ATE442189T1 - Kombination von cytochrom-p450-abhängigen protease-inhibitoren - Google Patents

Kombination von cytochrom-p450-abhängigen protease-inhibitoren

Info

Publication number
ATE442189T1
ATE442189T1 AT02793018T AT02793018T ATE442189T1 AT E442189 T1 ATE442189 T1 AT E442189T1 AT 02793018 T AT02793018 T AT 02793018T AT 02793018 T AT02793018 T AT 02793018T AT E442189 T1 ATE442189 T1 AT E442189T1
Authority
AT
Austria
Prior art keywords
cytochrome
combination
protease inhibitors
dependent protease
dependent
Prior art date
Application number
AT02793018T
Other languages
English (en)
Inventor
Der Geest Ronald Van
Paul Stoffels
Cornelis Groen
Dirk Jochmans
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8181408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE442189(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE442189T1 publication Critical patent/ATE442189T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02793018T 2001-12-12 2002-12-12 Kombination von cytochrom-p450-abhängigen protease-inhibitoren ATE442189T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01204841 2001-12-12
PCT/EP2002/014277 WO2003049746A2 (en) 2001-12-12 2002-12-12 Combination of cytochome p450 dependent protease inhibitors

Publications (1)

Publication Number Publication Date
ATE442189T1 true ATE442189T1 (de) 2009-09-15

Family

ID=8181408

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02793018T ATE442189T1 (de) 2001-12-12 2002-12-12 Kombination von cytochrom-p450-abhängigen protease-inhibitoren

Country Status (27)

Country Link
US (1) US20050119338A1 (de)
EP (1) EP1458447B1 (de)
JP (1) JP2005511723A (de)
KR (1) KR100974921B1 (de)
CN (1) CN100335060C (de)
AR (1) AR037797A1 (de)
AT (1) ATE442189T1 (de)
AU (1) AU2002358713B2 (de)
BR (1) BR0215043A (de)
CA (1) CA2469343C (de)
CY (1) CY1110604T1 (de)
DE (1) DE60233677D1 (de)
DK (1) DK1458447T3 (de)
ES (1) ES2333206T3 (de)
HR (1) HRP20040619A2 (de)
HU (1) HUP0402644A3 (de)
IL (1) IL162353A0 (de)
MX (1) MXPA04005755A (de)
NO (1) NO20042666L (de)
NZ (1) NZ533826A (de)
PL (1) PL373072A1 (de)
PT (1) PT1458447E (de)
RU (1) RU2329050C2 (de)
SI (1) SI1458447T1 (de)
TW (1) TWI286476B (de)
WO (1) WO2003049746A2 (de)
ZA (1) ZA200404633B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1670773T3 (pl) * 2003-09-30 2007-06-29 Tibotec Pharm Ltd Sposób wytwarzania sulfonamidów benzoksazolu i ich związków pośrednich
AU2004308712A1 (en) * 2003-12-23 2005-07-14 Tibotec Pharmaceuticals Ltd. Self-microemulsifying drug delivery systems of a HIV protease inhibitor
MXPA06012909A (es) * 2004-05-07 2007-09-06 Sequoia Pharmaceuticals Inc Inhibidores de proteasa retroviral repelente de resistencia.
CN1984654A (zh) * 2004-07-08 2007-06-20 泰博特克药品有限公司 抗－hiv逆转录酶和蛋白酶抑制剂的组合
AU2006217922B2 (en) 2005-02-25 2012-04-05 Janssen Sciences Ireland Uc Protease inhibitor precursor synthesis
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
AR053845A1 (es) * 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
AR058238A1 (es) * 2005-11-28 2008-01-23 Tibotec Pharm Ltd Compuestos y derivados de aminofenilsulfonamida sustituida como inhibidores de proteasa del vih
TWI385173B (zh) * 2005-11-28 2013-02-11 Tibotec Pharm Ltd 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物
BRPI0620865A2 (pt) * 2005-12-30 2011-11-29 Gilead Sciences Inc métodos para melhorar a farmacocinética de inibidores das integrases do hiv
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
US8048871B2 (en) 2006-08-18 2011-11-01 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome P450
EP2139883A4 (de) * 2007-03-23 2011-06-22 Univ Massachusetts Hiv-1-proteasehemmer
UA103013C2 (uk) 2007-12-06 2013-09-10 Тиботек Фармасьютикелз Амідні сполуки як активатори противірусних препаратів
GT200800303A (es) * 2007-12-24 2009-09-18 Combinacion anti-retroviral
CN101977610B (zh) 2008-01-25 2012-05-16 奇默里克斯公司 治疗病毒感染的方法
US8664391B2 (en) 2008-10-07 2014-03-04 Janssen R&D Ireland Ltd Amide compounds as boosters of antivirals
US8921349B2 (en) 2009-05-11 2014-12-30 Purdue Research Foundation Compounds and methods for treating AIDS and HIV infections
JO3090B1 (ar) * 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
PT2534150T (pt) 2010-02-12 2017-05-02 Chimerix Inc Métodos para tratar uma infecção viral
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes
EP2576544A4 (de) * 2010-06-01 2013-09-11 Angion Biomedica Corp Zytochrom-p450-hemmer und verwendungen davon
HUE030341T2 (en) 2011-07-07 2017-05-29 Janssen Sciences Ireland Uc Darunavir preparations
SI2729130T1 (en) 2011-07-07 2018-03-30 Janssen Sciences Ireland Uc Combined formulations of darunavir

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010281A1 (en) * 1993-10-13 1995-04-20 Merck & Co., Inc. Combination therapy for hiv infection
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
ES2262184T3 (es) * 1996-08-05 2006-11-16 Myriad Genetics, Inc. Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion.
US6180634B1 (en) * 1997-11-13 2001-01-30 Merck & Co., Inc. Combination therapy for the treatment of AIDS
US6436989B1 (en) * 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
JP4776775B2 (ja) * 1998-06-23 2011-09-21 アメリカ合衆国 Ｈｉｖ感染哺乳動物を治療するための医薬組成物
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
EP1159278B1 (de) * 1999-02-12 2005-11-30 Vertex Pharmaceuticals Incorporated Aspartyl-protease-inhibitoren
TWI260322B (en) * 1999-02-12 2006-08-21 Vertex Pharma Inhibitors of aspartyl protease

Also Published As

Publication number Publication date
CA2469343A1 (en) 2003-06-19
ZA200404633B (en) 2005-09-01
WO2003049746A3 (en) 2003-12-31
TWI286476B (en) 2007-09-11
CN100335060C (zh) 2007-09-05
SI1458447T1 (sl) 2010-01-29
NO20042666L (no) 2004-09-09
HRP20040619A2 (en) 2005-08-31
RU2329050C2 (ru) 2008-07-20
IL162353A0 (en) 2005-11-20
RU2004121144A (ru) 2005-04-20
WO2003049746A2 (en) 2003-06-19
NZ533826A (en) 2006-04-28
HK1070008A1 (en) 2005-06-10
PT1458447E (pt) 2009-12-16
DK1458447T3 (da) 2010-01-18
HUP0402644A3 (en) 2008-04-28
HUP0402644A2 (en) 2007-02-28
CY1110604T1 (el) 2015-04-29
ES2333206T3 (es) 2010-02-18
CA2469343C (en) 2008-05-13
AU2002358713B2 (en) 2009-01-29
MXPA04005755A (es) 2004-09-10
TW200409624A (en) 2004-06-16
KR20040071182A (ko) 2004-08-11
JP2005511723A (ja) 2005-04-28
EP1458447B1 (de) 2009-09-09
BR0215043A (pt) 2004-11-03
CN1604803A (zh) 2005-04-06
DE60233677D1 (de) 2009-10-22
AU2002358713A1 (en) 2003-06-23
EP1458447A2 (de) 2004-09-22
KR100974921B1 (ko) 2010-08-09
PL373072A1 (en) 2005-08-08
AR037797A1 (es) 2004-12-01
US20050119338A1 (en) 2005-06-02

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