DK1384477T3 - Anvendelse af pyrazolinderivater ved fremstilling af et medikament til forebyggelse og/eller behandling af proliferative cellesygdomme - Google Patents

Anvendelse af pyrazolinderivater ved fremstilling af et medikament til forebyggelse og/eller behandling af proliferative cellesygdomme

Info

Publication number
DK1384477T3
DK1384477T3 DK02714233T DK02714233T DK1384477T3 DK 1384477 T3 DK1384477 T3 DK 1384477T3 DK 02714233 T DK02714233 T DK 02714233T DK 02714233 T DK02714233 T DK 02714233T DK 1384477 T3 DK1384477 T3 DK 1384477T3
Authority
DK
Denmark
Prior art keywords
methyl
hydrogen
trifluoromethyl
fluorine
aminosulphonyl
Prior art date
Application number
DK02714233T
Other languages
English (en)
Inventor
Maria Rosa Cuberes-Altisent
Juana Maria Berrocal-Romero
Maria Montser Contijoch-Llobet
Jordi Frigola-Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Application granted granted Critical
Publication of DK1384477T3 publication Critical patent/DK1384477T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02714233T 2001-04-06 2002-03-21 Anvendelse af pyrazolinderivater ved fremstilling af et medikament til forebyggelse og/eller behandling af proliferative cellesygdomme DK1384477T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200100818A ES2174757B1 (es) 2001-04-06 2001-04-06 Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.

Publications (1)

Publication Number Publication Date
DK1384477T3 true DK1384477T3 (da) 2006-08-21

Family

ID=8497370

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02714233T DK1384477T3 (da) 2001-04-06 2002-03-21 Anvendelse af pyrazolinderivater ved fremstilling af et medikament til forebyggelse og/eller behandling af proliferative cellesygdomme

Country Status (26)

Country Link
US (1) US20040034082A1 (da)
EP (2) EP1516621A3 (da)
JP (1) JP4451599B2 (da)
KR (1) KR20040025912A (da)
CN (2) CN1299682C (da)
AT (1) ATE326966T1 (da)
AU (1) AU2002246152B2 (da)
BR (1) BR0208805A (da)
CA (1) CA2442974C (da)
CY (1) CY1105523T1 (da)
DE (1) DE60211681T2 (da)
DK (1) DK1384477T3 (da)
ES (2) ES2174757B1 (da)
HU (1) HUP0400918A3 (da)
IL (1) IL158269A0 (da)
IS (1) IS6973A (da)
MA (1) MA27019A1 (da)
MX (1) MXPA03009124A (da)
NO (1) NO20034470L (da)
NZ (1) NZ529304A (da)
PL (1) PL365220A1 (da)
PT (1) PT1384477E (da)
RU (1) RU2305545C2 (da)
UA (1) UA75402C2 (da)
WO (1) WO2002080909A1 (da)
ZA (1) ZA200308626B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077910A1 (en) * 2004-02-16 2005-08-25 Laboratorios Del Dr. Esteve S.A. Pyrazoline derivatives useful for the treatment of cancer
ES2238923B1 (es) * 2004-02-16 2006-11-01 Laboratorios Del Dr. Esteve, S.A. Nuevos derivados pirazolinicos sustituidos.
US7998996B2 (en) 2004-02-17 2011-08-16 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
EP1637522A1 (en) * 2004-09-16 2006-03-22 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
CA2556568A1 (en) * 2004-02-17 2005-08-25 Laboratorios Del Dr. Esteve S.A. Substituted pyrazoline compounds for reducing triglycerides in blood
TW200533657A (en) 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
EP1749525A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Combination of substituted pyrazolines and anti-addictive agent
WO2007009703A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. New formulations of substituted pyrazoline compounds
EP1746090A1 (en) * 2005-07-15 2007-01-24 Laboratorios del Dr. Esteve S.A. Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
EP1849776A1 (en) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Azepane- or Azocane-substituted pyrazoline compounds, their preparation and use as medicaments
ES2327379B1 (es) * 2005-07-15 2010-05-28 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina indolinsustituidos, su preparacion y su uso como medicamentos.
ES2319074B1 (es) * 2005-07-15 2009-12-03 Laboratorios Del Dr. Esteve, S.A. Combinacion de principios activos.
ES2327203B1 (es) * 2005-07-15 2010-06-07 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos relacionados con la coagulacion.
US7897589B2 (en) 2005-07-15 2011-03-01 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743642A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
ES2336883B1 (es) * 2005-07-15 2011-03-22 Laboratorios Del Dr. Esteve, S.A. Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre.
ES2326725B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos alimentarios, que incluyen la obesidad o el sindrome metabolico en pacientes con diabetes desarrollada.
EP1743639A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of coagulation related diseases
EP1749526A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes
WO2007009706A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
EP1749527A1 (en) * 2005-07-15 2007-02-07 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazoline compounds for the treatment of the lipid parameters of the metabolic syndrome
EP1743889A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood
EP1849784A1 (en) * 2006-04-26 2007-10-31 Laboratorios Del Dr. Esteve, S.A. Indoline-substituted pyrazoline compounds, their preparation and use as medicaments
EP1743637A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
ES2316306B1 (es) * 2005-07-15 2009-11-23 Laboratorios Del Dr. Esteve, S.A. Combinacion de un compuesto de pirazolina sustituido y un farmaco utilizado en trastornos relacionados con los alimentos.
ES2326857B1 (es) * 2005-07-15 2010-05-11 Laboratorios Del Dr. Esteve, S.A. Uso de compuestos de pirazolina sustituidos para el tratamiento de los parametros lipidicos del sindrome metabolico.
EP1743636A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Combination of a substituted pyrazoline compound and a drug used in food-related disorders
WO2007009699A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases
WO2007009701A2 (en) * 2005-07-15 2007-01-25 Laboratorios Del Dr. Esteve, S.A. Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome
EP1743890A1 (en) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments
EP1743643A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. New formulations of substituted pyrazoline compounds
KR101457637B1 (ko) * 2012-10-24 2014-11-20 건국대학교 산학협력단 디히드로피라졸카르보티오아미드 유도체 및 그 제법 및 그 유도체를 포함하는 항암제 조성물
CN103664785A (zh) * 2013-11-04 2014-03-26 南京大学 一类新颖的二氢吡唑磺胺衍生物的合成及在抗癌药物中的应用
WO2023043778A1 (en) * 2021-09-14 2023-03-23 Maverick Gold (Nv), Llc Methods and systems for titling and trading alternative reserves

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0674624T3 (da) * 1992-12-17 1999-09-13 Pfizer Pyrazoler med CRF-antagonistisk aktivitet
ES2141916T3 (es) * 1993-11-30 2000-04-01 Searle & Co Pirazolil-bencenosulfonamidas sustituidas para el tratamiento de la inflamacion.
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5972986A (en) * 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
ES2137138B1 (es) * 1998-05-29 2000-09-16 Esteve Labor Dr Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
US6376519B1 (en) * 1999-06-16 2002-04-23 Temple University-Of The Commonwealth Of Higher Education 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2

Also Published As

Publication number Publication date
EP1516621A2 (en) 2005-03-23
CY1105523T1 (el) 2010-07-28
HK1067311A1 (en) 2005-04-08
IL158269A0 (en) 2004-05-12
NZ529304A (en) 2006-02-24
CA2442974A1 (en) 2002-10-17
EP1384477B1 (en) 2006-05-24
EP1516621A3 (en) 2005-05-04
BR0208805A (pt) 2004-07-13
CN1509171A (zh) 2004-06-30
CN1299682C (zh) 2007-02-14
JP4451599B2 (ja) 2010-04-14
AU2002246152B2 (en) 2007-05-31
ES2264723T3 (es) 2007-01-16
ES2174757A1 (es) 2002-11-01
MXPA03009124A (es) 2005-04-11
RU2003132457A (ru) 2005-04-10
DE60211681T2 (de) 2007-05-16
HUP0400918A3 (en) 2004-10-28
JP2004525166A (ja) 2004-08-19
EP1384477A1 (en) 2004-01-28
IS6973A (is) 2003-10-03
DE60211681D1 (de) 2006-06-29
US20040034082A1 (en) 2004-02-19
MA27019A1 (fr) 2004-12-20
WO2002080909A1 (es) 2002-10-17
PT1384477E (pt) 2006-09-29
NO20034470D0 (no) 2003-10-06
HUP0400918A2 (hu) 2004-07-28
ATE326966T1 (de) 2006-06-15
CA2442974C (en) 2010-02-23
UA75402C2 (en) 2006-04-17
KR20040025912A (ko) 2004-03-26
NO20034470L (no) 2003-12-05
PL365220A1 (en) 2004-12-27
ZA200308626B (en) 2004-11-05
CN1698602A (zh) 2005-11-23
ES2174757B1 (es) 2003-11-01
RU2305545C2 (ru) 2007-09-10

Similar Documents

Publication Publication Date Title
DK1384477T3 (da) Anvendelse af pyrazolinderivater ved fremstilling af et medikament til forebyggelse og/eller behandling af proliferative cellesygdomme
NZ508990A (en) Pyrazoline derivatives, their preparation and application as medicaments
DK0745596T3 (da) Heteroaromatiske oxazolforbindelser og anvendelse deraf
DK1109813T3 (da) Pyrroloindoler, pyridoindoler og azepinoindoler som 5-HT2C-agonister
MY126951A (en) Beta2-adrenoceptor agonists
NZ527249A (en) Purine derivatives as purinergic receptor antagonists
DE60034961D1 (de) Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
DE69418789D1 (de) 2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
PT1202954E (pt) Novas aminobenzofenonas
TW200602317A (en) Novel androgens
PL364639A1 (en) Carbamate compounds for use in preventing or treating anxiety disorders
NO941516L (no) 3-kinolylsubstituerte dihydropyridiner, fremgangsmåter for deres fremstilling og deres anvendelse
HUP9904086A2 (hu) 4-es Helyzetben szubsztituált piperidinszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények
NZ336969A (en) Substituted 4-aminoalkoxy-1H-benzimidazole derivatives useful as dopamine autoreceptor (D2) agonists
ZA965409B (en) Iminooxybenzyl compounds, their preparation and their use.
TW200631943A (en) Chemical compounds, process for their preparation and use thereof
MX9704169A (es) Derivados de 3-benzoilpiridina, su preparacion y su uso como herbicidas.
MY147668A (en) Chemical compounds, process for their preparation and use thereof