DK1490332T3 - Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol - Google Patents
Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferolInfo
- Publication number
- DK1490332T3 DK1490332T3 DK03726113T DK03726113T DK1490332T3 DK 1490332 T3 DK1490332 T3 DK 1490332T3 DK 03726113 T DK03726113 T DK 03726113T DK 03726113 T DK03726113 T DK 03726113T DK 1490332 T3 DK1490332 T3 DK 1490332T3
- Authority
- DK
- Denmark
- Prior art keywords
- homopregnacalciferol
- methylene
- hydroxy
- alpha
- synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000746 allylic group Chemical group 0.000 abstract 1
- -1 bicyclic ketone Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- AUONHKJOIZSQGR-UHFFFAOYSA-N oxophosphane Chemical compound P=O AUONHKJOIZSQGR-UHFFFAOYSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36915902P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/009186 WO2003084925A1 (fr) | 2002-03-29 | 2003-03-26 | Procede de synthese de 1$g(a)-hydroxy-2-methylene-19-nor-homopregnacalciferol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1490332T3 true DK1490332T3 (da) | 2007-04-10 |
Family
ID=28791930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03726113T DK1490332T3 (da) | 2002-03-29 | 2003-03-26 | Fremgangsmåde til syntetisering af 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6774251B2 (fr) |
| EP (1) | EP1490332B1 (fr) |
| JP (1) | JP3957303B2 (fr) |
| KR (1) | KR20040095237A (fr) |
| CN (1) | CN1277817C (fr) |
| AT (1) | ATE346839T1 (fr) |
| AU (1) | AU2003228365B2 (fr) |
| BR (1) | BR0307896A (fr) |
| CA (1) | CA2477543C (fr) |
| DE (1) | DE60310050T2 (fr) |
| DK (1) | DK1490332T3 (fr) |
| ES (1) | ES2276062T3 (fr) |
| HK (1) | HK1079766B (fr) |
| MX (1) | MXPA04008227A (fr) |
| NZ (1) | NZ534863A (fr) |
| WO (1) | WO2003084925A1 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1079766B (zh) * | 2002-03-29 | 2007-05-25 | 威斯康星校友研究基金会 | 合成1α-羟基-2-亚甲基-19-去甲-高孕钙化醇的方法 |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| CA2544502A1 (fr) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Analogues de vitamine d pour prevenir et traiter l'obesite |
| US8404667B2 (en) | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| WO2005079464A2 (fr) * | 2004-02-17 | 2005-09-01 | Wisconsin Alumni Research Foundation | Antagonistes du recepteur de la vitamine d et leur utilisation dans le traitement de l'asthme |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| CA2586679A1 (fr) | 2004-11-12 | 2006-05-18 | Bioxell Spa | Emploi combine de derives de vitamine d et d'agents antiproliferants pour le traitement de cancers de la vessie |
| DE602005020842D1 (de) * | 2004-11-22 | 2010-06-02 | Wisconsin Alumni Res Found | 17,20(e)-dehydro-vitamin-d-analoga und deren verwendungen |
| JP2008520709A (ja) * | 2004-11-22 | 2008-06-19 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−（２０Ｓ）−１α−ヒドロキシ−トリスホモプレグナカルシフェロール |
| ATE499942T1 (de) * | 2004-11-22 | 2011-03-15 | Wisconsin Alumni Res Found | 2-methylen-19,21-dinor-1alpha-hydroxy- bishomopregnacalciferol |
| US7244719B2 (en) * | 2004-11-22 | 2007-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-19,26,27-trinor-(20S)-1α-hydroxyvitamin D3 and its uses |
| ES2349662T3 (es) * | 2004-11-22 | 2011-01-10 | Wisconsin Alumni Research Foundation | 2-metileno-18,19-dinor-1alfa-hidroxi-homopregnacalciferol y sus usos. |
| AU2005309818A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20R)-1-alpha-hydroxy-bishomopregnacalciferol |
| EP1848442B1 (fr) * | 2005-02-11 | 2012-04-25 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24epi)-1alpha,25-dihydroxyvitamine-d2 |
| CA2597624C (fr) * | 2005-02-11 | 2012-08-14 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24s)-1.alpha.,25-dhydroxyvitamine-d2 |
| CA2603328A1 (fr) * | 2005-03-29 | 2006-10-05 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(23s)-25-dehydro-1a-hydroxyvitamine d3-26,23-lactone et 2-methylene-19-nor-(23r)-25-dehydro-1a-hydroxyvitamine d3-26,23-lactone |
| EP1877063A4 (fr) * | 2005-05-03 | 2009-11-04 | Wisconsin Alumni Res Found | Composes de 19,26,27-trinor-1alpha, 25-dihydroxyvitamine d3 |
| ES2533719T3 (es) * | 2005-08-30 | 2015-04-14 | Wisconsin Alumni Research Foundation | Análogos Des-C,D de 1alfa,25-dihidroxi-19-norvitamina D3 |
| US7979024B2 (en) * | 2006-01-20 | 2011-07-12 | Atc Technologies, Llc | Systems and methods for satellite forward link transmit diversity using orthagonal space coding |
| US7491712B1 (en) * | 2007-12-10 | 2009-02-17 | Formosa Laboratories, Inc. | Process for preparation of paricalcitol and intermediates thereof |
| US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| JP5931845B2 (ja) * | 2010-03-23 | 2016-06-08 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー |
| WO2011119610A2 (fr) * | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | (20s)-2-méthylène-19-nor-22-diméthyl-1α,25-dihydroxyvitamine d3 et (20r)-2-méthylène-19-nor-22-diméthyl-1α,25-hydroxyvitamine d3 |
| WO2012166938A2 (fr) | 2011-06-03 | 2012-12-06 | Wisconsin Alumni Research Foundation | Dérivés de (22e)-2-méthylène-26,27-cyclo-22-déhydro-1alpha-hydroxy-19-norvitamine d3 |
| US8993547B2 (en) * | 2011-06-14 | 2015-03-31 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses |
| US11591280B2 (en) * | 2019-05-13 | 2023-02-28 | Faes Farma, S.A. | Process and intermediates for the preparation of eldecalcitol |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US4800198A (en) | 1985-04-23 | 1989-01-24 | Wisconsin Alumni Research Foundation | Method of inducing the differentiation of malignant cells with secosterol |
| CA1333616C (fr) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | Composes de type 19-nor-vitamine d |
| US5459136A (en) | 1990-08-24 | 1995-10-17 | Wisconsin Alumni Research Foundation | Methods using vitamin D compounds for improvement of skin conditions |
| US5089641A (en) * | 1991-03-11 | 1992-02-18 | Wisconsin Alumni Research Foundation | Synthesis of 1α-hydroxy-secosterol compounds |
| JP2898882B2 (ja) | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6306844B1 (en) | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5936105A (en) * | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
| US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
| ES2309069T3 (es) * | 2000-05-31 | 2008-12-16 | Wisconsin Alumni Research Foundation | Compuestos de 2-etil y 2-etiliden-19-nor-vitamina d. |
| BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| HK1079766B (zh) * | 2002-03-29 | 2007-05-25 | 威斯康星校友研究基金会 | 合成1α-羟基-2-亚甲基-19-去甲-高孕钙化醇的方法 |
-
2003
- 2003-03-26 HK HK05112140.9A patent/HK1079766B/zh not_active IP Right Cessation
- 2003-03-26 DK DK03726113T patent/DK1490332T3/da active
- 2003-03-26 AU AU2003228365A patent/AU2003228365B2/en not_active Ceased
- 2003-03-26 WO PCT/US2003/009186 patent/WO2003084925A1/fr not_active Ceased
- 2003-03-26 BR BR0307896-5A patent/BR0307896A/pt active Search and Examination
- 2003-03-26 CA CA2477543A patent/CA2477543C/fr not_active Expired - Fee Related
- 2003-03-26 EP EP03726113A patent/EP1490332B1/fr not_active Expired - Lifetime
- 2003-03-26 US US10/397,135 patent/US6774251B2/en not_active Expired - Lifetime
- 2003-03-26 DE DE60310050T patent/DE60310050T2/de not_active Expired - Lifetime
- 2003-03-26 CN CNB038072106A patent/CN1277817C/zh not_active Expired - Lifetime
- 2003-03-26 JP JP2003582124A patent/JP3957303B2/ja not_active Expired - Fee Related
- 2003-03-26 KR KR10-2004-7013435A patent/KR20040095237A/ko not_active Withdrawn
- 2003-03-26 ES ES03726113T patent/ES2276062T3/es not_active Expired - Lifetime
- 2003-03-26 AT AT03726113T patent/ATE346839T1/de not_active IP Right Cessation
- 2003-03-26 MX MXPA04008227A patent/MXPA04008227A/es active IP Right Grant
- 2003-03-26 NZ NZ534863A patent/NZ534863A/en not_active IP Right Cessation
-
2004
- 2004-05-17 US US10/847,040 patent/US7208484B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030191095A1 (en) | 2003-10-09 |
| CA2477543C (fr) | 2011-01-04 |
| US7208484B2 (en) | 2007-04-24 |
| NZ534863A (en) | 2005-05-27 |
| AU2003228365A1 (en) | 2003-10-20 |
| ATE346839T1 (de) | 2006-12-15 |
| MXPA04008227A (es) | 2005-08-19 |
| AU2003228365B2 (en) | 2008-02-14 |
| DE60310050D1 (de) | 2007-01-11 |
| WO2003084925A1 (fr) | 2003-10-16 |
| BR0307896A (pt) | 2004-12-07 |
| CN1642909A (zh) | 2005-07-20 |
| ES2276062T3 (es) | 2007-06-16 |
| US20040220418A1 (en) | 2004-11-04 |
| JP2005521742A (ja) | 2005-07-21 |
| US6774251B2 (en) | 2004-08-10 |
| CA2477543A1 (fr) | 2003-10-16 |
| KR20040095237A (ko) | 2004-11-12 |
| EP1490332B1 (fr) | 2006-11-29 |
| CN1277817C (zh) | 2006-10-04 |
| DE60310050T2 (de) | 2007-07-05 |
| JP3957303B2 (ja) | 2007-08-15 |
| HK1079766A1 (en) | 2006-04-13 |
| EP1490332A1 (fr) | 2004-12-29 |
| HK1079766B (zh) | 2007-05-25 |
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