DK129385A - Peptider og fremstilling deraf - Google Patents

Peptider og fremstilling deraf Download PDF

Info

Publication number: DK129385A
Authority: DK; Denmark
Prior art keywords: human insulin; precursors; prepared; insulin precursors; peptides
Prior art date: 1985-03-22

Application number

DK129385A

Other languages

Danish (da)

English (en)

Other versions

DK129385D0 (da

Inventor

Lars Thim

Mogens Trier Hansen

Kjeld Norris

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-22

Filing date

1985-03-22

Publication date

1986-09-23

1985-03-22 Application filed by Novo Industri As filed Critical Novo Industri As

1985-03-22 Priority to DK129385A priority Critical patent/DK129385A/da

1985-03-22 Publication of DK129385D0 publication Critical patent/DK129385D0/da

1986-03-17 Priority to ZA861953A priority patent/ZA861953B/xx

1986-03-19 Priority to DK125786A priority patent/DK158270C/da

1986-03-20 Priority to MX1947A priority patent/MX163837B/es

1986-03-20 Priority to JP61060995A priority patent/JPH0648993B2/ja

1986-03-20 Priority to CA000504650A priority patent/CA1340823C/en

1986-03-21 Priority to NO861120A priority patent/NO172646C/no

1986-03-21 Priority to DE8686302133T priority patent/DE3682303D1/de

1986-03-21 Priority to FI861198A priority patent/FI87801C/fi

1986-03-21 Priority to ES553231A priority patent/ES8802402A1/es

1986-03-21 Priority to PT82241A priority patent/PT82241B/pt

1986-03-21 Priority to EP86302133A priority patent/EP0195691B1/de

1986-03-21 Priority to GR860764A priority patent/GR860764B/el

1986-03-21 Priority to AU55005/86A priority patent/AU586855B2/en

1986-03-21 Priority to IE73786A priority patent/IE58842B1/en

1986-03-21 Priority to NZ215570A priority patent/NZ215570A/xx

1986-03-21 Priority to AT86302133T priority patent/ATE69266T1/de

1986-09-23 Publication of DK129385A publication Critical patent/DK129385A/da

1986-11-28 Priority to ES557227A priority patent/ES8708251A1/es

1993-05-24 Priority to JP5121394A priority patent/JPH088871B2/ja

1995-07-14 Priority to JP7178875A priority patent/JP2553326B2/ja

Links

102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 4
239000002243 precursor Substances 0.000 abstract 4
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
239000004475 Arginine Substances 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
238000011084 recovery Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Mycology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK129385A 1985-03-22 1985-03-22 Peptider og fremstilling deraf DK129385A (da)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
DK129385A DK129385A (da)	1985-03-22	1985-03-22	Peptider og fremstilling deraf
ZA861953A ZA861953B (en)	1985-03-22	1986-03-17	Insulin precursors,process for their preparation and process for the preparation of human insulin
DK125786A DK158270C (da)	1985-03-22	1986-03-19	Fremgangsmaade til fremstilling af human insulinprecursorer og af human insulin samt dna- sekvenser og plasmider til anvendelse i disse fremgangsmaader
MX1947A MX163837B (es)	1985-03-22	1986-03-20	Procedimiento para la preparacion de insulina humana
JP61060995A JPH0648993B2 (ja)	1985-03-22	1986-03-20	インシュリンの製造方法
CA000504650A CA1340823C (en)	1985-03-22	1986-03-20	Insulin precursors, process for their preparation and process for the preparation of human insulin
AT86302133T ATE69266T1 (de)	1985-03-22	1986-03-21	Verfahren zum herstellung von insulin-vorlaeufern und verfahren zur herstellung von humaninsulin.
FI861198A FI87801C (fi)	1985-03-22	1986-03-21	Foerfarande foer framstaellning av maenniskoinsulinprekursorer samt i foerfarandet anvaenda dna-sekvensen och plasmider
AU55005/86A AU586855B2 (en)	1985-03-22	1986-03-21	Insulin precursors, process for their preparation and process for the preparation of human insulin
NO861120A NO172646C (no)	1985-03-22	1986-03-21	Dna-sekvens, repliserbart ekspresjonsplasmid, samt fremstilling av insulin og human-insulin-forloepere
ES553231A ES8802402A1 (es)	1985-03-22	1986-03-21	Un metodo para producir precursores de insulina humana.
PT82241A PT82241B (pt)	1985-03-22	1986-03-21	Processo para a preparacao de precursores de insulina e de insulina humana
EP86302133A EP0195691B1 (de)	1985-03-22	1986-03-21	Verfahren zum Herstellung von Insulin-Vorläufern und Verfahren zur Herstellung von Humaninsulin
GR860764A GR860764B (en)	1985-03-22	1986-03-21	Insulin precursors process for their preparation and a process for the preparation of human insulin
DE8686302133T DE3682303D1 (de)	1985-03-22	1986-03-21	Verfahren zum herstellung von insulin-vorlaeufern und verfahren zur herstellung von humaninsulin.
IE73786A IE58842B1 (en)	1985-03-22	1986-03-21	Process for the preparation of insulin precursors and process for the preparation of human insulin
NZ215570A NZ215570A (en)	1985-03-22	1986-03-21	Human insulin precursor, its preparation and conversion to insulin
ES557227A ES8708251A1 (es)	1985-03-22	1986-11-28	Un metodo de producir insulina humana
JP5121394A JPH088871B2 (ja)	1985-03-22	1993-05-24	インシュリン前駆体をコードするｄｎａ配列
JP7178875A JP2553326B2 (ja)	1985-03-22	1995-07-14	インシュリン前駆体をコードするｄｎａ配列

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK129385A DK129385A (da)	1985-03-22	1985-03-22	Peptider og fremstilling deraf

Publications (2)

Publication Number	Publication Date
DK129385D0 DK129385D0 (da)	1985-03-22
DK129385A true DK129385A (da)	1986-09-23

Family

ID=8103207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK129385A DK129385A (da)	1985-03-22	1985-03-22	Peptider og fremstilling deraf

Country Status (16)

Country	Link
EP (1)	EP0195691B1 (de)
JP (3)	JPH0648993B2 (de)
AT (1)	ATE69266T1 (de)
AU (1)	AU586855B2 (de)
CA (1)	CA1340823C (de)
DE (1)	DE3682303D1 (de)
DK (1)	DK129385A (de)
ES (2)	ES8802402A1 (de)
FI (1)	FI87801C (de)
GR (1)	GR860764B (de)
IE (1)	IE58842B1 (de)
MX (1)	MX163837B (de)
NO (1)	NO172646C (de)
NZ (1)	NZ215570A (de)
PT (1)	PT82241B (de)
ZA (1)	ZA861953B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
EP0208418B1 (de) *	1985-06-12	1991-10-30	Lubrizol Genetics Inc.	Modifiziertes Zein
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
DK437786D0 (da) *	1986-09-12	1986-09-12	Nordisk Gentofte	Insulinprecursorer
US5426036A (en) *	1987-05-05	1995-06-20	Hoechst Aktiengesellschaft	Processes for the preparation of foreign proteins in streptomycetes
DE3837271A1 (de) *	1988-11-03	1990-05-10	Hoechst Ag	Verfahren zur selektiven spaltung von fusionsproteinen
CA1340772C (en) *	1987-12-30	1999-09-28	Patricia Tekamp-Olson	Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DK336188D0 (da) *	1988-06-20	1988-06-20	Nordisk Gentofte	Propeptider
EP0347781B1 (de) *	1988-06-23	1994-02-16	Hoechst Aktiengesellschaft	Mini-Proinsulin, seine Herstellung und Verwendung
US6875589B1 (en)	1988-06-23	2005-04-05	Hoechst Aktiengesellschaft	Mini-proinsulin, its preparation and use
ES2081826T3 (es) *	1988-11-03	1996-03-16	Hoechst Ag	Procedimiento para la preparacion de un producto previo de insulina en estreptomicetos.
US5716927A (en) *	1988-12-23	1998-02-10	Novo Nordisk A/S	Insulin analogs having a modified B-chain
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
IL93282A (en) *	1989-02-09	1995-08-31	Lilly Co Eli	Insulin analogues
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
CA2051375C (en) *	1989-05-04	2000-09-12	Dennis J. Henner	Process and compositions for the isolation of human relaxin
NZ239652A (en) *	1990-09-05	1992-09-25	Hoechst Ag	Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
TW224471B (de) *	1991-11-26	1994-06-01	Lilly Co Eli
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6001604A (en) *	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
ATE350053T1 (de) *	1994-12-29	2007-01-15	Ferring Int Ct Sa	Herstellung von humaninsulin
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
IL118127A0 (en) *	1995-05-05	1996-09-12	Lilly Co Eli	Single chain insulin with high bioactivity
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
KR100381494B1 (ko) *	1997-06-30	2003-07-22	바이오 테크놀로지 제네랄 코오포레이션	인간인슐린의제조방법
WO1999009816A1 (de) *	1997-08-22	1999-03-04	Roche Diagnostics Gmbh	Verfahren zur gewinnung von insulin precursorproteinen
DE19930676B4 (de)	1999-07-02	2006-01-19	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
AU4935701A (en)	2000-03-24	2001-10-08	Genentech Inc	Use of insulin for the treatment of cartilagenous disorders
US6926898B2 (en)	2000-04-12	2005-08-09	Human Genome Sciences, Inc.	Albumin fusion proteins
AR025646A1 (es)	2000-09-13	2002-12-04	Beta Lab Sa	Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7638618B2 (en)	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en)	2001-02-20	2007-04-10	Sanofi-Aventis Deutschland Gmbh	Fusion proteins capable of being secreted into a fermentation medium
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
WO2005003296A2 (en)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Albumin fusion proteins
CA2841097A1 (en)	2001-12-21	2003-07-24	Human Genome Sciences, Inc.	Albumin and g-csf fusion proteins
ES2570937T3 (es)	2008-08-07	2016-05-23	Biocon Ltd	Un proceso para la preparación de compuestos de insulina
AR072563A1 (es) *	2009-07-15	2010-09-08	Beta Lab Sa	Un procedimiento para obtener insulina aspartica que utiliza una cepa de levaduras de pichia pastoris
PL239062B1 (pl) *	2016-01-22	2021-11-02	Inst Biotechnologii I Antybiotykow	Sposób wytwarzania insuliny i jej pochodnych
BR112019004314A2 (pt) *	2016-09-06	2019-05-28	Chemical & Biopharmaceutical Laboratories Of Patras S A	derivados pró-insulina
KR102666154B1 (ko)	2018-08-08	2024-05-20	주식회사 대웅제약	지속형 인슐린 아날로그 및 그 복합체
KR102646845B1 (ko)	2018-08-08	2024-03-14	주식회사 대웅제약	클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법
CN113226284B (zh) *	2018-09-25	2024-12-03	美药星制药股份有限公司	高度纯化的重组人胰岛素（rhi）api及其生产方法
KR20200080747A (ko) *	2018-12-27	2020-07-07	주식회사 폴루스	인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH16156A (en) *	1980-03-27	1983-07-18	Lilly Co Eli	Process for producing an insulin precursor
NZ199391A (en) *	1981-01-02	1985-12-13	Genentech Inc	Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3209184A1 (de) *	1982-03-13	1983-09-15	Hoechst Ag, 6230 Frankfurt	Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
DK172738B1 (da) *	1983-04-07	1999-06-21	Chiron Corp	Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf

1985
- 1985-03-22 DK DK129385A patent/DK129385A/da not_active Application Discontinuation
1986
- 1986-03-17 ZA ZA861953A patent/ZA861953B/xx unknown
- 1986-03-20 JP JP61060995A patent/JPH0648993B2/ja not_active Expired - Lifetime
- 1986-03-20 MX MX1947A patent/MX163837B/es unknown
- 1986-03-20 CA CA000504650A patent/CA1340823C/en not_active Expired - Fee Related
- 1986-03-21 ES ES553231A patent/ES8802402A1/es not_active Expired
- 1986-03-21 NZ NZ215570A patent/NZ215570A/xx unknown
- 1986-03-21 FI FI861198A patent/FI87801C/fi not_active IP Right Cessation
- 1986-03-21 GR GR860764A patent/GR860764B/el unknown
- 1986-03-21 AT AT86302133T patent/ATE69266T1/de not_active IP Right Cessation
- 1986-03-21 IE IE73786A patent/IE58842B1/en not_active IP Right Cessation
- 1986-03-21 AU AU55005/86A patent/AU586855B2/en not_active Ceased
- 1986-03-21 NO NO861120A patent/NO172646C/no not_active IP Right Cessation
- 1986-03-21 EP EP86302133A patent/EP0195691B1/de not_active Expired - Lifetime
- 1986-03-21 DE DE8686302133T patent/DE3682303D1/de not_active Expired - Lifetime
- 1986-03-21 PT PT82241A patent/PT82241B/pt not_active IP Right Cessation
- 1986-11-28 ES ES557227A patent/ES8708251A1/es not_active Expired
1993
- 1993-05-24 JP JP5121394A patent/JPH088871B2/ja not_active Expired - Lifetime
1995
- 1995-07-14 JP JP7178875A patent/JP2553326B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0195691A1 (de)	1986-09-24
AU5500586A (en)	1986-09-25
FI861198A0 (fi)	1986-03-21
DK129385D0 (da)	1985-03-22
JPH0648993B2 (ja)	1994-06-29
ES8802402A1 (es)	1988-05-16
CA1340823C (en)	1999-11-16
GR860764B (en)	1986-07-21
EP0195691B1 (de)	1991-11-06
ATE69266T1 (de)	1991-11-15
JP2553326B2 (ja)	1996-11-13
FI87801C (fi)	1993-02-25
FI861198L (fi)	1986-09-23
ZA861953B (en)	1986-11-26
FI87801B (fi)	1992-11-13
JPH0823985A (ja)	1996-01-30
JPS61221200A (ja)	1986-10-01
NO172646B (no)	1993-05-10
PT82241B (pt)	1988-11-30
AU586855B2 (en)	1989-07-27
PT82241A (en)	1986-04-01
JPH088871B2 (ja)	1996-01-31
ES8708251A1 (es)	1987-10-01
ES553231A0 (es)	1988-05-16
NO861120L (no)	1986-09-23
JPH06133777A (ja)	1994-05-17
NO172646C (no)	1993-08-18
MX163837B (es)	1992-06-25
IE860737L (en)	1986-09-22
IE58842B1 (en)	1993-11-17
ES557227A0 (es)	1987-10-01
NZ215570A (en)	1989-07-27
DE3682303D1 (de)	1991-12-12

Legal Events

Date	Code	Title	Description
1987-07-06	AHS	Application shelved for other reasons than non-payment
1988-01-11	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
AU586855B2 (en)	1989-07-27	Insulin precursors, process for their preparation and process for the preparation of human insulin
AU561343B2 (en)	1987-05-07	Human immune interferon by recombinant dna
ES2109336T3 (es)	1998-01-16	Expresion de pace en celulas huesped y metodos de utilizacion de la misma.
AU3140589A (en)	1989-09-21	Composition inducing a binding
ATE69241T1 (de)	1991-11-15	Herstellung von polypeptiden mit humangammainterferon-aktivitaet.
ATE79403T1 (de)	1992-08-15	Herstellung von thrombin-inhibitoren.
DE68918673D1 (de)	1994-11-10	IgG-bindendes Protein H, kodierendes Gen dafür und Verfahren zu seiner Herstellung.
AU2430588A (en)	1989-04-27	Mutant acidic fibroblast growth factor
ATE89455T1 (de)	1993-06-15	Mittel zur bekaempfung von clostridien.
EP0302838A3 (en)	1989-11-08	Cloning of the gene coding the isoamylase enzyme and its use in the production of said enzyme
DK125786A (da)	1986-11-17	Peptider og fremstilling deraf
EP0390327A3 (de)	1990-11-14	Verfahren zur Züchtung von Gewebekulturen