DK1456662T3 - Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides - Google Patents

Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides

Info

Publication number: DK1456662T3
Authority: DK; Denmark
Prior art keywords: rheumatoid arthritis; patients suffering; autoantibodies; detection; peptide
Prior art date: 2001-12-11

Application number

DK02786237T

Other languages

Danish (da)

English (en)

Inventor

Venrooij Waltherus Jacobus Van

Jan Wouter Drijfhout

Boekel Martinus Adrianus M Van

Gerardus Jozef Maria Pruijn

Original Assignee

Stichting Tech Wetenschapp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-11

Filing date

2002-12-11

Publication date

2006-09-18

2002-12-11 Application filed by Stichting Tech Wetenschapp filed Critical Stichting Tech Wetenschapp

2006-09-18 Application granted granted Critical

2006-09-18 Publication of DK1456662T3 publication Critical patent/DK1456662T3/da

Links

206010039073 rheumatoid arthritis Diseases 0.000 title abstract 2
238000001514 detection method Methods 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
RHGKLRLOHDJJDR-UHFFFAOYSA-N citrulline Chemical group OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 2
102000009123 Fibrin Human genes 0.000 abstract 1
108010073385 Fibrin Proteins 0.000 abstract 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
102000008946 Fibrinogen Human genes 0.000 abstract 1
108010049003 Fibrinogen Proteins 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
102100023129 Keratin, type I cytoskeletal 9 Human genes 0.000 abstract 1
102100022905 Keratin, type II cytoskeletal 1 Human genes 0.000 abstract 1
101710194922 Keratin, type II cytoskeletal 1 Proteins 0.000 abstract 1
108010070585 Keratin-9 Proteins 0.000 abstract 1
102000013127 Vimentin Human genes 0.000 abstract 1
108010065472 Vimentin Proteins 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229950003499 fibrin Drugs 0.000 abstract 1
229940012952 fibrinogen Drugs 0.000 abstract 1
210000005048 vimentin Anatomy 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2410/00—Assays, e.g. immunoassays or enzyme assays, involving peptides of less than 20 animo acids
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Rehabilitation Therapy (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Amplifiers (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK02786237T 2001-12-11 2002-12-11 Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides DK1456662T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL1019540A NL1019540C2 (nl)	2001-12-11	2001-12-11	Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.

Publications (1)

Publication Number	Publication Date
DK1456662T3 true DK1456662T3 (da)	2006-09-18

Family

ID=19774384

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02786237T DK1456662T3 (da)	2001-12-11	2002-12-11	Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides

Country Status (16)

Country	Link
US (6)	US7888133B2 (fr)
EP (3)	EP2071335A3 (fr)
JP (1)	JP4098718B2 (fr)
CN (4)	CN105699648B (fr)
AT (1)	ATE329267T1 (fr)
AU (3)	AU2002354397B2 (fr)
BR (1)	BRPI0214872B8 (fr)
CA (5)	CA2708463C (fr)
CY (1)	CY1105537T1 (fr)
DE (1)	DE60212186T2 (fr)
DK (1)	DK1456662T3 (fr)
ES (1)	ES2266603T3 (fr)
NL (1)	NL1019540C2 (fr)
PT (1)	PT1456662E (fr)
SI (1)	SI1456662T1 (fr)
WO (1)	WO2003050542A2 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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NL1019540C2 (nl) *	2001-12-11	2003-07-01	Stichting Tech Wetenschapp	Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
SI1882946T1 (sl) *	2003-12-23	2010-06-30	Hoffmann La Roche	Postopek za ugotavljanje revmatoidnega artritisa z merjenjem anti CCP in interlevkina
DK1721162T3 (da)	2004-02-27	2008-12-15	Hoffmann La Roche	Fremgangsmåde til at bedömme rheumatoid arthritis ved at måle anti-CCP og serumamyloid A
ATE401338T1 (de) *	2004-11-04	2008-08-15	Biomerieux Sa	Von fibrin abgeleitete citrullinpeptide, die durch für rheumatoide arthritis spezifische autoantikörper erkannt werden, und deren verwendung
FR2879604B1 (fr) *	2004-12-22	2010-08-13	Biomerieux Sa	Peptides citrullines derives de la fibrine reconnus par des auto-anticorps specifiques de la polyarthrite rhumatoide, et leurs utilisations
EP1877795A4 (fr) *	2005-05-02	2010-04-28	Brigham & Womens Hospital	Profilage diagnostique d'anticorps seriques
FI20050814A0 (fi) *	2005-08-11	2005-08-11	Procollagen Oy	Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi
JP2010506147A (ja)	2006-09-29	2010-02-25	エフ．ホフマン−ラロシュアーゲー	関節リウマチを有する患者のための疾患進行のリスク評価
US20100047256A1 (en)	2007-01-25	2010-02-25	Imperial Innovations Limited	Methods
ES2307421B1 (es) *	2007-04-30	2009-09-28	Consejo Superiorde Investigaciones Cientificas (Csic)	Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide.
EP2058663A1 (fr)	2007-11-12	2009-05-13	Euro-Diagnostica B.V.	Procédé pour l'immobilisation d'un analyte sur un support solide
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CN102004154B (zh) *	2009-08-28	2013-06-19	上海荣盛生物药业有限公司	斑点金免疫渗滤法检测类风湿关节炎免疫抗体的组合物
CN102012431B (zh) *	2009-09-04	2013-06-19	上海荣盛生物药业有限公司	斑点金免疫渗滤法检测类风湿关节炎免疫抗体的ccp肽
EP2325195A1 (fr)	2009-11-23	2011-05-25	Toscana Biomarkers S.r.l.	Peptides à citrulline et utilisations associées
EP2336769A1 (fr)	2009-12-18	2011-06-22	F. Hoffmann-La Roche AG	Test pour différencier les troubles rhumatismaux des troubles non rhumatismaux
EP2402368A1 (fr)	2010-07-02	2012-01-04	Toscana Biomarkers S.r.l.	Peptides de citrulline histone et utilisations associées
CA2825765C (fr) *	2011-02-02	2020-03-10	Academisch Ziekenhuis Leiden H.O.D.N. Lumc	Anticorps diriges contre une proteine carbamylee et le risque de presenter une arthrite
DK3301107T3 (da)	2011-04-05	2020-05-18	Curara Ab	Nye peptider der bindes til typer af mhc klasse ii og deres anvendelse ved diagnosticering og behandling
EP2527841A1 (fr)	2011-05-25	2012-11-28	Toscana Biomarkers S.r.l.	Procédés pour le diagnostic de l'arthrite rhumatoïde
CN103703370B (zh) *	2011-05-27	2016-08-17	北欧生物科技公司	诊断性肽的检测
CN102590530B (zh) *	2012-03-02	2014-06-25	常晓天	Krt84自我免疫抗体作为诊断、检测类风湿性关节炎的诊断标记物的应用
JP6549554B2 (ja)	2013-03-15	2019-07-24	ザリージェンツオブザユニバーシティオブカリフォルニア	コレステロール流出を刺激する、減少した毒性を有するペプチド
US20160159922A1 (en)	2013-07-24	2016-06-09	Vilara Ab	Novel Antibodies for the Diagnosis and Treatment of Rheumatoid Arthritis
CA2946925C (fr)	2014-05-05	2023-08-15	Noviosmart	Methode pour le diagnostic serologique de la polyarthrite rhumatoide.
CN104262489B (zh) *	2014-09-30	2017-01-11	陈仁奋	一种环状瓜氨酸嵌合肽抗原及其应用
EP3056904A1 (fr)	2015-02-13	2016-08-17	F. Hoffmann-La Roche AG	Procédé pour l'évaluation de l'arthrite rhumatoïde par la mesure de l'anti-CCP et de l'anti-MCM3
JP2018506720A (ja)	2015-02-13	2018-03-08	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	抗ｃｃｐおよび抗ｐｉｋ３ｃｄを測定することによる関節リウマの査定方法
EP3056903A1 (fr)	2015-02-13	2016-08-17	F. Hoffmann-La Roche AG	Procédé d'évaluation de l'arthrite rhumatoïde par la mesure de l'anti-CCP et de l'anti-Casp8
EP3368904A1 (fr) *	2015-10-30	2018-09-05	Oxford University Innovation Ltd.	Peptide et biomarqueur associés à des troubles inflammatoires, et leurs utilisations
CN110073217A (zh)	2016-10-04	2019-07-30	豪夫迈·罗氏有限公司	用于鉴定合成分类器的系统和方法
CN106543277B (zh) *	2016-10-31	2020-02-14	中南大学	一种与移植排斥相关的内皮细胞抗原及其应用、试剂盒
CN108196073B (zh) *	2018-03-13	2019-09-13	江苏浩欧博生物医药股份有限公司	一种测定抗环瓜氨酸肽抗体的试剂盒及其应用
CN108948153B (zh) *	2018-05-22	2020-11-03	北京蛋白质组研究中心	一种瓜氨酸修饰肽抗原组合及其应用
CN108948173B (zh) *	2018-05-22	2020-11-03	北京蛋白质组研究中心	一种瓜氨酸修饰肽及其应用
CN112638935A (zh) *	2019-01-27	2021-04-09	中国医药大学	一种类风湿性关节炎自体抗体结合的肽及其应用
CN109929009B (zh) *	2019-03-20	2021-06-04	深圳市新产业生物医学工程股份有限公司	Ccp肽段、包含其的抗原、试剂、试剂盒及应用
WO2020221153A1 (fr) *	2019-04-28	2020-11-05	广州市雷德生物科技有限公司	Structure de fermeture à glissière permettant de favoriser la formation d'un dimère protéique et son utilisation
CN111655734A (zh) *	2019-04-28	2020-09-11	广州市雷德生物科技有限公司	一种促进蛋白二聚体形成的拉链扣结构及其应用
CN110456074B (zh) *	2019-08-27	2022-06-03	广东菲鹏生物有限公司	瓜氨酸肽及其应用、类风湿关节炎的检测试剂与试剂盒
GB202408954D0 (en)	2024-06-21	2024-08-07	Alivedx Suisse Sa	Immobilised biomolecule

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2001
- 2001-12-11 NL NL1019540A patent/NL1019540C2/nl not_active IP Right Cessation
2002
- 2002-12-11 US US10/497,667 patent/US7888133B2/en active Active
- 2002-12-11 EP EP09155765A patent/EP2071335A3/fr not_active Withdrawn
- 2002-12-11 CN CN201610039155.5A patent/CN105699648B/zh not_active Expired - Lifetime
- 2002-12-11 AU AU2002354397A patent/AU2002354397B2/en not_active Expired
- 2002-12-11 SI SI200230389T patent/SI1456662T1/sl unknown
- 2002-12-11 PT PT02786237T patent/PT1456662E/pt unknown
- 2002-12-11 CA CA2708463A patent/CA2708463C/fr not_active Expired - Lifetime
- 2002-12-11 DK DK02786237T patent/DK1456662T3/da active
- 2002-12-11 JP JP2003551544A patent/JP4098718B2/ja not_active Expired - Lifetime
- 2002-12-11 BR BRPI0214872A patent/BRPI0214872B8/pt not_active IP Right Cessation
- 2002-12-11 CN CNB028246470A patent/CN100424509C/zh not_active Expired - Lifetime
- 2002-12-11 DE DE60212186T patent/DE60212186T2/de not_active Expired - Lifetime
- 2002-12-11 ES ES02786237T patent/ES2266603T3/es not_active Expired - Lifetime
- 2002-12-11 EP EP06114882A patent/EP1693673A3/fr not_active Ceased
- 2002-12-11 WO PCT/NL2002/000815 patent/WO2003050542A2/fr not_active Ceased
- 2002-12-11 CA CA3076702A patent/CA3076702C/fr not_active Expired - Lifetime
- 2002-12-11 CN CN200810215984XA patent/CN101408546B/zh not_active Expired - Lifetime
- 2002-12-11 CA CA2489167A patent/CA2489167C/fr not_active Expired - Lifetime
- 2002-12-11 CA CA2892001A patent/CA2892001C/fr not_active Expired - Lifetime
- 2002-12-11 CA CA2969577A patent/CA2969577C/fr not_active Expired - Lifetime
- 2002-12-11 AT AT02786237T patent/ATE329267T1/de active
- 2002-12-11 EP EP02786237A patent/EP1456662B1/fr not_active Expired - Lifetime
- 2002-12-11 CN CN201310482892.9A patent/CN103524603B/zh not_active Expired - Lifetime
2006
- 2006-09-07 CY CY20061101278T patent/CY1105537T1/el unknown
- 2006-10-18 AU AU2006230702A patent/AU2006230702A1/en not_active Abandoned
2010
- 2010-02-22 AU AU2010200648A patent/AU2010200648B2/en not_active Expired
2011
- 2011-01-24 US US13/012,739 patent/US8481332B2/en not_active Expired - Fee Related
2013
- 2013-06-17 US US13/920,017 patent/US8759114B2/en not_active Expired - Lifetime
2014
- 2014-05-23 US US14/286,878 patent/US9689871B2/en not_active Expired - Fee Related
2017
- 2017-05-31 US US15/610,398 patent/US10119966B2/en not_active Expired - Lifetime
2018
- 2018-11-02 US US16/178,848 patent/US20190056393A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20170269078A1 (en)	2017-09-21
CA2969577A1 (fr)	2003-06-19
WO2003050542A2 (fr)	2003-06-19
CA2892001A1 (fr)	2003-06-19
EP1693673A2 (fr)	2006-08-23
CA2969577C (fr)	2020-04-14
US20110195861A1 (en)	2011-08-11
HK1128329A1 (en)	2009-10-23
EP2071335A3 (fr)	2009-09-02
US20130267677A1 (en)	2013-10-10
PT1456662E (pt)	2006-10-31
CY1105537T1 (el)	2010-07-28
EP2071335A2 (fr)	2009-06-17
CN105699648B (zh)	2017-10-20
CA2489167A1 (fr)	2003-06-19
WO2003050542A3 (fr)	2003-12-11
CA2708463A1 (fr)	2003-06-19
CN103524603B (zh)	2016-02-24
NL1019540C2 (nl)	2003-07-01
EP1693673A3 (fr)	2006-12-06
DE60212186T2 (de)	2007-04-12
US10119966B2 (en)	2018-11-06
BR0214872A (pt)	2004-10-26
ATE329267T1 (de)	2006-06-15
AU2006230702A1 (en)	2006-11-09
US20140336069A1 (en)	2014-11-13
EP1456662B1 (fr)	2006-06-07
CN101408546A (zh)	2009-04-15
CA3076702C (fr)	2022-03-29
AU2002354397A1 (en)	2003-06-23
JP2005512092A (ja)	2005-04-28
US9689871B2 (en)	2017-06-27
CN100424509C (zh)	2008-10-08
US8759114B2 (en)	2014-06-24
BRPI0214872B1 (pt)	2016-12-13
CA2892001C (fr)	2017-07-18
HK1072805A1 (en)	2005-09-09
HK1226143B (zh)	2017-09-22
CN103524603A (zh)	2014-01-22
HK1191962A1 (zh)	2014-08-08
ES2266603T3 (es)	2007-03-01
US7888133B2 (en)	2011-02-15
AU2010200648A1 (en)	2010-03-11
CA2708463C (fr)	2015-08-11
DE60212186D1 (de)	2006-07-20
CN1602426A (zh)	2005-03-30
US20190056393A1 (en)	2019-02-21
JP4098718B2 (ja)	2008-06-11
US8481332B2 (en)	2013-07-09
US20070087380A1 (en)	2007-04-19
CN101408546B (zh)	2013-10-30
EP1456662A2 (fr)	2004-09-15
CN105699648A (zh)	2016-06-22
CA3076702A1 (fr)	2003-06-19
BRPI0214872B8 (pt)	2021-07-27
SI1456662T1 (sl)	2006-12-31
AU2010200648B2 (en)	2012-07-12
CA2489167C (fr)	2010-08-10
AU2002354397B2 (en)	2006-07-20

Publication	Publication Date	Title
DK1456662T3 (da)	2006-09-18	Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides
ATE262178T1 (de)	2004-04-15	Identifizierung und charakterisierung von interagierenden molekülen
UA84432C2 (ru)	2008-10-27	Очищенные пептиды и соединения, которые их содержат
EP1051587A4 (fr)	2002-08-21	Separation du dioxyde de carbone par autorefrigeration
DK0941244T3 (da)	2007-04-30	Peptid, som er afledt fra et antigen, der genkendes af autoantistoffer fra patienter med rheumatoid arthritis, antistof rettet mod nævnte peptid og en fremgangsmåde til at detektere auto-immune antistoffer
DK0929564T3 (da)	2008-07-14	Höjniveau-ekspression af proteiner
DE60322188D1 (de)	2008-08-28	Zytokin (zcytor17-ligand)
DE69832628D1 (de)	2006-01-05	Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz
EP0621284A4 (fr)	1996-06-12	PEPTIDES CONTENANT DES SEQUENCES D'ACIDES AMINES RESPECTIVES SELECTIONNEES PARMI CELLES DE LA LIPOPROTEINE(a) ET DE L'APOLIPOPROTEINE(a), ANTICORPS RECONNAISSANT CES SEQUENCES D'ACIDES AMINES ET PROCEDE D'ANALYSE UTILISANT CES ANTICORPS.
WO2000023564A3 (fr)	2001-12-13	Automatisation de la conception des proteines pour l'elaboration des bibliotheques de proteines
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DK1144607T5 (da)	2009-10-05	Fremgangsmåde til præsentation af (poly)peptider/proteiner på bakteriofage partikler via disulfidbindinger
DE69816350D1 (de)	2003-08-21	Technik zur Erkennung von Bildstellungsfehlern
DE59301332D1 (de)	1996-02-15	Anordnung zur federelastischen Lagesicherung von Befestigungsmitteln in Ausnehmungen
DK0906094T3 (da)	2003-10-20	Substituerede N-[(aminoiminomethyl- eller aminomethyl)phenyl]propylamider
DK0498784T3 (da)	1997-10-27	Hæmmere af retroviral protease
ATE389881T1 (de)	2008-04-15	Detektion von kleinen molekülen mit piezo- elektrischem sensor
EP1203775A3 (fr)	2004-02-04	Facteur chémo-attirant des lymphocytes et ses utilisations
AUPP627498A0 (en)	1998-10-22	Novel peptides - i
DK450187D0 (da)	1987-08-28	Fremgangsmaade til fremstilling af proteiner
DK0923644T3 (da)	2003-08-04	G-koblet receptor, der udviser selektiv selektivitet for ATP
ATE250161T1 (de)	2003-10-15	Formamidinsulfinsäure-abmischungen
WO1996040763A3 (fr)	1997-02-06	Peptides destines a la detection du vih-1
BG97479A (bg)	1993-12-24	Инсталация за мокро почистване,по-специално за отделяне на газообразни и/или течни и/или твърди онечиствания от газови потоци
AU1548797A (en)	1997-08-20	Novel sweeteners derived from 3-monosubstituted n-(4-cyanophenylcarbamoyl or 2-cyanopyrid-5-ylcarbamoyl)-l-aspartic alpha-benzeneamide acid