DK15087D0 - Immunogenkomplekser og deres anvendelse i laegemidler, isaer vacciner - Google Patents

Immunogenkomplekser og deres anvendelse i laegemidler, isaer vacciner

Info

Publication number: DK15087D0
Authority: DK; Denmark
Prior art keywords: immunogenic; vaccines; pharmaceuticals; issues; detergent
Prior art date: 1986-01-14

Application number

DK015087A

Other languages

English (en)

Other versions

DK166762B1 (da

DK15087A (da

Inventor

Petra De Vries

Antonius Ludovicus Van Wezel

Eduard Coen Beuvery

Original Assignee

Nederlanden Staat

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-14

Filing date

1987-01-13

Publication date

1987-01-13

1987-01-13 Application filed by Nederlanden Staat filed Critical Nederlanden Staat

1987-01-13 Publication of DK15087D0 publication Critical patent/DK15087D0/da

1987-07-15 Publication of DK15087A publication Critical patent/DK15087A/da

1993-07-12 Application granted granted Critical

1993-07-12 Publication of DK166762B1 publication Critical patent/DK166762B1/da

Links

230000002163 immunogen Effects 0.000 title abstract 5
229960005486 vaccine Drugs 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229930182558 Sterol Natural products 0.000 abstract 2
239000000427 antigen Substances 0.000 abstract 2
230000000890 antigenic effect Effects 0.000 abstract 2
102000036639 antigens Human genes 0.000 abstract 2
108091007433 antigens Proteins 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
239000003599 detergent Substances 0.000 abstract 2
229930182470 glycoside Natural products 0.000 abstract 2
150000002338 glycosides Chemical class 0.000 abstract 2
239000000693 micelle Substances 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
150000003432 sterols Chemical class 0.000 abstract 2
235000003702 sterols Nutrition 0.000 abstract 2
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 1
UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
229930182490 saponin Natural products 0.000 abstract 1
150000007949 saponins Chemical class 0.000 abstract 1
235000017709 saponins Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK015087A 1986-01-14 1987-01-13 Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser DK166762B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8600066		1986-01-14
NL8600066		1986-01-14

Publications (3)

Publication Number	Publication Date
DK15087D0 true DK15087D0 (da)	1987-01-13
DK15087A DK15087A (da)	1987-07-15
DK166762B1 DK166762B1 (da)	1993-07-12

Family

ID=19847414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK015087A DK166762B1 (da)	1986-01-14	1987-01-13	Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser

Country Status (8)

Country	Link
US (1)	US4900549A (da)
EP (1)	EP0231039B1 (da)
JP (2)	JP2502558B2 (da)
AT (1)	ATE71303T1 (da)
CA (1)	CA1279012C (da)
DE (1)	DE3775783D1 (da)
DK (1)	DK166762B1 (da)
ES (1)	ES2039229T3 (da)

Families Citing this family (87)

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SE8405493D0 (sv) *	1984-11-01	1984-11-01	Bror Morein	Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
ES2039229T3 (es) *	1986-01-14	1993-09-16	De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur	Procedimiento para la preparacion de complejos inmunogenicos y composiciones farmaceuticas que contienen estos complejos.
US5583112A (en) *	1987-05-29	1996-12-10	Cambridge Biotech Corporation	Saponin-antigen conjugates and the use thereof
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US4981684A (en) *	1989-10-24	1991-01-01	Coopers Animal Health Limited	Formation of adjuvant complexes
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US5443832A (en) *	1990-04-16	1995-08-22	Institut Swisse De Recherches Experimentales Sur Le Cancer	Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response
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SE502569C2 (sv) *	1991-05-31	1995-11-13	British Tech Group	Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit
WO1993020802A1 (en) *	1992-04-09	1993-10-28	Northwestern University	Acoustically reflective liposomes and methods to make and use the same
DE4220653A1 (de) *	1992-06-26	1994-01-13	Boehringer Mannheim Gmbh	Verfahren und Mittel zum Nachweis eines Analyten enthaltend glykosidische Tenside
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AUPM500494A0 (en) *	1994-04-12	1994-05-05	Minister For Agriculture & Rural Affairs For The State Of New South Wales, The	Composition for use in increasing mucosal immunity
US6207646B1 (en)	1994-07-15	2001-03-27	University Of Iowa Research Foundation	Immunostimulatory nucleic acid molecules
GB9618119D0 (en)	1996-08-30	1996-10-09	Univ Southampton	Adjuvants for use in vaccines
US6455323B1 (en)	1997-07-03	2002-09-24	Pharmacia & Upjohn Company	Anti-bacterial methods and materials
US20070059327A2 (en) *	1998-01-15	2007-03-15	Wyeth	Streptococcus equi compositions and methods of use
GB2348203B (en)	1998-11-04	2002-06-19	Imp College Innovations Ltd	Solube beta-forms of prion proteins, methods of preparation and use
AUPP807399A0 (en) *	1999-01-08	1999-02-04	Csl Limited	Improved immunogenic lhrh composition and methods relating thereto
WO2000048630A1 (en)	1999-02-17	2000-08-24	Csl Limited	Immunogenic complexes and methods relating thereto
US6790950B2 (en)	1999-04-09	2004-09-14	Pharmacia & Upjohn Company	Anti-bacterial vaccine compositions
CA2366520C (en)	1999-04-09	2013-10-01	Zoetis Services Llc	Anti-bacterial vaccine compositions
AU5695701A (en)	2000-03-17	2001-10-03	Upjohn Co	Salmonella vaccine materials and methods
US6764823B2 (en)	2000-04-06	2004-07-20	Pharmacia & Upjohn Company	Antimicrobial methods and materials
US7323174B1 (en)	2000-06-12	2008-01-29	Arizona Board Of Regents On Behalf Of The University Of Arizona	Modulation of immune response and methods based thereon
CU23002A1 (es) *	2000-12-01	2004-11-18	Ct Ingenieria Genetica Biotech	Método de obtención de agregados antigénicos y su uso en formulaciones
CA2327950A1 (en) *	2000-12-08	2002-06-08	Groupe Minutia Inc.	Grain refining agent for cast aluminum or magnesium products
US7713942B2 (en) *	2001-04-04	2010-05-11	Nordic Vaccine Technology A/S	Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
GB0112126D0 (en)	2001-05-18	2001-07-11	Allergene Inc	Composition
IL145926A0 (en) *	2001-10-15	2002-07-25	Mor Research Applic Ltd	Peptide epitopes of mimotopes useful in immunomodulation
US6861410B1 (en)	2002-03-21	2005-03-01	Chiron Corporation	Immunological adjuvant compositions
SE0202110D0 (sv) *	2002-07-05	2002-07-05	Isconova Ab	Iscom preparation and use thereof
EP1578443B1 (en) *	2002-11-20	2011-01-12	Bestewil Holding B.V.	Compositions comprising antigen-complexes, method for making same as well as methods of using the antigen-complexes for vaccination
US7491395B2 (en)	2002-11-20	2009-02-17	Bestewil Holding B.V.	Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination
IL155136A0 (en)	2003-02-10	2003-10-31	Enzymotec Ltd	A composition for reducing blood cholesterol and triglycerides
US20060233863A1 (en)	2003-02-10	2006-10-19	Enzymotec Ltd.	Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy
EP1447080A1 (en) *	2003-02-13	2004-08-18	Bestewil Holding B.V.	Method for producing virosome-like particles
SE0300795D0 (sv) *	2003-03-24	2003-03-24	Isconova Ab	Composition comprising iscom particles and live micro-organisms
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US9023366B2 (en)	2003-07-01	2015-05-05	The Royal Veterinary College	Vaccine composition for vaccinating dogs against canine infectious respiratory disease (CIRD)
SE0301998D0 (sv) *	2003-07-07	2003-07-07	Isconova Ab	Quil A fraction with low toxicity and use thereof
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CN101035594B (zh) *	2004-08-09	2013-10-23	酶学技术有限公司	用于糖尿病患者的食品
AU2005270831B2 (en)	2004-08-10	2011-08-25	Enzymotec Ltd.	Mixture of phytosterol ester(s) and 1, 3-diglyceride(s) for use in the treatment of medical conditions
CA2592627C (en) *	2005-01-20	2014-02-25	Isconova Ab	Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide
EP1896067B1 (en)	2005-06-16	2011-07-20	Universiteit Gent	Vaccines for immunization against helicobacter
US20100129288A1 (en) *	2005-06-28	2010-05-27	Elior Peles	Gliomedin, Fragments Thereof and Methods of Using Same
JP5318573B2 (ja)	2005-07-28	2013-10-16	ゾエティス・ピー・エルエルシー	ワクチン投与の方法、新たなネコカリシウイルス、ならびにネコパルボウイルスおよびネコヘルペスウイルスに対して動物を免疫感作する治療
EP1764369A1 (de)	2005-09-16	2007-03-21	Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH	Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants
PH12011502633A1 (en)	2005-10-07	2012-11-12	Zoetis P Llc	Vaccines and methods to treat canine influenza
EP2762163B1 (en)	2006-12-27	2018-01-03	Zoetis Services LLC	Methods of vaccine administration
WO2008142693A2 (en) *	2007-05-22	2008-11-27	Yeda Research And Development Co. Ltd.	Regulation of myelination by nectin-like (necl) molecules
JP2010038051A (ja)	2008-08-06	2010-02-18	Denso Corp	車載動力発生装置のトルク制御装置
EP3705133B1 (en)	2010-05-14	2024-06-26	Baxalta Incorporated	Ospa chimeras and use thereof in vaccines
SG186783A1 (en) *	2010-06-24	2013-02-28	Genentech Inc	Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations
WO2012010290A1 (en)	2010-07-21	2012-01-26	Athera Biotechnologies Ab	Diagnostic and therapeutic methods and compositions for metabolic disease
WO2012010291A1 (en)	2010-07-21	2012-01-26	Athera Biotechnologies Ab	Diagnostic and therapeutic methods and compositions for metabolic disease
WO2012059593A1 (en)	2010-11-05	2012-05-10	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Vaccines for preventing meningococcal infections
EP2462950A1 (en)	2010-12-08	2012-06-13	Neovacs	Strongly inactivated and still highly immunogenic vaccine, and process of manufacturing thereof
WO2012076668A1 (en)	2010-12-08	2012-06-14	Neovacs	Strongly inactivated and still highly immunogenic vaccine and process of manufacturing thereof
EP2691111B1 (en)	2011-03-31	2017-09-20	Institut National de la Sante et de la Recherche Medicale (INSERM)	Use of blood or tissue bacteriome for prediction, diagnosis and prevention of metabolic diseases and their cardiovascular complications
CA2832260C (en)	2011-04-07	2021-06-22	Neovacs	Method for treating ifnalpha related conditions
EP2508197A1 (en)	2011-04-07	2012-10-10	Neovacs	Method for treating IFNalpha related conditions
US10047116B2 (en) *	2011-10-03	2018-08-14	Mx Adjuvac Ab	Nanoparticles, process for preparation and use thereof as carrier for amphipatic and hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
GB201200259D0 (en)	2012-01-09	2012-02-22	Ohlin Per M	Novel therapies
JP2015524802A (ja)	2012-07-27	2015-08-27	バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒＩｎｔｅｒｎａｔｉｏｎａｌＩｎｃｏｒｐ０Ｒａｔｅｄ	キメラｏｓｐａ分子を含む組成物およびその使用方法
EP2949339A1 (en)	2014-05-29	2015-12-02	Ospedale San Raffaele S.r.l.	Agonist of CD1c-restricted T cells and uses thereof
US11725044B2 (en)	2014-10-15	2023-08-15	Xenothera	Method for producing polyclonal antibodies with improved complement-dependent cytotoxicity
EP4494650A3 (en)	2015-09-03	2025-03-26	Novavax, Inc.	Vaccine compositions having improved stability and immunogenicity
WO2019023196A1 (en)	2017-07-24	2019-01-31	Novavax, Inc.	METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISEASE
EP3768308A4 (en)	2018-03-19	2022-01-26	Novavax, Inc.	MULTIVALENT INFLUENZA NANOPARTICLE VACCINES
US10953089B1 (en)	2020-01-27	2021-03-23	Novavax, Inc.	Coronavirus vaccine formulations
EP3922255A1 (en)	2020-06-10	2021-12-15	Prokarium Limited	Cancer therapy
EP4124342A1 (en)	2021-07-28	2023-02-01	Prokarium Limited	Cancer therapy with live attenuated bacteria
GB2622559A (en)	2022-05-10	2024-03-27	Johan Frostegaard	Compositions, methods and uses
GB202215134D0 (en)	2022-10-13	2022-11-30	Prokarium Ltd	Composition
GB202215576D0 (en)	2022-10-21	2022-12-07	Prokarium Ltd	Circuit
WO2025068401A1 (en)	2023-09-28	2025-04-03	Prokarium Limited	Interleukin 15 variant
AU2024352706A1 (en)	2023-09-28	2026-04-02	Prokarium Limited	Interleukin 18 variants
WO2025109155A1 (en)	2023-11-24	2025-05-30	Prokarium Limited	Interleukin variant
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WO2025224251A1 (en)	2024-04-24	2025-10-30	Prokarium Limited	Modified microorganisms

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ES2039229T3 (es) *	1986-01-14	1993-09-16	De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur	Procedimiento para la preparacion de complejos inmunogenicos y composiciones farmaceuticas que contienen estos complejos.
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1987
- 1987-01-13 ES ES198787200035T patent/ES2039229T3/es not_active Expired - Lifetime
- 1987-01-13 AT AT87200035T patent/ATE71303T1/de not_active IP Right Cessation
- 1987-01-13 EP EP87200035A patent/EP0231039B1/en not_active Expired - Lifetime
- 1987-01-13 DK DK015087A patent/DK166762B1/da not_active IP Right Cessation
- 1987-01-13 DE DE8787200035T patent/DE3775783D1/de not_active Expired - Lifetime
- 1987-01-14 JP JP62007384A patent/JP2502558B2/ja not_active Expired - Lifetime
- 1987-01-14 US US07/003,070 patent/US4900549A/en not_active Expired - Lifetime
- 1987-01-14 CA CA000527289A patent/CA1279012C/en not_active Expired - Lifetime
1995
- 1995-11-28 JP JP7309056A patent/JP2703528B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS632933A (ja)	1988-01-07
DK166762B1 (da)	1993-07-12
US4900549A (en)	1990-02-13
ATE71303T1 (de)	1992-01-15
ES2039229T3 (es)	1993-09-16
DK15087A (da)	1987-07-15
EP0231039B1 (en)	1992-01-08
EP0231039A1 (en)	1987-08-05
JP2703528B2 (ja)	1998-01-26
DE3775783D1 (de)	1992-02-20
JPH08208513A (ja)	1996-08-13
CA1279012C (en)	1991-01-15
JP2502558B2 (ja)	1996-05-29

Legal Events

Date	Code	Title
1987-01-13	A0	Application filed
1993-07-12	B1	Patent granted (law 1993)
2007-01-29	PUP	Patent expired

Publication	Publication Date	Title
DK15087D0 (da)	1987-01-13	Immunogenkomplekser og deres anvendelse i laegemidler, isaer vacciner
CA2086831C (en)	1999-03-16	Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
KR100871021B1 (ko)	2008-11-27	인플루엔자 백신 조성물
NO862193D0 (no)	1986-06-03	Antracyklingholdig preparater og fremgangsmaate for deres fremstilling.
DE69423383T2 (de)	2000-08-24	Herstellung und Verwendungen von LOS-verminderten Aussenmembran-Proteinen von Gram-negativen Kokken
DE69131709T2 (de)	2000-05-25	Liposomen enthaltende impfstoffzusammensetzungen
US5879685A (en)	1999-03-09	Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
DK86988D0 (da)	1988-02-19	Liposompraeparat og anvendelse deraf
JP2002522397A (ja)	2002-07-23	他の界面活性剤を含有しない、ステロールとサポニンから成るｉｓｃｏｍを含むワクチン
PT91856A (pt)	1990-03-30	Processo de preparacao de uma matriz com actividade imunomodulante, a base lipido e saponina
PL336698A1 (en)	2000-07-03	Immunological aqueous adjuvants containing monophosphoril lipide a
RO119068B1 (ro)	2004-03-30	Compoziţie de vaccin conţinând o saponină şi un sterol
SE8201351L (sv)	1982-03-04	Sett att framstella liposomberedningar
DK0754055T3 (da)	2000-12-18	Gruppe A-streptokok-polysaccharid-immunogen-præparater og metoder
ES2085920T3 (es)	1996-06-16	Liposomas dirigidos y metodos de acoplamiento liposoma-proteina.
ES2389061T3 (es)	2012-10-22	Un sistema adyuvante que comprende virosomas y liposomas
DE69505236T2 (de)	1999-05-20	Liposomen und deren verwendung insbesondere zur herstellung immunomodulatorischer mittel
RU2364418C2 (ru)	2009-08-20	ВАКЦИННЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ЛИПОПОЛИСАХАРИДЫ ИММУНОТИПА L2 И/ИЛИ L3, ПРОИСХОДЯЩИЕ ИЗ ШТАММА NEISSERIA MENINGITIDIS IgtB-
DE69710476T2 (de)	2002-10-10	Alkaloidglykoside zur verwendung als arzneimittel
KR0173365B1 (ko)	1999-02-01	C형 간염 바이러스의 펩타이드 항원을 함유하는 리포좀
Stewart-Tull	1996	The Use of Adjuvants in Experimental Vaccines: IV. ISCOMS
KR0173366B1 (ko)	1999-02-01	B형 간염 바이러스의 펩타이드 항원을 함유하는 리포좀
SE8400934D0 (sv)	1984-02-21	Forfarande for framstellning av lyofiliserade, adsorberade, polyvalenta vacciner