JPH01500116A - インシユリン製剤 - Google Patents

インシユリン製剤

Info

Publication number: JPH01500116A
Authority: JP; Japan
Prior art keywords: insulin; derivatives; administration; physiological; solution
Prior art date: 1986-04-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP62502696A

Other languages

English (en)

Japanese (ja)

Inventor

バルシユミツト．ペル

ハンセン，フイン　ベネド

ヨハンセン，ベンテ　ロゼ

Original Assignee

ノボ　ノルデイスク　アクツイエセルスカプ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-18

Filing date

1987-04-14

Publication date

1989-01-19

1987-04-14 Application filed by ノボ　ノルデイスク　アクツイエセルスカプ filed Critical ノボ　ノルデイスク　アクツイエセルスカプ

1989-01-19 Publication of JPH01500116A publication Critical patent/JPH01500116A/ja

Status Pending legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims description 171
102000004877 Insulin Human genes 0.000 title claims description 77
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239000004026 insulin derivative Substances 0.000 claims description 4
238000007911 parenteral administration Methods 0.000 claims description 4
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FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
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WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
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PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 3
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FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
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IWQPOPSAISBUAH-VOVMJQHHSA-M sodium;2-[[(2z)-2-[(3r,4s,5s,8s,9s,10s,11r,13r,14s,16s)-16-acetyl-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ylidene]-6-methylheptanoyl]amino]ethanesulfonate Chemical compound [Na+].C1C[C@@H](O)[C@@H](C)[C@@H]2CC[C@]3(C)[C@@]4(C)C[C@H](C(C)=O)/C(=C(C(=O)NCCS([O-])(=O)=O)/CCCC(C)C)[C@@H]4C[C@@H](O)[C@H]3[C@]21C IWQPOPSAISBUAH-VOVMJQHHSA-M 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
108700009606 tetrakis(3-nitro-Tyr)- insulin Proteins 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
230000008733 trauma Effects 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Otolaryngology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

JP62502696A 1986-04-18 1987-04-14 インシユリン製剤 Pending JPH01500116A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK1792/86		1986-04-18
DK179286A DK179286D0 (da)	1986-04-18	1986-04-18	Insulinpraeparat

Publications (1)

Publication Number	Publication Date
JPH01500116A true JPH01500116A (ja)	1989-01-19

Family

ID=8108089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP62502696A Pending JPH01500116A (ja)	1986-04-18	1987-04-14	インシユリン製剤

Country Status (13)

Country	Link
US (1)	US5053389A (da)
EP (1)	EP0267208B1 (da)
JP (1)	JPH01500116A (da)
AT (1)	ATE66614T1 (da)
AU (1)	AU598543B2 (da)
CA (1)	CA1283358C (da)
DE (1)	DE3772521D1 (da)
DK (2)	DK179286D0 (da)
ES (1)	ES2007607A6 (da)
FI (1)	FI87529C (da)
IL (1)	IL82209A0 (da)
NO (1)	NO875299D0 (da)
WO (1)	WO1987006137A1 (da)

Cited By (1)

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US9387176B2 (en)	2007-04-30	2016-07-12	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein

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FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP1607086A1 (en) *	1993-01-29	2005-12-21	Aradigm Corporation	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US6131567A (en) *	1993-01-29	2000-10-17	Aradigm Corporation	Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
TW404844B (en) *	1993-04-08	2000-09-11	Oxford Biosciences Ltd	Needleless syringe
US6893664B1 (en) *	1996-06-17	2005-05-17	Powderject Research Limited	Particle delivery techniques
US5948751A (en) *	1996-06-20	1999-09-07	Novo Nordisk A/S	X14-mannitol
UA65549C2 (uk) *	1996-11-05	2004-04-15	Елі Ліллі Енд Компані	Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
AR012894A1 (es) *	1997-06-13	2000-11-22	Lilly Co Eli	Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
DK1283051T3 (da) *	1997-06-13	2006-10-16	Lilly Co Eli	Stabile insulinformuleringer
US20010053761A1 (en) *	1998-01-08	2001-12-20	Dimarchi Richard Dennis	Method for administering aspb28-human insulin
US6350458B1 (en)	1998-02-10	2002-02-26	Generex Pharmaceuticals Incorporated	Mixed micellar drug deliver system and method of preparation
US6221378B1 (en)	1998-02-10	2001-04-24	Generex Pharmaceuticals Incorporated	Mixed micellar delivery system and method of preparation
US7070799B1 (en) *	1998-02-10	2006-07-04	Generex Pharmaceuticals, Inc.	Method for administering insulin to the buccal region
US7087215B2 (en) *	1998-12-21	2006-08-08	Generex Pharmaceuticals Incorporated	Methods of administering and enhancing absorption of pharmaceutical agents
US6375975B1 (en)	1998-12-21	2002-04-23	Generex Pharmaceuticals Incorporated	Pharmaceutical compositions for buccal and pulmonary application
US6294153B1 (en)	1998-12-21	2001-09-25	Generex Pharmaceuticals, Inc.	Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US6849263B2 (en) *	1998-12-21	2005-02-01	Generex Pharmaceutical Incorporated	Pharmaceutical compositions for buccal delivery of pain relief medications
US6451286B1 (en)	1998-12-21	2002-09-17	Generex Pharmaceuticals Incorporated	Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6350432B1 (en)	1999-03-19	2002-02-26	Generex Pharmaceuticals Incorporated	Pressurized container having an aerosolized pharmaceutical composition
AU5936400A (en)	1999-06-04	2000-12-28	Delrx Pharmaceutical Corporation	Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
GB2355009A (en) *	1999-07-30	2001-04-11	Univ Glasgow	Peptides conjugated to bile acids/salts
US6926898B2 (en)	2000-04-12	2005-08-09	Human Genome Sciences, Inc.	Albumin fusion proteins
US8061006B2 (en) *	2001-07-26	2011-11-22	Powderject Research Limited	Particle cassette, method and kit therefor
WO2005003296A2 (en)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Albumin fusion proteins
CA2841097A1 (en)	2001-12-21	2003-07-24	Human Genome Sciences, Inc.	Albumin and g-csf fusion proteins
US8147426B2 (en) *	2003-12-31	2012-04-03	Nipro Diagnostics, Inc.	Integrated diagnostic test system
WO2007140619A1 (en) *	2006-06-08	2007-12-13	Diabecore Medical Inc.	Derivatized insulin oligomers
ES2579229T3 (es)	2007-03-13	2016-08-08	Jds Therapeutics, Llc	Procedimientos y composiciones para la liberación sostenida de cromo
WO2009002867A2 (en)	2007-06-26	2008-12-31	Nutrition 21, Inc.	Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
EP2077132A1 (en)	2008-01-02	2009-07-08	Boehringer Ingelheim Pharma GmbH & Co. KG	Dispensing device, storage device and method for dispensing a formulation
EP2414560B1 (de)	2009-03-31	2013-10-23	Boehringer Ingelheim International GmbH	Verfahren zur beschichtung einer oberfläche eines bauteils
EP2432531B1 (de)	2009-05-18	2019-03-06	Boehringer Ingelheim International GmbH	Adapter, inhalationseinrichtung und zerstäuber
MX2012005961A (es)	2009-11-25	2012-06-14	Boehringer Ingelheim Int	Nebulizador.
WO2011064163A1 (en)	2009-11-25	2011-06-03	Boehringer Ingelheim International Gmbh	Nebulizer
US10016568B2 (en)	2009-11-25	2018-07-10	Boehringer Ingelheim International Gmbh	Nebulizer
EP2585151B1 (en)	2010-06-24	2018-04-04	Boehringer Ingelheim International GmbH	Nebulizer
AU2012223282B2 (en)	2011-03-01	2017-02-02	Nutrition 21, Llc	Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
WO2012130757A1 (de)	2011-04-01	2012-10-04	Boehringer Ingelheim International Gmbh	Medizinisches gerät mit behälter
US9827384B2 (en)	2011-05-23	2017-11-28	Boehringer Ingelheim International Gmbh	Nebulizer
WO2013152894A1 (de)	2012-04-13	2013-10-17	Boehringer Ingelheim International Gmbh	Zerstäuber mit kodiermitteln
JP6643231B2 (ja)	2013-08-09	2020-02-12	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ネブライザ
EP2835146B1 (en)	2013-08-09	2020-09-30	Boehringer Ingelheim International GmbH	Nebulizer
HUE058904T2 (hu)	2014-05-07	2022-09-28	Boehringer Ingelheim Int	Porlasztókészülék
US10722666B2 (en)	2014-05-07	2020-07-28	Boehringer Ingelheim International Gmbh	Nebulizer with axially movable and lockable container and indicator
CA2948071C (en)	2014-05-07	2022-08-30	Boehringer Ingelheim International Gmbh	Container, nebulizer and use
AU2017217466A1 (en)	2016-02-11	2018-08-23	Nutrition 21, Llc	Chromium containing compositions for improving health and fitness

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JPS58189118A (ja) *	1982-04-30	1983-11-04	Takeda Chem Ind Ltd	経鼻投与製剤
JPS59163313A (ja) *	1983-03-09	1984-09-14	Teijin Ltd	経鼻投与用ペプチドホルモン類組成物
JPS60224616A (ja) *	1984-04-24	1985-11-09	Teijin Ltd	経鼻投与用組成物

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GB1381273A (en) *	1971-01-28	1975-01-22	Nat Res Dev	Insulin derivatives
DK135268A (da) *	1973-02-09
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US4164573A (en) *	1975-06-13	1979-08-14	Galinsky Alvin M	Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal
GB1554157A (en) *	1975-06-13	1979-10-17	Takeda Chemical Industries Ltd	Stable insulin preparation for intra nasal administration
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US4534894A (en) *	1982-11-17	1985-08-13	The Rockefeller University	Process for sulphation and phosphorylation of proteins and peptides
IL68769A (en) *	1983-05-23	1986-02-28	Hadassah Med Org	Pharmaceutical compositions containing insulin for oral administration
US4746508A (en) *	1983-06-06	1988-05-24	Beth Israel Hospital Assn.	Drug administration

1986
- 1986-04-18 DK DK179286A patent/DK179286D0/da not_active Application Discontinuation
1987
- 1987-04-10 CA CA000534467A patent/CA1283358C/en not_active Expired - Lifetime
- 1987-04-13 IL IL82209A patent/IL82209A0/xx not_active IP Right Cessation
- 1987-04-14 JP JP62502696A patent/JPH01500116A/ja active Pending
- 1987-04-14 AT AT87902450T patent/ATE66614T1/de active
- 1987-04-14 US US07/132,969 patent/US5053389A/en not_active Expired - Fee Related
- 1987-04-14 EP EP87902450A patent/EP0267208B1/en not_active Expired - Lifetime
- 1987-04-14 WO PCT/DK1987/000038 patent/WO1987006137A1/en not_active Ceased
- 1987-04-14 DE DE8787902450T patent/DE3772521D1/de not_active Expired - Lifetime
- 1987-04-14 AU AU73561/87A patent/AU598543B2/en not_active Ceased
- 1987-04-15 ES ES8701124A patent/ES2007607A6/es not_active Expired
- 1987-12-08 DK DK642587A patent/DK160460C/da not_active IP Right Cessation
- 1987-12-16 FI FI875533A patent/FI87529C/fi not_active IP Right Cessation
- 1987-12-17 NO NO875299A patent/NO875299D0/no unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58189118A (ja) *	1982-04-30	1983-11-04	Takeda Chem Ind Ltd	経鼻投与製剤
JPS59163313A (ja) *	1983-03-09	1984-09-14	Teijin Ltd	経鼻投与用ペプチドホルモン類組成物
JPS60224616A (ja) *	1984-04-24	1985-11-09	Teijin Ltd	経鼻投与用組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9387176B2 (en)	2007-04-30	2016-07-12	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein

Also Published As

Publication number	Publication date
AU7356187A (en)	1987-11-09
WO1987006137A1 (en)	1987-10-22
ES2007607A6 (es)	1989-07-01
IL82209A0 (en)	1987-10-30
DK160460C (da)	1991-08-26
NO875299L (no)	1987-12-17
ATE66614T1 (de)	1991-09-15
EP0267208B1 (en)	1991-08-28
DK160460B (da)	1991-03-18
CA1283358C (en)	1991-04-23
DK179286D0 (da)	1986-04-18
FI87529C (fi)	1993-01-25
AU598543B2 (en)	1990-06-28
FI875533L (fi)	1987-12-16
EP0267208A1 (en)	1988-05-18
DE3772521D1 (de)	1991-10-02
US5053389A (en)	1991-10-01
DK642587A (da)	1987-12-08
FI875533A0 (fi)	1987-12-16
DK642587D0 (da)	1987-12-08
FI87529B (fi)	1992-10-15
NO875299D0 (no)	1987-12-17

Publication	Publication Date	Title
EP0267208B1 (en)	1991-08-28	An insulin preparation for non-parenteral administration
US6310038B1 (en)	2001-10-30	Pulmonary insulin crystals
US4654327A (en)	1987-03-31	Quaternary ammonium complexes of heparin
JP5269767B2 (ja)	2013-08-21	インスリン誘導体
RU2198181C2 (ru)	2003-02-10	Не содержащие цинк кристаллы инсулина для применения в легочных композициях
Lehr	1996	From sticky stuff to sweet receptors—achievements, limits and novel approaches to bioadhesion
CN1159950A (zh)	1997-09-24	控制活性成分释放的生物粘合药物组合物
EP0566135A1 (en)	1993-10-20	Transmucosal composition comprising a peptide and a cytidine derivative
US4734276A (en)	1988-03-29	L-lysine pyruvate and l- histidine pyruvate and their use in therapy of tissue and mucosa damage
JPH02101022A (ja)	1990-04-12	糖尿病治療用医薬組成物
JPH05508616A (ja)	1993-12-02	治療用エアロゾル剤
JPH08504756A (ja)	1996-05-21	副甲状腺ホルモンの活性フラグメントの肺導入
JPH026405A (ja)	1990-01-10	経肺薬物送達用組成物
JP2720899B2 (ja)	1998-03-04	経粘膜吸収促進剤及びこれを用いた経鼻投与剤
JPH08277226A (ja)	1996-10-22	経鼻吸収用生理活性ペプチド組成物
JPH04149126A (ja)	1992-05-22	経粘膜投与用医薬組成物
JPS6039647B2 (ja)	1985-09-06	ガンマ−ｌ−グルタミル−タウリンの単離方法
JPH0585942A (ja)	1993-04-06	インターフエロン−ヒアルロン酸及び／又はその塩の結合体
JP3655645B2 (ja)	2005-06-02	経粘膜投与剤
JP2001505222A (ja)	2001-04-17	生物体にペプチド系医薬を導入するための局所用製剤
US4820811A (en)	1989-04-11	Amine reacted therapeutic agents
JPH0242027A (ja)	1990-02-13	経粘膜吸収促進剤及びこれを用いた経鼻投与剤
AU726940B2 (en)	2000-11-23	Permucosal preparation
WO2004039961A2 (en)	2004-05-13	Trefoil domain-containing polypeptides and uses thereof
JPH02214A (ja)	1990-01-05	鼻腔内投与用製剤

JPH01500116A - インシユリン製剤 - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=8108089

Family Applications (1)

Country Status (13)

Cited By (1)

Families Citing this family (48)

Citations (3)

Family Cites Families (13)

Patent Citations (3)

Cited By (1)

Also Published As

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