DK1456662T3 - Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides - Google Patents

Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides

Info

Publication number: DK1456662T3
Authority: DK; Denmark
Prior art keywords: rheumatoid arthritis; patients suffering; autoantibodies; detection; peptide
Prior art date: 2001-12-11

Application number

DK02786237T

Other languages

Danish (da)

English (en)

Inventor

Venrooij Waltherus Jacobus Van

Jan Wouter Drijfhout

Boekel Martinus Adrianus M Van

Gerardus Jozef Maria Pruijn

Original Assignee

Stichting Tech Wetenschapp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-11

Filing date

2002-12-11

Publication date

2006-09-18

2002-12-11 Application filed by Stichting Tech Wetenschapp filed Critical Stichting Tech Wetenschapp

2006-09-18 Application granted granted Critical

2006-09-18 Publication of DK1456662T3 publication Critical patent/DK1456662T3/da

Links

206010039073 rheumatoid arthritis Diseases 0.000 title abstract 2
238000001514 detection method Methods 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
RHGKLRLOHDJJDR-UHFFFAOYSA-N citrulline Chemical group OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 2
102000009123 Fibrin Human genes 0.000 abstract 1
108010073385 Fibrin Proteins 0.000 abstract 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
102000008946 Fibrinogen Human genes 0.000 abstract 1
108010049003 Fibrinogen Proteins 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
102100023129 Keratin, type I cytoskeletal 9 Human genes 0.000 abstract 1
102100022905 Keratin, type II cytoskeletal 1 Human genes 0.000 abstract 1
101710194922 Keratin, type II cytoskeletal 1 Proteins 0.000 abstract 1
108010070585 Keratin-9 Proteins 0.000 abstract 1
102000013127 Vimentin Human genes 0.000 abstract 1
108010065472 Vimentin Proteins 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229950003499 fibrin Drugs 0.000 abstract 1
229940012952 fibrinogen Drugs 0.000 abstract 1
210000005048 vimentin Anatomy 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2410/00—Assays, e.g. immunoassays or enzyme assays, involving peptides of less than 20 animo acids
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Rehabilitation Therapy (AREA)
Pathology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Amplifiers (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Plant Substances (AREA)

DK02786237T 2001-12-11 2002-12-11 Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides DK1456662T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL1019540A NL1019540C2 (nl)	2001-12-11	2001-12-11	Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.

Publications (1)

Publication Number	Publication Date
DK1456662T3 true DK1456662T3 (da)	2006-09-18

Family

ID=19774384

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02786237T DK1456662T3 (da)	2001-12-11	2002-12-11	Detektion af autoantistoffer fra patienter, som lider af arthritis rheumatoides

Country Status (16)

Country	Link
US (6)	US7888133B2 (fr)
EP (3)	EP1456662B1 (fr)
JP (1)	JP4098718B2 (fr)
CN (4)	CN105699648B (fr)
AT (1)	ATE329267T1 (fr)
AU (3)	AU2002354397B2 (fr)
BR (1)	BRPI0214872B8 (fr)
CA (5)	CA2892001C (fr)
CY (1)	CY1105537T1 (fr)
DE (1)	DE60212186T2 (fr)
DK (1)	DK1456662T3 (fr)
ES (1)	ES2266603T3 (fr)
NL (1)	NL1019540C2 (fr)
PT (1)	PT1456662E (fr)
SI (1)	SI1456662T1 (fr)
WO (1)	WO2003050542A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL1019540C2 (nl) *	2001-12-11	2003-07-01	Stichting Tech Wetenschapp	Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
EP1882946B1 (fr) *	2003-12-23	2010-02-17	Roche Diagnostics GmbH	Méthode pur détecter l'arthrite rhumatoide par la mésure d'anti-CCP et d'interleukine-6
SI1721162T1 (sl)	2004-02-27	2009-02-28	Roche Diagnostics Gmbh	Postopek za ugotavljanje revmatoidnega artritisa z merjenjem anti-CCP in serumskega amiloida A
FR2879604B1 (fr) *	2004-12-22	2010-08-13	Biomerieux Sa	Peptides citrullines derives de la fibrine reconnus par des auto-anticorps specifiques de la polyarthrite rhumatoide, et leurs utilisations
US8207299B2 (en)	2004-11-04	2012-06-26	Biomerieux	Citrulline peptides derived from fibrin and recognized by rheumatoid arthritis specific autoantibodies, and the use thereof
EP1877795A4 (fr) *	2005-05-02	2010-04-28	Brigham & Womens Hospital	Profilage diagnostique d'anticorps seriques
FI20050814A0 (fi) *	2005-08-11	2005-08-11	Procollagen Oy	Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi
ES2545688T3 (es)	2006-09-29	2015-09-15	F. Hoffmann-La Roche Ag	Método de evaluación del riesgo de progresión de enfermedad de pacientes con artritis reumatoide
US20100047256A1 (en)	2007-01-25	2010-02-25	Imperial Innovations Limited	Methods
ES2307421B1 (es) *	2007-04-30	2009-09-28	Consejo Superiorde Investigaciones Cientificas (Csic)	Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide.
EP2058663A1 (fr)	2007-11-12	2009-05-13	Euro-Diagnostica B.V.	Procédé pour l'immobilisation d'un analyte sur un support solide
WO2009070875A1 (fr) *	2007-12-03	2009-06-11	Sqi Diagnostics Systems Inc.	Peptides synthétiques immunoréactifs avec des auto-anticorps de la polyarthrite rhumatoïde
US20090286256A1 (en) *	2008-05-19	2009-11-19	Abbott Laboratories	Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
WO2010075249A2 (fr)	2008-12-22	2010-07-01	Genentech, Inc.	Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b
EP2204655A1 (fr)	2008-12-23	2010-07-07	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Prédiction de diagnostic de l'arthrite rhumatoïde et lupus érythémateux systémique
FR2940292B1 (fr) *	2008-12-23	2013-05-10	Isp Investments Inc	Peptides derives d'hmg-coa reductase et composition cosmetique et/ou pharmaceutique les contenant
CN102004154B (zh) *	2009-08-28	2013-06-19	上海荣盛生物药业有限公司	斑点金免疫渗滤法检测类风湿关节炎免疫抗体的组合物
CN102012431B (zh) *	2009-09-04	2013-06-19	上海荣盛生物药业有限公司	斑点金免疫渗滤法检测类风湿关节炎免疫抗体的ccp肽
EP2325195A1 (fr)	2009-11-23	2011-05-25	Toscana Biomarkers S.r.l.	Peptides à citrulline et utilisations associées
EP2336769A1 (fr)	2009-12-18	2011-06-22	F. Hoffmann-La Roche AG	Test pour différencier les troubles rhumatismaux des troubles non rhumatismaux
EP2402368A1 (fr)	2010-07-02	2012-01-04	Toscana Biomarkers S.r.l.	Peptides de citrulline histone et utilisations associées
WO2012105838A1 (fr)	2011-02-02	2012-08-09	Academisch Ziekenhuis Leiden H.O.D.N. Lumc	Anticorps dirigés contre une protéine carbamylée et le risque de présenter une arthrite
EP3045468B1 (fr)	2011-04-05	2020-01-15	Fraunhofer Gesellschaft zur Förderung der Angewand	Nouveaux peptides et leur utilisation dans le diagnostic et le traitement
EP2527841A1 (fr)	2011-05-25	2012-11-28	Toscana Biomarkers S.r.l.	Procédés pour le diagnostic de l'arthrite rhumatoïde
WO2012163768A1 (fr) *	2011-05-27	2012-12-06	Nordic Bioscience A/S	Détection de peptides diagnostiques
CN102590530B (zh) *	2012-03-02	2014-06-25	常晓天	Krt84自我免疫抗体作为诊断、检测类风湿性关节炎的诊断标记物的应用
CA2902209C (fr)	2013-03-15	2025-02-04	The Regents Of The University Of California	Peptides à toxicité réduite stimulant un écoulement de cholestérol
EP3024849A2 (fr)	2013-07-24	2016-06-01	Vilara AB	Nouveaux anticorps pour le diagnostic et le traitement de la polyarthrite rhumatoïde
CA2946925C (fr)	2014-05-05	2023-08-15	Noviosmart	Methode pour le diagnostic serologique de la polyarthrite rhumatoide.
CN104262489B (zh) *	2014-09-30	2017-01-11	陈仁奋	一种环状瓜氨酸嵌合肽抗原及其应用
EP3056904A1 (fr)	2015-02-13	2016-08-17	F. Hoffmann-La Roche AG	Procédé pour l'évaluation de l'arthrite rhumatoïde par la mesure de l'anti-CCP et de l'anti-MCM3
EP3056903A1 (fr)	2015-02-13	2016-08-17	F. Hoffmann-La Roche AG	Procédé d'évaluation de l'arthrite rhumatoïde par la mesure de l'anti-CCP et de l'anti-Casp8
CN107484423A (zh)	2015-02-13	2017-12-15	豪夫迈·罗氏有限公司	通过测量抗ccp和抗pik3cd来评估类风湿性关节炎的方法
EP3368904A1 (fr) *	2015-10-30	2018-09-05	Oxford University Innovation Ltd.	Peptide et biomarqueur associés à des troubles inflammatoires, et leurs utilisations
EP3523657B1 (fr)	2016-10-04	2023-06-21	F. Hoffmann-La Roche AG	Système et procédé d'identification d'un classificateur synthétique
CN106543277B (zh) *	2016-10-31	2020-02-14	中南大学	一种与移植排斥相关的内皮细胞抗原及其应用、试剂盒
CN108196073B (zh) *	2018-03-13	2019-09-13	江苏浩欧博生物医药股份有限公司	一种测定抗环瓜氨酸肽抗体的试剂盒及其应用
CN108948173B (zh) *	2018-05-22	2020-11-03	北京蛋白质组研究中心	一种瓜氨酸修饰肽及其应用
CN108948153B (zh) *	2018-05-22	2020-11-03	北京蛋白质组研究中心	一种瓜氨酸修饰肽抗原组合及其应用
US12105097B2 (en) *	2019-01-27	2024-10-01	China Medical University	Rheumatoid arthritis auto-antibody-bound peptide and application thereof
CN109929009B (zh) *	2019-03-20	2021-06-04	深圳市新产业生物医学工程股份有限公司	Ccp肽段、包含其的抗原、试剂、试剂盒及应用
WO2020221153A1 (fr) *	2019-04-28	2020-11-05	广州市雷德生物科技有限公司	Structure de fermeture à glissière permettant de favoriser la formation d'un dimère protéique et son utilisation
US20220214340A1 (en) *	2019-04-28	2022-07-07	Leide Biosciences Co., Ltd.	Zipper structure that helps the formation of protein dimer and application thereof
US12622946B2 (en)	2019-08-09	2026-05-12	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	HLA-DR/CII peptide complexes for treating arthritis
CN110456074B (zh) *	2019-08-27	2022-06-03	广东菲鹏生物有限公司	瓜氨酸肽及其应用、类风湿关节炎的检测试剂与试剂盒
GB202408954D0 (en)	2024-06-21	2024-08-07	Alivedx Suisse Sa	Immobilised biomolecule

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992019649A1 (fr) *	1991-04-26	1992-11-12	Clonatec	Antigenes reconnus par des anticorps de la polyarthrite rhumatoide, leur preparation et leurs applications
US5650508A (en) *	1991-12-27	1997-07-22	Georgia Tech Research Corporation	Peptide ketoamides
US5314804A (en) *	1992-03-24	1994-05-24	Serim Research Corporation	Test for Helicobacter pylori
CN1153530A (zh) *	1995-03-09	1997-07-02	比奥美希奥公司	相关于类风湿性关节炎的msrv-1病毒和致病性和/或感染性msrv-2因子
KR0182853B1 (ko) *	1995-08-07	1999-05-15	김신규	자가면역 질환의 진단 방법
FR2752842B1 (fr) *	1996-08-30	1998-11-06	Biomerieux Sa	Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) *	1996-11-15	1998-05-20	Stichting Tech Wetenschapp	Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
EP1034186A2 (fr) *	1997-11-28	2000-09-13	Innogenetics N.V.	Peptides synthetiques contenant une citrulline reconnue par les serums de malades atteints de polyarthrite rhumatoide comme des outils de diagnostic et de traitement
FR2773157B1 (fr) *	1997-12-30	2001-10-05	Bio Merieux	Epitopes peptidiques reconnus par des auto-anticorps antifilaggrine presents dans le serum des patients atteints de polyarthrite rhumatoide
GB9805477D0 (en) *	1998-03-13	1998-05-13	Oxford Glycosciences Limited	Methods and compositions for diagnosis of rheumatoid arthritis
GB9822115D0 (en) *	1998-10-09	1998-12-02	King S College London	Treatment of inflammatory disease
FR2795735B1 (fr)	1999-07-01	2001-09-07	Univ Toulouse	Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
DE1240180T1 (de) *	1999-12-21	2003-08-14	Innogenetics N.V., Gent	Peptide zur diagnose und behandlung rheumatischer arthritis
AUPQ776100A0 (en) *	2000-05-26	2000-06-15	Australian National University, The	Synthetic molecules and uses therefor
NL1019540C2 (nl)	2001-12-11	2003-07-01	Stichting Tech Wetenschapp	Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.

2001
- 2001-12-11 NL NL1019540A patent/NL1019540C2/nl not_active IP Right Cessation
2002
- 2002-12-11 AT AT02786237T patent/ATE329267T1/de active
- 2002-12-11 EP EP02786237A patent/EP1456662B1/fr not_active Expired - Lifetime
- 2002-12-11 CN CN201610039155.5A patent/CN105699648B/zh not_active Expired - Lifetime
- 2002-12-11 EP EP09155765A patent/EP2071335A3/fr not_active Withdrawn
- 2002-12-11 DE DE60212186T patent/DE60212186T2/de not_active Expired - Lifetime
- 2002-12-11 CN CN200810215984XA patent/CN101408546B/zh not_active Expired - Lifetime
- 2002-12-11 CN CNB028246470A patent/CN100424509C/zh not_active Expired - Lifetime
- 2002-12-11 CN CN201310482892.9A patent/CN103524603B/zh not_active Expired - Lifetime
- 2002-12-11 WO PCT/NL2002/000815 patent/WO2003050542A2/fr not_active Ceased
- 2002-12-11 CA CA2892001A patent/CA2892001C/fr not_active Expired - Lifetime
- 2002-12-11 CA CA2969577A patent/CA2969577C/fr not_active Expired - Lifetime
- 2002-12-11 EP EP06114882A patent/EP1693673A3/fr not_active Ceased
- 2002-12-11 CA CA3076702A patent/CA3076702C/fr not_active Expired - Lifetime
- 2002-12-11 US US10/497,667 patent/US7888133B2/en active Active
- 2002-12-11 SI SI200230389T patent/SI1456662T1/sl unknown
- 2002-12-11 CA CA2489167A patent/CA2489167C/fr not_active Expired - Lifetime
- 2002-12-11 PT PT02786237T patent/PT1456662E/pt unknown
- 2002-12-11 JP JP2003551544A patent/JP4098718B2/ja not_active Expired - Lifetime
- 2002-12-11 BR BRPI0214872A patent/BRPI0214872B8/pt not_active IP Right Cessation
- 2002-12-11 ES ES02786237T patent/ES2266603T3/es not_active Expired - Lifetime
- 2002-12-11 DK DK02786237T patent/DK1456662T3/da active
- 2002-12-11 AU AU2002354397A patent/AU2002354397B2/en not_active Expired
- 2002-12-11 CA CA2708463A patent/CA2708463C/fr not_active Expired - Lifetime
2006
- 2006-09-07 CY CY20061101278T patent/CY1105537T1/el unknown
- 2006-10-18 AU AU2006230702A patent/AU2006230702A1/en not_active Abandoned
2010
- 2010-02-22 AU AU2010200648A patent/AU2010200648B2/en not_active Expired
2011
- 2011-01-24 US US13/012,739 patent/US8481332B2/en not_active Expired - Fee Related
2013
- 2013-06-17 US US13/920,017 patent/US8759114B2/en not_active Expired - Lifetime
2014
- 2014-05-23 US US14/286,878 patent/US9689871B2/en not_active Expired - Fee Related
2017
- 2017-05-31 US US15/610,398 patent/US10119966B2/en not_active Expired - Lifetime
2018
- 2018-11-02 US US16/178,848 patent/US20190056393A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PT1456662E (pt)	2006-10-31
CY1105537T1 (el)	2010-07-28
US20140336069A1 (en)	2014-11-13
ES2266603T3 (es)	2007-03-01
SI1456662T1 (sl)	2006-12-31
CA2708463A1 (fr)	2003-06-19
CN101408546A (zh)	2009-04-15
CN103524603A (zh)	2014-01-22
CA3076702C (fr)	2022-03-29
HK1128329A1 (en)	2009-10-23
CA2892001C (fr)	2017-07-18
CN105699648A (zh)	2016-06-22
US8759114B2 (en)	2014-06-24
CA2969577C (fr)	2020-04-14
CN1602426A (zh)	2005-03-30
JP2005512092A (ja)	2005-04-28
CN101408546B (zh)	2013-10-30
EP1456662A2 (fr)	2004-09-15
WO2003050542A2 (fr)	2003-06-19
CA2489167C (fr)	2010-08-10
CN103524603B (zh)	2016-02-24
WO2003050542A3 (fr)	2003-12-11
HK1191962A1 (zh)	2014-08-08
EP1693673A2 (fr)	2006-08-23
HK1226143B (zh)	2017-09-22
DE60212186T2 (de)	2007-04-12
US20170269078A1 (en)	2017-09-21
US20130267677A1 (en)	2013-10-10
NL1019540C2 (nl)	2003-07-01
EP2071335A2 (fr)	2009-06-17
BRPI0214872B1 (pt)	2016-12-13
AU2010200648A1 (en)	2010-03-11
JP4098718B2 (ja)	2008-06-11
US9689871B2 (en)	2017-06-27
CN105699648B (zh)	2017-10-20
US8481332B2 (en)	2013-07-09
ATE329267T1 (de)	2006-06-15
AU2006230702A1 (en)	2006-11-09
US20110195861A1 (en)	2011-08-11
BR0214872A (pt)	2004-10-26
CA2969577A1 (fr)	2003-06-19
DE60212186D1 (de)	2006-07-20
US7888133B2 (en)	2011-02-15
AU2002354397A1 (en)	2003-06-23
CN100424509C (zh)	2008-10-08
CA2708463C (fr)	2015-08-11
US20070087380A1 (en)	2007-04-19
AU2010200648B2 (en)	2012-07-12
AU2002354397B2 (en)	2006-07-20
EP2071335A3 (fr)	2009-09-02
HK1072805A1 (en)	2005-09-09
CA2892001A1 (fr)	2003-06-19
EP1456662B1 (fr)	2006-06-07
EP1693673A3 (fr)	2006-12-06
CA2489167A1 (fr)	2003-06-19
BRPI0214872B8 (pt)	2021-07-27
US10119966B2 (en)	2018-11-06
CA3076702A1 (fr)	2003-06-19
US20190056393A1 (en)	2019-02-21

Publication	Publication Date	Title
PT1456662E (pt)	2006-10-31	Deteccao de auto-anticorpos de pacientes que sofrem de artrite reumatoide
ATE262178T1 (de)	2004-04-15	Identifizierung und charakterisierung von interagierenden molekülen
UA84432C2 (ru)	2008-10-27	Очищенные пептиды и соединения, которые их содержат
EP1051587A4 (fr)	2002-08-21	Separation du dioxyde de carbone par autorefrigeration
DK0941244T3 (da)	2007-04-30	Peptid, som er afledt fra et antigen, der genkendes af autoantistoffer fra patienter med rheumatoid arthritis, antistof rettet mod nævnte peptid og en fremgangsmåde til at detektere auto-immune antistoffer
DE60322188D1 (de)	2008-08-28	Zytokin (zcytor17-ligand)
HUP9800727A3 (en)	1998-09-28	Thrombin inhibitors based on the amino acid sequence of hirudin
ATE311601T1 (de)	2005-12-15	Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz
EP0621284A4 (fr)	1996-06-12	PEPTIDES CONTENANT DES SEQUENCES D'ACIDES AMINES RESPECTIVES SELECTIONNEES PARMI CELLES DE LA LIPOPROTEINE(a) ET DE L'APOLIPOPROTEINE(a), ANTICORPS RECONNAISSANT CES SEQUENCES D'ACIDES AMINES ET PROCEDE D'ANALYSE UTILISANT CES ANTICORPS.
WO2000023564A3 (fr)	2001-12-13	Automatisation de la conception des proteines pour l'elaboration des bibliotheques de proteines
DK1144607T3 (da)	2009-08-24	Fremgangsmåde til præsentation af (poly)peptider/proteiner på bakteriofage partikler via disulfidbindinger
DE69816350D1 (de)	2003-08-21	Technik zur Erkennung von Bildstellungsfehlern
DE59301332D1 (de)	1996-02-15	Anordnung zur federelastischen Lagesicherung von Befestigungsmitteln in Ausnehmungen
DK1908772T3 (da)	2012-03-19	Polypeptider og polynucleinsyrer af phorphorymonas gingivalis
BR9305397A (pt)	1994-10-25	Polímero, e, processo para a preparação de polímeros terminados com amino-sulfeto
DK0498784T3 (da)	1997-10-27	Hæmmere af retroviral protease
ATE389881T1 (de)	2008-04-15	Detektion von kleinen molekülen mit piezo- elektrischem sensor
EP1203775A3 (fr)	2004-02-04	Facteur chémo-attirant des lymphocytes et ses utilisations
DK1681299T3 (da)	2010-02-01	Fremgangsmåde til rensning af højt anioniske proteiner
BR9714376A (pt)	2000-03-21	Antagonistas de somatostatina
DK450187D0 (da)	1987-08-28	Fremgangsmaade til fremstilling af proteiner
DK1342729T3 (da)	2006-07-31	Antistoffer og antisense-molekyler for G-koblet receptor der udviser selektiv affinitet for ATP
ATE250161T1 (de)	2003-10-15	Formamidinsulfinsäure-abmischungen
DK0994187T3 (da)	2001-12-27	Renin-aktivt stof omfattende humant prorenin og antistoffer mod prorenin-profragmentet
AU1548797A (en)	1997-08-20	Novel sweeteners derived from 3-monosubstituted n-(4-cyanophenylcarbamoyl or 2-cyanopyrid-5-ylcarbamoyl)-l-aspartic alpha-benzeneamide acid