DK1280531T3 - Formulering bestående af phentolaminmesylat og anvendelse heraf - Google Patents
Formulering bestående af phentolaminmesylat og anvendelse herafInfo
- Publication number
- DK1280531T3 DK1280531T3 DK01933419T DK01933419T DK1280531T3 DK 1280531 T3 DK1280531 T3 DK 1280531T3 DK 01933419 T DK01933419 T DK 01933419T DK 01933419 T DK01933419 T DK 01933419T DK 1280531 T3 DK1280531 T3 DK 1280531T3
- Authority
- DK
- Denmark
- Prior art keywords
- adrenergic receptor
- alpha adrenergic
- phentolamine mesylate
- anesthesia
- local
- Prior art date
Links
- PPWLAQVKIFDULF-UHFFFAOYSA-N 2-phenyl-1h-pyrrolo[2,3-b]pyridine Chemical compound N1C2=NC=CC=C2C=C1C1=CC=CC=C1 PPWLAQVKIFDULF-UHFFFAOYSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229960003056 phentolamine mesylate Drugs 0.000 title 1
- 239000000695 adrenergic alpha-agonist Substances 0.000 abstract 2
- 239000000674 adrenergic antagonist Substances 0.000 abstract 2
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 abstract 2
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 abstract 2
- 238000002690 local anesthesia Methods 0.000 abstract 2
- 239000003589 local anesthetic agent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Transplantation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20380000P | 2000-05-12 | 2000-05-12 | |
| US23585500P | 2000-09-27 | 2000-09-27 | |
| PCT/US2001/040711 WO2001085171A1 (en) | 2000-05-12 | 2001-05-11 | Local anesthetic methods and kits |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1280531T3 true DK1280531T3 (da) | 2007-05-29 |
Family
ID=26898913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01933419T DK1280531T3 (da) | 2000-05-12 | 2001-05-11 | Formulering bestående af phentolaminmesylat og anvendelse heraf |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US6432401B2 (da) |
| EP (2) | EP1280531B1 (da) |
| JP (2) | JP2003532678A (da) |
| AT (1) | ATE352300T1 (da) |
| AU (3) | AU2001259848B2 (da) |
| CA (1) | CA2408417C (da) |
| CY (1) | CY1107617T1 (da) |
| DE (1) | DE60126265T2 (da) |
| DK (1) | DK1280531T3 (da) |
| ES (1) | ES2281418T3 (da) |
| NZ (1) | NZ522930A (da) |
| PT (1) | PT1280531E (da) |
| WO (1) | WO2001085171A1 (da) |
| ZA (1) | ZA200209811B (da) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE352300T1 (de) * | 2000-05-12 | 2007-02-15 | Novalar Pharmaceuticals Inc | Zusammensetzung bestehend aus phentolaminmesylat und deren verwendung |
| US20030236306A1 (en) * | 2002-06-20 | 2003-12-25 | Chen Andrew X. | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
| US7229630B2 (en) * | 2002-06-20 | 2007-06-12 | Novalar Pharmaceuticals, Inc. | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
| CN100391460C (zh) * | 2002-06-20 | 2008-06-04 | 诺瓦乐医药公司 | α-肾上腺素能受体拮抗剂的稳定配方及其用途 |
| WO2004000219A2 (en) * | 2002-06-20 | 2003-12-31 | Novalar Pharmaceuticals, Inc. | Stabilized formulations of alpha adrenergic receptor antagonists and uses thereof |
| WO2008109124A1 (en) * | 2007-03-06 | 2008-09-12 | Novalar Pharmaceuticals, Inc. | Use of nitroglycerin to reverse local anesthesia |
| MX2010005046A (es) * | 2007-11-06 | 2010-10-15 | Stuart L Weg | Composicion anestesica, formulacion y metodo de uso. |
| US20090131832A1 (en) * | 2007-11-20 | 2009-05-21 | Innovamedica S.A.P.I. De C.V. | Electronic Syringe with Safety System for Spinal Injection |
| US8180447B2 (en) | 2007-12-05 | 2012-05-15 | The Invention Science Fund I, Llc | Method for reversible chemical modulation of neural activity |
| US8160695B2 (en) | 2007-12-05 | 2012-04-17 | The Invention Science Fund I, Llc | System for chemical modulation of neural activity |
| US8170659B2 (en) * | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | Method for thermal modulation of neural activity |
| US8180446B2 (en) | 2007-12-05 | 2012-05-15 | The Invention Science Fund I, Llc | Method and system for cyclical neural modulation based on activity state |
| US8195287B2 (en) * | 2007-12-05 | 2012-06-05 | The Invention Science Fund I, Llc | Method for electrical modulation of neural conduction |
| US8165668B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | Method for magnetic modulation of neural conduction |
| US8170658B2 (en) | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | System for electrical modulation of neural conduction |
| US8165669B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | System for magnetic modulation of neural conduction |
| US20090149799A1 (en) * | 2007-12-05 | 2009-06-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for chemical modulation of neural activity |
| US8523569B2 (en) * | 2007-12-28 | 2013-09-03 | Khashayar Kevin Neshat | Controlled release local anesthetic for post dental surgery and method of use |
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| KR20100135291A (ko) | 2008-04-14 | 2010-12-24 | 할로자임, 아이엔씨 | 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 |
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| WO2010136585A2 (en) * | 2009-05-29 | 2010-12-02 | Galderma Research & Development | Combination of adrenergic receptor agonist -1 or -2, preferably brimonidine with fillers, preferablyhyaluronic acid |
| US9107876B2 (en) | 2009-07-02 | 2015-08-18 | Yamaguchi University | Surface anesthetic agent |
| FR2951450B1 (fr) | 2009-10-20 | 2011-12-09 | Commissariat Energie Atomique | Peptides a proprietes d'antagoniste selectif des recepteurs adrenergiques alpha 2 et leurs applications |
| SE534862C2 (sv) | 2010-05-14 | 2012-01-24 | Vivoline Medical Ab | Användning av en medicinsk vätska för behandling av ett uttaget organ |
| US8997136B2 (en) | 2010-07-22 | 2015-03-31 | Time Warner Cable Enterprises Llc | Apparatus and methods for packetized content delivery over a bandwidth-efficient network |
| WO2012017077A1 (en) * | 2010-08-06 | 2012-02-09 | Galderma Research & Development | Combination of compounds for treating or preventing skin diseases |
| US20130310422A1 (en) | 2010-09-01 | 2013-11-21 | The General Hospital Corporation | Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine |
| US9602414B2 (en) | 2011-02-09 | 2017-03-21 | Time Warner Cable Enterprises Llc | Apparatus and methods for controlled bandwidth reclamation |
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| AU2014212275B2 (en) | 2013-02-01 | 2018-09-06 | Ocuphire Pharma, Inc. | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
| DK2950648T3 (da) | 2013-02-01 | 2019-12-02 | Ocuphire Pharma Inc | Vandige oftalmiske opløsninger af phentolamin og medicinske anvendelser deraf |
| CA2914608A1 (en) * | 2013-03-14 | 2014-09-25 | Jsn I, Llc | Taste masking of anesthetics and analgesics |
| US9579257B2 (en) | 2013-08-20 | 2017-02-28 | Anutra Medical, Inc. | Haptic feedback and audible output syringe |
| WO2015103450A1 (en) * | 2014-01-01 | 2015-07-09 | Real Time Imaging Technologies, Llc | Improved local anesthetic solution for dental and/or contrast media use |
| USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
| USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
| USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
| EP3244800A1 (en) | 2015-01-12 | 2017-11-22 | Real Time Imaging Technologies, LLC | Low-dose x-ray imaging system |
| CA3051467C (en) | 2017-01-30 | 2022-11-29 | Nevakar, Inc | Norepinephrine compositions and methods therefor |
| US20250177328A1 (en) | 2017-01-30 | 2025-06-05 | Nevakar Injectables Inc. | Norepinephrine compositions and methods therefor |
| KR20210008328A (ko) | 2018-03-07 | 2021-01-21 | 수부 랩스, 인크. | 열 섬유의 자극을 통한 통증 완화 개선을 위한 시스템 및 방법 |
| WO2019226599A1 (en) * | 2018-05-22 | 2019-11-28 | Alkalidx, Inc. | Diagnostics and treatments of anesthetic insensitive subjects |
| WO2020023084A1 (en) * | 2018-07-26 | 2020-01-30 | Applied Biology, Inc. | Taar receptor agonists for the treatment of alopecia |
| EP3866790A4 (en) | 2018-10-15 | 2022-08-03 | Ocuphire Pharma, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES |
| CA3116589A1 (en) | 2018-10-26 | 2020-04-30 | Ocuphire Pharma, Inc. | Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders |
| WO2020132310A1 (en) | 2018-12-19 | 2020-06-25 | The General Hospital Corporation | Dextroamphetamine and lisdexamfetamine to reverse dexmedetomidine sedation |
| CA3140715A1 (en) | 2019-05-17 | 2020-11-26 | The Governing Council Of The University Of Toronto | Sustained release local anesthetic hydrogel composition |
| CN110193011B (zh) * | 2019-06-19 | 2022-02-11 | 四川美大康华康药业有限公司 | 一种甲磺酸酚妥拉明注射液及其制备方法 |
| CN115368310B (zh) | 2021-05-18 | 2025-06-27 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
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| US5370613A (en) * | 1993-02-11 | 1994-12-06 | Helmy; Ali M. | Catheter apparatus for delivering drugs to the penis |
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| ATE352300T1 (de) * | 2000-05-12 | 2007-02-15 | Novalar Pharmaceuticals Inc | Zusammensetzung bestehend aus phentolaminmesylat und deren verwendung |
-
2001
- 2001-05-11 AT AT01933419T patent/ATE352300T1/de active
- 2001-05-11 CA CA002408417A patent/CA2408417C/en not_active Expired - Lifetime
- 2001-05-11 WO PCT/US2001/040711 patent/WO2001085171A1/en not_active Ceased
- 2001-05-11 NZ NZ522930A patent/NZ522930A/en not_active IP Right Cessation
- 2001-05-11 ES ES01933419T patent/ES2281418T3/es not_active Expired - Lifetime
- 2001-05-11 AU AU2001259848A patent/AU2001259848B2/en not_active Ceased
- 2001-05-11 EP EP01933419A patent/EP1280531B1/en not_active Expired - Lifetime
- 2001-05-11 JP JP2001581825A patent/JP2003532678A/ja active Pending
- 2001-05-11 PT PT01933419T patent/PT1280531E/pt unknown
- 2001-05-11 DE DE60126265T patent/DE60126265T2/de not_active Expired - Lifetime
- 2001-05-11 EP EP06024671.7A patent/EP1762236B1/en not_active Expired - Lifetime
- 2001-05-11 US US09/852,751 patent/US6432401B2/en not_active Expired - Lifetime
- 2001-05-11 AU AU5984801A patent/AU5984801A/xx active Pending
- 2001-05-11 DK DK01933419T patent/DK1280531T3/da active
-
2002
- 2002-05-28 US US10/155,171 patent/US6764678B2/en not_active Expired - Lifetime
- 2002-05-28 US US10/155,020 patent/US6872390B2/en not_active Expired - Lifetime
- 2002-12-03 ZA ZA200209811A patent/ZA200209811B/en unknown
-
2003
- 2003-09-24 US US10/668,248 patent/US20040063747A1/en not_active Abandoned
-
2004
- 2004-04-05 US US10/816,900 patent/US20040198816A1/en not_active Abandoned
-
2005
- 2005-03-17 US US11/081,640 patent/US7261889B2/en not_active Expired - Lifetime
- 2005-03-17 US US11/081,641 patent/US20050165098A1/en not_active Abandoned
- 2005-09-26 AU AU2005211689A patent/AU2005211689B2/en not_active Ceased
-
2006
- 2006-04-05 JP JP2006104732A patent/JP2006225400A/ja active Pending
-
2007
- 2007-04-19 CY CY20071100532T patent/CY1107617T1/el unknown
-
2008
- 2008-11-21 US US12/275,556 patent/US20090076023A1/en not_active Abandoned
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