DK1499738T3 - Recombinase-polymerease-amplifikation - Google Patents

Recombinase-polymerease-amplifikation

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Publication number
DK1499738T3
DK1499738T3 DK03711216T DK03711216T DK1499738T3 DK 1499738 T3 DK1499738 T3 DK 1499738T3 DK 03711216 T DK03711216 T DK 03711216T DK 03711216 T DK03711216 T DK 03711216T DK 1499738 T3 DK1499738 T3 DK 1499738T3
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DK
Denmark
Prior art keywords
dna
amplification
recombinase
polymerease
polymerase
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Application number
DK03711216T
Other languages
Danish (da)
English (en)
Inventor
Niall A Armes
Derek L Stemple
Original Assignee
Asm Scient Inc
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Publication of DK1499738T3 publication Critical patent/DK1499738T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/90Details of database functions independent of the retrieved data types
    • G06F16/95Retrieval from the web
    • G06F16/951Indexing; Web crawling techniques
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/90Details of database functions independent of the retrieved data types
    • G06F16/95Retrieval from the web
    • G06F16/957Browsing optimisation, e.g. caching or content distillation
    • G06F16/9574Browsing optimisation, e.g. caching or content distillation of access to content, e.g. by caching

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Data Mining & Analysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
  • Polyesters Or Polycarbonates (AREA)
DK03711216T 2002-02-21 2003-02-21 Recombinase-polymerease-amplifikation DK1499738T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35856302P 2002-02-21 2002-02-21
PCT/US2003/005492 WO2003072805A2 (en) 2002-02-21 2003-02-21 Recombinase polymerase amplification

Publications (1)

Publication Number Publication Date
DK1499738T3 true DK1499738T3 (da) 2008-11-17

Family

ID=27765964

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03711216T DK1499738T3 (da) 2002-02-21 2003-02-21 Recombinase-polymerease-amplifikation

Country Status (11)

Country Link
US (7) US7270981B2 (de)
EP (4) EP1992706B1 (de)
JP (4) JP4340543B2 (de)
AT (1) ATE400663T1 (de)
AU (1) AU2003215391B2 (de)
CA (1) CA2476481C (de)
DE (1) DE60322044D1 (de)
DK (1) DK1499738T3 (de)
ES (1) ES2310237T3 (de)
PT (1) PT1499738E (de)
WO (1) WO2003072805A2 (de)

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60226856D1 (de) 2001-04-20 2008-07-10 Penn State Res Found Verfahren zur manipulation von nukleinsäuren
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
CA2476481C (en) * 2002-02-21 2016-01-26 Asm Scientific, Inc. Recombinase polymerase amplification
DE60324810D1 (de) * 2002-09-20 2009-01-02 New England Biolabs Inc HELICASE-ABHuNGIGE AMPLIFIKATION VON NUKLEINSUREN
WO2004092330A2 (en) * 2003-04-11 2004-10-28 Applera Corporation Method of generating long nucleic acid molecules of defined sequence
JP2005110621A (ja) * 2003-10-10 2005-04-28 Aisin Seiki Co Ltd 核酸増幅方法及び核酸増幅用試薬キット
AU2011202896B2 (en) * 2004-06-01 2012-12-06 Abbott Diagnostics Scarborough, Inc. Recombinase Polymerase Amplification
EP3985125A1 (de) * 2004-06-01 2022-04-20 Abbott Diagnostics Scarborough, Inc. Rekombinase-polymerase-verstärkung
CA2569491A1 (en) 2004-06-02 2005-12-15 Asm Scientific, Inc. 2'-nitrobenzyl-modified ribonucleotides
JP4534138B2 (ja) * 2004-12-21 2010-09-01 アイシン精機株式会社 核酸増幅反応における高度好熱菌由来タンパク質の活性化方法およびその利用
WO2006081222A2 (en) * 2005-01-25 2006-08-03 Compass Genetics, Llc. Isothermal dna amplification
EP1929049B1 (de) * 2005-07-25 2013-04-10 Alere San Diego, Inc. Verfahren zur multiplexierung einer rekombinase-polymerase-verstärkung
US7368265B2 (en) * 2006-01-23 2008-05-06 Compass Genetics, Llc Selective genome amplification
JP2009535053A (ja) 2006-05-04 2009-10-01 エーエスエム サイエンティフィック, インコーポレイテッド レコンビナーゼポリメラーゼ増幅
EP2049262A2 (de) 2006-07-19 2009-04-22 Bionanomatrix, Inc. Nanodüsen-geräteanordnungen: ihre herstellung und verwendung zur makromolekularen analyse
CA2964611C (en) 2007-03-28 2021-06-01 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
CA3062190C (en) * 2008-06-30 2023-03-28 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
WO2010003132A1 (en) 2008-07-02 2010-01-07 Illumina Cambridge Ltd. Using populations of beads for the fabrication of arrays on surfaces
AU2009316628B2 (en) 2008-11-18 2016-06-16 Bionano Genomics, Inc. Polynucleotide mapping and sequencing
WO2010083250A2 (en) 2009-01-13 2010-07-22 Fluidigm Corporation Single-cell nucleic acid analysis
US8685648B2 (en) 2009-02-03 2014-04-01 Biohelix Corporation Endonuclease-enhanced helicase-dependent amplification
US9309557B2 (en) * 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US9469867B2 (en) 2009-05-20 2016-10-18 Alere San Diego, Inc. DNA glycosylase/lyase and AP endonuclease substrates
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
EP3360974B1 (de) 2009-06-05 2025-04-09 Abbott Diagnostics Scarborough, Inc. Reagentien zur rekombinase polymerase amplifikation
WO2010147804A1 (en) * 2009-06-10 2010-12-23 Wisconsin Alumni Research Foundation Method for dna double-strand break repair in vitro and applications thereof
NO20092315A (no) * 2009-06-16 2010-12-06 Agr Cannseal As Brønnverktøy og fremgangsmåte for in situ innføring av et behandlingsfluid i et ringrom i en brønn
US8951733B2 (en) 2009-10-16 2015-02-10 Monsanto Technology Llc Methods of polynucleotide detection
GB0922097D0 (en) 2009-12-17 2010-02-03 Atlas Genetics Ltd Microbial assay
EP2539464B1 (de) 2010-02-23 2016-11-16 Illumina, Inc. Verfahren zur minimierung sequenzabhängiger amplifikationsunterschiede
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
NZ610129A (en) 2010-10-04 2014-08-29 Genapsys Inc Systems and methods for automated reusable parallel biological reactions
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
CA2814532C (en) 2010-10-12 2021-07-27 Monsanto Technology Llc Soybean plant and seed corresponding to transgenic event mon87712 and methods for detection thereof
EP4059342A1 (de) 2010-12-17 2022-09-21 Monsanto Technology LLC Verfahren zur verbesserung der kompetenz von pflanzenzellen
CN110079588B (zh) 2010-12-17 2024-03-15 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
EP3978620A1 (de) 2011-04-07 2022-04-06 Abbott Diagnostics Scarborough, Inc. Überwachung von rekombinase-polymerase-verstärkungsmischungen
WO2012149193A2 (en) 2011-04-29 2012-11-01 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
EP2704554B1 (de) 2011-05-02 2019-04-10 The Board of Regents of the University of Nebraska Pflanzen mit nutzeigenschaften und zugehörige verfahren
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
WO2012166742A2 (en) 2011-05-27 2012-12-06 Genapsys, Inc. Systems and methods for genetic and biological analysis
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
EP2726618A1 (de) 2011-06-30 2014-05-07 Monsanto Technology LLC Alfalfa-pflanze und samen im zusammenhang mit dem transgenen ereignis kk 179-2 sowie verfahren zu ihrem nachweis
US9670540B2 (en) 2011-07-21 2017-06-06 Cornell University Methods and devices for DNA sequencing and molecular diagnostics
HUE059863T2 (hu) 2011-08-31 2023-01-28 Seminis Vegetable Seeds Inc Eljárás és készítmények görögdinnye keménységhez
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
JP6193252B2 (ja) 2011-12-01 2017-09-06 ジナプシス インコーポレイテッド 高効率電子配列決定及び検出のためのシステム並びに方法
JP5958034B2 (ja) * 2012-04-11 2016-07-27 富士レビオ株式会社 分子ビーコン型プローブを用いた標的核酸の検出方法
CN104471075B (zh) 2012-04-19 2018-06-22 生命技术公司 核酸扩增
EP3095879B1 (de) 2012-04-19 2018-09-19 Life Technologies Corporation Nukleinsäureamplifikation
CN114214394A (zh) 2012-06-08 2022-03-22 爱奥尼安技术公司 核苷酸扩增反应
DE102012014981B3 (de) 2012-07-26 2013-07-18 Sartorius Stedim Biotech Gmbh Verfahren zur Differenzierung zwischen lebenden und toten Zellen
EP2888371B1 (de) 2012-08-24 2017-08-02 Life Technologies Corporation Verfahren, zusammensetzungen, systeme, vorrichtungen und kits für nukleinsäuresequenzierung mit gepaartem ende
EP3257952B1 (de) 2012-09-11 2020-02-12 Life Technologies Corporation Nukleinsäureamplifikation
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
US9290800B2 (en) 2013-03-15 2016-03-22 Pacific Biosciences Of California, Inc. Targeted rolling circle amplification
US9809852B2 (en) 2013-03-15 2017-11-07 Genapsys, Inc. Systems and methods for biological analysis
CA2903874C (en) 2013-03-15 2024-02-20 Theranos, Inc. Nucleic acid amplification
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
JP2016521120A (ja) 2013-03-15 2016-07-21 セラノス, インコーポレイテッド 核酸増幅
AU2014233145A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
SG10201908167YA (en) 2013-09-04 2019-10-30 Fluidigm Corp Proximity assays for detecting nucleic acids and proteins in a single cell
CN103421777B (zh) * 2013-09-11 2015-05-13 北京市农林科学院林业果树研究所 无需pcr仪的侧翼核酸序列快速准确扩增方法及应用
US10767188B2 (en) 2013-09-25 2020-09-08 Nutech Ventures Methods and compositions for obtaining useful plant traits
NZ630628A (en) 2013-10-08 2015-04-24 Seminis Vegetable Seeds Inc Methods and compositions for peronospora resistance in spinach
EP3502127B1 (de) 2013-10-09 2023-07-26 Monsanto Technology LLC Transgenes ereignis mon87403 in mais und nachweisverfahren dafür
US10351918B2 (en) 2013-10-30 2019-07-16 Green Life Biotech, Llc Pathogenesis quantification systems and treatment methods for citrus greening blight
NZ767892A (en) 2013-11-27 2022-07-01 Seminis Vegetable Seeds Inc Disease resistance loci in onion
EP3792921A1 (de) 2013-12-11 2021-03-17 Genapsys, Inc. Systeme und verfahren für biologische analysen und berechnungen
US20170009288A1 (en) 2014-02-03 2017-01-12 Thermo Fisher Scientific Baltics Uab Method for controlled dna fragmentation
PT3632202T (pt) 2014-02-21 2022-10-03 Syngenta Participations Ag Locais genéticos associados a fertilidade acrescida em milho
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
WO2015161054A2 (en) 2014-04-18 2015-10-22 Genapsys, Inc. Methods and systems for nucleic acid amplification
GB201410022D0 (en) * 2014-06-05 2014-07-16 Orion Diagnostica Oy Method
US20150361481A1 (en) 2014-06-13 2015-12-17 Life Technologies Corporation Multiplex nucleic acid amplification
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
WO2016011280A1 (en) 2014-07-16 2016-01-21 Tangen Biosciences, Inc. Isothermal methods for amplifying nucleic acid samples
CA2962941C (en) 2014-09-29 2022-06-14 Illumina Cambridge Limited Recombinase mutants
EP3005862A1 (de) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melonenpflanzen mit verbesserter krankheitstoleranz
US11559801B2 (en) 2014-11-03 2023-01-24 Tangen Biosciences, Inc. Apparatus and method for cell, spore, or virus capture and disruption
CA3285074A1 (en) 2015-04-28 2026-03-02 Monsanto Technology Llc Methods and compositions for producing brachytic corn plants
UA126326C2 (uk) 2015-04-30 2022-09-21 Монсанто Текнолоджі Елелсі Спосіб відбору рослини каноли, стійкої до кили капустяних
JP6822974B2 (ja) 2015-05-29 2021-01-27 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft シトラコン酸無水物によって微生物を不活性化する方法
JP6698708B2 (ja) 2015-06-09 2020-05-27 ライフ テクノロジーズ コーポレーション 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体
BR112018000541B1 (pt) 2015-08-18 2023-11-28 Monsanto Technology Llc Métodos para selecionar uma população de plantas ou sementes de algodão staygreen (stg), para selecionar uma planta ou semente de algodão e para avaliar uma coleção de germoplasma de algodão
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
US10858709B2 (en) 2015-09-10 2020-12-08 Monsanto Technology Llc Methods for producing corn plants with downy mildew resistance and compositions thereof
GB201519565D0 (en) 2015-11-05 2015-12-23 Alere San Diego Inc Sample preparation device
US20180320228A1 (en) 2015-10-30 2018-11-08 Alere Inc. Determination of polymorphisms using isothermal nucleic acid amplification
WO2017100283A1 (en) 2015-12-09 2017-06-15 Life Technologies Corporation Detection and quantification of nucleic acid molecules associated with a surface
WO2017106731A1 (en) 2015-12-18 2017-06-22 Monsanto Technology Llc Methods for producing corn plants with northern leaf blight resistance and compositions thereof
US10329601B2 (en) 2015-12-28 2019-06-25 Ionian Technologies, Inc. Nicking and extension amplification reaction (NEAR) of Streptococcus species
WO2017121836A1 (en) 2016-01-15 2017-07-20 Thermo Fisher Scientific Baltics Uab Thermophilic dna polymerase mutants
WO2017147486A1 (en) 2016-02-26 2017-08-31 Alere San Diego Inc. Redox labeled oligonucleotide probes and their use
CA3268059A1 (en) 2016-03-04 2026-03-02 Abbott Diagnostics Scarborough, Inc. Automated nested recombinase polymerase amplification
AU2017241670B2 (en) 2016-03-28 2020-10-08 Illumina, Inc. Recombinase mutants
US9617587B1 (en) 2016-04-04 2017-04-11 Nat Diagnostics, Inc. Isothermal amplification components and processes
US11299777B2 (en) 2016-04-04 2022-04-12 Nat Diagnostics, Inc. Isothermal amplification components and processes
WO2017214561A1 (en) 2016-06-10 2017-12-14 Life Technologies Corporation Methods and compositions for nucleic acid amplification
US10544456B2 (en) 2016-07-20 2020-01-28 Genapsys, Inc. Systems and methods for nucleic acid sequencing
EP3496528A4 (de) 2016-08-11 2020-03-18 Monsanto Technology LLC Verfahren und zusammensetzungen zur erzeugung von maispflanzen mit resistenz gegen spätes verwelken
EP4417691A3 (de) 2016-09-15 2024-11-13 Abbott Laboratories Vorrichtungen und verfahren zur probenanalyse
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
CN106701738B (zh) * 2016-11-10 2020-05-08 中国科学院成都生物研究所 一种等温解开双链dna及制备单链dna的方法
JP7311420B2 (ja) 2017-02-28 2023-07-19 アボット・ダイアグノスティックス・スカボロー・インコーポレイテッド マイクロ流体デバイスおよび関連する方法
US11542540B2 (en) 2017-06-16 2023-01-03 Life Technologies Corporation Control nucleic acids, and compositions, kits, and uses thereof
US11618891B2 (en) 2017-06-26 2023-04-04 Thermo Fisher Scientific Baltics Uab Thermophilic DNA polymerase mutants
BR112020004071A2 (pt) 2017-08-31 2020-09-24 Ionian Technologies, Inc. reação de amplificação por nicking e extensão (near) de espécies do vírus sincicial respiratório
KR102800957B1 (ko) 2017-09-14 2025-04-30 애보트 다이어그노스틱스 스카보로, 인크. 이중-합텐 프로브를 이용한 재조합효소 폴리머라제 증폭의 검출
CA3076378A1 (en) 2017-09-21 2019-03-28 Genapsys, Inc. Systems and methods for nucleic acid sequencing
WO2019094524A1 (en) 2017-11-07 2019-05-16 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
US12226745B2 (en) 2017-11-07 2025-02-18 Life Technologies Corporation Methods and compositions for manipulating nucleic acids
CN108034763B (zh) * 2017-12-21 2021-10-22 北京卓诚惠生生物科技股份有限公司 检测甲型肝炎和戊型肝炎病毒的引物、探针及试剂盒
US10597714B2 (en) 2017-12-29 2020-03-24 Clear Labs, Inc. Automated priming and library loading device
US10101328B1 (en) 2017-12-29 2018-10-16 Clear Labs, Inc. Detection of microorganisms in food samples and food processing facilities
SG11201903333SA (en) 2017-12-29 2019-08-27 Clear Labs Inc Automated priming and library loading services
US11268102B2 (en) 2018-05-16 2022-03-08 University Of Florida Research Foundation, Incorporated Compositions and methods for identifying and selecting brachytic locus in solanaceae
WO2019238765A1 (en) 2018-06-12 2019-12-19 Keygene N.V. Nucleic acid amplification method
CN108410954A (zh) * 2018-07-10 2018-08-17 默禾医疗科技(上海)有限公司 一种室温扩增反应体系中反应缓冲液的制配方法
WO2020018824A1 (en) 2018-07-19 2020-01-23 Ultima Genomics, Inc. Nucleic acid clonal amplification and sequencing methods, systems, and kits
WO2020092268A2 (en) * 2018-10-29 2020-05-07 Kutyavin Igor V Thermokinetically balanced isothermal amplification of nucleic acid sequences
WO2020120179A1 (en) 2018-12-14 2020-06-18 Illumina Cambridge Limited Decreasing phasing with unlabeled nucleotides during sequencing
JP7562424B2 (ja) 2018-12-17 2024-10-07 イルミナ ケンブリッジ リミテッド シーケンシング用プライマーオリゴヌクレオチド
WO2020126593A1 (en) 2018-12-17 2020-06-25 Illumina Cambridge Limited Compositions for use in polyunucleotide sequencing
AU2020208190B2 (en) 2019-01-15 2022-07-28 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
EP4403648B1 (de) 2019-05-03 2025-08-20 Life Technologies Corporation Verfahren und zusammensetzungen zur manipulation von nukleinsäuren
US20220259641A1 (en) * 2019-07-17 2022-08-18 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Amplification assay for the detection of anaplasma phagocytophilum
EP4407043A3 (de) 2019-08-21 2024-10-09 Life Technologies Corporation System und verfahren zur sequenzierung
US11542513B2 (en) 2019-09-26 2023-01-03 Seminis Vegetable Seeds, Inc. Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
GB201916379D0 (en) 2019-11-11 2019-12-25 Biocrucible Ltd Biochemical reaction methods and reagents
WO2021226754A1 (zh) * 2020-05-09 2021-11-18 杭州梓晶生物有限公司 一种病毒重组酶-聚合酶扩增检测方法
WO2021228839A1 (en) 2020-05-11 2021-11-18 Deutsches Krebsforschungszentrum Polynucleotide detection by cas nucleases
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
EP4243986A1 (de) 2020-11-16 2023-09-20 Life Technologies Corporation System und verfahren zur sequenzierung
EP4305198A1 (de) 2021-03-09 2024-01-17 Etablissement Français du Sang Nachweis eines infektiösen mittels auf der basis von rekombinase-polymerase-amplifikation in kombination mit einer magnetfeldverstärkten agglutination
JP2024518331A (ja) 2021-04-29 2024-05-01 アボット・ラボラトリーズ 生体試料のハイスループット核酸検査
CN113891944A (zh) * 2021-06-24 2022-01-04 黄婉秋 检测病原体rna、及动物或人类基因rna的试剂盒及其应用
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
EP4373965A1 (de) 2021-07-21 2024-05-29 DNAe Diagnostics Limited Verfahren und system mit einer kartusche zur sequenzierung von zielpolynukleotiden
WO2023014222A1 (en) 2021-08-03 2023-02-09 Wageningen Universiteit Argonaute-based nucleic acid detection system
US12480157B2 (en) 2021-09-30 2025-11-25 Illumina, Inc. Polynucleotide sequencing
CN114237548B (zh) * 2021-11-22 2023-07-18 南京大学 基于非易失性存储器阵列的复数点乘运算的方法及系统
CN114085891A (zh) 2021-11-23 2022-02-25 广州达安基因股份有限公司 基于重组酶聚合酶扩增技术的逆转录扩增系统和方法
CN113981045B (zh) 2021-11-23 2025-09-16 广州达安基因股份有限公司 制备恒温扩增混合酶系的方法
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
EP4565720A1 (de) 2022-08-04 2025-06-11 Abbott Laboratories Assays zum nachweis des afepoxvirus
JP2025533369A (ja) 2022-09-29 2025-10-07 イルミナ インコーポレイテッド 動的光学システム較正
MX2024004405A (es) 2023-04-14 2024-11-08 Seminis Vegetable Seeds Inc Métodos y composiciones de resistencia a peronospora en la espinaca
WO2025049451A1 (en) 2023-08-28 2025-03-06 Abbott Molecular, Inc. Assays for detecting cytomegalovirus (cmv) or epstein-bar virus (ebv)
WO2025049450A1 (en) 2023-08-28 2025-03-06 Abbott Molecular, Inc. Assays for detecting bk virus (bkv)
WO2025111147A1 (en) 2023-11-21 2025-05-30 Abbott Laboratories Two-dimensional matrix droplet array
WO2025144626A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Sequencing with single-stranded binding proteins
WO2025144744A1 (en) 2023-12-29 2025-07-03 Life Technologies Corporation Enrichment of clonal substrates
WO2025188823A1 (en) 2024-03-07 2025-09-12 Illumina, Inc. Immersion microscopy arrangement for sequencing system with rapid scanning
WO2025244815A1 (en) 2024-05-21 2025-11-27 Illumina, Inc. Flow cell assemblies and related systems and methods
WO2026050593A2 (en) 2024-08-30 2026-03-05 Illumina, Inc. Apparatus and method to mitigate thermally induced aberrations in immersion optical system
WO2026059922A1 (en) 2024-09-10 2026-03-19 Illumina, Inc. Molecular deduplication analysis methods
US20260071285A1 (en) 2024-09-11 2026-03-12 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucurbit aphid-borne yellow virus
WO2026073129A1 (en) 2024-09-30 2026-04-02 Illumina, Inc. Targeted variant calling using target enrichment sequencing data
WO2026076044A1 (en) 2024-10-03 2026-04-09 Illumina, Inc. Read-level methylation detection
WO2026096670A1 (en) 2024-10-30 2026-05-07 Illumina, Inc. Precision, recall, and f-score for continuous distributions

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US603585A (en) 1898-05-03 cbowell
US5430136A (en) 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5635347A (en) * 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US5858652A (en) * 1988-08-30 1999-01-12 Abbott Laboratories Detection and amplification of target nucleic acid sequences
GB8903627D0 (en) 1989-02-17 1989-04-05 Unilever Plc Assays
DE69118930T2 (de) * 1990-01-26 1997-01-09 Abbott Lab Verbessertes Verfahren zur Amplifikation von Nuklein säurezielsequenz, einsetzbar für die Polymerase und Ligasekettenreaktion
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
FI941016A7 (fi) * 1990-05-07 1994-05-03 Daikin Indsutries Ltd Kaksois-D-silmukan muodostumisen diagnostiset sovellutukset
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
ES2128323T3 (es) 1990-07-24 1999-05-16 Hoffmann La Roche Reduccion de la amplificacion no-especifica durante la amplificacion in vitro del acido nucleico empleando bases de acido nucleico modificadas.
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5556751A (en) 1991-04-25 1996-09-17 Amoco Corporation Selective amplification system using Q-β replicase
EP0524349A1 (de) * 1991-07-08 1993-01-27 Opticon Sensors Europe B.V. Abtaster mit zwei Brennweiten und die Verwendung eines solchen Abtasters als Lesestift für Kodierungen
CA2077135A1 (en) * 1991-08-30 1993-03-01 Joh-E Ikeda A method of dna amplification
WO1994003624A1 (en) 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5834202A (en) 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5733733A (en) 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5614389A (en) 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
CA2122203C (en) 1993-05-11 2001-12-18 Melinda S. Fraiser Decontamination of nucleic acid amplification reactions
FR2708288B1 (fr) * 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US5705366A (en) 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US5656430A (en) 1995-06-07 1997-08-12 Trevigen, Inc. Oscillating signal amplifier for nucleic acid detection
US5916779A (en) 1995-09-21 1999-06-29 Becton, Dickinson And Company Strand displacement amplification of RNA targets
US5731150A (en) 1995-11-01 1998-03-24 Chiron Diagnostic Corporation IS6110 based molecular detection of mycobacterium tuberculosis
WO1997046715A1 (en) * 1996-06-03 1997-12-11 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Fc receptor polymorphism
US5853990A (en) * 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US6335164B1 (en) * 1996-08-29 2002-01-01 Daikin Industries, Ltd. Methods for targeting, enriching, detecting and/or isolating target nucleic acid sequence using RecA-like recombinase
WO1998045474A1 (en) 1997-04-04 1998-10-15 Innogenetics N.V. Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions
US6245506B1 (en) 1997-07-30 2001-06-12 Bbi Bioseq, Inc. Integrated sequencing device
ATE214104T1 (de) 1998-04-22 2002-03-15 Entpr Ie Trd As Bioresearch Ie Verfahren zur charakterisierung von nukleinsäuremolekulen, das die erzeugung von verlängerbaren aufwärtsgelegenen dns-fragmenten, die durch spaltung der nukleinsäure an einer abasischen stelle entsteht, umfasst
WO1999060158A1 (en) 1998-05-19 1999-11-25 Laboratory Of Molecular Biophotonics Solid phase for detecting nucleic acid and method for detecting nucleic acid
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
CA2375769A1 (en) 1999-01-11 2000-07-20 President And Fellows Of Harvard College Isothermal amplification of dna
US6699693B1 (en) * 1999-02-04 2004-03-02 Sloan-Kettering Institute For Cancer Research Process for DNA replication
WO2000046408A1 (en) 1999-02-04 2000-08-10 Sloan-Kettering Institute For Cancer Research Process for dna replication
US6387621B1 (en) 1999-04-27 2002-05-14 University Of Utah Research Foundation Automated analysis of real-time nucleic acid amplification
US6509157B1 (en) * 1999-11-05 2003-01-21 Roche Molecular Systems, Inc 3 blocked nucleic acid amplification primers
NO314091B1 (no) * 2000-01-12 2003-01-27 Biotec Pharmacon Asa Varmelabil uracil-DNA-glykosylase, DNA-sekvens som koder for enzymet, mikroorganisme som inneholder DNA-sekvensen, samt anvendelse av enzymet
AU2001243670A1 (en) 2000-03-20 2001-10-03 Maxygen, Inc. Method for generating recombinant dna molecules in complex mixtures
DK1715063T3 (da) 2000-03-29 2011-05-16 Lgc Ltd Hydridiseringsbeacon og fremgangsmåde til hurtig sekvensdetektion og distinktion
US20020061530A1 (en) 2000-07-31 2002-05-23 Belotserkovskii Boris P. Enhanced targeting of DNA sequences by recombinase protein and single-stranded homologous DNA probes using DNA analog activation
IE20000887A1 (en) 2000-11-03 2002-12-11 Univ College Cork Nat Univ Ie Method for the amplification and optional characterisation of nucleic acids
US6379899B1 (en) * 2001-03-13 2002-04-30 Discoverx Isothermal exponential RNA amplification in complex mixtures
DE60226856D1 (de) 2001-04-20 2008-07-10 Penn State Res Found Verfahren zur manipulation von nukleinsäuren
EP1275735A1 (de) 2001-07-11 2003-01-15 Roche Diagnostics GmbH Zusammensetzung und Methode zur 'Hot start' Nukleinsäureamplifizierung
WO2003008624A2 (en) 2001-07-15 2003-01-30 Keck Graduate Institute Nucleic acid amplification using nicking agents
AU2002365212A1 (en) 2001-07-15 2003-09-02 Keck Graduate Institute Gene expression analysis using nicking agents
JPWO2003016569A1 (ja) 2001-08-20 2004-12-02 タカラバイオ株式会社 核酸の増幅方法
AU2002341898A2 (en) 2001-09-28 2003-04-07 University Of Delaware Polymorphism detection and separation
KR100445560B1 (ko) 2001-10-31 2004-08-21 (주)바이오넥스 핵산 또는 생물학적 물질을 분리하기 위한 키트의 제조방법과, 그 방법에 의해 제조된 키트와, 그 키트를사용하는 장치
US7244562B2 (en) 2001-11-01 2007-07-17 Gene Check, Inc. RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences
CA2476481C (en) 2002-02-21 2016-01-26 Asm Scientific, Inc. Recombinase polymerase amplification
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US20040137456A1 (en) * 2002-04-04 2004-07-15 Hiroki Yokota Method for identifying and characterizing individual dna molecules
US20030228611A1 (en) 2002-05-01 2003-12-11 President And Fellows Of Harvard College Nucleic acid memory device
US6713262B2 (en) 2002-06-25 2004-03-30 Agilent Technologies, Inc. Methods and compositions for high throughput identification of protein/nucleic acid binding pairs
JP2005532827A (ja) 2002-07-12 2005-11-04 ブリティッシュ・バイオセル・インターナショナル・リミテッド 側方フローアッセイ用のデバイスおよびその方法
US20040038213A1 (en) 2002-08-06 2004-02-26 Kwon Jai W. Genotyping by in situ PCR amplification of a polynucleotide in a tissue biopsy
CA2494993A1 (en) 2002-08-21 2004-03-04 Epoch Biosciences, Inc. Abasic site endonuclease assay
DE60324810D1 (de) * 2002-09-20 2009-01-02 New England Biolabs Inc HELICASE-ABHuNGIGE AMPLIFIKATION VON NUKLEINSUREN
US7662594B2 (en) 2002-09-20 2010-02-16 New England Biolabs, Inc. Helicase-dependent amplification of RNA
WO2004081224A2 (en) * 2003-03-11 2004-09-23 Gene Check, Inc. Reca-assisted allele specific oligonucleotide extension method
DE10315640A1 (de) 2003-04-04 2004-10-14 Ignatov, Konstantin Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung
JP2005110621A (ja) * 2003-10-10 2005-04-28 Aisin Seiki Co Ltd 核酸増幅方法及び核酸増幅用試薬キット
CA2497324A1 (en) 2004-02-17 2005-08-17 Affymetrix, Inc. Methods for fragmenting and labelling dna
EP3985125A1 (de) * 2004-06-01 2022-04-20 Abbott Diagnostics Scarborough, Inc. Rekombinase-polymerase-verstärkung
US7745125B2 (en) 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
EP1659186B1 (de) 2004-10-11 2008-05-21 Epigenomics AG Verfahren zum Kontaminationsschutz von DNA-Amplifikationsreaktionen zur Methylierungsanalyse durch modifizierte Vorbehandlung der Nukleinsäuren
US20060110765A1 (en) 2004-11-23 2006-05-25 Wang Xiao B Detection of nucleic acid variation by cleavage-amplification (CleavAmp) method
US20070042427A1 (en) 2005-05-03 2007-02-22 Micronics, Inc. Microfluidic laminar flow detection strip
WO2006119280A2 (en) 2005-05-03 2006-11-09 Handylab, Inc. Lyophilized pellets
EP1883707B1 (de) 2005-05-26 2014-04-09 Human Genetic Signatures PTY Ltd Isothermische strangverdrängungsamplifikation unter verwendung von eine nichtreguläre base enthaltenden primern
WO2007008997A2 (en) 2005-07-12 2007-01-18 The Board Of Trustees Of The Leland Stanford Junior University Template specific inhibition of pcr
EP1929049B1 (de) * 2005-07-25 2013-04-10 Alere San Diego, Inc. Verfahren zur multiplexierung einer rekombinase-polymerase-verstärkung
JP2009535053A (ja) * 2006-05-04 2009-10-01 エーエスエム サイエンティフィック, インコーポレイテッド レコンビナーゼポリメラーゼ増幅
EP2155912B1 (de) 2007-05-18 2013-06-26 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Primer und sonden zur detektion von streptococcus pneumoniae
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
ES2320840B1 (es) 2007-11-27 2010-07-01 Nelson Alfonso Egued Tubo humectador de doble camara.
JP2009139487A (ja) 2007-12-04 2009-06-25 Nippon Sheet Glass Co Ltd 正立等倍レンズアレイプレート
US9469867B2 (en) 2009-05-20 2016-10-18 Alere San Diego, Inc. DNA glycosylase/lyase and AP endonuclease substrates
EP3360974B1 (de) 2009-06-05 2025-04-09 Abbott Diagnostics Scarborough, Inc. Reagentien zur rekombinase polymerase amplifikation
CN114214394A (zh) 2012-06-08 2022-03-22 爱奥尼安技术公司 核苷酸扩增反应

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