DK1585810T3 - Fremgangsmåde til dyrkning af celler til produktion af substanser - Google Patents

Fremgangsmåde til dyrkning af celler til produktion af substanser

Info

Publication number
DK1585810T3
DK1585810T3 DK03767406.6T DK03767406T DK1585810T3 DK 1585810 T3 DK1585810 T3 DK 1585810T3 DK 03767406 T DK03767406 T DK 03767406T DK 1585810 T3 DK1585810 T3 DK 1585810T3
Authority
DK
Denmark
Prior art keywords
glucose
limitation
dgl
culturing cells
produce substances
Prior art date
Application number
DK03767406.6T
Other languages
Danish (da)
English (en)
Inventor
Jochen Gaetgens
Christian Wandrey
Ruth Essers
Thomas Link
Thomas Noll
Kerstin Skopnik
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1585810T3 publication Critical patent/DK1585810T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK03767406.6T 2002-11-27 2003-11-07 Fremgangsmåde til dyrkning af celler til produktion af substanser DK1585810T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10255508A DE10255508A1 (de) 2002-11-27 2002-11-27 Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen
PCT/DE2003/003693 WO2004048556A1 (de) 2002-11-27 2003-11-07 Verfahren zur kultivierung von zellen zur produktion von substanzen

Publications (1)

Publication Number Publication Date
DK1585810T3 true DK1585810T3 (da) 2010-06-07

Family

ID=32318751

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03767406.6T DK1585810T3 (da) 2002-11-27 2003-11-07 Fremgangsmåde til dyrkning af celler til produktion af substanser
DK10152393.4T DK2226381T3 (en) 2002-11-27 2003-11-07 Process for the cultivation of cells for production of compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10152393.4T DK2226381T3 (en) 2002-11-27 2003-11-07 Process for the cultivation of cells for production of compounds

Country Status (12)

Country Link
US (2) US20060127975A1 (2)
EP (3) EP1585810B1 (2)
JP (2) JP4469283B2 (2)
AT (1) ATE462013T1 (2)
CY (2) CY1110267T1 (2)
DE (2) DE10255508A1 (2)
DK (2) DK1585810T3 (2)
ES (3) ES2340377T3 (2)
HU (1) HUE028862T2 (2)
PT (1) PT1585810E (2)
SI (3) SI2275530T1 (2)
WO (1) WO2004048556A1 (2)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322216A1 (en) 1997-03-21 2011-05-18 Chugai Seiyaku Kabushiki Kaisha A preventive or therapeutic agent for sensitized T cell-mediated diseases comprising IL-6 antagonist as an active ingredient
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
EP1623019B2 (en) * 2003-05-15 2017-01-25 Wyeth LLC Restricted glucose feed for animal cell culture
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
AU2016210748B2 (en) * 2009-10-26 2018-03-01 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
AU2015203309B2 (en) * 2009-10-26 2016-05-05 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
SI2493922T1 (sl) 2009-10-26 2017-06-30 F. Hoffmann-La Roche Ag Postopek za proizvodnjo glikoziliranega imunoglobulina
TWI537386B (zh) * 2009-12-22 2016-06-11 Ｄｓｍ智慧財產有限公司 由發酵法獲得的６－胺己酸製備己內醯胺
KR20190120439A (ko) 2010-11-08 2019-10-23 제넨테크, 인크. 피하 투여용 항―ｉｌ―6 수용체 항체
BR112015032960B1 (pt) 2013-07-04 2021-01-05 F. Hoffmann-La Roche Ag imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro
US10544395B2 (en) 2014-03-19 2020-01-28 Pfizer Inc. Method of cell culture
JP7001585B2 (ja) 2015-09-23 2022-02-04 ファイザー・インク 細胞および細胞培養の方法
EP3891292A1 (en) 2018-12-06 2021-10-13 Pfizer Inc. Cells with reduced inhibitor production and methods of use thereof
WO2025088516A1 (en) 2023-10-26 2025-05-01 Pfizer Inc. Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657863A (en) * 1982-07-02 1987-04-14 Celanese Corporation Stabilization of a mutant microorganism population
JPH066054B2 (ja) * 1987-10-15 1994-01-26 帝人株式会社 動物細胞の培養方法
JP3494300B2 (ja) * 1990-04-03 2004-02-09 ジェネンテック・インコーポレーテッド Ｈｉｖに対する予防接種のための方法および組成物
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
JPH08508875A (ja) * 1992-05-01 1996-09-24 帝人株式会社 蛋白分泌細胞の流加回分培養法
GB9506249D0 (en) * 1995-03-27 1995-05-17 Karobio Ab Media for insect cell cultures
WO1998041611A1 (en) 1997-03-20 1998-09-24 Regents Of The University Of Minnesota Process for the continuous culture of cells
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration

Also Published As

Publication number Publication date
ES2340377T3 (es) 2010-06-02
DE10255508A1 (de) 2004-06-17
EP2226381A1 (de) 2010-09-08
DK2226381T3 (en) 2016-04-11
SI1585810T1 (sl) 2010-06-30
JP2006507821A (ja) 2006-03-09
JP4469283B2 (ja) 2010-05-26
ES2749217T3 (es) 2020-03-19
JP2010110331A (ja) 2010-05-20
ATE462013T1 (de) 2010-04-15
JP5221573B2 (ja) 2013-06-26
ES2567161T3 (es) 2016-04-20
SI2226381T1 (sl) 2016-05-31
HUE028862T2 (en) 2017-01-30
EP1585810B1 (de) 2010-03-24
EP1585810A1 (de) 2005-10-19
EP2275530B1 (de) 2019-08-07
CY1117558T1 (el) 2017-04-26
EP2275530A2 (de) 2011-01-19
PT1585810E (pt) 2010-05-05
US20140329277A1 (en) 2014-11-06
SI2275530T1 (sl) 2019-11-29
EP2226381B1 (de) 2016-03-09
DE50312554D1 (de) 2010-05-06
US20060127975A1 (en) 2006-06-15
EP2275530A3 (de) 2012-05-23
WO2004048556A1 (de) 2004-06-10
CY1110267T1 (el) 2015-01-14

Similar Documents

Publication Publication Date Title
CY1117558T1 (el) Μεθοδος για καλλιεργεια κυτταρων για παραγωγη ουσιων
IL250313B (en) Expansion of renewable stem cell populations
DK1651758T3 (da) Fremgangsmåde tl fremstilling af L-lysin eller L-threonin ved anvendelse af Escherichia bakterier med svækket æblesyreenzymaktivitet
WO2003089567A3 (en) Apparatus and method for a cell culture in a bioreactor at high cell concentration
IL132598A0 (en) Method for purifying lactic acid
ATE549395T1 (de) Medium und kultur von embryonalen stammzellen
DE602004027905D1 (de) Kontrollierte glukosezufuhr für tierzellkultur
YU61799A (sh) Postupak za fermentacionu proizvodnju d-pantotenske kiseline pomoću pojačanja pan d-gena u mikroorganizmima
WO2005028626A3 (en) Cell culture media
ATE532871T1 (de) Transformierte pflanzen mit verbesserter biosynthese von prenylquinonen
ATE449175T1 (de) Bakterielle produktion von interferon-beta polypeptiden
TR200401091T4 (tr) Gelişim faktörleri ve L-glutamin içeren hücre kültürü besiyeri
DE60138127D1 (de) Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine
DK1085083T3 (da) Dyrkningsmedium for dyreceller og fremgangsmåde til proteinfremstilling under anvendelse af dette
UA92157C2 (ru) Способ продуцирования гормона роста
DE60307615D1 (de) Zellkulturmedium
DE60123397D1 (de) Methode zur erhöhung der fermentationsgeschwindigkeit von hefe
ATE449162T1 (de) Herstellung von tcr gamma delta t-zellen
MY146013A (en) Process for purifying mesotrione
WO2005054447A3 (en) Müller stem cells
BRPI0403200A (pt) Método para recrescimento de células embriogênicas crioconservadas de conìferas
ATE522604T1 (de) Verfahren zur herstellung von proteinen durch elektropulsierung
AU2003242533A1 (en) Glutamine-free medium
DK1238057T3 (da) Fremgangsmåde til produktion af vedhæftende dyreceller
DE60132466D1 (de) Verfahren zur kultivierung von menschlichen lungenmastzellen und deren anwendungen