DK160460C - Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet - Google Patents

Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet

Info

Publication number: DK160460C
Authority: DK; Denmark
Prior art keywords: preparation; insulin; nasal; pct; rectal administration
Prior art date: 1986-04-18

Application number

DK642587A

Other languages

English (en)

Other versions

DK160460B (da

DK642587A (da

DK642587D0 (da

Inventor

Per Balschmidt

Finn Benned Hansen

Bente Rose Johansen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-18

Filing date

1987-12-08

Publication date

1991-08-26

1987-12-08 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1987-12-08 Priority to DK642587A priority Critical patent/DK160460C/da

1987-12-08 Publication of DK642587A publication Critical patent/DK642587A/da

1987-12-08 Publication of DK642587D0 publication Critical patent/DK642587D0/da

1991-03-18 Publication of DK160460B publication Critical patent/DK160460B/da

1991-08-26 Application granted granted Critical

1991-08-26 Publication of DK160460C publication Critical patent/DK160460C/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 9
102000004877 Insulin Human genes 0.000 title abstract 5
108090001061 Insulin Proteins 0.000 title abstract 5
229940125396 insulin Drugs 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 4
239000004026 insulin derivative Substances 0.000 title abstract 2
238000010521 absorption reaction Methods 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000178 monomer Substances 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
238000001179 sorption measurement Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Otolaryngology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

DK642587A 1986-04-18 1987-12-08 Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet DK160460C (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK642587A DK160460C (da)	1986-04-18	1987-12-08	Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DK179286		1986-04-18
DK179286A DK179286D0 (da)	1986-04-18	1986-04-18	Insulinpraeparat
DK8700038		1987-04-14
PCT/DK1987/000038 WO1987006137A1 (en)	1986-04-18	1987-04-14	An insulin preparation for non-parenteral administration
DK642587A DK160460C (da)	1986-04-18	1987-12-08	Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet
DK642587		1987-12-08

Publications (4)

Publication Number	Publication Date
DK642587A DK642587A (da)	1987-12-08
DK642587D0 DK642587D0 (da)	1987-12-08
DK160460B DK160460B (da)	1991-03-18
DK160460C true DK160460C (da)	1991-08-26

Family

ID=8108089

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK179286A DK179286D0 (da)	1986-04-18	1986-04-18	Insulinpraeparat
DK642587A DK160460C (da)	1986-04-18	1987-12-08	Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK179286A DK179286D0 (da)	1986-04-18	1986-04-18	Insulinpraeparat

Country Status (13)

Country	Link
US (1)	US5053389A (da)
EP (1)	EP0267208B1 (da)
JP (1)	JPH01500116A (da)
AT (1)	ATE66614T1 (da)
AU (1)	AU598543B2 (da)
CA (1)	CA1283358C (da)
DE (1)	DE3772521D1 (da)
DK (2)	DK179286D0 (da)
ES (1)	ES2007607A6 (da)
FI (1)	FI87529C (da)
IL (1)	IL82209A0 (da)
NO (1)	NO875299D0 (da)
WO (1)	WO1987006137A1 (da)

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ES2062227T3 (es) *	1989-08-21	1994-12-16	Hoffmann La Roche	Composiciones farmaceuticas no parenterales para la insulina.
IL99699A (en) *	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP1607086A1 (en) *	1993-01-29	2005-12-21	Aradigm Corporation	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US6131567A (en) *	1993-01-29	2000-10-17	Aradigm Corporation	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
TW404844B (en) *	1993-04-08	2000-09-11	Oxford Biosciences Ltd	Needleless syringe
US6893664B1 (en) *	1996-06-17	2005-05-17	Powderject Research Limited	Particle delivery techniques
US5948751A (en) *	1996-06-20	1999-09-07	Novo Nordisk A/S	X14-mannitol
UA65549C2 (uk) *	1996-11-05	2004-04-15	Елі Ліллі Енд Компані	Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
AR012894A1 (es) *	1997-06-13	2000-11-22	Lilly Co Eli	Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
DK1283051T3 (da) *	1997-06-13	2006-10-16	Lilly Co Eli	Stabile insulinformuleringer
US20010053761A1 (en) *	1998-01-08	2001-12-20	Dimarchi Richard Dennis	Method for administering aspb28-human insulin
US6350458B1 (en)	1998-02-10	2002-02-26	Generex Pharmaceuticals Incorporated	Mixed micellar drug deliver system and method of preparation
US6221378B1 (en)	1998-02-10	2001-04-24	Generex Pharmaceuticals Incorporated	Mixed micellar delivery system and method of preparation
US7070799B1 (en) *	1998-02-10	2006-07-04	Generex Pharmaceuticals, Inc.	Method for administering insulin to the buccal region
US7087215B2 (en) *	1998-12-21	2006-08-08	Generex Pharmaceuticals Incorporated	Methods of administering and enhancing absorption of pharmaceutical agents
US6375975B1 (en)	1998-12-21	2002-04-23	Generex Pharmaceuticals Incorporated	Pharmaceutical compositions for buccal and pulmonary application
US6294153B1 (en)	1998-12-21	2001-09-25	Generex Pharmaceuticals, Inc.	Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US6849263B2 (en) *	1998-12-21	2005-02-01	Generex Pharmaceutical Incorporated	Pharmaceutical compositions for buccal delivery of pain relief medications
US6451286B1 (en)	1998-12-21	2002-09-17	Generex Pharmaceuticals Incorporated	Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6350432B1 (en)	1999-03-19	2002-02-26	Generex Pharmaceuticals Incorporated	Pressurized container having an aerosolized pharmaceutical composition
AU5936400A (en)	1999-06-04	2000-12-28	Delrx Pharmaceutical Corporation	Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
GB2355009A (en) *	1999-07-30	2001-04-11	Univ Glasgow	Peptides conjugated to bile acids/salts
US6926898B2 (en)	2000-04-12	2005-08-09	Human Genome Sciences, Inc.	Albumin fusion proteins
US8061006B2 (en) *	2001-07-26	2011-11-22	Powderject Research Limited	Particle cassette, method and kit therefor
WO2005003296A2 (en)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Albumin fusion proteins
CA2841097A1 (en)	2001-12-21	2003-07-24	Human Genome Sciences, Inc.	Albumin and g-csf fusion proteins
US8147426B2 (en) *	2003-12-31	2012-04-03	Nipro Diagnostics, Inc.	Integrated diagnostic test system
WO2007140619A1 (en) *	2006-06-08	2007-12-13	Diabecore Medical Inc.	Derivatized insulin oligomers
ES2579229T3 (es)	2007-03-13	2016-08-08	Jds Therapeutics, Llc	Procedimientos y composiciones para la liberación sostenida de cromo
WO2008132224A2 (en) *	2007-04-30	2008-11-06	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
WO2009002867A2 (en)	2007-06-26	2008-12-31	Nutrition 21, Inc.	Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
EP2077132A1 (en)	2008-01-02	2009-07-08	Boehringer Ingelheim Pharma GmbH & Co. KG	Dispensing device, storage device and method for dispensing a formulation
EP2414560B1 (de)	2009-03-31	2013-10-23	Boehringer Ingelheim International GmbH	Verfahren zur beschichtung einer oberfläche eines bauteils
EP2432531B1 (de)	2009-05-18	2019-03-06	Boehringer Ingelheim International GmbH	Adapter, inhalationseinrichtung und zerstäuber
MX2012005961A (es)	2009-11-25	2012-06-14	Boehringer Ingelheim Int	Nebulizador.
WO2011064163A1 (en)	2009-11-25	2011-06-03	Boehringer Ingelheim International Gmbh	Nebulizer
US10016568B2 (en)	2009-11-25	2018-07-10	Boehringer Ingelheim International Gmbh	Nebulizer
EP2585151B1 (en)	2010-06-24	2018-04-04	Boehringer Ingelheim International GmbH	Nebulizer
AU2012223282B2 (en)	2011-03-01	2017-02-02	Nutrition 21, Llc	Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
WO2012130757A1 (de)	2011-04-01	2012-10-04	Boehringer Ingelheim International Gmbh	Medizinisches gerät mit behälter
US9827384B2 (en)	2011-05-23	2017-11-28	Boehringer Ingelheim International Gmbh	Nebulizer
WO2013152894A1 (de)	2012-04-13	2013-10-17	Boehringer Ingelheim International Gmbh	Zerstäuber mit kodiermitteln
JP6643231B2 (ja)	2013-08-09	2020-02-12	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ネブライザ
EP2835146B1 (en)	2013-08-09	2020-09-30	Boehringer Ingelheim International GmbH	Nebulizer
HUE058904T2 (hu)	2014-05-07	2022-09-28	Boehringer Ingelheim Int	Porlasztókészülék
US10722666B2 (en)	2014-05-07	2020-07-28	Boehringer Ingelheim International Gmbh	Nebulizer with axially movable and lockable container and indicator
CA2948071C (en)	2014-05-07	2022-08-30	Boehringer Ingelheim International Gmbh	Container, nebulizer and use
AU2017217466A1 (en)	2016-02-11	2018-08-23	Nutrition 21, Llc	Chromium containing compositions for improving health and fitness

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Publication number	Priority date	Publication date	Assignee	Title
GB1381274A (en) *	1971-01-28	1975-01-22	Nat Res Dev	Insulin derivatives
IE36225B1 (en) *	1971-01-28	1976-09-15	Nat Res Dev	Improvements relating to insulin derivatives
GB1381273A (en) *	1971-01-28	1975-01-22	Nat Res Dev	Insulin derivatives
DK135268A (da) *	1973-02-09
US4153689A (en) *	1975-06-13	1979-05-08	Takeda Chemical Industries, Ltd.	Stable insulin preparation for nasal administration
US4164573A (en) *	1975-06-13	1979-08-14	Galinsky Alvin M	Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal
GB1554157A (en) *	1975-06-13	1979-10-17	Takeda Chemical Industries Ltd	Stable insulin preparation for intra nasal administration
GB1527605A (en) *	1975-08-20	1978-10-04	Takeda Chemical Industries Ltd	Insulin preparation for intranasal administration
US4442090A (en) *	1980-11-09	1984-04-10	Kyoto Yakuhin Kogyo Kabushiki Kaisha	Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use
JPS58189118A (ja) *	1982-04-30	1983-11-04	Takeda Chem Ind Ltd	経鼻投与製剤
EP0093551B1 (en) *	1982-04-30	1991-01-16	Ajinomoto Co., Inc.	Pharmaceutical composition
US4534894A (en) *	1982-11-17	1985-08-13	The Rockefeller University	Process for sulphation and phosphorylation of proteins and peptides
JPS59163313A (ja) *	1983-03-09	1984-09-14	Teijin Ltd	経鼻投与用ペプチドホルモン類組成物
IL68769A (en) *	1983-05-23	1986-02-28	Hadassah Med Org	Pharmaceutical compositions containing insulin for oral administration
US4746508A (en) *	1983-06-06	1988-05-24	Beth Israel Hospital Assn.	Drug administration
JPS60224616A (ja) *	1984-04-24	1985-11-09	Teijin Ltd	経鼻投与用組成物

1986
- 1986-04-18 DK DK179286A patent/DK179286D0/da not_active Application Discontinuation
1987
- 1987-04-10 CA CA000534467A patent/CA1283358C/en not_active Expired - Lifetime
- 1987-04-13 IL IL82209A patent/IL82209A0/xx not_active IP Right Cessation
- 1987-04-14 JP JP62502696A patent/JPH01500116A/ja active Pending
- 1987-04-14 AT AT87902450T patent/ATE66614T1/de active
- 1987-04-14 US US07/132,969 patent/US5053389A/en not_active Expired - Fee Related
- 1987-04-14 EP EP87902450A patent/EP0267208B1/en not_active Expired - Lifetime
- 1987-04-14 WO PCT/DK1987/000038 patent/WO1987006137A1/en not_active Ceased
- 1987-04-14 DE DE8787902450T patent/DE3772521D1/de not_active Expired - Lifetime
- 1987-04-14 AU AU73561/87A patent/AU598543B2/en not_active Ceased
- 1987-04-15 ES ES8701124A patent/ES2007607A6/es not_active Expired
- 1987-12-08 DK DK642587A patent/DK160460C/da not_active IP Right Cessation
- 1987-12-16 FI FI875533A patent/FI87529C/fi not_active IP Right Cessation
- 1987-12-17 NO NO875299A patent/NO875299D0/no unknown

Also Published As

Publication number	Publication date
AU7356187A (en)	1987-11-09
WO1987006137A1 (en)	1987-10-22
ES2007607A6 (es)	1989-07-01
IL82209A0 (en)	1987-10-30
NO875299L (no)	1987-12-17
ATE66614T1 (de)	1991-09-15
EP0267208B1 (en)	1991-08-28
DK160460B (da)	1991-03-18
CA1283358C (en)	1991-04-23
DK179286D0 (da)	1986-04-18
FI87529C (fi)	1993-01-25
AU598543B2 (en)	1990-06-28
FI875533L (fi)	1987-12-16
EP0267208A1 (en)	1988-05-18
DE3772521D1 (de)	1991-10-02
JPH01500116A (ja)	1989-01-19
US5053389A (en)	1991-10-01
DK642587A (da)	1987-12-08
FI875533A0 (fi)	1987-12-16
DK642587D0 (da)	1987-12-08
FI87529B (fi)	1992-10-15
NO875299D0 (no)	1987-12-17

Legal Events

Date	Code	Title	Description
1997-12-22	PBP	Patent lapsed

Publication	Publication Date	Title
FI875533A0 (fi)	1987-12-16	Insulinpreparat foer non-parenteral dosering.
PH23014A (en)	1989-03-03	Novel insulin derivatives,their use and pharmaceutical agents for the treatment of diabetes mellitus
HUP0002373A2 (hu)	2000-10-28	Glükagon antagonisták/inverz agonisták és ezeket tartalmazó gyógyászati készítmények
DE69011059D1 (de)	1994-09-01	Heterozyklische Acylaminothiazolderivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen.
DE19375061I2 (de)	2008-11-20	Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
NO884625D0 (no)	1988-10-18	N-substituerte derivater av 1-desoksynojirimycin og 1-desoksymannojirimycin, fremgangsmaate for deres fremstilling og deres anvendelse i legemiddel.
NO875378L (no)	1988-06-24	Fremgangsmaate for fremstilling av granulocyttstimulerendefaktor (polypeptidderivater).
IS1565B (is)	1994-12-13	Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
NO871295D0 (no)	1987-03-27	Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
IT1183181B (it)	1987-10-05	Derivati del 3-metil-imidazo(4,5-c)pirazolo con attivita' terapeutica e procedimento per la loropreparazione
NO870049D0 (no)	1987-01-06	Fremgangsmaate for fremstilling av terapeutisk aktive aminosyrederivater.
DK73287D0 (da)	1987-02-13	Insulinderivater, deres fremstilling og anvendelse
FI844153A7 (fi)	1985-04-25	1,2-ditiolaanijohdannaiset, niiden valmistusmenetelmät, niitä sisältävät farmaseuttiset valmisteet ja niiden käyttö.
DK197689D0 (da)	1989-04-24	Pyridazinderivater
NO870834D0 (no)	1987-02-27	Glysero-3(2)-fosfo-l-serinderivater og salter derav, fremgangsmaater for fremstilling derav og farmasoeytiske preparater inneholdende derivatene.
DE3751597D1 (de)	1995-12-21	Verwendung von 15-Deoxyspergualin als Arzneimittel.
DE3650368D1 (de)	1995-09-21	Verwendung von Depogen zur Behandlung von eingeschränktem Blutkreislauf.
DE3876425D1 (de)	1993-01-14	Gesteuerte verabreichung eines heilmittels an blut.
DE3788888D1 (de)	1994-03-10	Perhydrothiazepin- und Perhydroazepinderivate, ihre Herstellung und ihre therapeutische Verwendung.
DK314587A (da)	1987-12-25	1,4-dihydropyridinderivater, fremgangsmaade til deres fremstilling og laegemidler, der indeholder disse forbindelser
NO873385D0 (no)	1987-08-12	Oksiran-pseudooligosakkarider, fremgangsmaate til deres fremstilling, deres anvendelse og farmasoeytiske preparater.
ATE100803T1 (de)	1994-02-15	Perhydrothiazepin- und perhydroazepinderivate, ihre herstellung und ihre therapeutische verwendung.
ATA273988A (de)	2000-12-15	Neue verwendung von 11,28-dioxa-4-azatricyclo- (22.3.1.04,9)octacos-18-en-derivaten und sie enthaltende pharmazeutische zubereitungen
ATE75613T1 (de)	1992-05-15	17-benzylspartein-derivate enthaltende positiv inotrop wirksame pharmazeutische zubereitungen.
DK98788D0 (da)	1988-02-25	Benzylaminoaryl-dihydropyridinlactoner, fremgangmsaade til deres fremstilling samt deres anvendelse som laegemidler