DK12685D0 - Ergolinderivater - Google Patents

Ergolinderivater

Info

Publication number: DK12685D0
Authority: DK; Denmark
Prior art keywords: ergoline
Prior art date: 1984-01-12

Application number

DK12685A

Other languages

English (en)

Other versions

DK12685A (da

DK169891B1 (da

Inventor

Walter Haefliger

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-01-12

Filing date

1985-01-10

Publication date

1985-01-10

1985-01-10 Application filed by Sandoz Ag filed Critical Sandoz Ag

1985-01-10 Publication of DK12685D0 publication Critical patent/DK12685D0/da

1985-07-13 Publication of DK12685A publication Critical patent/DK12685A/da

1995-03-27 Application granted granted Critical

1995-03-27 Publication of DK169891B1 publication Critical patent/DK169891B1/da

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical compound O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK012685A 1984-01-12 1985-01-10 8alfa-acylaminoergoliner og syreadditionssalte deraf, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende 8alfa-acylaminoergolinerne eller syreadditionssaltene deraf samt 8alfa-acylaminoergolinerne og syreadditionssalte deraf til anvendelse til lægemidler DK169891B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3400853		1984-01-12
DE3400853		1984-01-12

Publications (3)

Publication Number	Publication Date
DK12685D0 true DK12685D0 (da)	1985-01-10
DK12685A DK12685A (da)	1985-07-13
DK169891B1 DK169891B1 (da)	1995-03-27

Family

ID=6224786

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK012685A DK169891B1 (da)	1984-01-12	1985-01-10	8alfa-acylaminoergoliner og syreadditionssalte deraf, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende 8alfa-acylaminoergolinerne eller syreadditionssaltene deraf samt 8alfa-acylaminoergolinerne og syreadditionssalte deraf til anvendelse til lægemidler

Country Status (28)

Country	Link
US (2)	US4950672A (da)
JP (1)	JPH0655739B2 (da)
AT (1)	AT391317B (da)
AU (3)	AU583489B2 (da)
BE (1)	BE901456A (da)
CA (1)	CA1245640A (da)
CH (1)	CH664568A5 (da)
CY (1)	CY1542A (da)
DE (1)	DE3500251C2 (da)
DK (1)	DK169891B1 (da)
ES (1)	ES8605514A1 (da)
FI (1)	FI82466C (da)
FR (1)	FR2560196B1 (da)
GB (1)	GB2152507B (da)
GR (1)	GR850065B (da)
HK (1)	HK48590A (da)
HU (1)	HU197569B (da)
IE (1)	IE58228B1 (da)
IL (1)	IL74043A (da)
IT (1)	IT1214648B (da)
LU (1)	LU85725A1 (da)
NL (1)	NL193541C (da)
NZ (1)	NZ210818A (da)
PH (1)	PH23286A (da)
PT (1)	PT79818B (da)
SE (1)	SE460420B (da)
SG (1)	SG32390G (da)
ZA (1)	ZA85276B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH664568A5 (de) *	1984-01-12	1988-03-15	Sandoz Ag	8-alpha-acylaminoergoline.
ATE107647T1 (de) *	1984-04-09	1994-07-15	Schering Ag	2-substituierte ergolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
NL8700046A (nl) *	1986-01-24	1987-08-17	Sandoz Ag	8 alfa-acylaminoergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
US4931447A (en) *	1987-06-15	1990-06-05	Eli Lilly And Company	Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines
US4981859A (en) *	1987-06-15	1991-01-01		Cycloalkylamides of (8 beta )-1-alkyl-6-(substituted)ergolines
DE3820159A1 (de) *	1987-06-23	1989-01-05	Sandoz Ag	8(alpha)-acylaminoergolin, seine herstellung und dieses enthaltende arzneimittel
IT1219652B (it) *	1987-06-23	1990-05-24	Sandoz Ag	8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto
DK338789A (da) *	1988-07-15	1990-01-16	Schering Ag	2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
GB8824744D0 (en) *	1988-10-21	1988-11-30	Erba Carlo Spa	Antiemesis ergoline derivatives
DE3915950A1 (de) *	1989-05-12	1990-11-15	Schering Ag	8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
BR112017015510A2 (pt) *	2015-01-20	2018-01-30	Xoc Pharmaceuticals Inc	composto de fórmula estrutural (i), método de tratamento e/ou prevenção, método de agonização do receptor d2 em um indivíduo, método de antagonização do receptor d3 em um indivíduo, método de agonização do receptor 5-ht1d em um indivíduo, método de agonização do receptor 5-ht1a em um indivíduo, método de agonização seletiva do receptor 5-ht1d em vez do receptor 5-ht1b em um indivíduo, método de agonização seletiva do re-ceptor 5-ht2c em vez do receptor 5-ht2a ou 5-ht2b em um indivíduo, método de agonização do receptor 5-ht2c em um indivíduo, método de fornecimento de atividade antagonista funcional no receptor 5-ht2b ou receptor 5-ht7, e, método de fornecimento de atividade antagonista funcional nos receptores adrenérgicos em um indivíduo
CN113149982A (zh)	2015-01-20	2021-07-23	Xoc制药股份有限公司	麦角灵化合物及其用途
JP2020522504A (ja)	2017-06-01	2020-07-30	エックスオーシーファーマシューティカルズインコーポレイテッドＸｏｃＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ	多環式化合物およびそれらの用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3218323A (en) *		1965-11-16		Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US2864822A (en) *	1956-10-22	1958-12-16	Lilly Co Eli	9-amino-7-methyl-belta10-ergolene and derivatives thereof
CH622519A5 (en) *	1974-07-05	1981-04-15	Hoechst Ag	Process for the preparation of hydroxyalkylxanthines
GB1517971A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	8alpha-substituted ergoline i derivatives
US4348392A (en) *	1974-07-19	1982-09-07	Sandoz Ltd.	8α-Substituted ergoline-I derivatives
US3922347A (en) *	1974-12-19	1975-11-25	Lilly Co Eli	Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) *	1975-06-02	1980-02-29	Sandoz Ag	Process for the preparation of novel ergoline compounds
DE2656344A1 (de) *	1975-12-23	1977-07-07	Sandoz Ag	Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) *	1976-12-14	1981-04-15	Sandoz Ag	Process for the preparation of novel ergoline compounds
CH644606A5 (de) *	1980-09-23	1984-08-15	Sandoz Ag	Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3151912A1 (de) *	1981-12-23	1983-06-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
CH664568A5 (de) *	1984-01-12	1988-03-15	Sandoz Ag	8-alpha-acylaminoergoline.
HU195810B (en) *	1984-12-24	1988-07-28	Sandoz Ag	Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
IT1219652B (it) *	1987-06-23	1990-05-24	Sandoz Ag	8-acilamminoergolina,la sua preparazione e il suo impiego come medicamneto

1985
- 1985-01-03 CH CH16/85A patent/CH664568A5/de not_active IP Right Cessation
- 1985-01-03 NL NL8500008A patent/NL193541C/nl not_active IP Right Cessation
- 1985-01-03 HU HU8524A patent/HU197569B/hu unknown
- 1985-01-05 DE DE3500251A patent/DE3500251C2/de not_active Expired - Fee Related
- 1985-01-07 FR FR8500217A patent/FR2560196B1/fr not_active Expired
- 1985-01-08 BE BE1/11168A patent/BE901456A/fr not_active IP Right Cessation
- 1985-01-08 GB GB08500454A patent/GB2152507B/en not_active Expired
- 1985-01-10 CA CA000471859A patent/CA1245640A/en not_active Expired
- 1985-01-10 IE IE6485A patent/IE58228B1/en not_active IP Right Cessation
- 1985-01-10 DK DK012685A patent/DK169891B1/da active
- 1985-01-10 PT PT79818A patent/PT79818B/pt not_active IP Right Cessation
- 1985-01-10 GR GR850065A patent/GR850065B/el unknown
- 1985-01-10 LU LU85725A patent/LU85725A1/fr unknown
- 1985-01-10 SE SE8500107A patent/SE460420B/sv not_active IP Right Cessation
- 1985-01-11 AT AT0005985A patent/AT391317B/de not_active IP Right Cessation
- 1985-01-11 IT IT8547538A patent/IT1214648B/it active
- 1985-01-11 ES ES539511A patent/ES8605514A1/es not_active Expired
- 1985-01-11 AU AU37609/85A patent/AU583489B2/en not_active Ceased
- 1985-01-11 FI FI850130A patent/FI82466C/fi not_active IP Right Cessation
- 1985-01-11 NZ NZ210818A patent/NZ210818A/xx unknown
- 1985-01-11 IL IL74043A patent/IL74043A/xx not_active IP Right Cessation
- 1985-01-11 JP JP60003913A patent/JPH0655739B2/ja not_active Expired - Lifetime
- 1985-01-11 ZA ZA85276A patent/ZA85276B/xx unknown
- 1985-01-14 PH PH31714A patent/PH23286A/en unknown
1988
- 1988-11-11 AU AU25067/88A patent/AU618290B2/en not_active Ceased
- 1988-11-11 AU AU25066/88A patent/AU609539B2/en not_active Ceased
1989
- 1989-02-27 US US07/316,363 patent/US4950672A/en not_active Expired - Fee Related
1990
- 1990-05-02 SG SG32390A patent/SG32390G/en unknown
- 1990-06-21 HK HK485/90A patent/HK48590A/xx not_active IP Right Cessation
- 1990-07-02 US US07/547,899 patent/US5077298A/en not_active Expired - Lifetime
1991
- 1991-03-22 CY CY1542A patent/CY1542A/en unknown

Also Published As

Publication number	Publication date
GB2152507B (en)	1987-07-15
DE3500251A1 (de)	1985-07-18
ES8605514A1 (es)	1986-03-16
US4950672A (en)	1990-08-21
IT1214648B (it)	1990-01-18
ZA85276B (en)	1986-08-27
IT8547538A0 (it)	1985-01-11
GB8500454D0 (en)	1985-02-13
ES539511A0 (es)	1986-03-16
GR850065B (da)	1985-05-03
AU2506688A (en)	1989-02-23
US5077298A (en)	1991-12-31
SE8500107L (sv)	1985-07-13
JPH0655739B2 (ja)	1994-07-27
JPS60174783A (ja)	1985-09-09
FI850130L (fi)	1985-07-13
ATA5985A (de)	1990-03-15
PT79818B (en)	1987-01-07
GB2152507A (en)	1985-08-07
NZ210818A (en)	1989-02-24
AU618290B2 (en)	1991-12-19
HUT37148A (en)	1985-11-28
CA1245640A (en)	1988-11-29
AU3760985A (en)	1985-07-18
CY1542A (en)	1991-03-22
PT79818A (en)	1985-02-01
FI82466C (fi)	1991-03-11
DK12685A (da)	1985-07-13
SE460420B (sv)	1989-10-09
FI82466B (fi)	1990-11-30
IL74043A (en)	1988-10-31
HU197569B (en)	1989-04-28
DK169891B1 (da)	1995-03-27
AU2506788A (en)	1989-03-02
IL74043A0 (en)	1985-04-30
NL8500008A (nl)	1985-08-01
BE901456A (fr)	1985-07-08
HK48590A (en)	1990-06-29
AU609539B2 (en)	1991-05-02
AT391317B (de)	1990-09-25
PH23286A (en)	1989-06-30
SE8500107D0 (sv)	1985-01-10
LU85725A1 (fr)	1985-10-22
FR2560196B1 (fr)	1986-07-18
IE58228B1 (en)	1993-08-11
CH664568A5 (de)	1988-03-15
IE850064L (en)	1985-07-12
SG32390G (en)	1990-08-03
NL193541C (nl)	2000-01-04
NL193541B (nl)	1999-09-01
FI850130A0 (fi)	1985-01-11
DE3500251C2 (de)	1995-01-26
FR2560196A1 (fr)	1985-08-30
AU583489B2 (en)	1989-05-04

Publication	Publication Date	Title
AT380762B (de)	1986-07-10	Hoergeraet
AT379929B (de)	1986-03-10	Hoergeraet
DK12685A (da)	1985-07-13	Ergolinderivater
ATA135485A (de)	1990-07-15	Maishaecksler
AT386724B (de)	1988-10-10	Haecksler
DK35787D0 (da)	1987-01-22	Ergolinderivater
ATA237384A (de)	1989-03-15	Maehwerk
ATE36715T1 (de)	1988-09-15	7-d-mandelamido-3-(1-sulfomethyltetrazol-5us840229
ATA45484A (de)	1985-05-15	Kimme
AT389296B (de)	1989-11-10	Elektrokoagulator
BR8402733A (pt)	1986-01-07	Divisoria
ES283027Y (es)	1988-06-16	Piezas portafichas
AR231237A1 (es)	1984-10-31	Calzado-patin
SE8405602D0 (sv)	1984-11-09	N-festet
BR8401157A (pt)	1985-10-29	Auto-balsa
BR6400113U (pt)	1984-08-21	Aquafolio
FI840371A0 (fi)	1984-01-30	Foerpackning foer skodon
IT8412207A0 (it)	1984-11-12	Ferristone
BR8404648A (pt)	1986-06-03	Minifone
BR8404566A (pt)	1986-04-15	Paramortecedor
BR8400832A (pt)	1985-10-01	Gasogenio
BR6400601U (pt)	1985-11-26	Fotocheque
BR8401156A (pt)	1985-10-29	Auto-balsa
BR8405261A (pt)	1986-05-13	Auto-balsa
BR6401644U (pt)	1986-05-13	Aduela balanco