BRPI0412695A - derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1 - Google Patents

derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1

Info

Publication number
BRPI0412695A
BRPI0412695A BRPI0412695-5A BRPI0412695A BRPI0412695A BR PI0412695 A BRPI0412695 A BR PI0412695A BR PI0412695 A BRPI0412695 A BR PI0412695A BR PI0412695 A BRPI0412695 A BR PI0412695A
Authority
BR
Brazil
Prior art keywords
quinoline
quinazoline derivatives
receptor affinity
affinity
derivatives
Prior art date
Application number
BRPI0412695-5A
Other languages
English (en)
Inventor
Markus Bergauer
Barbara Bertani
Matteo Biagetti
Steven Mark Bromidge
Alessandro Falchi
Colin Philip Leslie
Giancarlo Merlo
Domenica Antonia Pizzi
Marilisa Rinaldi
Luigi Piero Stasi
Jessica Tibasco
Antonio Kuok Keong Vong
Simon Edward Ward
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0412695A publication Critical patent/BRPI0412695A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE QUINOLINA E QUINAZOLINA DOTADOS DE AFINIDADE PARA RECEPTORES DO TIPO 5HT1". Os compostos de fórmula (I) e os sais farmaceuticamente aceitáveis dos mesmos são proporcionados: onde R~ 1~, m, X, R~ 2~, n, W, p, Y, Z, R~ 3~, R~ 4~, R~ 5~, e q apresentam os significados de acordo como definido na descrição. Os métodos de preparação e o uso dos mesmos em terapia, em particular para as desordens do SNC, tais como depressão ou ansiedade, são também descritos.
BRPI0412695-5A 2003-07-18 2004-07-15 derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1 BRPI0412695A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0316915.8A GB0316915D0 (en) 2003-07-18 2003-07-18 Compounds
PCT/EP2004/008000 WO2005014552A1 (en) 2003-07-18 2004-07-15 Quinoline and quinazoline derivatives having affinity for 5ht1-type receptors

Publications (1)

Publication Number Publication Date
BRPI0412695A true BRPI0412695A (pt) 2006-10-03

Family

ID=27764115

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412695-5A BRPI0412695A (pt) 2003-07-18 2004-07-15 derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1

Country Status (28)

Country Link
US (5) US7279481B2 (pt)
EP (3) EP2145622A1 (pt)
JP (1) JP2006528146A (pt)
KR (1) KR20060041242A (pt)
CN (1) CN100441571C (pt)
AR (1) AR046394A1 (pt)
AT (2) ATE448205T1 (pt)
AU (1) AU2004263268B2 (pt)
BR (1) BRPI0412695A (pt)
CA (1) CA2532452A1 (pt)
CY (1) CY1107974T1 (pt)
DE (2) DE602004012564T2 (pt)
DK (1) DK1646613T3 (pt)
ES (2) ES2302543T3 (pt)
GB (1) GB0316915D0 (pt)
HR (1) HRP20080226T3 (pt)
IL (1) IL173036A0 (pt)
IS (1) IS2744B (pt)
MA (1) MA27926A1 (pt)
MX (1) MXPA06000716A (pt)
NO (1) NO20060774L (pt)
NZ (1) NZ544586A (pt)
PL (1) PL1646613T3 (pt)
PT (1) PT1646613E (pt)
RU (1) RU2402533C2 (pt)
SI (1) SI1646613T1 (pt)
TW (1) TW200521115A (pt)
WO (1) WO2005014552A1 (pt)

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Also Published As

Publication number Publication date
EP2145622A1 (en) 2010-01-20
EP1876174A1 (en) 2008-01-09
DE602004024141D1 (de) 2009-12-24
HRP20080226T3 (en) 2008-06-30
JP2006528146A (ja) 2006-12-14
DE602004012564D1 (de) 2008-04-30
PT1646613E (pt) 2008-06-19
US7459456B2 (en) 2008-12-02
ES2336148T3 (es) 2010-04-08
CN100441571C (zh) 2008-12-10
CA2532452A1 (en) 2005-02-17
MA27926A1 (fr) 2006-06-01
US20080280919A1 (en) 2008-11-13
PL1646613T3 (pl) 2008-08-29
EP1646613A1 (en) 2006-04-19
AU2004263268B2 (en) 2010-12-16
CN1852896A (zh) 2006-10-25
AR046394A1 (es) 2005-12-07
CY1107974T1 (el) 2013-09-04
ES2302543T3 (es) 2008-07-16
US7592346B2 (en) 2009-09-22
US20060229312A1 (en) 2006-10-12
EP1876174B1 (en) 2009-11-11
US20090312546A1 (en) 2009-12-17
ATE448205T1 (de) 2009-11-15
NZ544586A (en) 2009-05-31
EP1646613B1 (en) 2008-03-19
IS2744B (is) 2011-08-15
RU2006104993A (ru) 2006-08-10
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US7732600B2 (en) 2010-06-08
TW200521115A (en) 2005-07-01
MXPA06000716A (es) 2006-03-30
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US7279481B2 (en) 2007-10-09
DK1646613T3 (da) 2008-07-14
GB0316915D0 (en) 2003-08-20
IS8304A (is) 2006-02-15
ATE389637T1 (de) 2008-04-15
US20100204273A1 (en) 2010-08-12
US20070167423A1 (en) 2007-07-19
SI1646613T1 (sl) 2008-08-31
KR20060041242A (ko) 2006-05-11
NO20060774L (no) 2006-04-06
DE602004012564T2 (de) 2009-04-30
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WO2005014552A1 (en) 2005-02-17
AU2004263268A1 (en) 2005-02-17

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