DK1265908T3 - Fremgangsmåde til fremstilling af derivater af 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A ud fra 9-deoxo-9(Z)-hydroxyiminoerythromycin A - Google Patents

Fremgangsmåde til fremstilling af derivater af 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A ud fra 9-deoxo-9(Z)-hydroxyiminoerythromycin A

Info

Publication number
DK1265908T3
DK1265908T3 DK01919556T DK01919556T DK1265908T3 DK 1265908 T3 DK1265908 T3 DK 1265908T3 DK 01919556 T DK01919556 T DK 01919556T DK 01919556 T DK01919556 T DK 01919556T DK 1265908 T3 DK1265908 T3 DK 1265908T3
Authority
DK
Denmark
Prior art keywords
deoxo
hydroxyiminoerythromycin
homoerythromycin
aza
alkyl
Prior art date
Application number
DK01919556T
Other languages
Danish (da)
English (en)
Inventor
Patrick Leon
Gilles Oddon
Frederic Lhermitte
Denis Pauze
Original Assignee
Merial Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas filed Critical Merial Sas
Application granted granted Critical
Publication of DK1265908T3 publication Critical patent/DK1265908T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DK01919556T 2000-03-24 2001-03-23 Fremgangsmåde til fremstilling af derivater af 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A ud fra 9-deoxo-9(Z)-hydroxyiminoerythromycin A DK1265908T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0003807A FR2806724B1 (fr) 2000-03-24 2000-03-24 Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
PCT/FR2001/000897 WO2001072763A1 (fr) 2000-03-24 2001-03-23 Procede pour la preparation de derives 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9(z)-hydroxyiminoerythromycine a

Publications (1)

Publication Number Publication Date
DK1265908T3 true DK1265908T3 (da) 2005-03-14

Family

ID=8848497

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01919556T DK1265908T3 (da) 2000-03-24 2001-03-23 Fremgangsmåde til fremstilling af derivater af 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A ud fra 9-deoxo-9(Z)-hydroxyiminoerythromycin A

Country Status (17)

Country Link
EP (1) EP1265908B1 (de)
JP (1) JP4975933B2 (de)
CN (1) CN1174992C (de)
AR (1) AR027706A1 (de)
AT (1) ATE281463T1 (de)
AU (2) AU4663601A (de)
BR (1) BRPI0109413B8 (de)
CA (1) CA2399634C (de)
DE (1) DE60106882T2 (de)
DK (1) DK1265908T3 (de)
ES (1) ES2232609T3 (de)
FR (1) FR2806724B1 (de)
NZ (1) NZ520878A (de)
PL (1) PL206683B1 (de)
PT (1) PT1265908E (de)
WO (1) WO2001072763A1 (de)
ZA (1) ZA200207443B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101648232B1 (ko) * 2008-10-24 2016-08-12 메리얼 인코포레이티드 마크롤라이드 화합물의 합성 방법
CN103833807B (zh) * 2012-11-21 2016-12-07 洛阳惠中兽药有限公司 一种加米霉素中间体的制备方法
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
WO2015098716A1 (ja) * 2013-12-26 2015-07-02 住友化学株式会社 ハロゲン置換フタリドの製造方法
CN109970827A (zh) * 2017-12-27 2019-07-05 洛阳惠中兽药有限公司 加米霉素中间体化合物i的晶型及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2062932A1 (en) * 1991-03-15 1992-09-16 Robert R. Wilkening 9-deoxo-9(z)-hydroxyiminoerythromycin a and o-derivatives thereof
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065674A1 (en) * 1991-04-10 1992-10-11 Robert R. Wilkening 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
CA2068951A1 (en) * 1991-05-20 1992-11-21 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic lactams
EP0549040A1 (de) * 1991-12-20 1993-06-30 Merck & Co. Inc. Verfahren zur Herstellung von 4"-Derivaten von 9-Deoxo-8a-Aza-8a-Alkyl-8a-Homoerythromycin A
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide

Also Published As

Publication number Publication date
CN1174992C (zh) 2004-11-10
FR2806724A1 (fr) 2001-09-28
JP4975933B2 (ja) 2012-07-11
NZ520878A (en) 2004-05-28
ES2232609T3 (es) 2005-06-01
DE60106882D1 (de) 2004-12-09
FR2806724B1 (fr) 2003-12-05
ZA200207443B (en) 2003-10-17
AU2001246636C1 (en) 2006-02-23
AU2001246636B2 (en) 2005-04-21
PL361225A1 (en) 2004-09-20
AU4663601A (en) 2001-10-08
CA2399634C (en) 2011-05-24
DE60106882T2 (de) 2005-12-01
AR027706A1 (es) 2003-04-09
EP1265908A1 (de) 2002-12-18
BRPI0109413B8 (pt) 2021-05-25
WO2001072763A1 (fr) 2001-10-04
BR0109413A (pt) 2002-12-10
EP1265908B1 (de) 2004-11-03
PL206683B1 (pl) 2010-09-30
BRPI0109413B1 (pt) 2015-08-04
ATE281463T1 (de) 2004-11-15
CA2399634A1 (en) 2001-10-04
PT1265908E (pt) 2005-03-31
JP2003528882A (ja) 2003-09-30
CN1425022A (zh) 2003-06-18

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DK1265908T3 (da) Fremgangsmåde til fremstilling af derivater af 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A ud fra 9-deoxo-9(Z)-hydroxyiminoerythromycin A
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