DK161965C - 6-thioxanthiner og salte deraf samt deres fremstilling og anvendelse - Google Patents

6-thioxanthiner og salte deraf samt deres fremstilling og anvendelse

Info

Publication number: DK161965C
Authority: DK; Denmark
Prior art keywords: group; thioxanthines; alkyl; salts; preparation
Prior art date: 1986-08-02

Application number

DK367787A

Other languages

English (en)

Other versions

DK367787A (da

DK367787D0 (da

DK161965B (da

Inventor

Peter Hofer

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-02

Filing date

1987-07-15

Publication date

1992-02-10

1987-07-15 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

1987-07-15 Publication of DK367787D0 publication Critical patent/DK367787D0/da

1988-02-03 Publication of DK367787A publication Critical patent/DK367787A/da

1991-09-02 Publication of DK161965B publication Critical patent/DK161965B/da

1992-02-10 Application granted granted Critical

1992-02-10 Publication of DK161965C publication Critical patent/DK161965C/da

Links

125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 3
-1 3,8-disubstituted-6-thioxanthines Chemical class 0.000 abstract 1
RJOXFJDOUQJOMQ-UHFFFAOYSA-N 6-sulfanylidene-3,7-dihydropurin-2-one Chemical compound S=C1NC(=O)NC2=C1NC=N2 RJOXFJDOUQJOMQ-UHFFFAOYSA-N 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

DK367787A 1986-08-02 1987-07-15 6-thioxanthiner og salte deraf samt deres fremstilling og anvendelse DK161965C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868618931A GB8618931D0 (en)	1986-08-02	1986-08-02	6-thioxanthines
GB8618931		1986-08-02

Publications (4)

Publication Number	Publication Date
DK367787D0 DK367787D0 (da)	1987-07-15
DK367787A DK367787A (da)	1988-02-03
DK161965B DK161965B (da)	1991-09-02
DK161965C true DK161965C (da)	1992-02-10

Family

ID=10602146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK367787A DK161965C (da)	1986-08-02	1987-07-15	6-thioxanthiner og salte deraf samt deres fremstilling og anvendelse

Country Status (13)

Country	Link
US (2)	US4925847A (da)
EP (1)	EP0256692B1 (da)
JP (1)	JP2590120B2 (da)
AT (1)	ATE80632T1 (da)
AU (1)	AU601456B2 (da)
CA (1)	CA1276147C (da)
DE (1)	DE3781743T2 (da)
DK (1)	DK161965C (da)
ES (1)	ES2046204T3 (da)
GB (1)	GB8618931D0 (da)
GR (1)	GR3005997T3 (da)
IE (1)	IE60510B1 (da)
ZA (1)	ZA875346B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4710503A (en) *	1985-02-07	1987-12-01	Euroceltique S.A.	6-thioxanthine derivatives
GB8618931D0 (en) *	1986-08-02	1986-09-10	Euro Celtique Sa	6-thioxanthines
JP2843634B2 (ja) *	1989-03-06	1999-01-06	協和醗酵工業株式会社	キサンチン誘導体
AU5436790A (en) *	1989-04-19	1990-11-16	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Sulfer-containing xanthine derivatives as adenosin antagonists
US5290782A (en) *	1989-09-01	1994-03-01	Kyowa Hakko Kogyo Co., Ltd.	Xanthine derivatives
JPH06102662B2 (ja) *	1989-09-01	1994-12-14	協和醗酵工業株式会社	キサンチン誘導体
GB9312853D0 (en) *	1993-06-22	1993-08-04	Euro Celtique Sa	Chemical compounds
US5922751A (en)	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) *	1994-06-24	1997-01-07	Euro-Celtique, S.A.	Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
EP0814809B1 (en)	1994-12-13	2003-08-13	Euroceltique S.A.	Aryl thioxanthines
JP2001523213A (ja)	1994-12-13	2001-11-20	ユーロ−セルティーク，エス．エイ．	三置換チオキサンチン類
US6025361A (en) *	1994-12-13	2000-02-15	Euro-Celtique, S.A.	Trisubstituted thioxanthines
US6268373B1 (en)	1995-06-07	2001-07-31	Euro-Celtique S.A.	Trisubstituted thioxanthines
US6166041A (en)	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en)	1996-04-10	2000-06-13	Euro-Celtique S.A.	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
AU2603197A (en)	1996-04-10	1997-10-29	United States Of America, Represented By The Secretary, Department Of Health And Human Services, The	Use of an a1 adenosine receptor agonist to treat cerebral ischaemia
US6294541B1 (en)	1996-06-06	2001-09-25	Euro-Celtique S.A.	Purine derivatives having phosphodiesterase IV inhibition activity
US5864037A (en) *	1996-06-06	1999-01-26	Euro-Celtique, S.A.	Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) *	1996-09-16	1998-04-28	Euro-Celtique, S.A.	PDE IV inhibitors: "bis-compounds"
US6040447A (en)	1997-12-12	2000-03-21	Euro-Celtique S.A.	Purine compounds having PDE IV inhibitory activity and methods of synthesis
US6319928B1 (en)	1998-11-30	2001-11-20	Euro-Celtique, S.A.	Purine derivatives having phosphodiesterase IV inhibition activity
CA2367143A1 (en)	1999-04-02	2000-10-12	Euro-Celtique S.A.	Purine derivatives having phosphodiesterase iv inhibition activity
ES2238335T3 (es)	1999-12-24	2005-09-01	Kyowa Hakko Kogyo Co., Ltd.	Derivados de purina condensados.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR188M (fr) *	1960-01-28	1961-02-20	May & Baker Ltd	Nouveaux dérivés de la thioxanthine et les compositions pharmaceutiques qui les contiennent.
US3900474A (en) *	1973-05-14	1975-08-19	Kendall & Co	Trifluoroalkyl, fluorobenzyl, pentafluorobenzyl, fluorobenzenesulfonyl, and pentafluorobenzenesulfonyl theophyllines
SE8002910L (sv) *	1980-04-18	1981-10-19	Draco Ab	3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar
US4710503A (en) *	1985-02-07	1987-12-01	Euroceltique S.A.	6-thioxanthine derivatives
GB8618931D0 (en) *	1986-08-02	1986-09-10	Euro Celtique Sa	6-thioxanthines

1986
- 1986-08-02 GB GB868618931A patent/GB8618931D0/en active Pending
1987
- 1987-07-15 DK DK367787A patent/DK161965C/da not_active IP Right Cessation
- 1987-07-21 ZA ZA875346A patent/ZA875346B/xx unknown
- 1987-07-22 CA CA000542734A patent/CA1276147C/en not_active Expired - Fee Related
- 1987-07-24 DE DE8787306557T patent/DE3781743T2/de not_active Expired - Fee Related
- 1987-07-24 AT AT87306557T patent/ATE80632T1/de not_active IP Right Cessation
- 1987-07-24 EP EP87306557A patent/EP0256692B1/en not_active Expired - Lifetime
- 1987-07-24 ES ES198787306557T patent/ES2046204T3/es not_active Expired - Lifetime
- 1987-07-28 US US07/078,545 patent/US4925847A/en not_active Expired - Lifetime
- 1987-07-30 JP JP62191515A patent/JP2590120B2/ja not_active Expired - Fee Related
- 1987-07-30 AU AU76286/87A patent/AU601456B2/en not_active Ceased
- 1987-07-31 IE IE207487A patent/IE60510B1/en not_active IP Right Cessation
1989
- 1989-10-02 US US07/415,970 patent/US5010081A/en not_active Expired - Lifetime
1992
- 1992-10-15 GR GR920402316T patent/GR3005997T3/el unknown

Also Published As

Publication number	Publication date
CA1276147C (en)	1990-11-13
JP2590120B2 (ja)	1997-03-12
DK367787A (da)	1988-02-03
EP0256692A3 (en)	1989-08-30
DE3781743T2 (de)	1993-03-25
DK367787D0 (da)	1987-07-15
JPS6341478A (ja)	1988-02-22
DK161965B (da)	1991-09-02
US4925847A (en)	1990-05-15
ES2046204T3 (es)	1994-02-01
IE60510B1 (en)	1994-07-27
AU601456B2 (en)	1990-09-13
AU7628687A (en)	1988-02-04
GB8618931D0 (en)	1986-09-10
IE872074L (en)	1988-02-02
EP0256692A2 (en)	1988-02-24
GR3005997T3 (da)	1993-06-07
DE3781743D1 (en)	1992-10-22
ZA875346B (en)	1988-01-27
ATE80632T1 (de)	1992-10-15
US5010081A (en)	1991-04-23
EP0256692B1 (en)	1992-09-16

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Legal Events

Date	Code	Title	Description
2006-04-18	PBP	Patent lapsed	Country of ref document: DK