009-09-21
IL152315A (en) 2010-04-15
RU2283847C2 (ru) 2006-09-20
CY2011019I1 (el) 2016-12-14
SK288131B6 (sk) 2013-10-02
CZ304451B6 (cs) 2014-05-14
PL206267B1 (pl) 2010-07-30
HUS1300012I1 (hu) 2016-08-29
JP2004511213A (ja) 2004-04-15
PE20011338A1 (es) 2002-01-13
BR0111191A (pt) 2004-07-06
EE200200659A (et) 2004-06-15
GEP20053658B (en) 2005-11-10
BE2011C041I2 (es) 2020-08-20
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
DE122011100063I1 (de) 2012-06-14
EP1248802B1 (en) 2004-07-14
CA2409748C (en) 2008-09-16
SK15702002A3 (sk) 2004-01-08
EG24459A (en) 2009-07-16
UY26723A1 (es) 2001-12-28
AU2001263466C1 (en) 2006-10-26
DE60104282D1 (de) 2004-08-19
BRPI0111191B1 (pt) 2019-12-31
EE05458B1 (et) 2011-08-15
HUP0302201A2 (hu) 2003-10-28
EP3029062A1 (en) 2016-06-08
HK1048126B (en) 2005-03-04
JP4328525B2 (ja) 2009-09-09
NO20025656L (no) 2002-11-25

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