DK1362855T3 - beta-lactam-forbindelser, en fremgangsmåde til fremstilling af disse forbindelser og serumkolesterolsænkende midler indeholdende disse forbindelser - Google Patents
beta-lactam-forbindelser, en fremgangsmåde til fremstilling af disse forbindelser og serumkolesterolsænkende midler indeholdende disse forbindelserInfo
- Publication number
- DK1362855T3 DK1362855T3 DK02703861T DK02703861T DK1362855T3 DK 1362855 T3 DK1362855 T3 DK 1362855T3 DK 02703861 T DK02703861 T DK 02703861T DK 02703861 T DK02703861 T DK 02703861T DK 1362855 T3 DK1362855 T3 DK 1362855T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- group
- carbon atoms
- chain
- chem
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003529 anticholesteremic agent Substances 0.000 title 1
- 229940127226 anticholesterol agent Drugs 0.000 title 1
- -1 beta-lactam compounds Chemical class 0.000 title 1
- 210000002966 serum Anatomy 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005243 carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001048202 | 2001-02-23 | ||
| JP2001128031 | 2001-04-25 | ||
| PCT/JP2002/001481 WO2002066464A1 (fr) | 2001-02-23 | 2002-02-20 | Composes de beta-lactame, leur procede de production et agents d'abaissement du taux de cholesterol contenant ces composes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1362855T3 true DK1362855T3 (da) | 2008-01-28 |
Family
ID=26609978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02703861T DK1362855T3 (da) | 2001-02-23 | 2002-02-20 | beta-lactam-forbindelser, en fremgangsmåde til fremstilling af disse forbindelser og serumkolesterolsænkende midler indeholdende disse forbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7045515B2 (da) |
| EP (1) | EP1362855B1 (da) |
| JP (1) | JP4229701B2 (da) |
| KR (1) | KR100721639B1 (da) |
| CN (1) | CN1273467C (da) |
| AT (1) | ATE374769T1 (da) |
| AU (1) | AU2002237522B2 (da) |
| BR (1) | BRPI0206193B1 (da) |
| CA (1) | CA2438961C (da) |
| DE (1) | DE60222742T2 (da) |
| DK (1) | DK1362855T3 (da) |
| ES (1) | ES2294101T3 (da) |
| MX (1) | MXPA03005073A (da) |
| PT (1) | PT1362855E (da) |
| RU (1) | RU2301799C2 (da) |
| TW (1) | TWI291957B (da) |
| WO (1) | WO2002066464A1 (da) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0208384B1 (pt) | 2001-03-28 | 2016-05-31 | Merck Sharp & Dohme | síntese enantiosseletiva de compostos intermediários de azetidinona |
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
| EP1682117A1 (en) * | 2003-10-30 | 2006-07-26 | Merck & Co., Inc. | 2-azetidinones as anti-hypercholesterolemic agents |
| EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| SI1682499T1 (sl) * | 2003-11-10 | 2008-02-29 | Microbia Inc | 4-biarilil-1-fenilazetidin-2-oni |
| DE602004008100T2 (de) * | 2003-11-10 | 2008-04-30 | Microbia Inc., Cambridge | 4-biarylyl-1-phenylazetidin-2-one |
| ATE485267T1 (de) | 2003-12-23 | 2010-11-15 | Astrazeneca Ab | Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung |
| JP2007516287A (ja) | 2003-12-23 | 2007-06-21 | メルク エンド カムパニー インコーポレーテッド | 抗高コレステロール血症化合物 |
| TW200611896A (en) * | 2004-05-21 | 2006-04-16 | Aventis Pharma Gmbh | Process for preparing 1, 4-diphenylazetidinone derivatives |
| EP1807070A1 (en) * | 2004-09-29 | 2007-07-18 | Schering Corporation | Combinations of substituted azetidinones and cb1 antagonists |
| US7700597B2 (en) | 2004-12-03 | 2010-04-20 | Schering Corporation | Substituted piperazines as CB1 antagonists |
| TW200726746A (en) * | 2005-05-06 | 2007-07-16 | Microbia Inc | Processes for production of 4-biphenylylazetidin-2-ones |
| AU2006244043A1 (en) * | 2005-05-11 | 2006-11-16 | Microbia, Inc. | Processes for production of phenolic 4-biphenylylazetidin-2-ones |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| EA200702614A1 (ru) * | 2005-05-25 | 2008-04-28 | Майкробиа, Инк. | Способы получения 4-(бифенилил)азетидин-2-оналкилфосфиновых кислот |
| US7696177B2 (en) * | 2005-06-15 | 2010-04-13 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
| DE602006010870D1 (de) | 2005-06-20 | 2010-01-14 | Schering Corp | Als antagonisten von histamin h3 geeignete piperidinderivate |
| UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
| AR057072A1 (es) | 2005-06-22 | 2007-11-14 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| NZ566877A (en) | 2005-09-29 | 2010-05-28 | Sanofi Aventis | Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| TW200806623A (en) * | 2005-10-05 | 2008-02-01 | Merck & Co Inc | Anti-hypercholesterolemic compounds |
| WO2007084450A2 (en) * | 2006-01-18 | 2007-07-26 | Schering Corporation | Cannibinoid receptor modulators |
| JP4880348B2 (ja) * | 2006-04-25 | 2012-02-22 | 壽製薬株式会社 | アズレン誘導体及びそれを有効成分とする血清コレステロール低下剤 |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| JP2010503675A (ja) | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 疼痛、糖尿病および脂質代謝の障害の治療に有用なスピロ縮合アゼチジン誘導体 |
| WO2008033431A1 (en) * | 2006-09-15 | 2008-03-20 | Schering Corporation | Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders |
| MX2009002921A (es) * | 2006-09-15 | 2009-04-01 | Schering Corp | Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico. |
| EP2061796A2 (en) | 2006-09-15 | 2009-05-27 | Schering Corporation | Azetidine and azetidinone derivatives useful in treating pain and disorders of lipid metabolism |
| CA2672221A1 (en) * | 2006-12-20 | 2008-07-17 | Merck & Co., Inc. | Anti-hypercholesterolemic compounds |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2008130616A2 (en) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
| CN101790521A (zh) * | 2007-06-28 | 2010-07-28 | 英特维特国际股份有限公司 | 作为cb1拮抗剂的取代哌嗪 |
| WO2009005646A2 (en) * | 2007-06-28 | 2009-01-08 | Schering Corporation | Substituted piperazines as cb1 antagonists |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
| US20110245209A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (zh) * | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| SG178880A1 (en) | 2009-08-26 | 2012-04-27 | Sanofi Sa | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| CN104860980B (zh) * | 2015-04-23 | 2018-06-19 | 上海弈柯莱生物医药科技有限公司 | 一种用于合成依折麦布的中间体及其制备方法和应用 |
| BR112021002207A2 (pt) | 2018-08-10 | 2021-05-04 | Diapin Therapeutics, Llc | tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios |
| JP7574206B2 (ja) | 2019-03-20 | 2024-10-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ステロール調節エレメント結合転写因子１（ｓｒｅｂｆ１）阻害剤による上昇した脂質レベルの治療 |
| JP2022525546A (ja) | 2019-03-20 | 2022-05-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ステロール調節エレメント結合転写タンパク質切断活性化タンパク質（ｓｃａｐ）阻害剤による上昇した脂質レベルの治療 |
| AU2024330793A1 (en) | 2023-08-29 | 2026-02-26 | Regeneron Pharmaceuticals, Inc. | Treatment of liver disease or metabolic disorder with folliculin interacting protein 1 (fnip1) inhibitors and/or folliculin (flcn) inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5857360A (ja) | 1981-10-01 | 1983-04-05 | Ajinomoto Co Inc | アゼチジノン誘導体 |
| AU658441B2 (en) | 1991-07-23 | 1995-04-13 | Schering Corporation | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
| UA50705C2 (uk) * | 1992-09-18 | 2002-11-15 | Мерк Енд Ко, Інк | СПОСОБИ ОДЕРЖАННЯ ПРОМІЖНИХ СПОЛУК <font face="Symbol">b</font>-МЕТИЛКАРБАПЕНЕМУ, ПРОМІЖНІ CПОЛУКИ |
| US5412092A (en) * | 1993-04-23 | 1995-05-02 | Bristol-Myers Squibb Company | N-substituted 2-azetidinones |
| US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| PT877750E (pt) * | 1995-10-31 | 2002-09-30 | Schering Corp | 2-azetidinonas substituidas por acucar uteis como agentes hipocolesterolemiantes |
| AU7472896A (en) * | 1995-11-02 | 1997-05-22 | Schering Corporation | Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon |
| CA2431995A1 (en) * | 2000-12-21 | 2002-06-27 | Aventis Pharma Deutschland Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
-
2002
- 2002-02-08 TW TW091102310A patent/TWI291957B/zh not_active IP Right Cessation
- 2002-02-20 RU RU2003128424/04A patent/RU2301799C2/ru not_active IP Right Cessation
- 2002-02-20 DE DE60222742T patent/DE60222742T2/de not_active Expired - Lifetime
- 2002-02-20 CN CNB028052013A patent/CN1273467C/zh not_active Expired - Fee Related
- 2002-02-20 MX MXPA03005073A patent/MXPA03005073A/es active IP Right Grant
- 2002-02-20 WO PCT/JP2002/001481 patent/WO2002066464A1/ja not_active Ceased
- 2002-02-20 BR BRPI0206193A patent/BRPI0206193B1/pt not_active IP Right Cessation
- 2002-02-20 DK DK02703861T patent/DK1362855T3/da active
- 2002-02-20 CA CA2438961A patent/CA2438961C/en not_active Expired - Fee Related
- 2002-02-20 AT AT02703861T patent/ATE374769T1/de active
- 2002-02-20 PT PT02703861T patent/PT1362855E/pt unknown
- 2002-02-20 EP EP02703861A patent/EP1362855B1/en not_active Expired - Lifetime
- 2002-02-20 US US10/450,171 patent/US7045515B2/en not_active Expired - Lifetime
- 2002-02-20 ES ES02703861T patent/ES2294101T3/es not_active Expired - Lifetime
- 2002-02-20 AU AU2002237522A patent/AU2002237522B2/en not_active Ceased
- 2002-02-20 JP JP2002565979A patent/JP4229701B2/ja not_active Expired - Lifetime
- 2002-02-20 KR KR1020037010927A patent/KR100721639B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030076690A (ko) | 2003-09-26 |
| US20040063929A1 (en) | 2004-04-01 |
| ATE374769T1 (de) | 2007-10-15 |
| US7045515B2 (en) | 2006-05-16 |
| CN1273467C (zh) | 2006-09-06 |
| MXPA03005073A (es) | 2003-09-05 |
| DE60222742D1 (de) | 2007-11-15 |
| JP4229701B2 (ja) | 2009-02-25 |
| CA2438961C (en) | 2010-02-16 |
| RU2301799C2 (ru) | 2007-06-27 |
| CA2438961A1 (en) | 2002-08-29 |
| TWI291957B (en) | 2008-01-01 |
| AU2002237522B2 (en) | 2007-08-02 |
| EP1362855B1 (en) | 2007-10-03 |
| CN1492865A (zh) | 2004-04-28 |
| JPWO2002066464A1 (ja) | 2004-06-17 |
| WO2002066464A1 (fr) | 2002-08-29 |
| PT1362855E (pt) | 2007-12-04 |
| BR0206193A (pt) | 2004-02-03 |
| RU2003128424A (ru) | 2005-01-27 |
| ES2294101T3 (es) | 2008-04-01 |
| KR100721639B1 (ko) | 2007-05-23 |
| BRPI0206193B1 (pt) | 2016-05-24 |
| DE60222742T2 (de) | 2008-07-17 |
| EP1362855A1 (en) | 2003-11-19 |
| EP1362855A4 (en) | 2005-02-23 |
| HK1060357A1 (en) | 2004-08-06 |
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