DK1480998T3 - Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger - Google Patents

Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger

Info

Publication number: DK1480998T3
Authority: DK; Denmark
Prior art keywords: intermediates; methods; preparing; analogs; synthesizing
Prior art date: 2002-02-27

Application number

DK03743130T

Other languages

Danish (da)

English (en)

Inventor

Kazimerz Wisniewski

Jacek Stalewski

Guancheng Jiang

Original Assignee

Ferring Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-27

Filing date

2003-02-13

Publication date

2007-03-26

2003-02-13 Application filed by Ferring Bv filed Critical Ferring Bv

2007-03-26 Application granted granted Critical

2007-03-26 Publication of DK1480998T3 publication Critical patent/DK1480998T3/da

Links

XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title abstract 4
239000000543 intermediate Substances 0.000 title abstract 3
230000002194 synthesizing effect Effects 0.000 abstract 4
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
101800000989 Oxytocin Proteins 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK03743130T 2002-02-27 2003-02-13 Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger DK1480998T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36034502P	2002-02-27	2002-02-27
PCT/US2003/004301 WO2003072597A1 (en)	2002-02-27	2003-02-13	Intermediates and methods for making heptapeptide oxytocin analogues

Publications (1)

Publication Number	Publication Date
DK1480998T3 true DK1480998T3 (da)	2007-03-26

Family

ID=27766223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03743130T DK1480998T3 (da)	2002-02-27	2003-02-13	Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger

Country Status (10)

Country	Link
US (3)	US7091314B2 (de)
EP (1)	EP1480998B1 (de)
JP (1)	JP4615221B2 (de)
AT (1)	ATE346084T1 (de)
AU (1)	AU2003211011A1 (de)
DE (1)	DE60309847T2 (de)
DK (1)	DK1480998T3 (de)
ES (1)	ES2277640T3 (de)
PT (1)	PT1480998E (de)
WO (1)	WO2003072597A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2260053B1 (de) *	2008-03-31	2014-05-14	Ferring BV	Oxytocin-analoga
CN102119023B (zh)	2008-07-03	2014-04-09	弗吉尼亚大学专利基金会	阿帕地松单位剂量
TWI463990B (zh)	2009-09-21	2014-12-11	Ferring Bv	催產素受體促進劑
ES2716862T3 (es)	2014-12-22	2019-06-17	Ferring Bv	Terapia con antagonistas del receptor de oxitocina en la fase lútea para la implantación y embarazo en mujeres que se someten a tecnologías de reproducción asistida
RU2726414C2 (ru) *	2015-10-06	2020-07-14	Ферринг Б.В.	Новые способы получения барусибана и его промежуточных соединений
JP6933322B2 (ja)	2016-01-04	2021-09-08	メルクセローノエス．エー．	ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形
CN115590849A (zh)	2016-07-21	2023-01-13	奥布赛瓦股份公司（Ch）	促进胚胎植入和预防流产的催产素拮抗剂给药方案
CA3149898A1 (en)	2019-09-03	2021-03-11	Ernest Loumaye	Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage
WO2021160597A1 (en)	2020-02-10	2021-08-19	ObsEva S.A.	Biomarkers for oxytocin receptor antagonist therapy
WO2025082311A1 (zh) *	2023-10-16	2025-04-24	高雄医学大学	肽醇的固相简便合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL194729C (nl) *	1986-10-13	2003-01-07	Novartis Ag	Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
SE9002384D0 (sv)	1990-07-09	1990-07-09	Ferring Ab	Derivat av baklobshormoner
JP3158507B2 (ja) *	1991-07-09	2001-04-23	チッソ株式会社	光学活性３−フェニル−３−ヒドロキシプロピオン酸エステルの製造方法
FR2680506B1 (fr) *	1991-08-19	1994-09-02	Rhone Poulenc Rorer Sa	Procede de preparation de derives de la beta-phenylisoserine et leur utilisation.
SE501678C2 (sv)	1993-07-13	1995-04-10	Ferring Bv	Peptid med oxytocinantagonistaktivitet samt farmaceutisk komposition innehållande nämnda peptid
US5856721A (en) *	1994-09-08	1999-01-05	Gordin; Myron K.	Discharge lamp with offset or tilted arc tube
US5858972A (en) *	1996-01-11	1999-01-12	La Jolla Cancer Research Foundation	Antithrombotic agents and methods of use
SE9604341D0 (sv) *	1996-11-26	1996-11-26	Ferring Bv	Hepta-peptide oxytocin analogue
US6114310A (en) *	1998-01-23	2000-09-05	Microcide Pharmaceuticals, Inc.	Efflux pump inhibitors
US6204279B1 (en) *	1998-06-03	2001-03-20	Microcide Pharmaceuticals, Inc.	Peptidomimetic efflux pump inhibitors
US6245746B1 (en) *	1998-01-23	2001-06-12	Microcide Pharmaceuticals, Inc.	Efflux pump inhibitors
ES2144357B1 (es) *	1998-01-29	2000-12-16	Lipotec Sa	Procedimiento para la obtencion del analogo de somatostatina octreotide.
GB0115515D0 (en)	2001-06-25	2001-08-15	Ferring Bv	Oxytocin agonisys

2003
- 2003-02-13 EP EP03743130A patent/EP1480998B1/de not_active Expired - Lifetime
- 2003-02-13 PT PT03743130T patent/PT1480998E/pt unknown
- 2003-02-13 AU AU2003211011A patent/AU2003211011A1/en not_active Abandoned
- 2003-02-13 DE DE60309847T patent/DE60309847T2/de not_active Expired - Lifetime
- 2003-02-13 JP JP2003571303A patent/JP4615221B2/ja not_active Expired - Fee Related
- 2003-02-13 WO PCT/US2003/004301 patent/WO2003072597A1/en not_active Ceased
- 2003-02-13 DK DK03743130T patent/DK1480998T3/da active
- 2003-02-13 AT AT03743130T patent/ATE346084T1/de active
- 2003-02-13 ES ES03743130T patent/ES2277640T3/es not_active Expired - Lifetime
2004
- 2004-07-08 US US10/888,704 patent/US7091314B2/en not_active Expired - Lifetime
2006
- 2006-07-14 US US11/457,743 patent/US7304181B2/en not_active Expired - Fee Related
2007
- 2007-10-30 US US11/929,494 patent/US7816489B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20040248776A1 (en)	2004-12-09
US20080177035A1 (en)	2008-07-24
US20060247157A1 (en)	2006-11-02
US7304181B2 (en)	2007-12-04
DE60309847D1 (de)	2007-01-04
US7816489B2 (en)	2010-10-19
AU2003211011A1 (en)	2003-09-09
ES2277640T3 (es)	2007-07-16
ATE346084T1 (de)	2006-12-15
JP4615221B2 (ja)	2011-01-19
EP1480998A1 (de)	2004-12-01
WO2003072597A1 (en)	2003-09-04
PT1480998E (pt)	2007-02-28
DE60309847T2 (de)	2007-10-18
EP1480998B1 (de)	2006-11-22
US7091314B2 (en)	2006-08-15
JP2005532996A (ja)	2005-11-04
EP1480998A4 (de)	2005-06-08

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