DK1381605T3 - Mercaptoacetylamidderivater, en fremgangsmåde til deres fremstilling og deres anvendelse - Google Patents

Mercaptoacetylamidderivater, en fremgangsmåde til deres fremstilling og deres anvendelse

Info

Publication number
DK1381605T3
DK1381605T3 DK02732549T DK02732549T DK1381605T3 DK 1381605 T3 DK1381605 T3 DK 1381605T3 DK 02732549 T DK02732549 T DK 02732549T DK 02732549 T DK02732549 T DK 02732549T DK 1381605 T3 DK1381605 T3 DK 1381605T3
Authority
DK
Denmark
Prior art keywords
preparation
mercaptoacetylamide derivatives
mercaptoacetylamide
derivatives
Prior art date
Application number
DK02732549T
Other languages
English (en)
Inventor
Shujaath Mehdi
Jack Roger Koehl
Barbara Ann Anderson
Manfred Gerken
Bernd Jablonka
Werner Seiz
Bernhard Seuring
Gary A Flynn
Heinz-Werner Kleemann
Wolfgang Linz
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Priority claimed from PCT/EP2002/003668 external-priority patent/WO2002083671A1/en
Application granted granted Critical
Publication of DK1381605T3 publication Critical patent/DK1381605T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02732549T 2001-04-12 2002-04-03 Mercaptoacetylamidderivater, en fremgangsmåde til deres fremstilling og deres anvendelse DK1381605T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12
GBGB0119305.1A GB0119305D0 (en) 2001-04-12 2001-08-08 Mercaptoacetylamide derivatives,a process for their preparation and their use
PCT/EP2002/003668 WO2002083671A1 (en) 2001-04-12 2002-04-03 Mercaptoacetylamide derivatives, a process for their preparation and their use
EP02732549A EP1381605B1 (en) 2001-04-12 2002-04-03 Mercaptoacetylamide derivatives, a process for their preparation and their use

Publications (1)

Publication Number Publication Date
DK1381605T3 true DK1381605T3 (da) 2005-05-09

Family

ID=23085405

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02732549T DK1381605T3 (da) 2001-04-12 2002-04-03 Mercaptoacetylamidderivater, en fremgangsmåde til deres fremstilling og deres anvendelse

Country Status (17)

Country Link
US (1) US6602866B2 (da)
KR (1) KR100910929B1 (da)
AR (1) AR034307A1 (da)
CR (1) CR7074A (da)
DK (1) DK1381605T3 (da)
EC (1) ECSP034782A (da)
GB (1) GB0119305D0 (da)
GT (1) GT200200069A (da)
IL (1) IL158289A (da)
MY (1) MY128226A (da)
PE (1) PE20021079A1 (da)
RS (1) RS50919B (da)
TN (1) TNSN03083A1 (da)
TW (1) TWI319764B (da)
UA (1) UA75647C2 (da)
UY (1) UY27255A1 (da)
ZA (1) ZA200307096B (da)

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JP2011518884A (ja) 2008-04-29 2011-06-30 セラヴァンス， インコーポレーテッド 二重活性抗高血圧剤
US7863309B2 (en) 2008-07-24 2011-01-04 Theravance, Inc. Dual-acting antihypertensive agents
US7956054B2 (en) 2009-07-07 2011-06-07 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
EP2456762B1 (en) 2009-07-22 2013-10-16 Theravance, Inc. Dual-acting oxazole antihypertensive agents
WO2011090929A1 (en) 2010-01-19 2011-07-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
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SI2651896T1 (sl) 2010-12-15 2015-11-30 Theravance Biopharma R&D Ip, Llc Inhibitorji neprilizina
US8449890B2 (en) 2011-02-17 2013-05-28 Theravance, Inc. Neprilysin inhibitors
AU2012217615B2 (en) 2011-02-17 2016-09-29 Theravance Biopharma R&D Ip, Llc Substituted aminobutyric derivatives as neprilysin inhibitors
CA2835281A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
ES2699773T3 (es) 2011-05-31 2019-02-12 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
ES2653215T3 (es) 2011-05-31 2018-02-06 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
LT2864292T (lt) 2012-06-08 2017-07-10 Theravance Biopharma R&D Ip, Llc Neprilizino inhibitoriai
ES2710932T3 (es) 2012-06-08 2019-04-29 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina
US9126956B2 (en) 2012-08-08 2015-09-08 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
HUE034210T2 (hu) 2013-03-05 2018-02-28 Theravance Biopharma R&D Ip Llc Neprilizininhibitorok
EP3099668B1 (en) 2014-01-30 2022-05-04 Theravance Biopharma R&D IP, LLC 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
MX2016009760A (es) 2014-01-30 2016-11-08 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
WO2016130650A1 (en) 2015-02-11 2016-08-18 Theravance Biopharma R&D Ip, Llc (2s, 4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor
RU2715241C2 (ru) 2015-02-19 2020-02-26 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота
TWI731943B (zh) 2016-03-08 2021-07-01 美商施萬生物製藥研發Ｉｐ有限責任公司 結晶型（2s，4r）－5－（5’－氯－2’－氟－［1，1’－聯苯］－4－基）－2－（乙氧基甲基）－4－（3－羥基異㗁唑－5－甲醯胺基）－2－甲基戊酸及其用途

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Also Published As

Publication number Publication date
KR100910929B1 (ko) 2009-08-06
GB0119305D0 (en) 2001-10-03
AR034307A1 (es) 2004-02-18
IL158289A (en) 2010-11-30
ECSP034782A (es) 2003-12-01
US20020193589A1 (en) 2002-12-19
PE20021079A1 (es) 2003-02-19
MY128226A (en) 2007-01-31
US6602866B2 (en) 2003-08-05
GT200200069A (es) 2002-12-17
RS50919B (sr) 2010-08-31
CR7074A (es) 2007-12-04
UY27255A1 (es) 2002-07-31
UA75647C2 (en) 2006-05-15
TNSN03083A1 (en) 2005-12-23
ZA200307096B (en) 2004-09-06
TWI319764B (en) 2010-01-21
KR20040008153A (ko) 2004-01-28
YU78703A (sh) 2006-05-25

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