ATE459599T1 - Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren - Google Patents

Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren

Info

Publication number
ATE459599T1
ATE459599T1 AT03745203T AT03745203T ATE459599T1 AT E459599 T1 ATE459599 T1 AT E459599T1 AT 03745203 T AT03745203 T AT 03745203T AT 03745203 T AT03745203 T AT 03745203T AT E459599 T1 ATE459599 T1 AT E459599T1
Authority
AT
Austria
Prior art keywords
lasofoxifen
recrystallization
purified
purifying racemic
racemic
Prior art date
Application number
AT03745203T
Other languages
English (en)
Inventor
Robert William Mclaughlin
Constantine Sklavounos
Harry Austin Watson
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE459599T1 publication Critical patent/ATE459599T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03745203T 2002-03-28 2003-03-17 Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren ATE459599T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36887202P 2002-03-28 2002-03-28
PCT/IB2003/001033 WO2003082814A1 (en) 2002-03-28 2003-03-17 Purified lasofoxifene and a method for purification of racemic lasofoxifene by recrystallization

Publications (1)

Publication Number Publication Date
ATE459599T1 true ATE459599T1 (de) 2010-03-15

Family

ID=28675551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03745203T ATE459599T1 (de) 2002-03-28 2003-03-17 Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren

Country Status (22)

Country Link
US (2) US6906202B2 (de)
EP (1) EP1487790B1 (de)
JP (1) JP4268055B2 (de)
KR (1) KR100636953B1 (de)
CN (1) CN1283625C (de)
AR (1) AR039152A1 (de)
AT (1) ATE459599T1 (de)
AU (1) AU2003209603B2 (de)
BR (1) BR0308758A (de)
CA (1) CA2479924C (de)
DE (1) DE60331527D1 (de)
DK (1) DK1487790T3 (de)
ES (1) ES2339936T3 (de)
HU (1) HUP0500025A3 (de)
IL (2) IL162929A0 (de)
MX (1) MXPA04009259A (de)
PL (1) PL372727A1 (de)
RS (1) RS80604A (de)
RU (1) RU2278861C2 (de)
TW (1) TW200306974A (de)
WO (1) WO2003082814A1 (de)
ZA (1) ZA200405209B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2278861C2 (ru) * 2002-03-28 2006-06-27 Пфайзер Продактс Инк. Очищенный лазофоксифен и способ очистки рацемического лазофоксифена рекристаллизацией
WO2007095161A2 (en) * 2006-02-14 2007-08-23 New York University Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
CZ2007373A3 (cs) * 2007-05-29 2008-12-10 Zentiva, A. S Zpusob prípravy lasofoxifenu
CN102311406A (zh) * 2010-06-29 2012-01-11 武汉启瑞药业有限公司 拉索昔芬中间体的制备方法
PL3525774T3 (pl) 2016-10-11 2022-04-25 Duke University Leczenie lazofoksyfenem raka piersi er+
WO2019199891A1 (en) 2018-04-10 2019-10-17 Duke University Lasofoxifene treatment of breast cancer
KR102412089B1 (ko) 2021-09-13 2022-06-22 주식회사 세라수 Dmts의 정제방법
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer
WO2025043004A1 (en) 2023-08-21 2025-02-27 Duke University Treatment of solid cancer with lasofoxifene
KR102663941B1 (ko) 2024-03-04 2024-05-08 주식회사 세라수 Drometrizole trisiloxane(DMTS)의 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7312262A (de) * 1972-09-11 1974-03-13
US5326865A (en) * 1990-06-08 1994-07-05 Hercules Incorporated Arylazo and poly(arylazo) dyes having at least one core radical selected from naphthyl or anthracyl and having at least one 2,3-dihydro-1,3-dialkyl perimidine substituent
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
EP0756205A3 (de) * 1995-07-26 1998-10-14 Eastman Kodak Company Verfahren zur Übertragung von Mustern in der Herstellung von Linsenreihenanordnungen unter Einsatz spezifischer Polyester
UA51676C2 (uk) * 1995-11-02 2002-12-16 Пфайзер Інк. (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція
YU26700A (sh) 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
EP1086692A3 (de) * 1999-07-28 2003-07-09 Pfizer Products Inc. Oestrogen Agonisten und Antagonisten für mehrere Indikationen
US6180375B1 (en) 1999-08-27 2001-01-30 Pfizer Inc. Microbial biotransformation
UA75135C2 (en) 2001-05-01 2006-03-15 Pfizer Prod Inc Dry granulation method for manufacturing pharmaceutical composition containing tetrahydronaphthalene-2-ol derivative and low dosage tablet compositions
RU2278861C2 (ru) * 2002-03-28 2006-06-27 Пфайзер Продактс Инк. Очищенный лазофоксифен и способ очистки рацемического лазофоксифена рекристаллизацией

Also Published As

Publication number Publication date
DE60331527D1 (de) 2010-04-15
BR0308758A (pt) 2004-12-28
KR100636953B1 (ko) 2006-10-19
RU2004128931A (ru) 2005-04-10
HK1073111A1 (en) 2005-09-23
TW200306974A (en) 2003-12-01
US20030212122A1 (en) 2003-11-13
IL162929A0 (en) 2005-11-20
EP1487790B1 (de) 2010-03-03
US20050171189A1 (en) 2005-08-04
DK1487790T3 (da) 2010-05-10
HUP0500025A2 (hu) 2005-04-28
AR039152A1 (es) 2005-02-09
EP1487790A1 (de) 2004-12-22
US6906202B2 (en) 2005-06-14
CA2479924C (en) 2008-07-15
PL372727A1 (en) 2005-07-25
CN1283625C (zh) 2006-11-08
US7358374B2 (en) 2008-04-15
MXPA04009259A (es) 2005-01-25
AU2003209603A1 (en) 2003-10-13
CA2479924A1 (en) 2003-10-09
ZA200405209B (en) 2005-08-31
KR20040108693A (ko) 2004-12-24
JP4268055B2 (ja) 2009-05-27
IL162929A (en) 2009-11-18
RS80604A (sr) 2007-02-05
AU2003209603B2 (en) 2008-07-17
WO2003082814A1 (en) 2003-10-09
JP2005521727A (ja) 2005-07-21
HUP0500025A3 (en) 2005-10-28
RU2278861C2 (ru) 2006-06-27
CN1625548A (zh) 2005-06-08
ES2339936T3 (es) 2010-05-27

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