ES2046204T3 - Un procedimiento para la preparacion de una 6-tioxantina. - Google Patents
Un procedimiento para la preparacion de una 6-tioxantina.Info
- Publication number
- ES2046204T3 ES2046204T3 ES198787306557T ES87306557T ES2046204T3 ES 2046204 T3 ES2046204 T3 ES 2046204T3 ES 198787306557 T ES198787306557 T ES 198787306557T ES 87306557 T ES87306557 T ES 87306557T ES 2046204 T3 ES2046204 T3 ES 2046204T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- thioxanthine
- alkyl
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RJOXFJDOUQJOMQ-UHFFFAOYSA-N 6-sulfanylidene-3,7-dihydropurin-2-one Chemical compound S=C1NC(=O)NC2=C1NC=N2 RJOXFJDOUQJOMQ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 3
- -1 3,8-disubstituted-6-thioxanthines Chemical class 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION TRATA DE UNA 6-TIOXANTINA DE FORMULA GENERAL (I) O DE UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ELLA, EN LA QUE R3 ES UN GRUPO ALQUILO DE 2 A 6 C, CICLOALQUILO DE 3 A 7 C O CICLOALQUILALQUILO DE 4 A 8 C, Y R8 ES UN GRUPO ALQUILO DE 1 A 6 C, CICLOALQUILO DE 3 A 7 C O CICLOALQUILALQUILO DE 4 A 8 C, SIEMPRE QUE CUANDO R3 SEA UN GRUPO ETILO, N-PROPILO O N-BUTILO, R8 SEA UN ALQUILO DE 3 A 6 C, CICLOALQUILO DE 3 A 7 C, O CICLOALQUILALQUILO DE 4 A 8 C. ESTAS 6-TIOXANTINAS 3,8-DISUSTITUIDAS TIENEN UNA ACTIVIDAD BRONCODILATADORA MEJORADA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868618931A GB8618931D0 (en) | 1986-08-02 | 1986-08-02 | 6-thioxanthines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2046204T3 true ES2046204T3 (es) | 1994-02-01 |
Family
ID=10602146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198787306557T Expired - Lifetime ES2046204T3 (es) | 1986-08-02 | 1987-07-24 | Un procedimiento para la preparacion de una 6-tioxantina. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US4925847A (es) |
| EP (1) | EP0256692B1 (es) |
| JP (1) | JP2590120B2 (es) |
| AT (1) | ATE80632T1 (es) |
| AU (1) | AU601456B2 (es) |
| CA (1) | CA1276147C (es) |
| DE (1) | DE3781743T2 (es) |
| DK (1) | DK161965C (es) |
| ES (1) | ES2046204T3 (es) |
| GB (1) | GB8618931D0 (es) |
| GR (1) | GR3005997T3 (es) |
| IE (1) | IE60510B1 (es) |
| ZA (1) | ZA875346B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4710503A (en) * | 1985-02-07 | 1987-12-01 | Euroceltique S.A. | 6-thioxanthine derivatives |
| GB8618931D0 (en) * | 1986-08-02 | 1986-09-10 | Euro Celtique Sa | 6-thioxanthines |
| JP2843634B2 (ja) * | 1989-03-06 | 1999-01-06 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| WO1990012797A1 (en) * | 1989-04-19 | 1990-11-01 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Sulfer-containing xanthine derivatives as adenosin antagonists |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| GB9312853D0 (en) * | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| EP0799040B1 (en) * | 1994-12-13 | 2003-08-20 | Euroceltique S.A. | Trisubstituted thioxanthines |
| US6066641A (en) * | 1994-12-13 | 2000-05-23 | Euro-Celtique S.A. | Aryl thioxanthines |
| US6268373B1 (en) | 1995-06-07 | 2001-07-31 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
| US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| AU2603197A (en) | 1996-04-10 | 1997-10-29 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Use of an a1 adenosine receptor agonist to treat cerebral ischaemia |
| US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| US5864037A (en) | 1996-06-06 | 1999-01-26 | Euro-Celtique, S.A. | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity |
| US6294541B1 (en) | 1996-06-06 | 2001-09-25 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
| US5744473A (en) * | 1996-09-16 | 1998-04-28 | Euro-Celtique, S.A. | PDE IV inhibitors: "bis-compounds" |
| DE19882892T1 (de) | 1997-12-12 | 2001-02-22 | Euro Celtique Sa | Herstellung von 3-substituierten Adeninen und Imidazopyridinen |
| US6319928B1 (en) | 1998-11-30 | 2001-11-20 | Euro-Celtique, S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
| AR029347A1 (es) | 1999-04-02 | 2003-06-25 | Euro Celtique Sa | Compuesto de adenina, compuesto de isognanina y 2,6-ditioxantina como precursor del mismo, uso de dichos compuestos para preparar una composicion farmaceutica y dicha composicion farmaceutica |
| AU2223501A (en) | 1999-12-24 | 2001-07-09 | Kyowa Hakko Kogyo Co. Ltd. | Fused purine derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR188M (fr) * | 1960-01-28 | 1961-02-20 | May & Baker Ltd | Nouveaux dérivés de la thioxanthine et les compositions pharmaceutiques qui les contiennent. |
| US3900474A (en) * | 1973-05-14 | 1975-08-19 | Kendall & Co | Trifluoroalkyl, fluorobenzyl, pentafluorobenzyl, fluorobenzenesulfonyl, and pentafluorobenzenesulfonyl theophyllines |
| SE8002910L (sv) * | 1980-04-18 | 1981-10-19 | Draco Ab | 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar |
| US4710503A (en) * | 1985-02-07 | 1987-12-01 | Euroceltique S.A. | 6-thioxanthine derivatives |
| GB8618931D0 (en) * | 1986-08-02 | 1986-09-10 | Euro Celtique Sa | 6-thioxanthines |
-
1986
- 1986-08-02 GB GB868618931A patent/GB8618931D0/en active Pending
-
1987
- 1987-07-15 DK DK367787A patent/DK161965C/da not_active IP Right Cessation
- 1987-07-21 ZA ZA875346A patent/ZA875346B/xx unknown
- 1987-07-22 CA CA000542734A patent/CA1276147C/en not_active Expired - Fee Related
- 1987-07-24 AT AT87306557T patent/ATE80632T1/de not_active IP Right Cessation
- 1987-07-24 DE DE8787306557T patent/DE3781743T2/de not_active Expired - Fee Related
- 1987-07-24 ES ES198787306557T patent/ES2046204T3/es not_active Expired - Lifetime
- 1987-07-24 EP EP87306557A patent/EP0256692B1/en not_active Expired - Lifetime
- 1987-07-28 US US07/078,545 patent/US4925847A/en not_active Expired - Lifetime
- 1987-07-30 AU AU76286/87A patent/AU601456B2/en not_active Ceased
- 1987-07-30 JP JP62191515A patent/JP2590120B2/ja not_active Expired - Fee Related
- 1987-07-31 IE IE207487A patent/IE60510B1/en not_active IP Right Cessation
-
1989
- 1989-10-02 US US07/415,970 patent/US5010081A/en not_active Expired - Lifetime
-
1992
- 1992-10-15 GR GR920402316T patent/GR3005997T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK367787D0 (da) | 1987-07-15 |
| GB8618931D0 (en) | 1986-09-10 |
| DK161965B (da) | 1991-09-02 |
| DK367787A (da) | 1988-02-03 |
| JPS6341478A (ja) | 1988-02-22 |
| DE3781743D1 (en) | 1992-10-22 |
| AU7628687A (en) | 1988-02-04 |
| IE60510B1 (en) | 1994-07-27 |
| JP2590120B2 (ja) | 1997-03-12 |
| IE872074L (en) | 1988-02-02 |
| AU601456B2 (en) | 1990-09-13 |
| GR3005997T3 (es) | 1993-06-07 |
| ZA875346B (en) | 1988-01-27 |
| CA1276147C (en) | 1990-11-13 |
| US4925847A (en) | 1990-05-15 |
| EP0256692A2 (en) | 1988-02-24 |
| EP0256692B1 (en) | 1992-09-16 |
| DK161965C (da) | 1992-02-10 |
| ATE80632T1 (de) | 1992-10-15 |
| DE3781743T2 (de) | 1993-03-25 |
| EP0256692A3 (en) | 1989-08-30 |
| US5010081A (en) | 1991-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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