CR7074A - Derivados de mercaptoacetylamida y proceso para su preparacion y uso - Google Patents

Derivados de mercaptoacetylamida y proceso para su preparacion y uso

Info

Publication number
CR7074A
CR7074A CR7074A CR7074A CR7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A CR 7074 A CR7074 A CR 7074A
Authority
CR
Costa Rica
Prior art keywords
compounds
inhibitory activity
heart failure
relates
present
Prior art date
Application number
CR7074A
Other languages
English (en)
Inventor
A Flynn Gary
Mehdi Shujaath
Roger Koehl Jack
Ann Anderson Barbara
Gerken Manfred
Jablonka Bernd
Kleeman Heinz-Werner
Linz Wolfgang
Seiz Werner
Seuring Bernhard
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of CR7074A publication Critical patent/CR7074A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevos compuestos que poseen tanto actividad inhibidora de la enzima convertidota de angiotensina, como actividad inhibidora de la endopeptidasa neutra, y a metodos para preparar dichos compuestos. La presente invencion se refiere asi mismo a composiciones farmaceuticas que contienen dichos compuestos inhibidores dobles o sus sales farmaceuticamente aceptables y a su uso en la fabricacion de medicamentos usados en la insuficiencia cardiaca, para reducir la mortalidad en pacientes con insuficiencia cardiaca (ICC) o con disfuncion ventricular izquierda, tras un infarto del miocardio, insuficiencia renal, hipertension esencial y la cirrosis.
CR7074A 2001-04-12 2003-09-12 Derivados de mercaptoacetylamida y proceso para su preparacion y uso CR7074A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28330501P 2001-04-12 2001-04-12
GBGB0119305.1A GB0119305D0 (en) 2001-04-12 2001-08-08 Mercaptoacetylamide derivatives,a process for their preparation and their use

Publications (1)

Publication Number Publication Date
CR7074A true CR7074A (es) 2007-12-04

Family

ID=23085405

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7074A CR7074A (es) 2001-04-12 2003-09-12 Derivados de mercaptoacetylamida y proceso para su preparacion y uso

Country Status (17)

Country Link
US (1) US6602866B2 (es)
KR (1) KR100910929B1 (es)
AR (1) AR034307A1 (es)
CR (1) CR7074A (es)
DK (1) DK1381605T3 (es)
EC (1) ECSP034782A (es)
GB (1) GB0119305D0 (es)
GT (1) GT200200069A (es)
IL (1) IL158289A (es)
MY (1) MY128226A (es)
PE (1) PE20021079A1 (es)
RS (1) RS50919B (es)
TN (1) TNSN03083A1 (es)
TW (1) TWI319764B (es)
UA (1) UA75647C2 (es)
UY (1) UY27255A1 (es)
ZA (1) ZA200307096B (es)

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EP2297113A1 (en) 2008-04-29 2011-03-23 Theravance, Inc. Dual-acting antihypertensive agents
JP2011529072A (ja) 2008-07-24 2011-12-01 セラヴァンス， インコーポレーテッド 二重作用血圧降下薬
WO2011005674A1 (en) 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
JP2012533626A (ja) 2009-07-22 2012-12-27 セラヴァンス， インコーポレーテッド 二重作用オキサゾール降圧剤
EP2526095A1 (en) 2010-01-19 2012-11-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
HUE028051T2 (hu) 2010-12-15 2016-11-28 Theravance Biopharma R&D Ip Llc Neprilizin inhibitorok
CA2819153A1 (en) 2010-12-15 2012-06-21 Theravance, Inc. Neprilysin inhibitors
JP5959065B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP5959066B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
CN103582630B (zh) 2011-05-31 2016-08-17 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
CN103748070B (zh) 2011-05-31 2015-06-24 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
SMT201700306T1 (it) 2012-06-08 2017-07-18 Theravance Biopharma R&D Ip Llc Inibitori di neprilisina
WO2013184898A1 (en) 2012-06-08 2013-12-12 Theravance, Inc. Neprilysin inhibitors
MX366149B (es) 2012-08-08 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
DK2964616T3 (en) 2013-03-05 2017-08-28 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2934936A1 (en) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CA2934898A1 (en) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
JP6766055B2 (ja) 2015-02-11 2020-10-07 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての（２ｓ，４ｒ）−５−（５’−クロロ−２’−フルオロビフェニル−４−イル）−４−（エトキシオキサリルアミノ）−２−ヒドロキシメチル−２−メチルペンタン酸
LT3259255T (lt) 2015-02-19 2021-04-26 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5`-chlor-2`-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentano rūgštis
JP7306828B2 (ja) 2016-03-08 2023-07-11 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 結晶性（２ｓ，４ｒ）－５－（５’－クロロ－２’－フルオロ－［１，１’－ビフェニル］－４－イル）－２－（エトキシメチル）－４－（３－ヒドロキシイソオキサゾール－５－カルボキサミド）－２－メチルペンタン酸およびその使用

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Also Published As

Publication number Publication date
IL158289A (en) 2010-11-30
TNSN03083A1 (en) 2005-12-23
GT200200069A (es) 2002-12-17
YU78703A (sh) 2006-05-25
MY128226A (en) 2007-01-31
US6602866B2 (en) 2003-08-05
RS50919B (sr) 2010-08-31
PE20021079A1 (es) 2003-02-19
ZA200307096B (en) 2004-09-06
US20020193589A1 (en) 2002-12-19
UA75647C2 (en) 2006-05-15
AR034307A1 (es) 2004-02-18
KR100910929B1 (ko) 2009-08-06
ECSP034782A (es) 2003-12-01
TWI319764B (en) 2010-01-21
UY27255A1 (es) 2002-07-31
DK1381605T3 (da) 2005-05-09
KR20040008153A (ko) 2004-01-28
GB0119305D0 (en) 2001-10-03

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Legal Events

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