DK162282C - Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden

Info

Publication number
DK162282C
DK162282C DK137083A DK137083A DK162282C DK 162282 C DK162282 C DK 162282C DK 137083 A DK137083 A DK 137083A DK 137083 A DK137083 A DK 137083A DK 162282 C DK162282 C DK 162282C
Authority
DK
Denmark
Prior art keywords
1alfa
hexafluor
dihydroxycholecalciferoles
trihyd
3beta
Prior art date
Application number
DK137083A
Other languages
Danish (da)
English (en)
Other versions
DK162282B (da
DK137083A (da
DK137083D0 (da
Inventor
Hector F Deluca
Yoko Tanaka
Nobuo Ikekawa
Yoshiro Kobayashi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK137083A publication Critical patent/DK137083A/da
Publication of DK137083D0 publication Critical patent/DK137083D0/da
Priority to DK554084A priority Critical patent/DK165695C/da
Publication of DK162282B publication Critical patent/DK162282B/da
Application granted granted Critical
Publication of DK162282C publication Critical patent/DK162282C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK137083A 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden DK162282C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK554084A DK165695C (da) 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28679081 1981-07-27
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
PCT/US1982/000909 WO1983000335A1 (en) 1981-07-27 1982-07-06 26,26,26,27,27,27-HEXAFLUORO-1'alpha',25-DIHYDROXYCHOLECALCIFEROL AND PROCESS FOR PREPARING SAME
US8200909 1982-07-06

Publications (4)

Publication Number Publication Date
DK137083A DK137083A (da) 1983-03-25
DK137083D0 DK137083D0 (da) 1983-03-25
DK162282B DK162282B (da) 1991-10-07
DK162282C true DK162282C (da) 1992-03-16

Family

ID=23100174

Family Applications (2)

Application Number Title Priority Date Filing Date
DK137083A DK162282C (da) 1981-07-27 1983-03-25 Analogifremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholecalciferoler samt 26,26,26-27,27,27-hexafluor-1alfa,3beta,25-trihydroxycholest-5,7-dien til anvendelse som udgangsmateriale ved fremgangsmaaden
DK554084A DK165695C (da) 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK554084A DK165695C (da) 1981-07-27 1984-11-22 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol

Country Status (14)

Country Link
US (1) US4358406A (de)
JP (1) JPS58501176A (de)
AU (2) AU552210B2 (de)
BE (1) BE893943A (de)
CH (2) CH656134A5 (de)
DE (2) DE3250034C2 (de)
DK (2) DK162282C (de)
FR (1) FR2510566B1 (de)
GB (2) GB2102806B (de)
IE (2) IE54370B1 (de)
IL (5) IL76090A (de)
IT (1) IT1157309B (de)
NL (1) NL8220265A (de)
WO (1) WO1983000335A1 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (de) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorin enthaltende Vitamin-D3-Derivate und Zelldifferenzierung induzierende Mittel, die sie als aktiven Wirkstoff enthalten
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
AU666313B2 (en) * 1991-05-06 1996-02-08 Procter & Gamble Company, The Combined calcium and vitamin D supplements
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
PT665221E (pt) * 1992-10-16 2000-06-30 Chugai Pharmaceutical Co Ltd Derivado da vitamina d e processo para a sua producao
AU6247194A (en) * 1993-02-19 1994-09-14 Wisconsin Alumni Research Foundation Use of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife rol for the treatment of calcium metabolism disorders
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
IL139241A0 (en) 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
JP2011508743A (ja) * 2007-12-28 2011-03-17 ウィスコンシン アラムナイ リサーチ ファンデーション （２０ｓ）−２３，２３−ジフルオロ−２−メチレン−１９−ノル−ビスホモプレグナカルシフェロール−ビタミンｄ類縁体
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (de) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 und analoge davon zur behandlung von alopezie
FI2753632T3 (fi) * 2011-09-08 2023-08-02 Sage Therapeutics Inc Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä
RS67266B1 (sr) 2013-03-13 2025-10-31 Sage Therapeutics Inc Neuroaktivni steroidi i postupci za njihovu upotrebu
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
ES2536256B2 (es) 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
FI3828194T3 (fi) 2015-07-06 2025-07-17 Sage Therapeutics Inc Oxysteroleita ja menetelmiä niiden käyttämiseksi
US20190330259A1 (en) 2016-04-01 2019-10-31 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP7149266B2 (ja) 2016-09-30 2022-10-06 セージ セラピューティクス， インコーポレイテッド Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
MA46566A (fr) 2016-10-18 2019-08-28 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
IL66351A0 (en) 1982-11-30
DE3248900T1 (de) 1983-07-07
IL76091A (en) 1987-12-31
IT8222574A0 (it) 1982-07-26
IL76091A0 (en) 1985-12-31
WO1983000335A1 (en) 1983-02-03
US4358406A (en) 1982-11-09
NL8220265A (nl) 1983-06-01
IL66351A (en) 1987-12-31
AU586267B2 (en) 1989-07-06
DK554084D0 (da) 1984-11-22
IL76090A0 (en) 1985-12-31
DK162282B (da) 1991-10-07
CH656134A5 (de) 1986-06-13
IE821797L (en) 1983-01-27
FR2510566A1 (fr) 1983-02-04
JPS58501176A (ja) 1983-07-21
CH655307A5 (de) 1986-04-15
IL76090A (en) 1987-12-31
AU552210B2 (en) 1986-05-22
GB8311517D0 (en) 1983-06-02
IE54370B1 (en) 1989-09-13
DK165695C (da) 1993-06-07
AU8760582A (en) 1983-03-17
AU6056086A (en) 1986-12-18
JPH0348903B2 (de) 1991-07-25
GB2118556B (en) 1985-02-27
GB2102806B (en) 1985-02-27
DE3250034C2 (de) 1991-02-28
DK165695B (da) 1993-01-04
FR2510566B1 (fr) 1985-06-28
DK137083A (da) 1983-03-25
DE3248900C2 (de) 1990-12-13
GB2118556A (en) 1983-11-02
DK554084A (da) 1984-11-22
IE891226L (en) 1983-01-27
IT1157309B (it) 1987-02-11
GB2102806A (en) 1983-02-09
IE54369B1 (en) 1989-09-13
BE893943A (fr) 1982-11-16
DK137083D0 (da) 1983-03-25

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