DK1465921T3 - Agonister til corticotropinfrigörelsesfaktor receptor-2 - Google Patents

Agonister til corticotropinfrigörelsesfaktor receptor-2

Info

Publication number: DK1465921T3
Authority: DK; Denmark
Prior art keywords: agonists; factor receptor; release factor; corticotropin release; corticotropin
Prior art date: 2002-01-16

Application number

DK03703867T

Other languages

English (en)

Inventor

Robert Joseph Isfort

Wieslaw Adam Mazur

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-16

Filing date

2003-01-16

Publication date

2006-11-27

2003-01-16 Application filed by Procter & Gamble filed Critical Procter & Gamble

2006-11-27 Application granted granted Critical

2006-11-27 Publication of DK1465921T3 publication Critical patent/DK1465921T3/da

Links

102400000739 Corticotropin Human genes 0.000 title 1
101800000414 Corticotropin Proteins 0.000 title 1
239000000556 agonist Substances 0.000 title 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
229960000258 corticotropin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Toxicology (AREA)
Zoology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK03703867T 2002-01-16 2003-01-16 Agonister til corticotropinfrigörelsesfaktor receptor-2 DK1465921T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US34911702P	2002-01-16	2002-01-16
US37633702P	2002-04-29	2002-04-29
US38889502P	2002-06-14	2002-06-14
US41198802P	2002-09-19	2002-09-19

Publications (1)

Publication Number	Publication Date
DK1465921T3 true DK1465921T3 (da)	2006-11-27

Family

ID=27617822

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK03703867T DK1465921T3 (da)	2002-01-16	2003-01-16	Agonister til corticotropinfrigörelsesfaktor receptor-2
DK03731965T DK1465923T3 (da)	2002-01-16	2003-01-16	Corticotroprinafgivende faktor 2-receptoragonister

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK03731965T DK1465923T3 (da)	2002-01-16	2003-01-16	Corticotroprinafgivende faktor 2-receptoragonister

Country Status (29)

Country	Link
US (7)	US7192923B2 (da)
EP (4)	EP1724283B1 (da)
JP (3)	JP4489434B2 (da)
KR (3)	KR100758857B1 (da)
CN (3)	CN1617887A (da)
AR (3)	AR038142A1 (da)
AT (4)	ATE334147T1 (da)
AU (2)	AU2003205197B2 (da)
BR (3)	BR0306826A (da)
CA (3)	CA2470731C (da)
CY (1)	CY1106133T1 (da)
DE (4)	DE60313845T2 (da)
DK (2)	DK1465921T3 (da)
ES (4)	ES2309909T3 (da)
IL (5)	IL162431A0 (da)
MA (3)	MA27590A1 (da)
MX (3)	MXPA04006884A (da)
MY (1)	MY140306A (da)
NO (3)	NO20043366L (da)
NZ (3)	NZ533599A (da)
PE (3)	PE20030849A1 (da)
PL (3)	PL371364A1 (da)
PT (2)	PT1465923E (da)
RU (1)	RU2294333C2 (da)
SA (3)	SA03230564B1 (da)
SI (1)	SI1465921T1 (da)
TW (3)	TW200302278A (da)
WO (3)	WO2003062277A1 (da)
ZA (1)	ZA200404995B (da)

Families Citing this family (20)

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AU2001289916A1 (en) *	2000-09-22	2002-04-02	Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US7192923B2 (en) *	2002-01-16	2007-03-20	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists
WO2005103690A2 (en) *	2004-04-24	2005-11-03	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with corticotropin releasing hormone receptor 2 (crhr2)
AU2006235045A1 (en) *	2005-03-30	2006-10-19	J. Craig Venter Institute, Inc.	Haemophilus influenzae type b
WO2007090087A2 (en) *	2006-01-27	2007-08-09	Research Development Foundation	Use of corticotropin releasing factor receptor-2 inhibitors for treating insulin-related diseases
AU2008303893A1 (en) *	2007-09-11	2009-04-02	Mondobiotech Laboratories Ag	Use of adrenomedullin as a therapeutic agent for the treatment of excessive angiogenesis
WO2009043469A2 (en) *	2007-09-11	2009-04-09	Mondobiotech Laboratories Ag	Use of pneumadin as a therapeutic agent
WO2009046874A1 (en) *	2007-09-11	2009-04-16	Mondobiotech Laboratories Ag	Therapeutic combination of trh-potentiating peptide and stresscopin
BRPI0921640A2 (pt) *	2008-11-04	2019-09-24	Janssen Pharmaceutica Nv	agonistas peptídicos do crhr2 e usos do mesmo
EP2206726A1 (en) *	2009-01-08	2010-07-14	Universite Joseph Fourier	Non-invasive tools for detecting vulnerable atherosclerotic plaques
KR20120103606A (ko) *	2009-11-04	2012-09-19	얀센 파마슈티카 엔.브이.	스트레스코핀-유사 펩타이드를 이용해 심부전을 치료하는 방법
WO2013063046A1 (en)	2011-10-24	2013-05-02	Research Development Foundation	Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors
JP6562632B2 (ja) *	2012-02-14	2019-08-21	ザリージェンツオブザユニバーシティオブカリフォルニア	心血管疾患および他の状態のためのパラクリン遺伝子の全身送達および制御された発現
JOP20170153A1 (ar) *	2016-07-15	2019-01-30	Lilly Co Eli	نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
KR20190084055A (ko)	2016-10-20	2019-07-15	코르텐 인코포레이티드	부적응 스트레스 반응에서 기인한 질환의 치료 방법
CN110755434B (zh) *	2018-07-27	2022-03-15	中国医学科学院药物研究所	化合物palosuran防治骨骼肌萎缩等疾病的用途
WO2025184558A1 (en) *	2024-02-28	2025-09-04	Caradon Therapeutics, Inc.	Modified urocortin 3
TW202544027A (zh) *	2024-04-19	2025-11-16	美商紐羅克里生物科學有限公司	促皮質素釋放因子受體２（ｃｒｆｒ２）促效劑
WO2025230248A1 (ko) *	2024-04-30	2025-11-06	한미약품 주식회사	Crf2 수용체 작용제와 그 아실화 결합체의 용도
WO2026139062A1 (zh) *	2024-12-26	2026-07-02	杭州先为达生物科技股份有限公司	促肾上腺皮质激素释放因子2受体激动剂及其应用

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US5235036A (en)	1991-05-31	1993-08-10	The Salk Institute For Biological Studies	Crf analogs
US5786203A (en)	1994-06-14	1998-07-28	Neurocrine Biosciences, Inc.	Isolated nucleic acid encoding corticotropin-releasing factor2 receptors
EP0860501A3 (en)	1994-06-14	1999-05-19	Neurocrine Biosciences, Inc.	Corticotropin-releasing factor2 receptors
US5824771A (en) *	1994-12-12	1998-10-20	The Salk Institute For Biological Studies	Cyclic CRF agonists
US5663292A (en) *	1994-12-12	1997-09-02	The Salk Institute For Biological Studies	Cyclic CRF analogs
US5660824A (en)	1995-05-24	1997-08-26	Grabstein; Kenneth H.	Muscle trophic factor
AU6277796A (en)	1995-06-13	1997-01-15	Salk Institute For Biological Studies, The	Urocortin peptides
US5869450A (en)	1996-03-06	1999-02-09	The Regents Of The University Of California	Anti-inflammatory compositions and method with corticotropin-releasing factor analogs
ATE408622T1 (de)	2000-08-04	2008-10-15	Res Dev Foundation	Urocortinproteine und deren verwendungen
AU2001289916A1 (en) *	2000-09-22	2002-04-02	Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US20020082409A1 (en)	2000-10-26	2002-06-27	Hsu Sheau Yu	Stresscopins and their uses
US6670140B2 (en) *	2001-03-06	2003-12-30	The Procter & Gamble Company	Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US7192923B2 (en) *	2002-01-16	2007-03-20	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists

2002
- 2002-12-11 US US10/315,964 patent/US7192923B2/en not_active Expired - Fee Related
- 2002-12-11 US US10/317,251 patent/US7192924B2/en not_active Expired - Fee Related
- 2002-12-11 US US10/317,252 patent/US6936585B2/en not_active Expired - Lifetime
2003
- 2003-01-10 TW TW092100535A patent/TW200302278A/zh unknown
- 2003-01-10 TW TW092100532A patent/TW200302276A/zh unknown
- 2003-01-10 TW TW092100533A patent/TWI300442B/zh not_active IP Right Cessation
- 2003-01-14 PE PE2003000041A patent/PE20030849A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000039A patent/PE20030747A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000040A patent/PE20030974A1/es not_active Application Discontinuation
- 2003-01-15 AR ARP030100099A patent/AR038142A1/es unknown
- 2003-01-15 AR ARP030100100A patent/AR038143A1/es unknown
- 2003-01-15 MY MYPI20030136A patent/MY140306A/en unknown
- 2003-01-15 AR ARP030100101A patent/AR038144A1/es unknown
- 2003-01-16 WO PCT/US2003/001454 patent/WO2003062277A1/en not_active Ceased
- 2003-01-16 JP JP2003562154A patent/JP4489434B2/ja not_active Expired - Fee Related
- 2003-01-16 NZ NZ533599A patent/NZ533599A/en unknown
- 2003-01-16 DE DE60313845T patent/DE60313845T2/de not_active Expired - Lifetime
- 2003-01-16 EP EP06117810A patent/EP1724283B1/en not_active Expired - Lifetime
- 2003-01-16 DE DE60321730T patent/DE60321730D1/de not_active Expired - Lifetime
- 2003-01-16 AT AT03703867T patent/ATE334147T1/de not_active IP Right Cessation
- 2003-01-16 PL PL03371364A patent/PL371364A1/xx unknown
- 2003-01-16 CN CNA038023709A patent/CN1617887A/zh active Pending
- 2003-01-16 ES ES06117810T patent/ES2309909T3/es not_active Expired - Lifetime
- 2003-01-16 WO PCT/US2003/001461 patent/WO2003062269A2/en not_active Ceased
- 2003-01-16 EP EP03731965A patent/EP1465923B1/en not_active Expired - Lifetime
- 2003-01-16 AT AT03731963T patent/ATE383372T1/de not_active IP Right Cessation
- 2003-01-16 CN CNB038023644A patent/CN100391972C/zh not_active Expired - Fee Related
- 2003-01-16 IL IL16243103A patent/IL162431A0/xx unknown
- 2003-01-16 EP EP03703867A patent/EP1465921B1/en not_active Expired - Lifetime
- 2003-01-16 BR BR0306826-9A patent/BR0306826A/pt not_active IP Right Cessation
- 2003-01-16 NZ NZ533598A patent/NZ533598A/en unknown
- 2003-01-16 ES ES03731965T patent/ES2287484T3/es not_active Expired - Lifetime
- 2003-01-16 AT AT06117810T patent/ATE398632T1/de not_active IP Right Cessation
- 2003-01-16 DK DK03703867T patent/DK1465921T3/da active
- 2003-01-16 DK DK03731965T patent/DK1465923T3/da active
- 2003-01-16 WO PCT/US2003/001451 patent/WO2003062268A2/en not_active Ceased
- 2003-01-16 SI SI200330360T patent/SI1465921T1/sl unknown
- 2003-01-16 BR BR0306878-1A patent/BR0306878A/pt not_active IP Right Cessation
- 2003-01-16 ES ES03731963T patent/ES2299701T3/es not_active Expired - Lifetime
- 2003-01-16 JP JP2003562146A patent/JP4508649B2/ja not_active Expired - Fee Related
- 2003-01-16 JP JP2003562145A patent/JP4508648B2/ja not_active Expired - Fee Related
- 2003-01-16 PT PT03731965T patent/PT1465923E/pt unknown
- 2003-01-16 CA CA2470731A patent/CA2470731C/en not_active Expired - Fee Related
- 2003-01-16 AU AU2003205197A patent/AU2003205197B2/en not_active Ceased
- 2003-01-16 IL IL16253003A patent/IL162530A0/xx unknown
- 2003-01-16 AU AU2003237419A patent/AU2003237419B2/en not_active Ceased
- 2003-01-16 CA CA2470656A patent/CA2470656C/en not_active Expired - Fee Related
- 2003-01-16 MX MXPA04006884A patent/MXPA04006884A/es active IP Right Grant
- 2003-01-16 CN CNB038023520A patent/CN100475844C/zh not_active Expired - Fee Related
- 2003-01-16 ES ES03703867T patent/ES2269976T3/es not_active Expired - Lifetime
- 2003-01-16 EP EP03731963A patent/EP1465922B1/en not_active Expired - Lifetime
- 2003-01-16 CA CA2470743A patent/CA2470743C/en not_active Expired - Fee Related
- 2003-01-16 PT PT03703867T patent/PT1465921E/pt unknown
- 2003-01-16 MX MXPA04006883A patent/MXPA04006883A/es active IP Right Grant
- 2003-01-16 BR BR0306838-2A patent/BR0306838A/pt not_active Application Discontinuation
- 2003-01-16 DE DE60318547T patent/DE60318547T2/de not_active Expired - Lifetime
- 2003-01-16 MX MXPA04006885A patent/MXPA04006885A/es active IP Right Grant
- 2003-01-16 KR KR1020047011052A patent/KR100758857B1/ko not_active Expired - Fee Related
- 2003-01-16 PL PL03373139A patent/PL373139A1/xx not_active Application Discontinuation
- 2003-01-16 PL PL03373529A patent/PL373529A1/xx not_active Application Discontinuation
- 2003-01-16 AT AT03731965T patent/ATE362488T1/de not_active IP Right Cessation
- 2003-01-16 KR KR1020047011057A patent/KR100758858B1/ko not_active Expired - Fee Related
- 2003-01-16 IL IL15252903A patent/IL162529A0/xx unknown
- 2003-01-16 NZ NZ533600A patent/NZ533600A/en unknown
- 2003-01-16 KR KR1020047011051A patent/KR100735586B1/ko not_active Expired - Fee Related
- 2003-01-16 RU RU2004124847/13A patent/RU2294333C2/ru active
- 2003-01-16 DE DE60307044T patent/DE60307044T2/de not_active Expired - Lifetime
- 2003-03-01 SA SA3230564A patent/SA03230564B1/ar unknown
- 2003-03-01 SA SA3230565A patent/SA03230565B1/ar unknown
- 2003-03-01 SA SA03230564D patent/SA03230564A/ar unknown
2004
- 2004-06-24 ZA ZA2004/04995A patent/ZA200404995B/en unknown
- 2004-07-13 MA MA27778A patent/MA27590A1/fr unknown
- 2004-07-13 MA MA27779A patent/MA27591A1/fr unknown
- 2004-07-13 MA MA27780A patent/MA27592A1/fr unknown
- 2004-08-13 NO NO20043366A patent/NO20043366L/no not_active Application Discontinuation
- 2004-08-13 NO NO20043371A patent/NO20043371L/no not_active Application Discontinuation
- 2004-08-16 NO NO20043396A patent/NO20043396L/no not_active Application Discontinuation
2005
- 2005-05-04 US US11/121,612 patent/US7462597B2/en not_active Expired - Fee Related
2006
- 2006-07-28 CY CY20061101051T patent/CY1106133T1/el unknown
2007
- 2007-02-02 US US11/701,576 patent/US7608701B2/en not_active Expired - Fee Related
- 2007-02-02 US US11/701,912 patent/US7632933B2/en not_active Expired - Fee Related
2009
- 2009-01-07 IL IL196384A patent/IL196384A0/en unknown
- 2009-03-24 IL IL197774A patent/IL197774A0/en unknown
- 2009-10-26 US US12/605,718 patent/US7897731B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1617887A (zh)	2005-05-18
AR038143A1 (es)	2004-12-29
RU2004124847A (ru)	2005-04-20
EP1465922B1 (en)	2008-01-09
AU2003237419B2 (en)	2006-04-13
NZ533599A (en)	2007-03-30
US7192924B2 (en)	2007-03-20
RU2294333C2 (ru)	2007-02-27
TW200302278A (en)	2003-08-01
SA03230564B1 (ar)	2006-10-31
EP1465923B1 (en)	2007-05-16
HK1078095A1 (zh)	2006-03-03
PE20030849A1 (es)	2003-12-01
NO20043371L (no)	2004-10-06
MXPA04006884A (es)	2004-12-06
SI1465921T1 (sl)	2006-10-31
US20030148958A1 (en)	2003-08-07
KR20040082389A (ko)	2004-09-24
SA03230565B1 (ar)	2006-10-31
PL373139A1 (en)	2005-08-22
AR038144A1 (es)	2004-12-29
BR0306838A (pt)	2005-04-05
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EP1465923A1 (en)	2004-10-13
CN1617885A (zh)	2005-05-18
KR100758858B1 (ko)	2007-09-14
CA2470731C (en)	2011-06-21
CA2470731A1 (en)	2003-07-31
KR100735586B1 (ko)	2007-07-04
JP2005525101A (ja)	2005-08-25
TW200302277A (en)	2003-08-01
JP2005521387A (ja)	2005-07-21
DE60318547T2 (de)	2008-12-24
NZ533598A (en)	2007-03-30
IL197774A0 (en)	2009-12-24
KR20040082390A (ko)	2004-09-24
DE60321730D1 (de)	2008-07-31
WO2003062268A2 (en)	2003-07-31
ES2309909T3 (es)	2008-12-16
PT1465921E (pt)	2006-12-29
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ZA200404995B (en)	2005-06-29
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US20030148957A1 (en)	2003-08-07
MXPA04006883A (es)	2004-12-06
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SA03230564A (ar)	2005-12-03
MY140306A (en)	2009-12-31
ES2299701T3 (es)	2008-06-01
ATE362488T1 (de)	2007-06-15
IL196384A0 (en)	2011-07-31
EP1465922A2 (en)	2004-10-13
KR20040082392A (ko)	2004-09-24
CA2470743C (en)	2011-12-13
ES2269976T3 (es)	2007-04-01
WO2003062268A3 (en)	2003-11-27
US20090124793A1 (en)	2009-05-14
CN100391972C (zh)	2008-06-04
JP4508649B2 (ja)	2010-07-21
US7632933B2 (en)	2009-12-15
US7192923B2 (en)	2007-03-20
WO2003062269A2 (en)	2003-07-31
IL162530A0 (en)	2005-11-20
TW200302276A (en)	2003-08-01
US20100197579A1 (en)	2010-08-05
JP4508648B2 (ja)	2010-07-21
CN100475844C (zh)	2009-04-08
ES2287484T3 (es)	2007-12-16
PL371364A1 (en)	2005-06-13
DE60307044D1 (de)	2006-09-07
US6936585B2 (en)	2005-08-30
EP1724283B1 (en)	2008-06-18
CA2470656C (en)	2011-06-28
EP1724283A2 (en)	2006-11-22
US7462597B2 (en)	2008-12-09
DE60313845T2 (de)	2008-01-31
TWI300442B (en)	2008-09-01
CA2470656A1 (en)	2003-07-31
EP1724283A3 (en)	2007-04-11
BR0306826A (pt)	2005-09-06
ATE383372T1 (de)	2008-01-15
DK1465923T3 (da)	2007-07-02
PE20030974A1 (es)	2003-12-26
MA27592A1 (fr)	2005-11-01
DE60307044T2 (de)	2007-02-15
US20060025339A1 (en)	2006-02-02
PE20030747A1 (es)	2003-10-23
CN1617886A (zh)	2005-05-18
US7608701B2 (en)	2009-10-27
US20030148956A1 (en)	2003-08-07
JP4489434B2 (ja)	2010-06-23
WO2003062277A1 (en)	2003-07-31
US20080004435A1 (en)	2008-01-03
BR0306878A (pt)	2004-10-26
ATE398632T1 (de)	2008-07-15
ATE334147T1 (de)	2006-08-15
DE60313845D1 (de)	2007-06-28
AU2003205197B2 (en)	2006-03-02
EP1465921A2 (en)	2004-10-13
JP2005522191A (ja)	2005-07-28
SA03230565A (ar)	2005-12-03
MA27590A1 (fr)	2005-11-01
NO20043396L (no)	2004-10-06
NZ533600A (en)	2007-02-23
PL373529A1 (en)	2005-09-05
KR100758857B1 (ko)	2007-09-14
IL162431A0 (en)	2005-11-20
NO20043366L (no)	2004-10-06
CA2470743A1 (en)	2003-07-31
MA27591A1 (fr)	2005-11-01
CY1106133T1 (el)	2011-06-08

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