DK1490332T3 - Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol - Google Patents

Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol

Info

Publication number: DK1490332T3
Authority: DK; Denmark
Prior art keywords: homopregnacalciferol; methylene; hydroxy; alpha; synthesis
Prior art date: 2002-03-29

Application number

DK03726113T

Other languages

Danish (da)

English (en)

Inventor

Hector F Deluca

Rafal R Sicinski

Sumithra Gowlugari

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-29

Filing date

2003-03-26

Publication date

2007-04-10

2003-03-26 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

2007-04-10 Application granted granted Critical

2007-04-10 Publication of DK1490332T3 publication Critical patent/DK1490332T3/da

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
125000000746 allylic group Chemical group 0.000 abstract 1
-1 bicyclic ketone Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
AUONHKJOIZSQGR-UHFFFAOYSA-N oxophosphane Chemical compound P=O AUONHKJOIZSQGR-UHFFFAOYSA-N 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

DK03726113T 2002-03-29 2003-03-26 Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol DK1490332T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36915902P	2002-03-29	2002-03-29
PCT/US2003/009186 WO2003084925A1 (fr)	2002-03-29	2003-03-26	Procede de synthese de 1$g(a)-hydroxy-2-methylene-19-nor-homopregnacalciferol

Publications (1)

Publication Number	Publication Date
DK1490332T3 true DK1490332T3 (da)	2007-04-10

Family

ID=28791930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03726113T DK1490332T3 (da)	2002-03-29	2003-03-26	Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol

Country Status (16)

Country	Link
US (2)	US6774251B2 (fr)
EP (1)	EP1490332B1 (fr)
JP (1)	JP3957303B2 (fr)
KR (1)	KR20040095237A (fr)
CN (1)	CN1277817C (fr)
AT (1)	ATE346839T1 (fr)
AU (1)	AU2003228365B2 (fr)
BR (1)	BR0307896A (fr)
CA (1)	CA2477543C (fr)
DE (1)	DE60310050T2 (fr)
DK (1)	DK1490332T3 (fr)
ES (1)	ES2276062T3 (fr)
HK (1)	HK1079766B (fr)
MX (1)	MXPA04008227A (fr)
NZ (1)	NZ534863A (fr)
WO (1)	WO2003084925A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0307896A (pt) *	2002-03-29	2004-12-07	Wisconsin Alumni Res Found	Método de produção de 1(alfa)-hidroxi-2-metileno-19-nor-homopregnacalcif erol
US6846811B2 (en) *	2002-04-22	2005-01-25	Wisconsin Alumni Research Foundation	(20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
CA2544502A1 (fr) *	2003-11-25	2005-06-09	Wisconsin Alumni Research Foundation	Analogues de vitamine d pour prevenir et traiter l'obesite
US8404667B2 (en) *	2006-12-29	2013-03-26	Wisconsin Alumni Research Foundation	Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
US7915242B2 (en) *	2004-02-17	2011-03-29	Wisconsin Alumni Research Foundation	Vitamin D receptor antagonists and their use in treating asthma
US7713951B2 (en) *	2004-04-09	2010-05-11	Wisconsin Alumni Research Foundation	2-alkylidene-18,19-dinor-vitamin D compounds
CA2586679A1 (fr)	2004-11-12	2006-05-18	Bioxell Spa	Emploi combine de derives de vitamine d et d'agents antiproliferants pour le traitement de cancers de la vessie
EP1827452B1 (fr) *	2004-11-22	2011-03-02	Wisconsin Alumni Research Foundation	2-methylene-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol
US7238681B2 (en) *	2004-11-22	2007-07-03	Wisconsin Alumni Research Foundation	2-Methylene-18,19-dinor-1α-hydroxy-homopregnacalciferol and its uses
ATE467614T1 (de) *	2004-11-22	2010-05-15	Wisconsin Alumni Res Found	2-methylen-19,26,27-trinor-(20s)-1-alpha- hydroxyvitamin d3 and dessen verwendungen
JP2008520708A (ja) *	2004-11-22	2008-06-19	ウイスコンシンアラムニリサーチファンデーション	２−メチレン−１９−ノル−（２０Ｒ）−１α−ヒドロキシ−ビスホモプレグナカルシフェロール
JP5161582B2 (ja) *	2004-11-22	2013-03-13	ウィスコンシン・アルムニ・リサーチ・ファウンデーション	１７，２０（ｚ）−デヒドロビタミンｄ類似体およびそれらの使用
US7541348B2 (en) *	2004-11-22	2009-06-02	Wisconsin Alumni Research Foundation	2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol
AU2006213727B2 (en) *	2005-02-11	2011-08-18	Wisconsin Alumni Research Foundation	2-methylene-19-nor- (20S-24S) - 1alpha, 25-dihydroxyvitamin-D2
NZ561076A (en) *	2005-02-11	2010-01-29	Wisconsin Alumni Res Found	2-methylene-19-nor-(20S-24EPI)-1alpha,25-dihydroxyvitamin-D2
AU2006230296B2 (en) *	2005-03-29	2011-07-07	Wisconsin Alumni Research Foundation	2-methylene-19-nor-(23s)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone and 2-methylene-19-nor-(23R)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone
CA2605727A1 (fr) *	2005-05-03	2006-11-09	Wisconsin Alumni Research Foundation	Composes de 19,26,27-trinor-1.alpha.,25-dihydroxyvitamine d3
AU2006284622B2 (en) *	2005-08-30	2011-10-06	Wisconsin Alumni Research Foundation	Des-C,D analogs of 1alpha,25-dihydroxy-19-norvitamin D3
WO2007084682A1 (fr) *	2006-01-20	2007-07-26	Atc Technologies, Llc	Systèmes et procédés de mise en forme de faisceau en boucle fermée sur liaison aval
US7491712B1 (en) *	2007-12-10	2009-02-17	Formosa Laboratories, Inc.	Process for preparation of paricalcitol and intermediates thereof
US7893043B2 (en) *	2008-07-10	2011-02-22	Wisconsin Alumni Research Foundation	2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
US8222236B2 (en) *	2008-07-10	2012-07-17	Wisconsin Alumni Research Foundation	2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
US7888339B2 (en) *	2008-07-10	2011-02-15	Wisconsin Alumni Research Foundation	2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
JP5931845B2 (ja) *	2010-03-23	2016-06-08	ウイスコンシンアラムニリサーチファンデーション	２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー
AU2011232633B2 (en) *	2010-03-23	2014-05-29	Wisconsin Alumni Research Foundation	(20S)-2-methylene-19-nor-22-dimethyl-1alpha,25- dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22- dimethyl-1alpha,25-hydroxyvitamin D3
US8664206B2 (en)	2010-03-23	2014-03-04	Wisconsin Alumni Research Foundation	Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
US9834512B2 (en)	2011-06-03	2017-12-05	Wisconsin Alumni Research Foundation	(22E)-2-methylene-26,27-cyclo-22-dehydro-1α-hydroxy-19-norvitamin D3 derivatives
JP6035331B2 (ja) *	2011-06-14	2016-11-30	ウイスコンシンアラムニリサーチファンデーション	３−デスオキシ−２−メチレン−１９−ノル−ビタミンｄ類似体およびそれらの使用
PT3969459T (pt) *	2019-05-13	2023-11-20	Faes Farma Sa	Processo e intermediários para a preparação de eldecalcitol

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4666634A (en)	1984-12-05	1987-05-19	Chugai Seiyaku Kabushiki Kaisha	vitamin D3 derivatives having a substituent at 2-position
US4800198A (en)	1985-04-23	1989-01-24	Wisconsin Alumni Research Foundation	Method of inducing the differentiation of malignant cells with secosterol
CA1333616C (fr)	1989-03-09	1994-12-20	Hector F. Deluca	Composes de type 19-nor-vitamine d
US5459136A (en)	1990-08-24	1995-10-17	Wisconsin Alumni Research Foundation	Methods using vitamin D compounds for improvement of skin conditions
US5089641A (en) *	1991-03-11	1992-02-18	Wisconsin Alumni Research Foundation	Synthesis of 1α-hydroxy-secosterol compounds
DE69400495T2 (de)	1993-04-05	1997-04-30	Wisconsin Alumni Res Found	19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle
US5877168A (en)	1995-02-10	1999-03-02	Chugai Seiyaku Kabushiki Kaisha	Vitamin D derivative with substituent at the 2β-position
US6306844B1 (en)	1997-03-17	2001-10-23	Wisconsin Alumni Research Foundation	Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US5945410A (en)	1997-03-17	1999-08-31	Wisconsin Alumni Research Foundation	2-alkyl-19-nor-vitamin D compounds
US5843928A (en) *	1997-03-17	1998-12-01	Wisconsin Alumni Research Foundation	2-alkylidene-19-nor-vitamin D compounds
US5936105A (en) *	1997-06-13	1999-08-10	Tetrionics, Inc.	14-EPI-19-nor-vitamin D compounds and methods
US5972917A (en) *	1998-05-29	1999-10-26	Bone Care Int Inc	1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US6806262B2 (en) *	2000-05-31	2004-10-19	Wisconsin Alumni Research Foundation	2-ethyl and 2-ethylidene-19-nor-vitamin D compounds
WO2002020021A1 (fr) *	2000-09-08	2002-03-14	Wisconsin Alumni Research Foundation	1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol et ses applications therapeutiques
US6627622B2 (en) *	2002-02-18	2003-09-30	Wisconsin Alumni Research Foundation	(20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
US6566352B1 (en) *	2002-02-18	2003-05-20	Wisconsin Alumni Research Foudation	1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
BR0307896A (pt) *	2002-03-29	2004-12-07	Wisconsin Alumni Res Found	Método de produção de 1(alfa)-hidroxi-2-metileno-19-nor-homopregnacalcif erol

2003
- 2003-03-26 BR BR0307896-5A patent/BR0307896A/pt active Search and Examination
- 2003-03-26 DK DK03726113T patent/DK1490332T3/da active
- 2003-03-26 KR KR10-2004-7013435A patent/KR20040095237A/ko not_active Withdrawn
- 2003-03-26 CN CNB038072106A patent/CN1277817C/zh not_active Expired - Lifetime
- 2003-03-26 WO PCT/US2003/009186 patent/WO2003084925A1/fr not_active Ceased
- 2003-03-26 HK HK05112140.9A patent/HK1079766B/zh not_active IP Right Cessation
- 2003-03-26 MX MXPA04008227A patent/MXPA04008227A/es active IP Right Grant
- 2003-03-26 CA CA2477543A patent/CA2477543C/fr not_active Expired - Fee Related
- 2003-03-26 ES ES03726113T patent/ES2276062T3/es not_active Expired - Lifetime
- 2003-03-26 AU AU2003228365A patent/AU2003228365B2/en not_active Ceased
- 2003-03-26 EP EP03726113A patent/EP1490332B1/fr not_active Expired - Lifetime
- 2003-03-26 NZ NZ534863A patent/NZ534863A/en not_active IP Right Cessation
- 2003-03-26 US US10/397,135 patent/US6774251B2/en not_active Expired - Lifetime
- 2003-03-26 DE DE60310050T patent/DE60310050T2/de not_active Expired - Lifetime
- 2003-03-26 JP JP2003582124A patent/JP3957303B2/ja not_active Expired - Fee Related
- 2003-03-26 AT AT03726113T patent/ATE346839T1/de not_active IP Right Cessation
2004
- 2004-05-17 US US10/847,040 patent/US7208484B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU2003228365B2 (en)	2008-02-14
WO2003084925A1 (fr)	2003-10-16
DE60310050D1 (de)	2007-01-11
CN1642909A (zh)	2005-07-20
US20040220418A1 (en)	2004-11-04
JP3957303B2 (ja)	2007-08-15
JP2005521742A (ja)	2005-07-21
US20030191095A1 (en)	2003-10-09
CA2477543C (fr)	2011-01-04
EP1490332A1 (fr)	2004-12-29
HK1079766B (zh)	2007-05-25
HK1079766A1 (en)	2006-04-13
US7208484B2 (en)	2007-04-24
EP1490332B1 (fr)	2006-11-29
CN1277817C (zh)	2006-10-04
ATE346839T1 (de)	2006-12-15
DE60310050T2 (de)	2007-07-05
US6774251B2 (en)	2004-08-10
CA2477543A1 (fr)	2003-10-16
ES2276062T3 (es)	2007-06-16
BR0307896A (pt)	2004-12-07
AU2003228365A1 (en)	2003-10-20
NZ534863A (en)	2005-05-27
MXPA04008227A (es)	2005-08-19
KR20040095237A (ko)	2004-11-12

Publication	Publication Date	Title
DK1490332T3 (da)	2007-04-10	Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol
AU4621096A (en)	1996-08-07	Organic compounds and processes for their manufacture
ATE444151T1 (de)	2009-10-15	Verfahren zur herstellung von uv-härtbaren dichtungsanordnungen
AR047769A1 (es)	2006-02-22	Metodos de produccion de apolipoproteinas en las plantas transgenicas
ATE359384T1 (de)	2007-05-15	Verfahren zur herstellung eines zerstäubungstargets
AU2002309670A1 (en)	2002-11-18	Method for the isolation of stem cells by immuno-labeling with hla/mhc gene product marker
TR199902941T2 (xx)	2000-08-21	Bitki transformasyon y�ntemleri.
TW200502076A (en)	2005-01-16	Method of manufacturing a replica, as well as a replica obtained by carrying out a uv light-initiated or thermal curing treatment of a reactive mixture
AU2003250263A1 (en)	2003-12-31	Method for the gasification of biomass and corresponding plant
EA199900741A1 (ru)	2000-02-28	Способ получения эпросартана
ATE310790T1 (de)	2005-12-15	Verfahren zur herstellung von rohstoffen für die gewinnung von konjugierter linolsäure
DK1713788T3 (da)	2009-06-08	Fremgangsmåde til fremstilling af enantiometrisk rene aminoalkoholer
AU2003267424A1 (en)	2004-04-23	Method for the production of fatty acid esters of monovalent alcohols by alcoholysis using special basic catalysts
MXPA02012112A (es)	2003-06-06	Composiciones que contienen policarbonato.
EA199900740A1 (ru)	2000-02-28	Способ получения эпросартана (варианты)
AU2002214326A1 (en)	2002-05-27	Process for preparing fluorinated esters by gas chromatography
EP1510512A8 (fr)	2005-06-22	Procédé de préparation d'aldéhydes alicycliques
ATE349409T1 (de)	2007-01-15	Verfahren zur herstellung alkoxyreiner erdalkalialkoxide
WO2005062724A3 (fr)	2006-04-06	Procede pour l'elaboration de derives d'aminoadamantane
ATE414757T1 (de)	2008-12-15	Verfahren zur herstellung von alkylestern unter anwendung von druck
AU2003246436A1 (en)	2004-02-02	Method for producing biomass fuel
ATE517890T1 (de)	2011-08-15	Verfahren zur herstellung von reinem irbesartan
TW200636879A (en)	2006-10-16	Method and system for performing die attach using a flame
AU2003302637A1 (en)	2004-06-23	Method for producing alcohol
AU2002325796A1 (en)	2003-06-26	Method for producing tablets from plant extracts