DK1487790T3 - Renset lasofoxifen og fremgangsmåde til opensning af racemisk lasofoxifen ved omkrystallisering - Google Patents

Renset lasofoxifen og fremgangsmåde til opensning af racemisk lasofoxifen ved omkrystallisering

Info

Publication number
DK1487790T3
DK1487790T3 DK03745203.4T DK03745203T DK1487790T3 DK 1487790 T3 DK1487790 T3 DK 1487790T3 DK 03745203 T DK03745203 T DK 03745203T DK 1487790 T3 DK1487790 T3 DK 1487790T3
Authority
DK
Denmark
Prior art keywords
lasofoxifene
recrystallization
opening
purified
racemic
Prior art date
Application number
DK03745203.4T
Other languages
English (en)
Inventor
Robert William Mclaughlin
Constantine Sklavounos
Harry Austin Watson Jr
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1487790T3 publication Critical patent/DK1487790T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03745203.4T 2002-03-28 2003-03-17 Renset lasofoxifen og fremgangsmåde til opensning af racemisk lasofoxifen ved omkrystallisering DK1487790T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36887202P 2002-03-28 2002-03-28
PCT/IB2003/001033 WO2003082814A1 (en) 2002-03-28 2003-03-17 Purified lasofoxifene and a method for purification of racemic lasofoxifene by recrystallization

Publications (1)

Publication Number Publication Date
DK1487790T3 true DK1487790T3 (da) 2010-05-10

Family

ID=28675551

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03745203.4T DK1487790T3 (da) 2002-03-28 2003-03-17 Renset lasofoxifen og fremgangsmåde til opensning af racemisk lasofoxifen ved omkrystallisering

Country Status (22)

Country Link
US (2) US6906202B2 (da)
EP (1) EP1487790B1 (da)
JP (1) JP4268055B2 (da)
KR (1) KR100636953B1 (da)
CN (1) CN1283625C (da)
AR (1) AR039152A1 (da)
AT (1) ATE459599T1 (da)
AU (1) AU2003209603B2 (da)
BR (1) BR0308758A (da)
CA (1) CA2479924C (da)
DE (1) DE60331527D1 (da)
DK (1) DK1487790T3 (da)
ES (1) ES2339936T3 (da)
HU (1) HUP0500025A3 (da)
IL (2) IL162929A0 (da)
MX (1) MXPA04009259A (da)
PL (1) PL372727A1 (da)
RS (1) RS80604A (da)
RU (1) RU2278861C2 (da)
TW (1) TW200306974A (da)
WO (1) WO2003082814A1 (da)
ZA (1) ZA200405209B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2479924C (en) * 2002-03-28 2008-07-15 Pfizer Products Inc. Purified lasofoxifene and a method for purification of racemic lasofoxifene by recrystallization
US7795427B2 (en) * 2006-02-14 2010-09-14 New York University Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass
CZ2007373A3 (cs) * 2007-05-29 2008-12-10 Zentiva, A. S Zpusob prípravy lasofoxifenu
CN102311406A (zh) * 2010-06-29 2012-01-11 武汉启瑞药业有限公司 拉索昔芬中间体的制备方法
CN110099680B (zh) 2016-10-11 2021-02-05 杜克大学 Er+乳腺癌的拉索昔芬治疗
CN117771239A (zh) 2018-04-10 2024-03-29 杜克大学 乳腺癌的拉索昔芬治疗
KR102412089B1 (ko) 2021-09-13 2022-06-22 주식회사 세라수 Dmts의 정제방법
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer
WO2025043004A1 (en) 2023-08-21 2025-02-27 Duke University Treatment of solid cancer with lasofoxifene
KR102663941B1 (ko) 2024-03-04 2024-05-08 주식회사 세라수 Drometrizole trisiloxane(DMTS)의 제조방법
WO2026096820A1 (en) 2024-10-30 2026-05-07 Sermonix Pharmaceuticals, Inc. Neoadjuvant treatment of er+ breast cancer with lasofoxifene
WO2026095931A1 (en) 2024-10-30 2026-05-07 Sermonix Pharmaceuticals, Inc. Neoadjuvant treatment of er+ breast cancer with lasofoxifene

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903111A (en) * 1972-09-11 1975-09-02 Sandoz Ltd 4-{8 3-Phenyl-pyrrolidin-1-yl{9 -butyrophenone derivatives
US5326865A (en) * 1990-06-08 1994-07-05 Hercules Incorporated Arylazo and poly(arylazo) dyes having at least one core radical selected from naphthyl or anthracyl and having at least one 2,3-dihydro-1,3-dialkyl perimidine substituent
US5552412A (en) 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
EP0756205A3 (en) * 1995-07-26 1998-10-14 Eastman Kodak Company Pattern transfer techniques for fabrication of lenslet arrays using specialized polyesters
UA51676C2 (uk) * 1995-11-02 2002-12-16 Пфайзер Інк. (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція
YU26700A (sh) 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
EP1086692A3 (en) * 1999-07-28 2003-07-09 Pfizer Products Inc. Estrogen agonists and antagonists for multiple indications
US6180375B1 (en) 1999-08-27 2001-01-30 Pfizer Inc. Microbial biotransformation
AP2003002900A0 (en) 2001-05-01 2003-12-31 Pfizer Prod Inc Method for manufacturing a low dose pharmaceutical composition
CA2479924C (en) * 2002-03-28 2008-07-15 Pfizer Products Inc. Purified lasofoxifene and a method for purification of racemic lasofoxifene by recrystallization

Also Published As

Publication number Publication date
AU2003209603A1 (en) 2003-10-13
PL372727A1 (en) 2005-07-25
HUP0500025A3 (en) 2005-10-28
CN1625548A (zh) 2005-06-08
KR100636953B1 (ko) 2006-10-19
KR20040108693A (ko) 2004-12-24
BR0308758A (pt) 2004-12-28
EP1487790B1 (en) 2010-03-03
RU2004128931A (ru) 2005-04-10
ATE459599T1 (de) 2010-03-15
TW200306974A (en) 2003-12-01
US20030212122A1 (en) 2003-11-13
HUP0500025A2 (hu) 2005-04-28
CN1283625C (zh) 2006-11-08
JP2005521727A (ja) 2005-07-21
HK1073111A1 (en) 2005-09-23
JP4268055B2 (ja) 2009-05-27
AR039152A1 (es) 2005-02-09
AU2003209603B2 (en) 2008-07-17
US6906202B2 (en) 2005-06-14
ES2339936T3 (es) 2010-05-27
WO2003082814A1 (en) 2003-10-09
MXPA04009259A (es) 2005-01-25
IL162929A (en) 2009-11-18
US20050171189A1 (en) 2005-08-04
RS80604A (sr) 2007-02-05
ZA200405209B (en) 2005-08-31
DE60331527D1 (de) 2010-04-15
EP1487790A1 (en) 2004-12-22
RU2278861C2 (ru) 2006-06-27
US7358374B2 (en) 2008-04-15
CA2479924A1 (en) 2003-10-09
CA2479924C (en) 2008-07-15
IL162929A0 (en) 2005-11-20

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