EE200100422A - Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine - Google Patents

Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine

Info

Publication number
EE200100422A
EE200100422A EEP200100422A EEP200100422A EE200100422A EE 200100422 A EE200100422 A EE 200100422A EE P200100422 A EEP200100422 A EE P200100422A EE P200100422 A EEP200100422 A EE P200100422A EE 200100422 A EE200100422 A EE 200100422A
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical use
epothilone derivatives
epothilone
derivatives
Prior art date
Application number
EEP200100422A
Other languages
English (en)
Inventor
Klar Ulrich
Skuballa Werner
Buchmann Bernd
Schwede Wolfgang
Schirner Michael
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107480 external-priority patent/DE19907480A1/de
Priority claimed from DE19954229A external-priority patent/DE19954229A1/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of EE200100422A publication Critical patent/EE200100422A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200100422A 1999-02-11 2000-02-11 Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine EE200100422A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999107480 DE19907480A1 (de) 1999-02-11 1999-02-11 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954229A DE19954229A1 (de) 1999-11-04 1999-11-04 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
PCT/EP2000/001104 WO2000047584A2 (de) 1999-02-11 2000-02-11 Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung

Publications (1)

Publication Number Publication Date
EE200100422A true EE200100422A (et) 2002-12-16

Family

ID=26051977

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100422A EE200100422A (et) 1999-02-11 2000-02-11 Epotilooni derivaadid, nende valmistamismeetod jafarmatseutiline kasutamine

Country Status (21)

Country Link
US (2) US7001916B1 (et)
EP (1) EP1161430A2 (et)
JP (1) JP2002536450A (et)
KR (1) KR20010094763A (et)
CN (1) CN1340053A (et)
AU (1) AU4101800A (et)
BG (1) BG105803A (et)
BR (1) BR0008206A (et)
CA (1) CA2360952A1 (et)
CZ (1) CZ20012886A3 (et)
EA (1) EA200100833A1 (et)
EE (1) EE200100422A (et)
HK (1) HK1044946A1 (et)
HU (1) HUP0105330A2 (et)
IL (1) IL144370A0 (et)
MX (1) MXPA01008148A (et)
NO (1) NO20013900L (et)
PL (1) PL350190A1 (et)
SK (1) SK11452001A3 (et)
WO (1) WO2000047584A2 (et)
YU (1) YU57601A (et)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001124A1 (en) 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
AU772750C (en) * 1999-04-30 2005-02-24 Schering Aktiengesellschaft 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
AU2002308218B2 (en) * 2001-02-27 2005-11-10 Novartis Ag Combination comprising a signal transduction inhibitor and an epothilone derivative
ES2315399T3 (es) * 2001-08-23 2009-04-01 Novartis Ag Analogos de epotilona ciclobutilo y ciclopropilo.
SI1483251T1 (sl) 2002-03-12 2010-03-31 Bristol Myers Squibb Co C cian epotilonski derivati
EP2179745A1 (en) * 2002-06-10 2010-04-28 Novartis AG Combinations comprising epothilones and pharmaceutical uses thereof
RU2379032C9 (ru) * 2002-06-10 2010-03-27 Новартис Аг Комбинации, включающие эпотилоны, и их фармацевтическое применение
RU2338741C2 (ru) * 2002-07-31 2008-11-20 Мершан Корпорейшн Новые физиологически активные вещества
US20050215604A1 (en) * 2004-03-26 2005-09-29 Kosan Biosciences, Inc. Combination therapies with epothilones and carboplatin
EP1589011A1 (en) * 2004-04-22 2005-10-26 Schering Aktiengesellschaft Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation
EP2634252B1 (en) 2005-02-11 2018-12-19 University of Southern California Method of expressing proteins with disulfide bridges
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
US20100113128A1 (en) * 2008-11-05 2010-05-06 Snow Richard N Methods and apparatus for determining a reel strip position
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
US20100125146A1 (en) * 2008-11-19 2010-05-20 Johnson Matthey Public Limited Company Method for making pharmaceutical compounds
AU2011255647A1 (en) 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
AU2016340093A1 (en) * 2015-10-16 2018-05-10 William Marsh Rice University Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof
WO2017096559A1 (en) * 2015-12-09 2017-06-15 Rhodia Operations Production of xylene derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
US5469145A (en) 1992-05-29 1995-11-21 Johnson; Lonnie Wet diaper detector
DK1186606T4 (da) 1995-11-17 2011-12-05 Biotechnolog Forschung Gmbh Epothilonderivater, deres fremstilling og anvendelse
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
EP0923583A1 (de) 1996-08-30 1999-06-23 Novartis AG Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
US5969145A (en) 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
US6867305B2 (en) * 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO1999001124A1 (en) 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
ES2290993T3 (es) * 1997-08-09 2008-02-16 Bayer Schering Pharma Aktiengesellschaft Nuevos derivados de epotilona, proceso para su produccion y su utilizacion farmaceutica.
AU4775299A (en) * 1998-06-22 2000-01-10 Nicolaou, Kyriacos Costa Desmethyl epothilones
WO2001066154A2 (de) 2000-03-09 2001-09-13 Klar, Ulrich Radioaktiv markierte epothilon-derivate, verfahren zu deren herstellung und ihre biochemische und pharmazeutische verwendung
CA2359267A1 (en) 2000-10-19 2002-04-19 Manabu Takami Wavelength selecting module and wavelength selecting apparatus
EP1340498A1 (en) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Use of epothilones in the treatment of brain diseases associated with proliferative processes
HRP20050186A2 (en) * 2002-07-31 2005-10-31 Schering Aktiengesellschaft New effector conjugates, process for their production and their pharmaceutical use
WO2004015088A2 (en) 2002-08-13 2004-02-19 Kosan Biosciences, Inc. Transposon-based transformation system

Also Published As

Publication number Publication date
BR0008206A (pt) 2002-02-19
NO20013900L (no) 2001-10-11
SK11452001A3 (sk) 2002-04-04
CA2360952A1 (en) 2000-08-17
AU4101800A (en) 2000-08-29
BG105803A (en) 2002-03-29
JP2002536450A (ja) 2002-10-29
EA200100833A1 (ru) 2002-02-28
CN1340053A (zh) 2002-03-13
PL350190A1 (en) 2002-11-18
HK1044946A1 (zh) 2002-11-08
KR20010094763A (ko) 2001-11-01
YU57601A (sh) 2005-06-10
NO20013900D0 (no) 2001-08-10
WO2000047584A3 (de) 2000-12-28
EP1161430A2 (de) 2001-12-12
WO2000047584A2 (de) 2000-08-17
US7001916B1 (en) 2006-02-21
CZ20012886A3 (cs) 2001-11-14
HUP0105330A2 (hu) 2002-05-29
US20060040990A1 (en) 2006-02-23
IL144370A0 (en) 2002-05-23
MXPA01008148A (es) 2003-07-21

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