ATE80632T1 - 6-thioxanthine. - Google Patents

6-thioxanthine.

Info

Publication number: ATE80632T1
Authority: AT; Austria
Prior art keywords: group; alkyl; thioxanthine; cycloalkylalkyl; cycloalkyl group
Prior art date: 1986-08-02

Application number

AT87306557T

Other languages

English (en)

Inventor

Peter Hofer

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-02

Filing date

1987-07-24

Publication date

1992-10-15

1987-07-24 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE80632T1 publication Critical patent/ATE80632T1/de

Links

RJOXFJDOUQJOMQ-UHFFFAOYSA-N 6-sulfanylidene-3,7-dihydropurin-2-one Chemical compound S=C1NC(=O)NC2=C1NC=N2 RJOXFJDOUQJOMQ-UHFFFAOYSA-N 0.000 title abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 3
-1 3,8-disubstituted-6-thioxanthines Chemical class 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

AT87306557T 1986-08-02 1987-07-24 6-thioxanthine. ATE80632T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868618931A GB8618931D0 (en)	1986-08-02	1986-08-02	6-thioxanthines
EP87306557A EP0256692B1 (de)	1986-08-02	1987-07-24	6-Thioxanthine

Publications (1)

Publication Number	Publication Date
ATE80632T1 true ATE80632T1 (de)	1992-10-15

Family

ID=10602146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87306557T ATE80632T1 (de)	1986-08-02	1987-07-24	6-thioxanthine.

Country Status (13)

Country	Link
US (2)	US4925847A (de)
EP (1)	EP0256692B1 (de)
JP (1)	JP2590120B2 (de)
AT (1)	ATE80632T1 (de)
AU (1)	AU601456B2 (de)
CA (1)	CA1276147C (de)
DE (1)	DE3781743T2 (de)
DK (1)	DK161965C (de)
ES (1)	ES2046204T3 (de)
GB (1)	GB8618931D0 (de)
GR (1)	GR3005997T3 (de)
IE (1)	IE60510B1 (de)
ZA (1)	ZA875346B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4710503A (en) *	1985-02-07	1987-12-01	Euroceltique S.A.	6-thioxanthine derivatives
GB8618931D0 (en) *	1986-08-02	1986-09-10	Euro Celtique Sa	6-thioxanthines
JP2843634B2 (ja) *	1989-03-06	1999-01-06	協和醗酵工業株式会社	キサンチン誘導体
AU5436790A (en) *	1989-04-19	1990-11-16	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Sulfer-containing xanthine derivatives as adenosin antagonists
JPH06102662B2 (ja) *	1989-09-01	1994-12-14	協和醗酵工業株式会社	キサンチン誘導体
US5290782A (en) *	1989-09-01	1994-03-01	Kyowa Hakko Kogyo Co., Ltd.	Xanthine derivatives
GB9312853D0 (en)	1993-06-22	1993-08-04	Euro Celtique Sa	Chemical compounds
US5591776A (en)	1994-06-24	1997-01-07	Euro-Celtique, S.A.	Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en)	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US6025361A (en) *	1994-12-13	2000-02-15	Euro-Celtique, S.A.	Trisubstituted thioxanthines
EP0799040B1 (de) *	1994-12-13	2003-08-20	Euroceltique S.A.	Dreifachsubstituierte thioxanthine
DE69531506T2 (de)	1994-12-13	2004-06-24	Euroceltique S.A.	Arylthioxanthine
US6268373B1 (en)	1995-06-07	2001-07-31	Euro-Celtique S.A.	Trisubstituted thioxanthines
US6166041A (en)	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en)	1996-04-10	2000-06-13	Euro-Celtique S.A.	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
AU2603197A (en)	1996-04-10	1997-10-29	United States Of America, Represented By The Secretary, Department Of Health And Human Services, The	Use of an a1 adenosine receptor agonist to treat cerebral ischaemia
US5864037A (en)	1996-06-06	1999-01-26	Euro-Celtique, S.A.	Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US6294541B1 (en)	1996-06-06	2001-09-25	Euro-Celtique S.A.	Purine derivatives having phosphodiesterase IV inhibition activity
US5744473A (en) *	1996-09-16	1998-04-28	Euro-Celtique, S.A.	PDE IV inhibitors: "bis-compounds"
CN1294590A (zh)	1997-12-12	2001-05-09	欧罗赛铁克股份有限公司	通过2－硫代黄嘌呤制备3－取代腺嘌呤的方法
US6319928B1 (en)	1998-11-30	2001-11-20	Euro-Celtique, S.A.	Purine derivatives having phosphodiesterase IV inhibition activity
CA2367143A1 (en)	1999-04-02	2000-10-12	Euro-Celtique S.A.	Purine derivatives having phosphodiesterase iv inhibition activity
EP1251130B1 (de)	1999-12-24	2005-02-16	Kyowa Hakko Kogyo Co., Ltd.	Kondensierte purinderivate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR188M (fr) *	1960-01-28	1961-02-20	May & Baker Ltd	Nouveaux dérivés de la thioxanthine et les compositions pharmaceutiques qui les contiennent.
US3900474A (en) *	1973-05-14	1975-08-19	Kendall & Co	Trifluoroalkyl, fluorobenzyl, pentafluorobenzyl, fluorobenzenesulfonyl, and pentafluorobenzenesulfonyl theophyllines
SE8002910L (sv) *	1980-04-18	1981-10-19	Draco Ab	3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar
US4710503A (en) *	1985-02-07	1987-12-01	Euroceltique S.A.	6-thioxanthine derivatives
GB8618931D0 (en) *	1986-08-02	1986-09-10	Euro Celtique Sa	6-thioxanthines

1986
- 1986-08-02 GB GB868618931A patent/GB8618931D0/en active Pending
1987
- 1987-07-15 DK DK367787A patent/DK161965C/da not_active IP Right Cessation
- 1987-07-21 ZA ZA875346A patent/ZA875346B/xx unknown
- 1987-07-22 CA CA000542734A patent/CA1276147C/en not_active Expired - Fee Related
- 1987-07-24 EP EP87306557A patent/EP0256692B1/de not_active Expired - Lifetime
- 1987-07-24 ES ES198787306557T patent/ES2046204T3/es not_active Expired - Lifetime
- 1987-07-24 AT AT87306557T patent/ATE80632T1/de not_active IP Right Cessation
- 1987-07-24 DE DE8787306557T patent/DE3781743T2/de not_active Expired - Fee Related
- 1987-07-28 US US07/078,545 patent/US4925847A/en not_active Expired - Lifetime
- 1987-07-30 AU AU76286/87A patent/AU601456B2/en not_active Ceased
- 1987-07-30 JP JP62191515A patent/JP2590120B2/ja not_active Expired - Fee Related
- 1987-07-31 IE IE207487A patent/IE60510B1/en not_active IP Right Cessation
1989
- 1989-10-02 US US07/415,970 patent/US5010081A/en not_active Expired - Lifetime
1992
- 1992-10-15 GR GR920402316T patent/GR3005997T3/el unknown

Also Published As

Publication number	Publication date
JPS6341478A (ja)	1988-02-22
DE3781743D1 (en)	1992-10-22
EP0256692A3 (en)	1989-08-30
DK161965C (da)	1992-02-10
DK367787D0 (da)	1987-07-15
US4925847A (en)	1990-05-15
IE60510B1 (en)	1994-07-27
AU7628687A (en)	1988-02-04
ES2046204T3 (es)	1994-02-01
DK367787A (da)	1988-02-03
ZA875346B (en)	1988-01-27
EP0256692A2 (de)	1988-02-24
JP2590120B2 (ja)	1997-03-12
IE872074L (en)	1988-02-02
CA1276147C (en)	1990-11-13
EP0256692B1 (de)	1992-09-16
GR3005997T3 (de)	1993-06-07
GB8618931D0 (en)	1986-09-10
DK161965B (da)	1991-09-02
US5010081A (en)	1991-04-23
DE3781743T2 (de)	1993-03-25
AU601456B2 (en)	1990-09-13

Legal Events

Date	Code	Title	Description
1993-03-15	UEP	Publication of translation of european patent specification
2006-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE80632T1 (de)	1992-10-15	6-thioxanthine.
AR241528A1 (es)	1992-08-31	Un procedimiento para la preparacion de n-(3- o 4-((alquilamino)alquil)-fenil)alcansulfonamidas y sus sales.
AU666702B2 (en)	1996-02-22	Morphinan derivative and medicinal use
FI892787A0 (fi)	1989-06-07	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
NL950022I2 (nl)	1996-12-02	Analoga van mevalolacton en derivaten daarvan, werkwijzen voor hun bereiding, farmaceutische prepar aten die ze bevatten en hun toepassing als farmaceutica.
SE8503922D0 (sv)	1985-08-22	Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
AU1433588A (en)	1988-10-13	1-phenyl-3-naphthalenyloxypropanamines
EP0270362A3 (de)	1989-11-08	Pyridinyl-Pyrimidin-Derivate, Verfahren zu deren Herstellung und diese als wirksamen Stoff enthaltendes fungicides Mittel
PT83104A (en)	1986-08-01	Novel guanidinomethylbenzoic acid derivatives
GR3035646T3 (en)	2001-06-29	Imidazole derivatives having anti-HIV activity
EP0331078A3 (de)	1990-09-12	Verfahren zur Herstellung von optisch wirksamer 4-Oxo-1-Benzopyran-2-carbonsäure und deren Zwischenprodukte
EP0272596A3 (en)	1990-03-28	Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included
EP0726269A4 (de)	1997-01-22	Quinolincarbonsäurederivat une seine salze
DE69001004D1 (de)	1993-04-08	Zusammensetzung gegen leberkrankheiten.
SE8601799D0 (sv)	1986-04-18	(-)-1beta-ethyl-1alfa-hydroxymethyl-1,2,3,4,6,7,12,12balfa-octahydroindolo/2,3-a/quinolizine, process for its preparation and pharmaceutical compositions containing same
DE69405999D1 (de)	1997-11-06	Pharmazeutisch wirksame enantiomere
AU2013888A (en)	1989-02-02	Uricosuric composition
DK644487A (da)	1988-06-10	Farmaceutisk praeparat indeholdende en 2-oxo-imidazolidinforbindelse
DE3782229D1 (de)	1992-11-19	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
FR2598914B1 (fr)	1991-10-25	Composition prophylactique et curative pour l'arteriosclerose
ZA86809B (en)	1986-11-26	Esters of n,n'-methylene-bis-(n-diaryloxy-phosphinyl)methyl)glycine)as herbicides