NO832610L - Derivater av morfolinyl-daunorubicin og morfolinyl-doxorubicin og analoge derav samt fremgangsmaate for fremstilling av disse - Google Patents

Derivater av morfolinyl-daunorubicin og morfolinyl-doxorubicin og analoge derav samt fremgangsmaate for fremstilling av disse

Info

Publication number: NO832610L
Authority: NO; Norway
Prior art keywords: morpholinyl; daunorubicin; doxorubicin; analogs; derivatives
Prior art date: 1982-07-20

Application number

NO832610A

Other languages

English (en)

Other versions

NO157146B (no

NO157146C (no

Inventor

Carol Walker Mosher

George Low Tong

Edward Mcintosh Acton

Original Assignee

Stanford Res Inst Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-20

Filing date

1983-07-18

Publication date

1984-01-23

1983-07-18 Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int

1984-01-23 Publication of NO832610L publication Critical patent/NO832610L/no

1987-10-19 Publication of NO157146B publication Critical patent/NO157146B/no

1988-01-27 Publication of NO157146C publication Critical patent/NO157146C/no

Links

SXCIMUIAZXOVIR-PUCKCBAPSA-N (7s,9s)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7-[(2r,4s,5s,6s)-5-hydroxy-6-methyl-4-morpholin-4-yloxan-2-yl]oxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound N1([C@H]2C[C@@H](O[C@@H](C)[C@H]2O)O[C@H]2C[C@@](O)(CC=3C(O)=C4C(=O)C=5C=CC=C(C=5C(=O)C4=C(O)C=32)OC)C(=O)CO)CCOCC1 SXCIMUIAZXOVIR-PUCKCBAPSA-N 0.000 title 1
229960000975 daunorubicin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NO832610A 1982-07-20 1983-07-18 Analogifremgangsmaate ved fremstilling av terapeutisk, aktive derivater av morfolinyl-daunorbicin og morfolinyl-doksorubicin. NO157146C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40012082A	1982-07-20	1982-07-20
US06/496,122 US4464529A (en)	1982-07-20	1983-05-24	Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Publications (3)

Publication Number	Publication Date
NO832610L true NO832610L (no)	1984-01-23
NO157146B NO157146B (no)	1987-10-19
NO157146C NO157146C (no)	1988-01-27

Family

ID=27016900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO832610A NO157146C (no)	1982-07-20	1983-07-18	Analogifremgangsmaate ved fremstilling av terapeutisk, aktive derivater av morfolinyl-daunorbicin og morfolinyl-doksorubicin.

Country Status (24)

Country	Link
US (1)	US4464529A (no)
KR (1)	KR880002461B1 (no)
AT (1)	AT381319B (no)
AU (1)	AU555902B2 (no)
BE (1)	BE897312A (no)
CA (1)	CA1239396A (no)
CH (1)	CH655729A5 (no)
DE (1)	DE3325816A1 (no)
DK (1)	DK158269C (no)
ES (2)	ES8501415A1 (no)
FI (1)	FI75174C (no)
FR (1)	FR2530640B1 (no)
GB (1)	GB2124224B (no)
GR (1)	GR78885B (no)
IE (1)	IE55795B1 (no)
IL (1)	IL69260A (no)
IT (1)	IT1163818B (no)
NL (1)	NL188905C (no)
NO (1)	NO157146C (no)
NZ (1)	NZ204911A (no)
PH (1)	PH21860A (no)
PT (1)	PT77060B (no)
SE (1)	SE459921B (no)
YU (2)	YU155083A (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4826964A (en) *	1982-07-20	1989-05-02	Sri International	Bridged oxygen analogs of daunorubcin and doxorubicin
JPS59212499A (ja) *	1983-05-13	1984-12-01	アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド	抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
GB2140006A (en) *	1983-05-17	1984-11-21	Erba Farmitalia	Anthracycline derivatives
US4585859A (en) *	1983-05-24	1986-04-29	Sri International	Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
FR2560876B1 (fr) *	1984-03-09	1987-01-16	Hoechst Lab	Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
FR2565982B1 (fr) *	1984-06-15	1988-01-15	Hoechst Lab	Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
GB8426672D0 (en) *	1984-10-22	1984-11-28	Erba Farmitalia	Pharmaceutical compositions
US4705850A (en) *	1984-10-25	1987-11-10	Sri International	C-glycosidic adriamycin analogs
US4591637A (en) *	1985-01-17	1986-05-27	Sri International	Open chain-morpholino adriamycins
US4710564A (en) *	1985-01-18	1987-12-01	Microbial Chemistry Research Foundation	Anthracycline compounds
GB2172594B (en) *	1985-03-22	1988-06-08	Erba Farmitalia	New morpholino derivatives of daunorubicin and doxorubicin
GB8519452D0 (en) *	1985-08-02	1985-09-11	Erba Farmitalia	Injectable solutions
US5124317A (en) *	1985-08-02	1992-06-23	Farmitalia Carlo Erba S.P.A.	Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5137877B1 (en) *	1990-05-14	1996-01-30	Bristol Myers Squibb Co	Bifunctional linking compounds conjugates and methods for their production
GB9019933D0 (en) *	1990-09-12	1990-10-24	Erba Carlo Spa	13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
US5196522A (en) *	1990-11-01	1993-03-23	Board Of Regents, The University Of Texas System	Anthracycline analogues bearing latent alkylating substituents
US5843903A (en) *	1995-11-27	1998-12-01	The Administrators Of The Tulane Educational Fund	Targeted cytotoxic anthracycline analogs
ATE344801T1 (de) *	1999-12-29	2006-11-15	Immunogen Inc	Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
WO2005086951A2 (en) *	2004-03-10	2005-09-22	Threshold Pharmaceuticals, Inc.	Hypoxia-activated anti-cancer agents
US20070060534A1 (en) *	2005-06-30	2007-03-15	Threshold Pharmaceuticals, Inc.	Anthracycline analogs
WO2009124468A1 (zh) *	2008-04-11	2009-10-15	天津和美生物技术有限公司	具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
RU2013103763A (ru)	2010-07-02	2014-08-10	Ангиохем Инк.	Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
WO2016040825A1 (en)	2014-09-12	2016-03-17	Genentech, Inc.	Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en)	2021-11-10	2023-05-17	Nerviano Medical Sciences S.r.l.	Anthracycline derivative linker reagents, antibody-drug conjugates and methods
WO2025168481A1 (en)	2024-02-05	2025-08-14	Nerviano Medical Sciences S.R.L.	Imino-anthracycline derivatives and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4109076A (en) *	1977-09-08	1978-08-22	Sri International	5-iminodaunomycin
US4202967A (en) *	1978-10-02	1980-05-13	Sri International	N,N-pentamethylene derivatives of daunomycin and adriamycin
US4301277A (en) *	1980-10-20	1981-11-17	Sri International	3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) *	1981-03-23	1982-02-02	Sri International	3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin

1983
- 1983-05-24 US US06/496,122 patent/US4464529A/en not_active Expired - Lifetime
- 1983-07-15 NZ NZ204911A patent/NZ204911A/en unknown
- 1983-07-15 AT AT0260883A patent/AT381319B/de not_active IP Right Cessation
- 1983-07-15 GB GB08319165A patent/GB2124224B/en not_active Expired
- 1983-07-18 DE DE19833325816 patent/DE3325816A1/de active Granted
- 1983-07-18 FR FR8311803A patent/FR2530640B1/fr not_active Expired
- 1983-07-18 BE BE0/211190A patent/BE897312A/fr not_active IP Right Cessation
- 1983-07-18 IL IL69260A patent/IL69260A/xx unknown
- 1983-07-18 PH PH29236A patent/PH21860A/en unknown
- 1983-07-18 AU AU16946/83A patent/AU555902B2/en not_active Ceased
- 1983-07-18 YU YU01550/83A patent/YU155083A/xx unknown
- 1983-07-18 NO NO832610A patent/NO157146C/no unknown
- 1983-07-19 SE SE8304045A patent/SE459921B/sv not_active IP Right Cessation
- 1983-07-19 KR KR1019830003323A patent/KR880002461B1/ko not_active Expired
- 1983-07-19 ES ES524271A patent/ES8501415A1/es not_active Expired
- 1983-07-19 DK DK332983A patent/DK158269C/da not_active IP Right Cessation
- 1983-07-19 FI FI832637A patent/FI75174C/fi not_active IP Right Cessation
- 1983-07-19 NL NLAANVRAGE8302586,A patent/NL188905C/xx not_active IP Right Cessation
- 1983-07-19 GR GR71976A patent/GR78885B/el unknown
- 1983-07-19 CA CA000432737A patent/CA1239396A/en not_active Expired
- 1983-07-19 PT PT77060A patent/PT77060B/pt not_active IP Right Cessation
- 1983-07-19 CH CH3949/83A patent/CH655729A5/de not_active IP Right Cessation
- 1983-07-19 IE IE1680/83A patent/IE55795B1/en not_active IP Right Cessation
- 1983-07-20 IT IT22143/83A patent/IT1163818B/it active
1984
- 1984-03-14 ES ES530593A patent/ES8602032A1/es not_active Expired
1985
- 1985-09-09 YU YU01405/85A patent/YU140585A/xx unknown

Also Published As

Publication number	Publication date
NZ204911A (en)	1986-04-11
ES524271A0 (es)	1984-11-16
ES530593A0 (es)	1985-11-01
ES8501415A1 (es)	1984-11-16
DK332983A (da)	1984-01-21
IL69260A (en)	1987-03-31
GB2124224B (en)	1985-12-04
KR880002461B1 (ko)	1988-11-14
DK158269B (da)	1990-04-23
IT8322143A1 (it)	1985-01-20
DE3325816A1 (de)	1984-01-26
NL188905C (nl)	1992-11-02
IT1163818B (it)	1987-04-08
KR840005443A (ko)	1984-11-12
SE459921B (sv)	1989-08-21
NO157146B (no)	1987-10-19
CH655729A5 (de)	1986-05-15
ATA260883A (de)	1986-02-15
AU555902B2 (en)	1986-10-16
FR2530640B1 (fr)	1985-07-12
DE3325816C2 (no)	1990-05-03
PT77060B (en)	1986-04-09
NL8302586A (nl)	1984-02-16
IE55795B1 (en)	1991-01-16
BE897312A (fr)	1984-01-18
GB2124224A (en)	1984-02-15
GR78885B (no)	1984-10-02
FI75174B (fi)	1988-01-29
YU155083A (en)	1986-02-28
SE8304045L (sv)	1984-01-21
PH21860A (en)	1988-03-25
FI832637A0 (fi)	1983-07-19
NO157146C (no)	1988-01-27
IT8322143A0 (it)	1983-07-20
DK332983D0 (da)	1983-07-19
AT381319B (de)	1986-09-25
AU1694683A (en)	1984-01-26
US4464529A (en)	1984-08-07
FI75174C (fi)	1988-05-09
ES8602032A1 (es)	1985-11-01
GB8319165D0 (en)	1983-08-17
DK158269C (da)	1990-10-08
IL69260A0 (en)	1983-11-30
YU140585A (en)	1986-02-28
FI832637A7 (fi)	1984-01-21
PT77060A (en)	1983-08-01
CA1239396A (en)	1988-07-19
SE8304045D0 (sv)	1983-07-19
FR2530640A1 (fr)	1984-01-27
IE831680L (en)	1984-01-20

Publication	Publication Date	Title
NO832610L (no)	1984-01-23	Derivater av morfolinyl-daunorubicin og morfolinyl-doxorubicin og analoge derav samt fremgangsmaate for fremstilling av disse
NO163668C (no)	1990-07-04	Fremgangsmaate for fremstilling av immunogent kompleks.
NO166218C (no)	1991-06-19	Fremgangsmaate for hydrolysering av cos.
DK307883A (da)	1984-01-06	Carbostyrilderivater samt fremgangsmaade til fremstilling deraf
FI841522A0 (fi)	1984-04-16	Processtyrsystem med felsoekning.
NO158461C (no)	1988-09-14	Analogifremgangsmaate for fremstilling av fenyl-piperidin-propanol-derivater.
RO90861A (ro)	1987-04-30	Procedeu pentru prepararea etielnglicolului
NO162158C (no)	1989-11-15	Fremgangsmaate for fremstilling av polyolefiner.
RO86213A (ro)	1985-03-15	Procedeu pentru prepararea izobutenei
ES531285A0 (es)	1985-11-01	Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina
NO812464L (no)	1982-01-19	Fremgangsmaate til fremstilling av antiviralt virksomme forbindelser, samt preparater inneholdende disse
DK409784D0 (da)	1984-08-28	Substituerede phenyl-alifatiske isoxaler, fremgangsmaade til fremstilling deraf samt antivirale praeparater indeholdende disse
DK446082A (da)	1983-04-22	Fremgangsmaade til fremstilling af chlordioxid samt apparat til anvendelse derved
FI832257A0 (fi)	1983-06-21	Foerfarande foer framstaellning av fenolskum med hjaelp av vattenfria arylsulfonsyrakatalyter
FI832004A7 (fi)	1983-12-04	Menetelmä 1-sulfo-2-oksoatsetidiini- johdannaisten valmistamiseksi.
AR229519A1 (es)	1983-09-15	Procedimiento de preparacion de derivados de 2,3-dihidro-9-fenil-1h-pirazolo(1,2-a)-indazolio
NO159716C (no)	1989-02-01	Apparat til fremstilling av mellomofaseagglomerater.
NO830176L (no)	1983-07-29	Fremgangsmaate for fremstilling av ultrarent toriumfluorid
NO160335C (no)	1989-04-12	Fremgangsmaate for fremstilling av roerkokiller.
NO162018C (no)	1989-10-25	Fremgangsmaate for fremstilling av 4-metyl-5-alkyltiometylimidazoler.
ES533618A0 (es)	1985-10-16	Procedimiento de preparacion de nuevos derivados de guarnina.
NO811628L (no)	1981-11-16	Fremgangsmaate for fremstilling av karbapenam- og karbapen-2-em-derivater.
DK423284A (da)	1985-03-09	Naphthalenylimidazopyridin og derivater heraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DK364483D0 (da)	1983-08-10	14-aminosteroid-derivater samt fremgangsmade til fremstilling deraf
NO831874L (no)	1983-11-28	Fremgangsmaate for fremstilling av trifenylbuten-derivater