DK1425280T3 - Kemiske forbindelser - Google Patents

Kemiske forbindelser

Info

Publication number: DK1425280T3
Authority: DK; Denmark
Prior art keywords: alkyl; halo; alkoxy; halogen; hydrogen
Prior art date: 2001-07-17

Application number

DK02764696T

Other languages

Danish (da)

English (en)

Inventor

Fabio Romano Di

Fabrizio Micheli

Yves St-Denis

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2002-07-15

Publication date

2007-01-02

2002-07-15 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2007-01-02 Application granted granted Critical

2007-01-02 Publication of DK1425280T3 publication Critical patent/DK1425280T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
-1 -NR 6 R 7 Chemical group 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 3
125000004093 cyano group Chemical group *C#N 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 2
108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 2
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Nutrition Science (AREA)
Immunology (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02764696T 2001-07-17 2002-07-15 Kemiske forbindelser DK1425280T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0117396.2A GB0117396D0 (en)	2001-07-17	2001-07-17	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK1425280T3 true DK1425280T3 (da)	2007-01-02

Family

ID=9918655

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02764696T DK1425280T3 (da)	2001-07-17	2002-07-15	Kemiske forbindelser

Country Status (26)

Country	Link
US (2)	US7253284B2 (de)
EP (2)	EP1695974B1 (de)
JP (1)	JP4459616B2 (de)
KR (2)	KR100961287B1 (de)
CN (1)	CN100447141C (de)
AT (2)	ATE338042T1 (de)
AU (1)	AU2002328899B2 (de)
BR (1)	BR0211171A (de)
CA (1)	CA2451530A1 (de)
CO (1)	CO5550437A2 (de)
CY (1)	CY1105780T1 (de)
DE (2)	DE60235729D1 (de)
DK (1)	DK1425280T3 (de)
ES (2)	ES2342417T3 (de)
GB (2)	GB0117396D0 (de)
HU (1)	HUP0400465A2 (de)
IL (1)	IL159254A0 (de)
MX (1)	MXPA04000494A (de)
NO (1)	NO20040206L (de)
NZ (1)	NZ530043A (de)
PL (1)	PL368053A1 (de)
PT (1)	PT1425280E (de)
RU (1)	RU2310655C2 (de)
SI (1)	SI1425280T1 (de)
WO (1)	WO2003008412A2 (de)
ZA (1)	ZA200309708B (de)

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US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
GB0308208D0 (en) *	2003-04-09	2003-05-14	Glaxo Group Ltd	Chemical compounds
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GB0519957D0 (en)	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
ATE430746T1 (de) *	2004-10-19	2009-05-15	Smithkline Beecham Cork Ltd	Crf-rezeptor-antagonisten und zugehörige verfahren
US8088779B2 (en)	2005-09-30	2012-01-03	Smithkline Beecham (Cork) Limited	Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists
US8513420B2 (en)	2007-03-19	2013-08-20	Monika Mazik	Amino-naphthyridine derivatives
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es)	2007-06-04	2010-02-15	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
WO2009008552A1 (en) *	2007-07-11	2009-01-15	Taisho Pharmaceutical Co., Ltd.	8-aryl-4-alkylpyrrolo[2,3,4-de]quinolin-5(4h)-one and 8-aryl-4-alkyl-4,5-dihydropyrrolo[2,3,4-de]quinolin-5-ol derivatives
EP2810951B1 (de)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
MX2015009270A (es)	2013-01-18	2015-10-30	Hoffmann La Roche	Pirazoles sustituidos en posicion 3 y uso de los mismos como inhibidores de la cinasa cremallera de leucinas dual (dlk).
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト

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ATE359782T1 (de)	2003-01-16	2007-05-15	Sb Pharmco Inc	Heteroaryl-substituierte pyrrol(2, 3- b)pyridin- derivate als crf-rezeptor-antagonisten
CA2515571A1 (en)	2003-02-14	2004-09-02	Wyeth	Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
GB0308208D0 (en)	2003-04-09	2003-05-14	Glaxo Group Ltd	Chemical compounds

2001
- 2001-07-17 GB GBGB0117396.2A patent/GB0117396D0/en not_active Ceased
2002
- 2002-07-11 GB GB0216041A patent/GB2378702A/en not_active Withdrawn
- 2002-07-15 KR KR1020047000696A patent/KR100961287B1/ko not_active Expired - Fee Related
- 2002-07-15 NZ NZ530043A patent/NZ530043A/xx unknown
- 2002-07-15 AU AU2002328899A patent/AU2002328899B2/en not_active Ceased
- 2002-07-15 EP EP06076176A patent/EP1695974B1/de not_active Expired - Lifetime
- 2002-07-15 CA CA002451530A patent/CA2451530A1/en not_active Abandoned
- 2002-07-15 KR KR1020097020632A patent/KR20090110386A/ko not_active Ceased
- 2002-07-15 AT AT02764696T patent/ATE338042T1/de not_active IP Right Cessation
- 2002-07-15 SI SI200230419T patent/SI1425280T1/sl unknown
- 2002-07-15 US US10/483,792 patent/US7253284B2/en not_active Expired - Fee Related
- 2002-07-15 ES ES06076176T patent/ES2342417T3/es not_active Expired - Lifetime
- 2002-07-15 HU HU0400465A patent/HUP0400465A2/hu unknown
- 2002-07-15 WO PCT/EP2002/007865 patent/WO2003008412A2/en not_active Ceased
- 2002-07-15 EP EP02764696A patent/EP1425280B1/de not_active Expired - Lifetime
- 2002-07-15 CN CNB02813866XA patent/CN100447141C/zh not_active Expired - Fee Related
- 2002-07-15 IL IL15925402A patent/IL159254A0/xx unknown
- 2002-07-15 PL PL02368053A patent/PL368053A1/xx unknown
- 2002-07-15 RU RU2004104349/04A patent/RU2310655C2/ru not_active IP Right Cessation
- 2002-07-15 MX MXPA04000494A patent/MXPA04000494A/es active IP Right Grant
- 2002-07-15 AT AT06076176T patent/ATE461197T1/de not_active IP Right Cessation
- 2002-07-15 DK DK02764696T patent/DK1425280T3/da active
- 2002-07-15 BR BR0211171-3A patent/BR0211171A/pt not_active IP Right Cessation
- 2002-07-15 ES ES02764696T patent/ES2271327T3/es not_active Expired - Lifetime
- 2002-07-15 DE DE60235729T patent/DE60235729D1/de not_active Expired - Lifetime
- 2002-07-15 DE DE60214401T patent/DE60214401T2/de not_active Expired - Lifetime
- 2002-07-15 JP JP2003513971A patent/JP4459616B2/ja not_active Expired - Fee Related
- 2002-07-15 PT PT02764696T patent/PT1425280E/pt unknown
2003
- 2003-12-15 ZA ZA200309708A patent/ZA200309708B/xx unknown
2004
- 2004-01-16 NO NO20040206A patent/NO20040206L/no not_active Application Discontinuation
- 2004-01-16 CO CO04002410A patent/CO5550437A2/es not_active Application Discontinuation
2006
- 2006-11-14 CY CY20061101650T patent/CY1105780T1/el unknown
2007
- 2007-05-16 US US11/749,433 patent/US20070219232A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2002328899B2 (en)	2006-12-21
KR20040023651A (ko)	2004-03-18
DE60214401T2 (de)	2007-02-22
CN100447141C (zh)	2008-12-31
KR100961287B1 (ko)	2010-06-04
WO2003008412A2 (en)	2003-01-30
DE60235729D1 (de)	2010-04-29
BR0211171A (pt)	2004-08-10
GB0216041D0 (en)	2002-08-21
US20070219232A1 (en)	2007-09-20
NO20040206L (no)	2004-03-16
ES2271327T3 (es)	2007-04-16
HK1066535A1 (en)	2005-03-24
MXPA04000494A (es)	2004-05-04
EP1425280A2 (de)	2004-06-09
CO5550437A2 (es)	2005-08-31
RU2004104349A (ru)	2005-03-27
PL368053A1 (en)	2005-03-21
ZA200309708B (en)	2005-01-21
IL159254A0 (en)	2004-06-01
NZ530043A (en)	2006-03-31
EP1695974B1 (de)	2010-03-17
RU2310655C2 (ru)	2007-11-20
WO2003008412A3 (en)	2003-05-01
CN1525972A (zh)	2004-09-01
EP1425280B1 (de)	2006-08-30
PT1425280E (pt)	2006-12-29
CY1105780T1 (el)	2011-02-02
ES2342417T3 (es)	2010-07-06
HUP0400465A2 (hu)	2005-01-28
US7253284B2 (en)	2007-08-07
JP4459616B2 (ja)	2010-04-28
SI1425280T1 (sl)	2006-12-31
KR20090110386A (ko)	2009-10-21
ATE338042T1 (de)	2006-09-15
GB0117396D0 (en)	2001-09-05
JP2005514328A (ja)	2005-05-19
ATE461197T1 (de)	2010-04-15
EP1695974A1 (de)	2006-08-30
GB2378702A (en)	2003-02-19
DE60214401D1 (de)	2006-10-12
CA2451530A1 (en)	2003-01-30
US20040171607A1 (en)	2004-09-02

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