DK1299559T3 - Fremgangsmåde til identificering af inhibitorer for det anafase-promoverende kompleks - Google Patents
Fremgangsmåde til identificering af inhibitorer for det anafase-promoverende kompleksInfo
- Publication number
- DK1299559T3 DK1299559T3 DK01957896T DK01957896T DK1299559T3 DK 1299559 T3 DK1299559 T3 DK 1299559T3 DK 01957896 T DK01957896 T DK 01957896T DK 01957896 T DK01957896 T DK 01957896T DK 1299559 T3 DK1299559 T3 DK 1299559T3
- Authority
- DK
- Denmark
- Prior art keywords
- anaphase
- identifying inhibitors
- promoting complex
- apc
- promoting
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102000005446 Anaphase-Promoting Complex-Cyclosome Human genes 0.000 title 1
- 108010031677 Anaphase-Promoting Complex-Cyclosome Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000052593 Anaphase-Promoting Complex-Cyclosome Apc11 Subunit Human genes 0.000 abstract 1
- 108700004610 Anaphase-Promoting Complex-Cyclosome Apc11 Subunit Proteins 0.000 abstract 1
- 101100109073 Dictyostelium discoideum anapc11 gene Proteins 0.000 abstract 1
- 101150075333 apc11 gene Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000034512 ubiquitination Effects 0.000 abstract 1
- 238000010798 ubiquitination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/9015—Ligases (6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00113832A EP1167539A1 (fr) | 2000-06-29 | 2000-06-29 | Méthodes pour l'identification des inhibiteurs des complexes promoteurs de l'anaphase |
| PCT/EP2001/007329 WO2002000923A1 (fr) | 2000-06-29 | 2001-06-27 | Procedes servant a identifier des inhibiteurs du complexe de promotion d'anaphase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1299559T3 true DK1299559T3 (da) | 2004-07-26 |
Family
ID=8169106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01957896T DK1299559T3 (da) | 2000-06-29 | 2001-06-27 | Fremgangsmåde til identificering af inhibitorer for det anafase-promoverende kompleks |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP1167539A1 (fr) |
| JP (1) | JP2004501655A (fr) |
| AT (1) | ATE265543T1 (fr) |
| AU (1) | AU2001279695A1 (fr) |
| DE (1) | DE60103061T2 (fr) |
| DK (1) | DK1299559T3 (fr) |
| WO (1) | WO2002000923A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6740495B1 (en) | 2000-04-03 | 2004-05-25 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase assay |
| US6979551B2 (en) | 2000-04-03 | 2005-12-27 | Rigel Pharmaceuticals, Inc. | Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents |
| WO2003000726A1 (fr) * | 2001-06-22 | 2003-01-03 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Structure cristalline de la sous-unite apc10/doc1 du complexe de promotion de l'anaphase chez l'homme |
| EP1469082A1 (fr) * | 2003-04-16 | 2004-10-20 | Boehringer Ingelheim International GmbH | Méthode d'identification de substances qui inhibent spécifiquement le complexe de promotion d'anaphase. |
| CN104877017A (zh) * | 2015-05-06 | 2015-09-02 | 东南大学 | 一种抗肿瘤泛素化蛋白及其提取方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726025A (en) * | 1995-04-20 | 1998-03-10 | President And Fellows Of Harvard College | Assay and reagents for detecting inhibitors of ubiquitin-dependent degradation of cell cycle regulatory proteins |
| WO1997037027A1 (fr) * | 1996-04-01 | 1997-10-09 | President And Fellows Of Harvard College | Nouveaux polypeptides porteurs d'ubiquitine et selectionnant les cyclines |
| EP0843008A1 (fr) * | 1996-11-14 | 1998-05-20 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Méthodes pour la production du complexe promoteur de l'anaphase |
-
2000
- 2000-06-29 EP EP00113832A patent/EP1167539A1/fr not_active Withdrawn
-
2001
- 2001-06-27 AU AU2001279695A patent/AU2001279695A1/en not_active Abandoned
- 2001-06-27 DE DE60103061T patent/DE60103061T2/de not_active Expired - Fee Related
- 2001-06-27 DK DK01957896T patent/DK1299559T3/da active
- 2001-06-27 JP JP2002506237A patent/JP2004501655A/ja active Pending
- 2001-06-27 WO PCT/EP2001/007329 patent/WO2002000923A1/fr not_active Ceased
- 2001-06-27 AT AT01957896T patent/ATE265543T1/de not_active IP Right Cessation
- 2001-06-27 EP EP01957896A patent/EP1299559B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1299559B1 (fr) | 2004-04-28 |
| DE60103061D1 (de) | 2004-06-03 |
| JP2004501655A (ja) | 2004-01-22 |
| WO2002000923A1 (fr) | 2002-01-03 |
| EP1299559A1 (fr) | 2003-04-09 |
| EP1167539A1 (fr) | 2002-01-02 |
| ATE265543T1 (de) | 2004-05-15 |
| AU2001279695A1 (en) | 2002-01-08 |
| DE60103061T2 (de) | 2004-09-02 |
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