DK1535901T3 - Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl - Google Patents

Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl

Info

Publication number: DK1535901T3
Authority: DK; Denmark
Prior art keywords: cyanobiphenyl; bromomethyl; bromine; oxidant; hydrogen bromide
Prior art date: 2002-06-12

Application number

DK02788757T

Other languages

Danish (da)

English (en)

Inventor

Seiji Yamada

Ken Ishihara

T Nakamatsu

Original Assignee

Sumitomo Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-12

Filing date

2002-12-09

Publication date

2008-04-07

2002-12-09 Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co

2008-04-07 Application granted granted Critical

2008-04-07 Publication of DK1535901T3 publication Critical patent/DK1535901T3/da

Links

LFFIEVAMVPCZNA-UHFFFAOYSA-N 2-[4-(bromomethyl)phenyl]benzonitrile Chemical group C1=CC(CBr)=CC=C1C1=CC=CC=C1C#N LFFIEVAMVPCZNA-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 4
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
229910052794 bromium Inorganic materials 0.000 abstract 3
229910000042 hydrogen bromide Inorganic materials 0.000 abstract 2
239000007800 oxidant agent Substances 0.000 abstract 2
230000001590 oxidative effect Effects 0.000 abstract 2
ZGQVZLSNEBEHFN-UHFFFAOYSA-N 2-(4-methylphenyl)benzonitrile Chemical group C1=CC(C)=CC=C1C1=CC=CC=C1C#N ZGQVZLSNEBEHFN-UHFFFAOYSA-N 0.000 abstract 1
238000005893 bromination reaction Methods 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000003999 initiator Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
229940127557 pharmaceutical product Drugs 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02788757T 2002-06-12 2002-12-09 Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl DK1535901T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2002172016		2002-06-12
PCT/JP2002/012847 WO2003106406A1 (fr)	2002-06-12	2002-12-09	Procede de production de 4'-bromomethyl-2-cyanobiphenyle

Publications (1)

Publication Number	Publication Date
DK1535901T3 true DK1535901T3 (da)	2008-04-07

Family

ID=29727838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02788757T DK1535901T3 (da)	2002-06-12	2002-12-09	Fremgangsmåde til fremstilling af 4' -brommethyl-2-cyanobiphenyl

Country Status (12)

Country	Link
US (1)	US6861549B2 (fr)
EP (1)	EP1535901B8 (fr)
JP (1)	JPWO2003106406A1 (fr)
KR (1)	KR100885148B1 (fr)
CN (1)	CN1285570C (fr)
AT (1)	ATE388136T1 (fr)
AU (1)	AU2002354446A1 (fr)
DE (1)	DE60225486T2 (fr)
DK (1)	DK1535901T3 (fr)
ES (1)	ES2299616T3 (fr)
PT (1)	PT1535901E (fr)
WO (1)	WO2003106406A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004103947A1 (fr) *	2003-05-20	2004-12-02	Sumitomo Chemical Company, Limited	Procede de production d'un compose d'ester carboxylique aromatique a substitution bromomethyle
CN1993355A (zh) *	2004-09-02	2007-07-04	特瓦制药工业有限公司	奥美沙坦酯的纯化方法
WO2006029057A1 (fr) *	2004-09-02	2006-03-16	Teva Pharmaceutical Industries, Ltd.	Epuration d'olmesartan medoxomil
US20070054948A1 (en) *	2004-09-02	2007-03-08	Lilach Hedvati	Purification of olmesartan medoxomil
US20060258727A1 (en) *	2005-01-03	2006-11-16	Lilach Hedvati	Olmesartan medoxomil with reduced levels of impurities
JP2006206446A (ja) *	2005-01-25	2006-08-10	Sumitomo Chemical Co Ltd	アラルキルハライド化合物の脱ハロゲン化方法及びこれを用いるアラルキル化合物の回収方法
CN101597243B (zh) *	2009-06-26	2012-11-21	凯莱英生命科学技术(天津)有限公司	一种2-氰基-4’-溴甲基联苯的合成方法
HUP0900788A2 (en) *	2009-12-16	2011-11-28	Sanofi Aventis	Process for producing 4-bromomethyl-biphenyl derivatives
CN108947870B (zh) *	2018-07-23	2021-03-19	湖北宇阳药业有限公司	一种溴代沙坦联苯的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1334092C (fr)	1986-07-11	1995-01-24	David John Carini	Imidazoles bloquant les recepteurs de l'angiotensine ii
GB8806584D0 (en) *	1988-03-19	1988-04-20	Interox Chemicals Ltd	Bromination
GB9017480D0 (en)	1990-08-09	1990-09-26	Ici Plc	Chemical process
GB9017482D0 (en)	1990-08-09	1990-09-26	Ici Plc	Manufacturing process
JP2859791B2 (ja)	1992-01-31	1999-02-24	吉富製薬株式会社	４−ブロモメチルビフェニル化合物の製造法
FR2689887B1 (fr)	1992-04-13	1995-06-23	Sanofi Elf	Procede de preparation d'un derive de biphenyle.
JPH06298684A (ja)	1993-04-15	1994-10-25	Sankyo Co Ltd	新規な４−（２−置換）フェニルベンジルブロミド類の製造法
JP2928982B2 (ja) *	1994-10-27	1999-08-03	住化ファインケム株式会社	４’−ブロモメチル−２−シアノビフェニルの製造法
US5892094A (en) *	1997-01-08	1999-04-06	Sumika Fine Chemicals Co., Ltd.	Process for preparing 4'-methyl-2-cyanobiphenyl
DE19712339C1 (de) *	1997-03-25	1998-04-09	Clariant Gmbh	Verfahren zur Herstellung von in 2'-Stellung substituierten 4-Brommethyl-biphenyl-Verbindungen
IT1291551B1 (it) *	1997-04-11	1999-01-11	Luso Farmaco Inst	Processo per la preparazione di composti 4-bromometil bifenilici
FR2771090B1 (fr)	1997-11-17	2000-02-04	Sanofi Sa	Procede de preparation de derives de bromomethyl-biphenyle
DE19757995A1 (de)	1997-12-29	1999-07-08	Great Lakes Chem Konstanz Gmbh	Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
JP2000256298A (ja) *	1999-03-05	2000-09-19	Sumika Fine Chemicals Co Ltd	芳香族α−ブロモアルキル化合物の製造方法
JP2002088044A (ja) *	2000-09-14	2002-03-27	Sumitomo Seika Chem Co Ltd	４’−ブロモメチル−２−シアノビフェニルの製造方法

2002
- 2002-12-09 ES ES02788757T patent/ES2299616T3/es not_active Expired - Lifetime
- 2002-12-09 EP EP02788757A patent/EP1535901B8/fr not_active Expired - Lifetime
- 2002-12-09 DK DK02788757T patent/DK1535901T3/da active
- 2002-12-09 KR KR1020047020182A patent/KR100885148B1/ko not_active Expired - Fee Related
- 2002-12-09 WO PCT/JP2002/012847 patent/WO2003106406A1/fr not_active Ceased
- 2002-12-09 DE DE60225486T patent/DE60225486T2/de not_active Expired - Lifetime
- 2002-12-09 AT AT02788757T patent/ATE388136T1/de active
- 2002-12-09 AU AU2002354446A patent/AU2002354446A1/en not_active Abandoned
- 2002-12-09 PT PT02788757T patent/PT1535901E/pt unknown
- 2002-12-09 CN CNB028291190A patent/CN1285570C/zh not_active Expired - Fee Related
- 2002-12-09 JP JP2004513240A patent/JPWO2003106406A1/ja active Pending
- 2002-12-17 US US10/322,017 patent/US6861549B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6861549B2 (en)	2005-03-01
JPWO2003106406A1 (ja)	2005-10-13
EP1535901A4 (fr)	2006-04-12
EP1535901A1 (fr)	2005-06-01
US20030233009A1 (en)	2003-12-18
CN1628094A (zh)	2005-06-15
WO2003106406A1 (fr)	2003-12-24
AU2002354446A1 (en)	2003-12-31
ATE388136T1 (de)	2008-03-15
EP1535901B8 (fr)	2008-09-24
PT1535901E (pt)	2008-04-10
ES2299616T3 (es)	2008-06-01
CN1285570C (zh)	2006-11-22
DE60225486T2 (de)	2009-04-02
KR100885148B1 (ko)	2009-02-23
EP1535901B1 (fr)	2008-03-05
DE60225486D1 (de)	2008-04-17
KR20050010046A (ko)	2005-01-26

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